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Id: biblio-1038556
Autor: Dracoulakis, Marianna Deway Andrade; Gurbel, Paul; Cattaneo, Marco; Martins, Herlon Saraiva; Nicolau, José Carlos; Kalil Filho, Roberto.
Título: High Residual Platelet Reactivity during Aspirin Therapy in Patients with Non-St Segment Elevation Acute Coronary Syndrome: Comparison Between Initial and Late Phases / Alta Atividade Plaquetária Residual em Resposta ao Ácido Acetilsalicílico na Síndrome Coronariana Aguda Sem Supra de ST: Comparação entre as Fases Aguda e Tardia
Fonte: Arq. bras. cardiol;113(3):357-363, Sept. 2019. tab, graf.
Idioma: en.
Resumo: Abstract Background: High platelet reactivity (HPR) during therapy with acetylsalicylic acid (ASA) is a poor prognostic factor in acute coronary syndromes (ACS). The prevalence of HPR during ACS is greater than that reported in stable diseases. However, it is unclear whether this prevalence of HPR is a transient phenomenon or a characteristic of this high-risk population. Objective: The main objective is to compare the effects of ASA on platelet function in the initial and late phases of ACS in a single population. Secondary objectives are: correlation between the tests between themselves and the relationship between the tests and the variation of the inflammatory markers (C-reactive protein and interleukin-6). Methods: Seventy patients with non-ST segment elevation (NSTE) ACS in use of 100-200 mg of ASA per day for at least 7 days were prospectively studied. Platelet function was assessed in the first 48 hours and subsequently after 3 months using four methods: VerifyNow™ (VFN), whole blood platelet aggregation (WBPA) with arachidonic acid (AA) and collagen as agonists, and platelet function analyzer (PFA). The level of statistical significance considered was < 0.05. Results: According to the more specific methods (WBPA with AA and VFN), the incidence of HPR was significantly higher in the early phase than in the late phase: WBPA with AA: 31% versus 13%, p = 0.015; VFN: 32% versus 16%, p = 0.049. The other methods tested, which were less specific for ASA, did not show significant differences between phases. The correlation between the methods was weak or moderate (r ranging from 0.3 to 0.5, p < 0.05), and there were no significant associations between HPR and inflammatory markers. Conclusion: The prevalence of HPR during AAS therapy, assessed by specific methods for cyclooxygenase 1 (COX-1), is higher during the acute phase than in the late phase of NSTE ACS.

Resumo Fundamento: A alta atividade plaquetária (AAP) durante a terapia com ácido acetilsalicílico (AAS) é fator de mau prognóstico nas síndromes coronarianas agudas (SCA). A prevalência de AAP durante a SCA é maior do que a relatada na doença estável. No entanto, não está claro se esta prevalência de AAP é um fenômeno transitório ou característica dessa população de alto risco. Objetivo: O objetivo principal é comparar, em uma mesma população, os efeitos do AAS sobre a função plaquetária nas fases inicial e tardia da SCA. Os objetivos secundários são: correlação entre os testes entre si e a relação entre os testes e a variação dos marcadores inflamatórios (proteína C reativa e interleucina-6). Métodos: Foram estudados prospectivamente 70 pacientes com SCA sem elevação de ST (SCSST) em uso de 100 a 200 mg de AAS por dia por pelo menos 7 dias. A função plaquetária foi avaliada nas primeiras 48 horas e 3 meses após por quatro métodos: VerifyNow™ (VFN), agregometria de sangue total (AST) com ácido araquidônico (AA) e colágeno como agonistas, e analisador de função plaquetária (PFA). O nível de significância estatístico considerado foi < 0,05. Resultados: A média de idade foi de 65 ±9,7 anos e 54% da população eram do sexo feminino. De acordo com os métodos mais específicos (AST com AA e VFN), a incidência de AAP foi significativamente maior na fase inicial, em relação à tardia: AST com AA 31% versus 13%, p = 0,015; VFN 32% versus 16%, p = 0,049. Os outros métodos testados, menos específicos para o AAS, não mostraram diferenças significativas entre as fases. A correlação entre os métodos foi fraca ou moderada (r variando de 0,3 a 0,5, p < 0,05), e não houve associações significativas entre AAP e marcadores inflamatórios. Conclusão: A prevalência de AAP durante a terapia com AAS, avaliada por métodos específicos para cicloxigenase 1 (COX-1), é maior durante a fase aguda do que na tardia da SCASST.
