Base de dados : LILACS
Pesquisa : C12.777.419.570 [Categoria DeCS]
Referências encontradas : 79 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 8 ir para página                    

  1 / 79 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-949524
Autor: Restrepo, Mauricio; Morales, Laura; González, Luis Alonso.
Título: Paquimeningitis, aortitis y nefritis simulando arteritis temporal / Pachymeningitis, aortitis and nephritis simulating temporal arteritis
Fonte: Acta méd. colomb;41(4):259-265, oct.-dic. 2016. tab, graf.
Idioma: es.
Resumo: Resumen Se presenta el caso de un hombre de 65 años con cuadro clínico de cefalea y velocidad de sedimentación globular elevada en quien se sospechó arteritis de células gigantes (ACG), pero durante el proceso diagnóstico se le documentó paquimeningitis, hiperproteinorraquia y biopsia de arteria temporal reportada como normal. La búsqueda de otras enfermedades sistémicas que explicaran el cuadro clínico evidenció además la presencia de aortitis, glomerulonefritis y anticuerpos anticitoplasma de neutrófilos (ANCA) positivos, lo cual permitió hacer el diagnóstico de granulomatosis con poliangeítis (GP). Se presenta el análisis y enfoque diagnóstico de esta inusual asociación de paquimeningitis, aortitis y glomerulonefritis. (Acta Med Colomb 2016; 40: 259-265).

Abstract The case of a 65-year-old man with a clinical picture of headache and elevated erythrocyte sedimentation rate in whom giant cell arteritis (GCA) was suspected, but that during the diagnostic process was documented as pachymeningitis, hyperproteinorrachia and temporal artery biopsy reported as normal, is presented. The search for other systemic diseases that could explain the clinical picture also revealed the presence of aortitis, glomerulonephritis and anti-neutrophil cytoplasmic antibodies (ANCA), and allowed to make the diagnosis of granulomatosis with poliangeítis (GPA). The analysis and diagnostic approach of this unusual association of pachymeningitis, aortitis and glomerulonephritis is reported. (Acta Med Colomb 2016; 40:259-265).
Descritores: Aortite
Meningite
-Relatos de Casos
Granulomatose com Poliangiite
Nefrite
Limites: Humanos
Masculino
Idoso
Tipo de Publ: Relatos de Casos
Responsável: CO70 - Asociación Colombiana de Medicina Interna