Descritores: Plaquetas/efeitos dos fármacos
Inibidores da Agregação de Plaquetas/uso terapêutico
Aspirina/uso terapêutico
Síndrome Coronariana Aguda/tratamento farmacológico
-Testes de Função Plaquetária
Transtornos Plaquetários/tratamento farmacológico
Plaquetas/metabolismo
Inibidores da Agregação de Plaquetas/farmacologia
Aspirina/farmacologia
Estudos Prospectivos
Fatores de Risco
Infarto do Miocárdio sem Supradesnível do Segmento ST/fisiopatologia
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-1124624
Autor: de la Torre Fonseca, Luis M; Mederos Hernández, Jorge; Pérez Fernández, Anabel.
Título: Caracterización del síndrome de Wellens y su relación como predictor de obstrucción grave de la arteria descendente anterior. Unidad de Cuidados Coronarios Intensivos Hospital Manuel Fajardo 2016-2017 / Characterization of Wellens syndrome and its relationship as a predictor of severe obstruction of the left anterior descending artery. Intensive Coronary Care Unit Hospital Manuel Fajardo 2016-2017
Fonte: CorSalud;11(4):271-277, oct.-dic. 2019. tab, graf.
Idioma: es.
Resumo: RESUMEN Introducción: El síndrome de Wellens es un patrón electrocardiográfico que se ha sugerido desde la década del 80 como indicador de obstrucción grave de la arteria descendente anterior, a pesar de ello es poco conocido y no se encuentra en las principales guías de tratamiento de los síndromes coronarios agudos. Objetivo: Demostrar la utilidad del diagnóstico del síndrome de Wellens como predictor de obstrucción grave de la descendente anterior. Método: Se realizó un estudio transversal con componente analítico, que abarcó a los 40 pacientes ingresados en la Unidad de Cuidados Coronarios Intensivos del Hospital Manuel Fajardo, en el período enero de 2016 hasta diciembre de 2017, con diagnóstico de síndrome coronario agudo sin elevación del segmento ST, a los que se les realizó coronariografía. Resultados: Se encontró la presencia de síndrome de Wellens en un 13,5% de los pacientes ingresados con este tipo de síndrome coronario agudo. La edad, el sexo y la presencia de comorbilidades no se relacionaron significativamente con la presencia de este síndrome. El estudio angiográfico evidenció, en los pacientes con un síndrome de Wellens, un riesgo relativo 3,4 veces mayor que el resto, de presentar una obstrucción grave de la arteria descendente anterior. Conclusiones: La identificación oportuna del síndrome de Wellens y su relación con una obstrucción coronaria grave deben motivar una estrategia intervencionista precoz en estos casos.

ABSTRACT Introduction: Wellens syndrome is an electrocardiographic pattern that has been suggested, since the 1980s, as indicator of severe obstruction of the left anterior descending artery, although it is poorly understood and it is not found in the main treatment guidelines for acute coronary syndromes. Objective: To demonstrate the usefulness of the diagnosis of Wellens syndrome as a predictor of severe obstruction of the left anterior descending artery. Method: A cross-sectional study with an analytical component was carried out, covering the 40 patients admitted to the Intensive Coronary Care Unit of the Hospital Manuel Fajardo, in the period from January 2016 to December 2017, with a diagnosis of non-ST-segment elevation acute coronary syndrome, who underwent coronary angiography. Results: The presence of Wellens syndrome was found in 13.5% of the patients admitted with this type of acute coronary syndrome. Age, sex and the presence of comorbidities were not significantly related to the presence of this syndrome. The angiographic study showed, in patients with a Wellens syndrome, a relative risk -3.4 times greater than the rest- of presenting a severe obstruction of the left anterior descending artery. Conclusions: The timely identification of Wellens syndrome and its relationship with a severe coronary obstruction should motivate an early interventionist strategy in these cases.
Descritores: Síndrome
Isquemia Miocárdica
Angina Microvascular
Infarto do Miocárdio sem Supradesnível do Segmento ST
Angina Instável
Responsável: CU425.1 - Centro Provincial de Información de Ciencias Médicas de Villa Clara


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Id: biblio-995338
Autor: Poll Pineda, Jorge Armando; Rueda Macías, Nuris María; Poll Rueda, Armando; Linares Despaigne, Manuel de Jesús.
Título: Caracterización clinicoepidemiológica de pacientes con síndrome coronario agudo según sexo / Clinical and epidemiological characterization of patients with acute coronary syndrome according to sex
Fonte: Medisan;21(10), oct.2017. tab.
Idioma: es.
Resumo: Se realizó una investigación descriptiva, longitudinal y retrospectiva de 486 adultos egresados vivos tras presentar alguna forma clínica del síndrome coronario agudo, pertenecientes a 4 áreas de salud del municipio de Santiago de Cuba, desde el 2004 hasta el 2007, a fin de identificar algunas características clinicoepidemiológicas de dicha afección según sexo. En esta casuística los hombres de 45-64 años expuestos a la habituación tabáquica resultaron ser los más afectados por el síndrome coronario con elevación del segmento ST, no complicado, lo cual demostró que este problema de salud fue más frecuente en el sexo masculino que en el femenino.

A descriptive, longitudinal and retrospective investigation of 486 adults discharged alive after presenting some clinical form of the acute coronary syndrome belonging to 4 health areas of Santiago de Cuba was carried out, from 2004 to 2007, aimed at identifying some clinical epidemiological characteristics of this disorder according to sex. In this case material men aged 45-64 exposed to nicotine addiction were the most affected by the non complicated coronary syndrome with elevation of the ST segment, which demonstrated that this health problem was more frequent in male than in the female sex.
Descritores: Síndrome Coronariana Aguda
Infarto do Miocárdio sem Supradesnível do Segmento ST
Infarto do Miocárdio com Supradesnível do Segmento ST
Infarto do Miocárdio
-Epidemiologia Descritiva
Estudos Retrospectivos
Estudos Longitudinais
Limites: Humanos
Masculino
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Artigo Clássico
Responsável: CU418.1 - Centro Provincial de Información de Ciencias Médicas de Santiago de Cuba


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Id: biblio-1093914
Autor: Giralt-Herrera, Alejandro; Rojas-Velázquez, Jesús Miguel; de la Torre Fonseca, Luis Mariano; Machín-Legón, Milagro.
Título: Factores predictivos de complicaciones intrahospitalarias en el Síndrome Coronario Agudo sin elevación del segmento ST / Predictive factors of intra-hospital complications in Non-ST-segment elevation Acute Coronary Syndrome
Fonte: Rev. habanera cienc. méd;18(6):886-897, nov.-dic. 2019. tab.
Idioma: es.