  2 / 79 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-892978
Autor: Ma, Liang; Yu, Yanlan; Ge, Guangju; Li, Gonghui.
Título: Laparoscopic nephrectomy outside gerota fascia and en bloc ligation of the renal hilum for management of inflammatory renal diseases
Fonte: Int. braz. j. urol;44(2):280-287, Mar.-Apr. 2018. tab, graf.
Idioma: en.
Projeto: Department of Education of Zhejiang Province.
Resumo: ABSTRACT Objectives This study aims to improve laparoscopic nephrectomy techniques for inflammatory renal diseases (IRD) and to reduce complications. Materials and Methods Thirty-three patients underwent laparoscopic nephrectomy for IRD, with a method of outside Gerota fascia dissection and en-bloc ligation and division of the renal pedicle. Operative time, blood loss, complications, analgesia requirement, post-operative recovery of intestinal function and hospital stay were recorded. The degrees of perinephric adhesion were classified based on the observation during operation and post-operative dissection of the specimen, and the association of different types of adhesion with the difficulty of the procedures was examined. Results Among 33 cases, three were converted to hand-assisted laparoscopy, and one was converted to open surgery. Mean operative time was 99.6±29.2min, and blood loss was 75.2±83.5 mL. Postoperative recovery time of intestinal function was 1.6±0.7 days and average hospital stay was 4.8±1.4 days. By classification and comparison of the perinephric adhesions, whether inflammation extending beyond Gerota fascia or involving renal hilum was found to be not only an important factor influencing the operative time and blood loss, but also the main reason for conversion to hand-assisted laparoscopy or open surgery. Conclusions In laparoscopic nephrectomy, outside Gerota fascia dissection of the kidney and en-bloc ligation of the renal pedicle using EndoGIA could reduce the difficulty of procedure and operative time, with satisfactory safety and reliability. Inflammation and adhesion extending beyond Gerota fascia or involving renal hilum is an important predictor of the difficulty related to laparoscopic nephrectomy for IRD.
Descritores: Pielonefrite/cirurgia
Tuberculose Renal/cirurgia
Pionefrose/cirurgia
Laparoscopia Assistida com a Mão/efeitos adversos
Nefropatias/cirurgia
Nefrectomia/métodos
Nefrite/cirurgia
-Pielonefrite Xantogranulomatosa/cirurgia
Reprodutibilidade dos Testes
Perda Sanguínea Cirúrgica
Fístula Intestinal/cirurgia
Doenças do Colo/cirurgia
Duração da Cirurgia
Fístula/cirurgia
Tempo de Internação
Pessoa de Meia-Idade
Nefrectomia/efeitos adversos
Limites: Humanos
Masculino
Feminino
Adulto
Idoso
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  3 / 79 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-1088627
Autor: Schinzel, Vânia; Fernandez, Jade Dib; Clemente, Gleice; Fraga, Melissa Mariti; Andrade, Maria Cristina; Len, Claudio Arnaldo; Terreri, Maria Teresa.
Título: The profile and clinical outcomes of patients with renal involvement due to IgA vasculitis: is azathioprine a good option for treatment?
Fonte: Adv Rheumatol;59:21, 2019. tab, graf.
Idioma: en.
Resumo: Abstract Background: The Henoch-Schonlein Purpura (HSP) or IgA vasculitis is the most common vasculitis of childhood and may occur with renal involvement, with hematuria and / or proteinuria, and may cause severe and non-reversible sequelae. Objectives: To establish the profile of patients with renal involvement due to IgA vasculitisand to describe our experience with the use of azathioprine to treat patients with nephritis. Methods: Clinical data were retrospectively collected from medical records of patients with IgA vasculitiswho attended the pediatric rheumatology unit between 1995 and 2017. Patients were separated into two groups based on whether or notthey weretreated with non-glucocorticoid immunosuppressants. Results: From the178 patients with IgA vasculitis, nephritis was found in67 patients (37.6%), 13 of whom receivedtreatment with non-glucocorticoid immunosuppressants. Ten patients responded well to azathioprine and 1 patient to cyclosporine. Forty patients received oral glucocorticoids, whilst 16received intravenous glucocorticoids. Conclusion: Azathioprine may be beneficial in the treatment of IgA vasculitis with renal involvement.
Descritores: Púrpura de Schoenlein-Henoch/fisiopatologia
Azatioprina/uso terapêutico
Vasculite/fisiopatologia
Nefrite/tratamento farmacológico
-Perfil de Saúde
Limites: Humanos
Responsável: BR1.1 - BIREME


  4 / 79 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-1088640
Autor: Delfino, Juliana; Santos, Thiago Alberto F. G. dos; Skare, Thelma L.
Título: Comparison of lupus patients with early and late onset nephritis: a study in 71 patients from a single referral center
Fonte: Adv Rheumatol;60:05, 2020. tab.
Idioma: en.
Resumo: Abstract Background: Nephritis occurs frequently in systemic lupus erythematosus (SLE) and may worsen disease morbidity and mortality. Knowing all characteristics of this manifestation helps to a prompt recognition and treatment. Aim: To compare the differences in clinical data, serological profile and treatment response of nephritis of early and late onset. Methods: Retrospective study of 71 SLE patients with biopsy proven nephritis divided in early nephritis group (diagnosis of nephritis in the first 5 years of the disease) and late nephritis (diagnosis of nephritis after 5 years). Epidemiological, serological, clinical and treatment data were collected from charts and compared. Results: In this sample, 70. 4% had early onset nephritis and 29.6% had late onset. No differences were noted in epidemiological, clinical, serological profile, SLICC and SLEDAI, except that late onset nephritis patients were older at nephritis diagnosis (p = 0.01). Regarding renal biopsy classification, C3 and C4 levels, serum creatinine, 24 h proteinuria and response rate to treatment the two groups were similar (p = NS). Patients with early onset had lower levels of hemoglobin at nephritis onset than those of late onset (p = 0.02). Conclusions: Most of SLE patients had nephritis in the first 5 years of disease. No major differences were noted when disease profile or treatment outcome of early and late onset nephritis were compared.(AU)
Descritores: Lúpus Eritematoso Sistêmico/fisiopatologia
Nefrite/diagnóstico
-Prognóstico
Estudos Retrospectivos
Diagnóstico Tardio
Limites: Humanos
Responsável: BR1.1 - BIREME