Resumo: Introducción: El espectro clínico de los Síndromes Coronarios Agudos sin elevación del segmento ST incluye tanto a pacientes asintomáticos como a los que presentan isquemia activa, inestabilidad eléctrica, hemodinámica o parada cardiaca. Objetivo: Evaluar probables factores predictivos de complicaciones intrahospitalarias no letales en pacientes con diagnóstico de Síndrome Coronario Agudo sin elevación del segmento ST. Material y Métodos: Estudio observacional, analítico, de corte transversal con un universo de 218 individuos ingresados en la Unidad de Cuidados Coronarios Intensivos del Hospital Clínico-Quirúrgico Manuel Fajardo en 2016 y 2017. Resultados: Predominó el sexo masculino (51.4 por ciento) y la edad media fue de 68 años. Prevaleció la Hipertensión Arterial como factor de riesgo coronario. La edad mostró asociación estadística significativa con la aparición de cualquier complicación (p=0.015) y con las complicaciones hemodinámicas (p=0,014). El riesgo intermedio-alto, según el score TIMI, tuvo asociación estadísticamente muy significativa con las complicaciones hemodinámicas (p<0.01). Conclusiones: La edad tuvo asociación estadística con la aparición de complicaciones intrahospitalarias no letales. El sexo no se asoció con las complicaciones ni los antecedentes estudiados tampoco. Los pacientes con un riesgo intermedio-alto al ingreso, se asociaron con las complicaciones hemodinámicas(AU)

Introduction: The clinical spectrum of Non-ST-segment elevation Acute Coronary Syndromes includes both asymptomatic patients and those with active ischemia, electrical instability, hemodynamic or cardiac arrest. Objective: To evaluate probable predictive factors of non-lethal intra-hospital complications in patients diagnosed with Non-ST-segment elevation Acute Coronary Syndrome. Material and Methods: An observational, analytical, cross-sectional study was conducted with a universe of 218 individuals admitted into the Intensive Coronary Care Unit of Manuel Fajardo Clinical and Surgical Hospital between 2016 and 2017. Results: Male sex predominated (51.4 percent) and the mean age was 68 years. Arterial Hypertension prevailed as a coronary risk factor. The age showed significant statistical association with the appearance of any complication (p = 0.015) and with hemodynamic complications (p =0,014). The intermediate-high risk, according to the TIMI score, had a statistically significant association with hemodynamic complications (p <0.01). Conclusions: Age was statistically associated with the appearance of non-lethal intra-hospital complications. Sex was not associated with complications, nor did the background studied either. Patients with an intermediate-high risk at admission were associated with hemodynamic complications(AU)
Descritores: Valor Preditivo dos Testes
Unidades de Cuidados Coronarianos/métodos
Infarto do Miocárdio sem Supradesnível do Segmento ST/epidemiologia
-Estudos Transversais
Síndrome Coronariana Aguda/complicações
Estudo Observacional
Hemodinâmica/fisiologia
Limites: Humanos
Masculino
Feminino
Idoso
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-1097421
Autor: Ugalde P, Héctor; Romero A, Pablo; Cifuentes R, Ignacio.
Título: Caracterización clínica y angiográfica según sexo de pacientes con síndrome coronario agudo sin supradesnivel del segmento ST / Clinical and angiographic characterization according to sex of patients with acute coronary syndrome without ST segment elevation
Fonte: Rev. Hosp. Clin. Univ. Chile;31(1):4-9, 2020. tab.
Idioma: es.
Resumo: Ischemic Heart Disease is the leading cause of death and of potential years of life lost in Chile. The most frequent acute presentation of this group of pathologies is the Acute Coronary Syndrome (ACS) without ST segment elevation. According to the literature, there is a proportion of patients with non-ST elevated ACS in which coronary angiography reveals a mild coronary lesion or even shows no detectable lesion at all. This scenario is more common in women than in men. Compared with men, women with non-ST elevated ACS are older than men and more frequently have hypertension. Furthermore, women are less likely to have previous cardiac diseases, and are less common to present serum troponin rise at admission. In Chile, there are no previous studies about the differences between sexes in this disease. The objective of this study is to determine if there are major differences between sexes in aspects like clinical and angiographic findings in patients with non-ST elevated ACS. The study used a database of 1900 consecutive patients who were submitted for coronary angiography and had been previously diagnosticated with non-ST elevated ACS, between the years 2001-2017. Clinical assessment, laboratory and angiographic results were collected and analyzed to establish major differences considering p<0,05. 69% of patients were men. When comparing, the proportion of smokers was greater in men, who also more frequently had progressive worsening of angina or treatment-resistant chest pain as clinical presentations. Furthermore, previous coronary bypass surgery, previous percutaneous coronary intervention and previous myocardial infarction were more common in men. As to women, they were older and more frequently had hypertension and/or hypothyroidism. Unstable angina as a clinical presentation was more usual than in men and electrocardiographic findings as a negative T-wave in the anterior wall, evolutive segment changes and left branch bundle block were also more common. In addition, serum troponin rise was more frequent than in men. There was no difference in risk stratification with TIMI score. When comparing angiographic findings, women had more frequently mild lesions or no lesions at all (44% in women versus 27% in men). In conclusion, clinical aspects are different in between sexes as to presence of comorbidities, cardiovascular risk factors and previous cardiovascular disease. Clinical presentation is also different, as to symptoms and as to electrocardiographic findings and laboratory exams. At last, and as evidence suggests, there is a greater proportion of women with mild coronary lesions or without lesions than in men when comparing angiographic findings. (AU)
Descritores: Epidemiologia Descritiva
Síndrome Coronariana Aguda
Infarto do Miocárdio sem Supradesnível do Segmento ST/diagnóstico por imagem
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Tipo de Publ: Estudo Clínico
Responsável: CL36.1 - Biblioteca Hospital Clínico


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Id: biblio-977999
Autor: Hameau, René; Fuensalida, Alberto; Sepúlveda, Pablo; Martínez, Alejandro; Martínez, Gonzalo.
Título: Exceso de mortalidad no cardíaca en pacientes sometidos a angioplastía de puentes coronarios / Excess non cardiac mortality in patients undergoing PCI of venous coronary bypass grafts
Fonte: Rev. chil. cardiol;37(3):176-182, dic. 2018. tab, graf.
Idioma: es.
Resumo: Resumen: Introducción Las fallas de los puentes venosos pueden llegar casi al 50% a 10 años y la angioplastía percutánea es el tratamiento de elección. Estos pacientes constituyen un grupo de muy alto riesgo cardiovascular con tasas de mortalidad cercanas al 30% en el mediano plazo. Objetivo Caracterizar a la población sometida a angioplastia de puentes coronarios (APC) y comparar su mortalidad con un grupo pareado de pacientes intervenidos con Infarto agudo al miocardio con elevación del segmento ST (IAMCEST). Métodos Estudio retrospectivo de tipo Caso-Control que incluyó a pacientes con APC entre los años 2010-2016 comparados con igual número de controles con IAMCEST pareados por edad y sexo. Se analizaron características clínicas del procedimiento y mortalidad, tanto global como de causa cardiaca usando T Student, Chi2 y curvas de Kaplan Meier. Resultados Se identificaron 63 pacientes sometidos a APC (total 76 procedimientos). Los puentes más comúnmente intervenidos fueron a la arteria circunfleja 48,7%. Hubo 18 (28,5%) pacientes fallecidos en el grupo APC y 6 (9,5%) pacientes en el grupo con IAM-CEST, lo que resultó en un exceso de mortalidad global en pacientes con APC (HR 3,02; IC 95% 1,11 - 8,22, p=0,02). Esta diferencia se debió a una mayor mortalidad de causa no cardiaca en el grupo APC (12,7% (n=8) vs 3,2% (n= 2) [p=0,04]). Conclusión Los pacientes sometidos a APC presentan una mortalidad 3 veces mayor que aquellos pacientes con IAMCEST, principalmente derivada de una mayor mortalidad no cardíaca.