  5 / 79 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Texto completo
Id: biblio-1122950
Autor: Garrido Baza, Jorge; Rojano Rada, Jairo; Fernández Mestre, Mercedes.
Título: Relevancia del polimorfismo de eliminación del gen gstm1 y gstt1 en pacientes con nefritis lupica / Relevance of the elimination polymorphism of the gstm1 and gstt1 gene in patients with lupic nephritis
Fonte: Biociencias;15(1):59-72, jun.2020.
Idioma: es.
Resumo: Objective: To identify if the absence of the GSTM1 and / or GSTT1 genes is correlated with the response to cyclophosphamide and the presence of anti DNA in a patient with SLE. Methodology: An correlational cross study that included 46 patients with a diagnosis of systemic lupus erythematosus. (LES), who attended the rheumatology clinic of the Venezuelan Institute of Social Security- Central Hospital "Dr. Miguel Pérez Carreño ", during the period June 2016 - June 2017. Patients with SLE were classified according to the presence or absence of renal involvement (lupus nephritis). Each individual was extracted 5 mL of peripheral blood, from which the genomic DNA was extracted. The presence or absence of the GSTM1 and GSTT1 genes was determined using the multiplex polymerase chain reaction method with specific primers. Results: In the studied population (n = 46), 95.7% were women and only 4.3% men. The average age was 31 years, being mostly young women of childbearing age. The treatment of patients included the use of chloroquine (78%), mycophenolate (69.6%) and corticoids (38.7%). The GST genes were present, the GSTM1 gene with a frequency.

Objetivo: Identificar si la ausencia de los genes GSTM1 y/o GSTT1 está correlacionada con la respuesta a ciclofosfamida y con la presencia de anti DNA en paciente con LES. Metodología: Estudio transversal correlacional, que incluyó 46 pacientes con diagnóstico de lupus eritematoso sistémico (LES), que acudieron a la consulta de reumatología del Instituto Venezolano del Seguro Sociales- Hospital Central "Dr. Miguel Pérez Carreño", durante el período septiembre 2016 ­ junio de 2017. Los pacientes con LES se clasificaron de acuerdo a la presencia o no de afectación renal (nefritis lúpica). A cada individuo se le extrajo 5 mL de sangre periférica, a partir de la cual se extrajo el ADN genómico. La presencia o ausencia de los genes GSTM1 y GSTT1 se determinó utilizando el método de reacción en cadena de la polimerasa múltiplex con iniciadores específicos. Resultados: En la población estudiada (n= 46), 95,7% eran mujeres y sólo 4,3% hombres. La edad media fue de 31 años, siendo en su mayoría mujeres jóvenes en edad fértil. El tratamiento de los pacientes, comprendió el uso de cloroquina (78%), micofenolato (69,6 %) y corticoides (38,7%). Los genes GST estuvieron presentes, el gen GSTM1 con una frecuencia del 100 % y GSTT1 del 93,5%. Solo un 6,5% de los pacientes no presentaron el gen GSTT1. Conclusión: No se observó una correlación entre la presencia y/o ausencia de los genes GSTM1 y GSTT1 con la respuesta al tratamiento con Ciclofosfamida ni a la presencia de anti-DNA
Descritores: Polimorfismo Genético
-DNA
GENEALOGY AND HERALDRYABDOMEN, ACUTE
PATIENT CARE0
Nefrite
Limites: Humanos
Responsável: CO69.3 - Biblioteca