Abstract: Background Failure rates of saphenous vein grafts can reach almost 50% at 10 years and percutaneous angioplasty is the treatment of choice. This is a group with a very high cardiovascular risk, with mid-term mortality rates close to 30%. Aim To describe the population undergoing coronary bypass angioplasty (CBA) and compare their mortality with an age and gender matched group of patients with acute myocardial infarction with ST segment elevation (STEMI) Methods This was a retrospective case-control study including patients with CBA between 2010-2016. This group was compared with the same number of controls with STEMI matched by age and sex. Clinical characteristics, procedure variables and overall mortality as well as cardiac mortality were analyzed using Student's T test, Chi squared test and Kaplan Meier curves (significance set at p <0.05). Results: We identified 63 patients undergoing CBA (76 procedures). The most commonly intervened bypasses were to the circumflex artery (48.7%). There were 18 (28.5%) patients who died in the CBA group and 6 (9.5%) patients in the STEMI group, which resulted in an excess of global mortality risk in patients with CBA (HR 3.02, 95% CI 1.11 - 8.22, p = 0.02). This difference was driven by a higher non-cardiac mortality in the CBA group (12.7% (n = 8) vs 3.2% (n = 2) [p = 0.04]) Conclusion Patients undergoing CBA have a mortality rate more than three times that of the STEMI patients, mainly due to a higher non-cardiac mortality.
Descritores: Angioplastia Coronária com Balão/mortalidade
Infarto do Miocárdio com Supradesnível do Segmento ST/mortalidade
-Veia Safena
Estudos de Casos e Controles
Análise de Sobrevida
Ponte de Artéria Coronária/mortalidade
Estudos Retrospectivos
Causas de Morte
Infarto do Miocárdio sem Supradesnível do Segmento ST/terapia
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: CL126.2 - Biblioteca Médica Dr. Profesor Hernán Alessandri R.


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Id: biblio-960526
Autor: Martínez García, Geovedy; Valdés Carrazana, Eliset; Cruz Rodríguez, Liz Odelnis; Cárdenas Fernández, Yoanis; Ravelo Dopico, Roger; Perera Lombillo, Carmen Rosa.
Título: Características de pacientes de 50 años o menos de edad sometidos a intervención coronaria en los años 2006-2015 / Characteristics of Patients Aged 50 Years or Less Undergoing Coronary Intervention from 2006 to 2015
Fonte: Rev. cuba. med. mil;45(2):155-164, abr.-jun. 2016. tab.
Idioma: es.
Resumo: Introducción: las enfermedades cardiovasculares en el adulto joven (menor de 51 años de edad) aumentaron su incidencia en la última década, con el consiguiente aumento en la demanda de atención médica y hospitalización. Objetivos: describir las características clínicas y angiográficas de una serie de pacientes menores de 51 años de edad sometidos a intervención coronaria percutánea. Métodos: estudio descriptivo, transversal y de exposición de las características clínicas y angiográficas de 373 pacientes de 50 años o menos, sometidos a intervención coronaria percutánea en el Hospital Militar Central Dr. Carlos J. Finlay, entre septiembre 2006 y diciembre 2015. Resultados: la edad media fue de 45,7 ± 5,6 años, predominó el sexo masculino (76,4 por ciento). Los principales factores de riesgo fueron la hipertensión arterial (67 por ciento) y el tabaquismo (63,5 por ciento). El síndrome coronario agudo sin elevación del segmento ST fue el diagnóstico más frecuente (61,4 por ciento). Los vasos más afectados fueron la arteria descendente anterior y la coronaria derecha. El 61,7 por ciento de las lesiones se localizó en la porción media de los vasos coronarios. Se realizó el proceder de manera exitosa en el 94,1 por ciento de los pacientes y fallecieron tres pacientes. Existió asociación significativa entre los factores de riesgo y el resultado angiográfico. Conclusiones: la intervención coronaria percutánea en el adulto menor de 50 años no es frecuente, la mayoría de los procederes son exitosos y la mortalidad es baja. Existió asociación significativa entre los factores de riesgo y el resultado del proceder(AU)