  6 / 79 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: lil-559299
Autor: Teniente Urbina, Maria Elena; Casas Castañeda, Jorge; Ortiz Saavedra, Pedro José.
Título: Pancreatitis, miocarditis y nefritis intersticial asociadas a infección aguda por el virus de Epstein barr / Pancreatitis, myocarditis and interstitial nephritis associated with acute infection with Epstein barr virus
Fonte: Rev. gastroenterol. Perú;29(4):367-373, oct.-dic. 2009. graf, tab.
Idioma: es.
Resumo: INTRODUCCION: El virus de Epstein-Barr (EBV) es un herpes virus ampliamente diseminado, que se transmite por el contacto entre personas susceptibles y portadores asintomáticos. Las manifestaciones clínicas varían desde mononucleosis infecciosa no complicada hasta linfoma de Burkitt. La mayoría de las infecciones primarias son subclínicas, después de un pródromo de febrícula y malestar general, se presenta la tríada clásica de dolor de garganta, fiebre y linfadenitis. En algunos casos se presentan cuadros atípicos con complicaciones potencialmente fatales. Se presenta el caso de una mujer de 39 años que ingresa por dolor abdominal, nauseas y vómito; una semana antes del ingreso presentó odinofagia y fiebre. Durante la hospitalización presenta niveles elevados de amilasa, azoemia, y posteriormente insuficiencia respiratoria y shock distributivo asociado a injuria miocárdica. El cuadro remite con medidas de soporte de forma espontánea. Se enfoca el caso como pancreatitis, insuficiencia renal y miocarditis asociadas a infección aguda por el EBV, el diagnóstico fueconfirmado por pruebas serológicas.CONCLUSIÓN: El EBV puede afectar virtualmente cualquier sistema y puede dar en forma inusual una gran variedad de presentaciones clínicas por lo que se debe considerar en el diagnostico diferencial en cuadros febriles sin etiología conocida y con compromiso devarios órganos.

INTRODUCTION: Epstein-Barr virus (EBV) is a widely disseminated herpesvirus that is spreadby intimate contact between susceptible persons and asymptomatic EBV shedders. Clinical manifestations range from uncomplicated infectious mononucleosis to Burkitt lymphoma.The majority of primary EBV infections throughout the world are subclinical, after a prodromal period of feverishness, and malaise, the disease presents with the classic triad of severesore throat, fever and lymphadenopathy. In some cases an atypical presentation can occur that may lead to potentially fatal complication. CASE PRESENTATION: A 39-year-old woman was admitted because of abdominal pain,nausea and vomiting; one week before admission the patient noticed sore throath and fever. During hospitalization an acute pancreatitis was documented with elevated serum amylase and Balthazar B CT, in addition to an acute renal failure; subsequently presentedrespiratory failure and distributive shock associated to myocardial injury. These serious complications progressively resolved with supportive measures. The final diagnosis was pancreatitis, myocarditis and acute renal failure due to Epstein-Barr virus, confirmed by serological markers.CONCLUSION: EBV can affect virtually any organ system and can have a variety of clinical presentations. It should be considered in the differential diagnosis of febrile processes ofunknown etiology with multisystem involvement.
Descritores: HERPESVIRUS HUMANO ABBREVIATIONS AS TOPIC
Miocardite
Nefrite
Pancreatite
Limites: Humanos
Feminino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: PE1.1 - Oficina Universitária de Biblioteca


  7 / 79 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: biblio-1040393
Autor: Wilches-Cuadros, María Angélica; Roca-López, Stefania; Sosa, Luis Miguel.
Título: Nefronía lobar aguda derecha secundaria a apendicitis aguda no perforada: reporte de caso / Acute right lobar nephronia secondary to acute non-perforated appendicitis: a case report
Fonte: Med. UIS;32(1):33-37, ene.-jun. 2019. graf.
Idioma: es.
Resumo: Resumen La apendicitis aguda en pediatría ocurre generalmente en escolares y adolescentes, siendo su principal complicación el absceso intraabdominal. Por su parte, la nefronía lobar aguda es una infección localizada del parénquima renal, de la cual no existen casos reportados de ésta como secundaria a apendicitis no perforada. Se presenta el caso de una preadolescente, quien seis días después de una apendicectomía consulta por dolor abdominal, vómito y fiebre. Ingresa con signos de respuesta inflamatoria sistémica, por lo que se inicia terapia antibiótica, y luego de tres días sin mejoría clínica, se realiza una ecografía abdominal que evidencia una lesión renal derecha sugestiva de nefronía lobar aguda y un absceso hepático del segmento VI y VII. Se inicia terapia antibiótica de amplio espectro con adecuada respuesta clínica. La nefronía lobar aguda debe tenerse en cuenta entre las complicaciones de la apendicitis, dado su comportamiento agresivo, rápida progresión a sepsis y frecuente asociación a cicatrices renales. MÉD.UIS.2019;32(1):33-7.

Abstract Acute appendicitis in pediatrics presented in scholar and adolescent ages have as its main complication an intraabdominal abscess. Moreover, acute lobar nephronia is a localized infection in the renal parenchyma. There are no cases reported about nephronia as a consequence of acute non-perforated appendicitis. This case describes a preadolescent presenting abdominal pain, vomit and fever, six days after acute appendicitis. She was admitted with signs of systemic inflammatory response syndrome, so antibiotic therapy was started. After three days there was no clinical improvement, whereby an abdominal ultrasound was performed, which reported injury in the right kidney suggestive of acute lobar nephronia and an hepatic abscess of VI and VII segments. Broad spectrum of antibiotic therapy was started with adequate clinic response. Acute lobar nephronia should be considered when studying acute appendicitis complications, given it's aggressive behavior, accelerated progression to sepsis and frequent association with renal scarring. MÉD.UIS.2019;32(1):33-7.
Descritores: Nefrite
-Pediatria
Apendicectomia
Complicações Pós-Operatórias
Infecções Intra-Abdominais
Limites: Humanos
Feminino
Criança
Tipo de Publ: Relatos de Casos
Responsável: CO48.1 - Biblioteca Médica


  8 / 79 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-984585
Autor: Cury, Maria Fernanda Ribeiro; Olivares, Estéfany Queiroz; Garcias, Renata Correia; Toledo, Giovana Queda; Anselmo, Natassia Alberici; Paskakulis, Leticia Colombo; Botelho, Fernanda Fortuci Resende; Carvalho, Natiele Zanardo; Silva, Analice Andreoli da; Agren, Camila; Carlos, Carla Patrícia.
Título: Inflammation and kidney injury attenuated by prior intake of Brazil nuts in the process of ischemia and reperfusion / Inflamação e lesão renal atenuadas pela ingestão prévia de castanha-do-Brasil no processo de isquemia e reperfusão
Fonte: J. bras. nefrol;40(4):312-318, Out.-Dec. 2018. graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de São Paulo.
Resumo: ABSTRACT Introduction: Ischemia and reperfusion (IR) is a process inherent to the procedures involved in the transplantation of organs that causes inflammation, cell death and cell injury, and may lead to rejection of the graft. It is possible that the anti-inflammatory properties of the Brazil nuts (BN) can mitigate the renal injury caused by IR. Objective: To investigate whether the previous intake of BN reduces the expression of markers of inflammation, injury, and cell death after renal IR. Methods: Male Wistar rats were distributed into six groups (N = 6/group): SHAM (control), SHAM treated with 75 or 150 mg of BN, IR, and IR treated with 75 or 150 mg of BN. The IR procedure consisted of right nephrectomy and occlusion of the left renal artery with a non-traumatic vascular clamp for 30 min. BN was given daily from day 1 to 7 before surgery (SHAM or IR), and maintained until sacrifice (48 h after surgery). Inflammation was evaluated by renal expression of COX-2 and TGF-β, injury by the expression of vimentin, and cell death by apoptosis through caspase-3 expression (immunohistochemistry). Results: Pretreatment with 75 mg of BN reduced renal expression of the COX-2, TGF-β, vimentin, and caspase-3. The dose of 150 mg caused increased expression of COX-2. Conclusion: In experimental IR, the damage can be minimized with a prior low-dose intake of BN, improving inflammation, injury, and cell death.