Introduction: Cardiovascular diseases in the young adults (younger than 51 years of age) increased their incidence in the last decade, with the consequent increase in the demand for medical attention and hospitalization. Objectives: Describe the clinical and angiographic characteristics of a series of patients under 51 years of age undergoing percutaneous coronary intervention. Methods: A descriptive, cross-sectional study was conducted in clinical and angiographic characteristics of 373 patients aged 50 years or younger submitted to percutaneous coronary intervention at Dr. Carlos J. Finlay Central Military Hospital from September 2006 to December 2015. Results: Mean age was 45.7 ± 5.6 years, male (76.4%) predominated. The main risk factors were hypertension (67 percent) and smoking (63.5 percent). Acute coronary syndrome without ST segment elevation was the most frequent diagnosis (61.4 percent). The most affected vessels were the anterior descending artery and the right coronary artery. 61.7 percent of the lesions were located in the middle portion of the coronary vessels. The procedure was successful in 94.1 percent of the patients and three patients died. There was a significant association between risk factors and angiographic outcome. Conclusions: Percutaneous coronary intervention in the adult under 50 years is not frequent, most of the procedures are successful and mortality is low. There was a significant association between the risk factors and the outcome of the procedure(AU)
Descritores: Doenças Cardiovasculares/epidemiologia
Fatores de Risco
Intervenção Coronária Percutânea/métodos
Infarto do Miocárdio sem Supradesnível do Segmento ST/diagnóstico
-Epidemiologia Descritiva
Estudos Transversais
Limites: Humanos
Masculino
Pessoa de Meia-Idade
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-986672
Autor: Ugalde P, Héctor.
Título: Síndrome coronario agudo sin supradesnivel ST. Diagnóstico y tratamiento inicial / Acute coronary syndrome without ST segment elevation. Diagnosis and initial treatmen
Fonte: Rev. Hosp. Clin. Univ. Chile;29(2):115-135, 2018.
Idioma: es.
Resumo: Coronary heart disease can manifest as stable or unstable forms, being these variations differentiated mainly by the underlying pathophysiological cause, their clinical presentation and the risk associated to each of these clinical presentations. In the unstable form, nowadays known as acute coronary syndrome, recommendations over its characterization and particularly its management are periodically updated in published international guidelines about this topic. Their epidemiological relevance makes important that these aspects should be known by anyone that sees patients in their practices, motivating this review in which we will summarize aspects of the clinical presentation, initial studies and management of the acute coronary syndrome without ST segment elevation emphasizing novelties from the last few years. (AU)
Descritores: Infarto do Miocárdio sem Supradesnível do Segmento ST/diagnóstico
Infarto do Miocárdio sem Supradesnível do Segmento ST/terapia
-Infarto do Miocárdio sem Supradesnível do Segmento ST/fisiopatologia
Infarto do Miocárdio sem Supradesnível do Segmento ST/tratamento farmacológico
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Revisão
Responsável: CL36.1 - Biblioteca Hospital Clínico


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Id: biblio-999804
Autor: Garcés, Ney; Montenegro, Luis; Narváez, Alberto; Guzmán, Edwin.
Título: Comparación de la capacidad discriminatoria de los puntajes de riesgo GRACE y TIMI para eventos cardiovasculares durante la hospitalización en pacientes con infarto agudo de miocardio sin elevación ST y angina inestable / Comparison of the discriminatory capacity of GRACE and TIMI risk scores for cardiovascular events during hospitalization in patients with acute myocardial infarction without ST elevation and unstable angina
Fonte: VozAndes;26(1):25-30, 2015.
Idioma: es.