RESUMO Introdução: Isquemia e reperfusão (IR) é um processo inerente aos procedimentos envolvidos no transplante de órgãos, que causa inflamação, morte celular e lesão, podendo levar à rejeição do enxerto. É possível que a castanha-do-brasil (CB), por suas propriedades anti-inflamatórias, possa atenuar a lesão renal causada pela IR. Objetivo: Investigar se a ingestão prévia de CB reduz a expressão de marcadores renais de inflamação, lesão e morte celular após a IR. Métodos: Ratos Wistar machos foram distribuídos em seis grupos (N = 6/grupo): SHAM (controle), SHAM tratado com 75 ou 150 mg de CB, IR, e IR tratado com 75 ou 150 mg de CB. O procedimento de IR consistiu na nefrectomia à direita e oclusão da artéria renal esquerda por 30 minutos. A castanha foi administrada diariamente por sete dias antes da cirurgia (SHAM ou IR), e mantida até o sacrifício (48 horas pós-cirurgia). A inflamação foi avaliada pela expressão renal de COX-2 e TGF-β; a lesão pela expressão de vimentina, e a morte celular por apoptose pela expressão de caspase-3, por imuno-histoquímica. Resultados: O pré-tratamento com 75 mg de CB reduziu a expressão renal de COX-2, de TGF-β, de vimentina e de caspase-3. A dose de 150 mg causou elevação da expressão de COX-2. Conclusão: No modelo experimental de IR renal, os danos podem ser minimizados com a ingestão prévia de baixas doses de CB, melhorando a inflamação, a lesão e a morte celular.
Descritores: Bertholletia
Injúria Renal Aguda/prevenção & controle
Fitoterapia
Nefrite/prevenção & controle
-Traumatismo por Reperfusão/complicações
Ratos Wistar
Injúria Renal Aguda/etiologia
Rim/irrigação sanguínea
Nefrite/etiologia
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  9 / 79 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-785754
Autor: Silva, Leonardo Sales da; Almeida, Bruna Laiza Fontes; Melo, Ana Karla Guedes de; Brito, Danielle Christine Soares Egypto de; Braz, Alessandra Sousa; Freire, Eutília Andrade Medeiros.
Título: IgA nephropathy in systemic lupus erythematosus patients: case report and literature review / Nefropatia por IgA em paciente portadora de lúpus eritematoso sistêmico: relato de caso e revisão de literatura
Fonte: Rev. bras. reumatol;56(3):270-273graf.
Idioma: en.
Resumo: Abstract Systemic erythematosus lupus (SLE) is a multisystemic autoimmune disease which has nephritis as one of the most striking manifestations. Although it can coexist with other autoimmune diseases, and determine the predisposition to various infectious complications, SLE is rarely described in association with non‐lupus nephropathies etiologies. We report the rare association of SLE and primary IgA nephropathy (IgAN), the most frequent primary glomerulopathy in the world population. The patient was diagnosed with SLE due to the occurrence of malar rash, alopecia, pleural effusion, proteinuria, ANA 1: 1,280, nuclear fine speckled pattern, and anticardiolipin IgM and 280 U/mL. Renal biopsy revealed mesangial hypercellularity with isolated IgA deposits, consistent with primary IgAN. It was treated with antimalarial drug, prednisone and inhibitor of angiotensin converting enzyme, showing good progress. Since they are relatively common diseases, the coexistence of SLE and IgAN may in fact be an uncommon finding for unknown reasons or an underdiagnosed condition. This report focus on the importance of the distinction between the activity of renal disease in SLE and non‐SLE nephropathy, especially IgAN, a definition that has important implications on renal prognosis and therapeutic regimens to be adopted in the short and long term.

Resumo O lúpus eritematoso sistêmico (LES) é uma doença autoimune multissistêmica que tem como uma das manifestações mais marcantes a nefrite. Apesar de poder coexistir com outras doenças autoimunes e determinar a predisposição a diversas complicações infecciosas, o LES raramente é descrito em associação a nefropatias de etiologia não lúpica. Relatamos o caso da rara associação entre LES e nefropatia por IgA (NIgA) primária, a glomerulopatia primária mais frequente na população mundial. A paciente foi diagnosticada com LES pela ocorrência de eritema malar, alopecia, derrame pleural, proteinúria, pancitopenia, FAN 1:1.280 padrão nuclear pontilhado fino e anticardiolipina IgM 280 U/mL. A biópsia renal revelou hipercelularidade mesangial com depósitos isolados de IgA, compatível com NIgA primária. Foi tratada com antimalárico, prednisona e inibidor da enzima conversora de angiotensina e apresentou boa evolução. Por consistirem em doenças relativamente frequentes, a coexistência de LES e NIgA pode ser de fato um achado incomum por motivos desconhecidos ou uma condição subdiagnosticada. Este relato atenta para a importância da distinção entre a atividade de doença renal do LES e nefropatias não lúpicas, em especial a NIgA, definição que tem implicações importantes sobre o prognóstico renal e regimes terapêuticos a serem adotados em curto e longo prazo.
Descritores: Glomerulonefrite por IGA/epidemiologia
Lúpus Eritematoso Sistêmico/epidemiologia
-Proteinúria
Glomerulonefrite por IGA/diagnóstico
Glomerulonefrite por IGA/etiologia
Rim/patologia
Nefrite
Limites: Humanos
Tipo de Publ: Relatos de Casos
Revisão
Responsável: BR1.1 - BIREME