Resumo: En pacientes con síndrome coronario agudo los puntajes de riesgo GRACE y TIMI son herramientas para estimar el pronóstico de desenlaces cardiovasculares. Las comparaciones entre ambos puntajes en poblaciones latinoamericanas son escasas. Objetivo Comparar la capacidad discriminatoria de los puntajes GRACE y TIMI para eventos cardiovasculares durante la hospitalización en pacientes con infarto de miocardio sin elevación ST (IMSEST) y angina inestable (AI). Diseño Cohorte retrospectiva. Lugar y sujetos 378 pacientes con diagnóstico de IMSEST o AI atendidos durante el período 2011 ­ 2014 en el Hospital Carlos Andrade Marín de la ciudad de Quito. Mediciones principales Puntaje de riesgo GRACE, puntaje de riesgo TIMI, aparición de eventos cardiovasculares (muerte, reinfarto, angina refractaria e intervención coronaria de urgencia) durante la hospitalización. Capacidad discriminatoria de los puntajes evaluada mediante curvas ROC. Resultados En los pacientes predominó el sexo masculino (78%). En orden de frecuencia los eventos cardiovasculares fueron: intervención coronaria de urgencia (51%), angina refractaria (12%), muerte (9%) y reinfarto (5%). El score GRACE presentó resultados de área bajo la curva (AUC) mayores y estadísticamente signifcativos para muerte (AUC: 0.72; ρ<0.0001), mientras que para angina refractaria e intervención coronaria de urgencia, el score TIMI tuvo resultados estadísticamente signifcativos; sin embargo su AUC no presentó valores representativos. Para el reinfarto el score GRACE presentó valores estadísticos limítrofes con una AUC baja. Conclusión El score GRACE tiene una mejor capacidad pronóstica para muerte y reinfarto frente al score TIMI en pacientes con IMSEST y AI

The risk scores GRACE and TIMI are tools to estimate the prognosis of cardiovascular outcomes in patients with acute coronary syndrome. There are few comparisons between the two scores in Latin American populations. Objective To compare the discriminatory ability of GRACE and TIMI scores for cardiovascular events during hospitalization in patients with myocardial infarction without ST elevation (NSTEMI) and unstable angina (UA). Design Retrospective cohort. Subjects and settings 378 patients with a diagnosis of NSTEMI or UA attended during the period 2011-2014 in the Carlos Andrade Marín Hospital, Quito-Ecuador. Main measurements GRACE risk score, TIMI risk score, cardiovascular events (death, reinfarction, refractory angina and emergency coronary angioplasty) during hospitalization. Discriminatory capacity of the scores assessed by ROC curves. Results Male patients were the most frequent (78%). The frequency of cardiovascular events was: emergency coronary angioplasty (51%), refractory angina (12%), death (9%) and re-infarction (5%). The GRACE score showed higher and statistically signifcant results of area under the curve (AUC) for death (AUC: 0.72; ρ<0.0001), whereas for refractory angina and emergency coronary angioplasty the TIMI score had statistically signifcant results; however the AUC did not provide representative values. For re-infarction the GRACE score presented borderline statistical values with low AUC. Conclusion The GRACE score has a better prognostic value for death and reinfarction compared to TIMI score in patients with NSTEMI and AI
Descritores: Síndrome Coronariana Aguda
Infarto do Miocárdio sem Supradesnível do Segmento ST
Angina Instável
-Prognóstico
Hospitalização
Infarto do Miocárdio
Limites: Humanos
Tipo de Publ: Artigo Clássico
Responsável: EC147.1 - Biblioteca


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Id: biblio-987707
Autor: Spineti, Pedro Pimenta de Mello.
Título: Biomarkers and mortality in ST-Segment elevation myocardial infarction / Biomarcadores e mortalidade no infarto do miocárdio com elevação do segmento ST
Fonte: Int. j. cardiovasc. sci. (Impr.);32(2):100-101, mar.-abr. 2019.
Idioma: en.
Descritores: Biomarcadores
Mortalidade
Infarto do Miocárdio sem Supradesnível do Segmento ST/mortalidade
-Troponina
Proteína C-Reativa
Fatores de Risco
Avaliação de Resultados em Cuidados de Saúde
Síndrome Coronariana Aguda
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Editorial
Responsável: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt



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