  10 / 79 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
Texto completo
Id: biblio-966260
Autor: Wilson, Tais Meziara; Magalhães, Larissa Fernandes; Souza, Rafael Rocha; Ronchi, Alessandra Aparecida Medeiros; Limongi, Jean Ezequiel.
Título: Renal lesions in dogs naturally infected with Leishmania infantum / Alterações renais de cães naturalmente infectados com Leishmania infantum
Fonte: Biosci. j. (Online);33(4):990-995, july/aug. 2017. ilus, tab.
Idioma: en.
Resumo: We analyzed serum urea and creatinine levels and the renal histology of dogs with canine visceral leishmaniasis, and conducted a urinalysis to evaluate their renal damage. Urine, blood, and kidney samples were obtained from 43 dogs. The dogs were divided into 3 groups according to their clinical presentation: asymptomatic (n= 9), oligosymptomatic (n= 17), and symptomatic (n=17). We detected increased creatinine and urea levels in 7/43 and 8/43 of the dogs, respectively. In the urinalysis, nephritis was found in 22/43 seropositive dogs. Histopathologic alterations included tubulointerstitial alterations (39/43) and glomerulonephritis (25/43). Membranoproliferative glomerulonephritis (11/43) was the most common glomerular alteration, followed bymembranous glomerulonephritis (6/43), proliferative glomerulonephritis (7/43), and glomerular sclerosis (1/43). Our data indicate that alterations in the urinalysis and renal histopathology in dogs with leishmaniasis can appear before increases in serum urea and creatinine levels can be detected, even when clinical symptoms of the disease are absent. A diagnosis of leishmaniasis should be considered in dogs with renal damage, and renal function should be evaluated in dogs with leishmaniasis.

Objetivou-se avaliar a função renal de cães sororreagentes para leishmaniose visceral, através da dosagem séricas de ureia e creatinina urinálise e alterações histopatológicas do tecido renal, associando com as alterações clínicas. Foram utilizados 43 cães positivos, divididos em assintomáticos (9/43), oligossintomáticos(17/43) e sintomáticos (17/43). Verificou-se creatina aumentada em 1/9 dos assintomáticos; 1/17 dos oligossintomáticos e 1/17 sintomáticos. 4/17 dos oligossintomáticos e 4/17 dos sintomáticos tiveram valores de ureia aumentados. Constatou-se na urinálise nefrite em 22/43 cães soropositivos, destes 6/22 eram assintomáticos, 8/22 oligossintomáticos e 8/22 sintomáticos. Na avaliação histopatológica verificaram-se alterações tubulointersticiais e glomerulares. A glomerulonefrite membranoproliferativa foi o tipo mais frequente e ocorreu em 11/43 cães sendo que 5/11 eram sintomáticos, 4/11oligossintomáticos e 2/11 eram assintomáticos. Glomerulonefrite membranosa foi observada em 6/43 animais e destes 3/6 eram oligossintomáticos e 3/6 sintomáticos. A glomerulonefrite proliferativa foi observada em 7/43 cães sendo que 3/7 cães eram oligossintomáticos, 2/7 era sintomático e 2/7 eram assintomáticos. A esclerose glomerular foi em 1/43 animal sintomático. A leishmaniose visceral canina pode causar lesões glomerulares e tubulares do tecido renais levando a alterações urinárias e dos valores séricos ureia e creatinina. Cães com leishmaniose podem apresentar lesões renais mesmo sem sinais clínicos da doença.
Descritores: Cães
Glomerulonefrite
Rim
Leishmaniose Visceral
Nefrite
Responsável: BR396.1 - Biblioteca Central



página 1 de 8 ir para página                    
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde