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Id: biblio-1040167
Autor: Norambuena-Mardones, Leandra; Pinto-Daza, Dominique Evelyn; Troncoso-Fernández, Karla Daniela; Pacheco, Alejandro; Vitzel, Kaio Fernando; Marzuca-Nassr, Gabriel Nasri.
Título: Effectiveness of short-term physical agents treatment on macroscopic morphology in patients with plaque psoriasis / Efectividad del tratamiento a corto plazo de los agentes físicos en la morfología macroscópica de las placas de psoriasis
Fonte: Int. j. morphol;37(4):1541-1550, Dec. 2019. tab, graf.
Idioma: en.
Projeto: Universidad de La Frontera; . FONDECYT.
Resumo: Psoriasis is a chronic inflammatory disease that presents skin rashes which can arise through plaques. The aim of this work was to compare the effectiveness of short-term physical agents treatment on macroscopic morphology (area and erythema) in patients with plaque psoriasis. This prospective randomized experimental study included fourteen subjects, medically diagnosed with psoriasis, with more than one plaque in the skin and voluntarily without topical treatment. All subjects completed the study that consisted of 12 treatment sessions divided in control (C), artificial balneotherapy (AB), phototherapy (PT) or balneophototherapy (BPT) groups. After session 12, there was a significant reduction of the plaque area by all treatments when compared to C group and BPT was the most effective one. However, only AB and PT presented a reduction of erythema. Regarding severity, 9 patients changed to a lower category on the PASI test, and 5 of them maintained a mild psoriasis, but lowered their score. Finally, 13 of 14 subjects improved their quality of life. The physical agents used reduced the severity of psoriasis and improved quality of life of patients after 12 sessions of treatment during a onemonth period. The BPT was the more effective in controlling psoriasis by diminishing its area and PT by attenuating the erythema.

La Psoriasis es una enfermedad inflamatoria crónica que presenta irritación cutánea que puede derivar a placas. El objetivo de este trabajo fue comparar la efectividad del tratamiento a corto plazo con agentes físicos en la morfología macroscópica (área y eritema) en pacientes con placas de psoriasis. Estudio experimental, prospectivo, randomizado. Catorce sujetos participaron con diagnóstico médico de psoriasis, con más de una placa en la piel y sin tener tratamiento tópico de forma voluntaria. Todos los sujetos completaron el estudio, el cual consistió de 12 sesiones de tratamiento dividido en grupo control (C), BA, FT y BFA. Posterior a la sesión 12, se observó una reducción significativa en toda el área de las placas que recibieron tratamiento al compararlas al grupo C y el grupo BFA fue el más efectivo. Sin embargo, solo los grupos BA y FT presentaron una reducción del eritema. Respecto a la severidad, 9 pacientes cambiaron de la baja categoría en el test de PASI y 5 de ellos se mantuvieron en el nivel medio, pero disminuyeron su puntaje. Finalmente, 13 de 14 sujetos mejoraron su calidad de vida. Los agentes físicos usados redujeron la severidad de la psoriasis y mejoraron la calidad de vida de los pacientes después de 12 sesiones de tratamiento durante el período de un mes. La BFA fue la más efectiva en controlar la psoriasis por la disminución en el área y la FT por la atenuación del eritema.
Descritores: Fototerapia/métodos
Psoríase/terapia
Balneologia/métodos
-Psoríase/patologia
Psoríase/psicologia
Qualidade de Vida
Fatores de Tempo
Índice de Gravidade de Doença
Estudos Prospectivos
Inquéritos e Questionários
Resultado do Tratamento
Limites: Seres Humanos
Masculino
Feminino
Adulto
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1038277
Autor: Gui, Xin-Yu; Jin, Hong-Zhong; Wang, Zhen-Jie; Xu, Teng-Da.
Título: Serum uric acid levels and hyperuricemia in patients with psoriasis: a hospital-based cross-sectional study
Fonte: An. bras. dermatol;93(5):761-763, Sept.-Oct. 2018. tab.
Idioma: en.
Projeto: Chinese Academy of Medical Sciences.
Resumo: Abstract: A hospital-based cross-sectional study was performed, including 117 psoriatic patients and 117 controls matched for age, gender, and body mass index. Psoriatic patients had higher levels of serum uric acid (6.25 ± 1.62 vs 5.71 ± 1.35 mg/dl; P=0.019) and significantly greater prevalence of hyperuricemia (31.6% vs 16.2%; P=0.009) than individuals without psoriasis. Psoriatic patients had significantly higher serum uric acid than controls in subjects without metabolic syndrome. Multivariate logistic regression analysis showed that psoriasis can be a strong predictor of hyperuricemia (odds ratio 2.61; 95% confidence interval 1.34-5.00; P=0.004).
Descritores: Psoríase/sangue
Ácido Úrico/sangue
Síndrome Metabólica/sangue
Hiperuricemia/sangue
-Índice de Massa Corporal
Estudos Transversais
Análise Multivariada
Limites: Seres Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-973646
Autor: Salman, Andac; Yucelten, Ayse Deniz; Sarac, Esra; Saricam, Merve Hatun; Perdahli-Fis, Nese.
Título: Impact of psoriasis in the quality of life of children, adolescents and their families: a cross-sectional study
Fonte: An. bras. dermatol;93(6):819-823, Nov.-Dec. 2018. tab.
Idioma: en.
Resumo: Abstract: Background: Psoriasis is a chronic and inflammatory disease that impairs quality of life and causes psychological symptoms. Despite the high prevalence of psoriasis in pediatric patients, studies investigating the impact of psoriasis in the quality of life of children, adolescents and families are sparse. Objective: To investigate the impact of psoriasis in the quality of life of children and adolescents with psoriasis and their families and to determine depression and anxiety levels of the patients. Methods: A total of 58 patients with psoriasis aged 7-18 years (median age: 11) and a family member of each patient were included in the study. Children's Dermatology Life Quality Index (CDLQI), Family Dermatology Life Quality Index (FDLQI), Children's Depression Inventory (CDI) and State-Trait Anxiety Inventory for Children (STAIC) were used in the study. Results: The median PASI score of the patients included in the study was 1.8. The median CDLQI and FDLQI scores in the study groups were 5 and 10, respectively. The median CDI score, STAIC-state and STAIC-trait scores of the patients were 6, 28 and 32.5, respectively. Study limitations: Lack of a control group and patient assessment of disease severity. Relatively mild disease severity of the subjects. Conclusions: Psoriasis has a negative impact in the quality of life of children, adolescents and their families, even in the presence of mild disease. Considering that impairment in quality of life may be associated with psychosocial morbidity, a combined approach with medical therapy, family counseling and quality of life assessment may be beneficial in this patient group.
Descritores: Ansiedade/psicologia
Psoríase/psicologia
Qualidade de Vida/psicologia
Família/psicologia
Depressão/psicologia
-Índice de Gravidade de Doença
Estudos Transversais
Inquéritos e Questionários
Limites: Seres Humanos
Masculino
Feminino
Criança
Adolescente
Responsável: BR1.1 - BIREME


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Id: biblio-973641
Autor: Morais, Marina Resener de; Martins, Gladys Aires; Romiti, Ricardo; Tonoli, Renata Elise; Carvalho, André Vicente Esteves.
Título: Translation and validation of the Simplified Psoriasis Index (SPI) into Brazilian Portuguese
Fonte: An. bras. dermatol;93(6):813-818, Nov.-Dec. 2018. tab.
Idioma: en.
Resumo: Abstract: Background: The Simplified Psoriasis Index is a tool that assesses the current severity, psychosocial impact, past history and interventions in patients with psoriasis through separate components. Two versions are available, one in which the current severity of the disease is evaluated by the patient themselves and another by the physician. Objectives: Translate the Simplified Psoriasis Index into Brazilian Portuguese and verify its validity. Methods: The study was conducted in two stages; the first stage was the translation of the instrument; the second stage was the instrument's validation. Results: We evaluated 62 patients from Complexo Hospitalar Santa Casa de Porto Alegre and Hospital Universitário de Brasília. The Simplified Psoriasis Index translated into Portuguese showed high internal consistency (Cronbach test 0.68). Study limitations: Some individuals, because of poor education, might not understand some questions of the Simplified Psoriasis Index. Conclusions: The Brazilian Portuguese version of the Simplified Psoriasis Index was validated for our population and can be recommended as a reliable instrument to assess the patients with psoriasis.
Descritores: Psoríase/diagnóstico
-Psoríase/classificação
Traduções
Índice de Gravidade de Doença
Brasil
Valor Preditivo dos Testes
Inquéritos e Questionários
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Características Culturais
Linguagem
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Tipo de Publ: Estudos de Validação
Responsável: BR1.1 - BIREME


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Id: biblio-973637
Autor: Kurizky, Patricia Shu; Martins, Gladys Aires; Carneiro, Jamille Nascimento; Gomes, Ciro Martins; Mota, Licia Maria Henrique da.
Título: Evaluation of the occurrence of sexual dysfunction and general quality of life in female patients with psoriasis
Fonte: An. bras. dermatol;93(6):801-806, Nov.-Dec. 2018. tab.
Idioma: en.
Resumo: Abstract: Background: Psoriasis has a significant impact on quality of life (QoL). Sexual life can also be affected, with sexual dysfunction being reported by 25-70% of patients. Objectives: To determine the occurrence of sexual dysfunction and evaluate QoL in women with psoriasis. Methods: This case-control study included women aged 18-69 years. The validated Brazilian Portuguese versions of the Female Sexual Function Index (FSFI) and of the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) were administered to all participants to assess sexual function and QoL, respectively. Patients with psoriasis underwent clinical evaluation for the presence of comorbidities, especially psoriatic arthritis and other rheumatic manifestations. Location of lesions and the extent of skin involvement were also assessed. Results: The sample consisted of 150 women, 75 with diagnosis of psoriasis and 75 healthy controls. Prevalence of sexual dysfunction was high in women with psoriasis (58.6% of the sample). Prevalence was statistically higher in women with psoriasis than in controls (P = 0.014). The SF-36 domain scores were also lower in women with psoriasis, with role limitations due to physical health, limitations due to emotional problems, and mental health being the most affected domains. Study limitations: Sample size was calculated to evaluate the association between the occurrence of sexual dysfunction and psoriasis, but it did not include the determination of the possible causes of this dysfunction. Conclusions: QoL and sexual function were altered in women with psoriasis and should be taken into consideration when assessing disease severity.
Descritores: Psoríase/psicologia
Qualidade de Vida/psicologia
Disfunções Sexuais Psicogênicas/psicologia
-Psoríase/complicações
Psoríase/epidemiologia
Índice de Gravidade de Doença
Brasil/epidemiologia
Estudos de Casos e Controles
Prevalência
Inquéritos e Questionários
Disfunções Sexuais Psicogênicas/epidemiologia
Limites: Seres Humanos
Feminino
Adolescente
Adulto
Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1001141
Autor: Vargas, Pablo; Giacaman, Paula; Fernández, Javier; Morales, Claudia.
Título: Bullous pemphigoid associated with psoriasis: a good response to methotrexate
Fonte: An. bras. dermatol;94(2):224-226, Mar.-Apr. 2019. graf.
Idioma: en.
Resumo: Abstract Psoriasis has been associated with various autoimmune diseases, however, its relation to bullous diseases is infrequent. Of these, bullous pemphigoid appears as the main associated entity, even though both conditions differ considerably in demographic and clinical aspects. We report the case of a 42-year-old female patient, with long-standing psoriasis who consulted due to the exacerbation of psoriatic plaques associated with generalized bullous lesions on the skin and oral mucosa, with one-week duration. With clinical signs and histopathological findings compatible with bullous pemphigoid associated with psoriasis, we decided to treat her with methotrexate 10mg a week. The patient had an excellent response after two months of treatment.
Descritores: Psoríase/tratamento farmacológico
Metotrexato/uso terapêutico
Penfigoide Bolhoso/tratamento farmacológico
Fármacos Dermatológicos/uso terapêutico
-Psoríase/complicações
Psoríase/diagnóstico
Penfigoide Bolhoso/complicações
Penfigoide Bolhoso/diagnóstico
Resultado do Tratamento
Técnica Direta de Fluorescência para Anticorpo
Limites: Seres Humanos
Adulto
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-1001137
Autor: Chaibub, Sulamita Costa Wirth.
Título: High prevalence of psoriasis in a family from Goiás State, Brazil
Fonte: An. bras. dermatol;94(2):245-246, Mar.-Apr. 2019. graf.
Idioma: en.
Descritores: Psoríase/genética
-Linhagem
Psoríase/epidemiologia
Brasil/epidemiologia
Saúde da Família
Prevalência
Distribuição por Sexo
Padrões de Herança/genética
Limites: Seres Humanos
Masculino
Feminino
Tipo de Publ: Relatos de Casos
Carta
Responsável: BR1.1 - BIREME


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Id: biblio-983749
Autor: Souza, Bruno de Castro e; Bandeira, Luisa Groba; Cunha, Thais do Amaral Carneiro; Valente, Neusa Yuriko Sakai.
Título: Follicular psoriasis: an underdiagnosed entity?
Fonte: An. bras. dermatol;94(1):116-118, Jan.-Feb. 2019. graf.
Idioma: en.
Descritores: Psoríase/patologia
Folículo Piloso/patologia
Doenças do Cabelo/patologia
-Psoríase/diagnóstico
Biópsia
Eritema/patologia
Doenças do Cabelo/diagnóstico
Limites: Seres Humanos
Feminino
Meia-Idade
Tipo de Publ: Relatos de Casos
Carta
Responsável: BR1.1 - BIREME


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Id: biblio-1011088
Autor: Arnone, Marcelo; Takahashi, Maria Denise Fonseca; Carvalho, André Vicente Esteves de; Bernardo, Wanderley Marques; Bressan, Aline Lopes; Ramos, Andrea Machado Coelho; Terena, Aripuanã Cobério; Souza, Cacilda da Silva; Nunes, Daniel Holthausen; Bortoletto, Maria Cecília de Carvalho; Oliveira, Maria de Fátima Santos Paim de; Neffá, Jane Marcy; Fieri, Luciana Cristina; Azulay-Abulafia, Luna; Felix, Paulo Antônio Oldani; Magalhaes, Renata Ferreira; Romiti, Ricardo; Jaime, Tatiana Jerez.
Título: Diagnostic and therapeutic guidelines for plaque psoriasis - Brazilian Society of Dermatology
Fonte: An. bras. dermatol;94(2,supl.1):76-107, Mar.-Apr. 2019. tab, graf.
Idioma: en.
Resumo: Abstract: Psoriasis is a chronic inflammatory disease that affects 1.3% of the Brazilian population. The most common clinical manifestations are erythematous, scaling lesions that affect both genders and can occur on any anatomical site, preferentially involving the knees, elbows, scalp and genitals. Besides the impact on the quality of life, the systemic nature of the disease makes psoriasis an independent risk factor for cardiovascular disease, especially in young patients with severe disease. By an initiative of the Brazilian Society of Dermatology, dermatologists with renowned clinical experience in the management of psoriasis were invited to form a work group that, in a partnership with the Brazilian Medical Association, dedicated themselves to create the Plaque Psoriasis Diagnostic and Treatment Guidelines. The relevant issues for the diagnosis (evaluation of severity and comorbidities) and treatment of plaque psoriasis were defined. The issues generated a search strategy in the Medline-PubMed database up to July 2018. Subsequently, the answers to the questions of the recommendations were devised, and each reference selected presented the respective level of recommendation and strength of scientific evidence. The final recommendations for making up the final text were worded by the coordinators.
Descritores: Psoríase/diagnóstico
Psoríase/terapia
-Fototerapia/métodos
Psoríase/epidemiologia
Sociedades Médicas
Fatores de Tempo
Vitamina D/análise
Índice de Gravidade de Doença
Brasil
Comorbidade
Antralina/uso terapêutico
Metotrexato/uso terapêutico
Ciclosporina/uso terapêutico
Corticosteroides/uso terapêutico
Fármacos Dermatológicos/uso terapêutico
Dermatologia
Combinação de Medicamentos
Inibidores de Calcineurina/uso terapêutico
Anticorpos Monoclonais/uso terapêutico
Limites: Seres Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME


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Id: biblio-1001146
Autor: Ermis, Esra; Celik, Sevim Karakas; Solak, Nilgun; Genc, Gunes Cakmak; Dursun, Ahmet.
Título: The role of GNLY gene polymorphisms in psoriasis pathogenesis
Fonte: An. bras. dermatol;94(2):198-203, Mar.-Apr. 2019. tab, graf.
Idioma: en.
Projeto: Unit of Scientific Research Projects of Bulent Ecevit University.
Resumo: Abstract BACKGROUND: Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems. The most accepted mechanism in the etiopathogenesis of psoriasis is the induction of inflammation with keratinocyte hyperproliferation. Granulysin (GNLY) is a cytolytic antimicrobial peptide (AMP) that is secreted together with granzyme and perforin from the granules of human cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It has been immunohistochemically proven that the expression of granulysin is increased in lesions of psoriasis. OBJECTIVE: This study aimed to investigate the relationship between psoriasis disease and granulysin gene polymorphisms. METHODS: GNLY rs7908 and rs10180391 polymorphisms were studied by PCR-RFLP in 100 psoriasis patients under treatment in the Dermatology Polyclinic of Bulent Ecevit University. In addition, 100 healthy individuals with similar age and sex distribution were used as a control group. RESULTS: In the control group, GNLY rs7908 CC genotype was significantly higher than in psoriasis patients (P= 0.031; OR= 0.305; Cl= 0.305 (0.121 - 0.773). In our study, the genotype distributions in patients and control groups were GNLY rs7908 (SNP) GG (51%, 37%), GC (41%, 44%), CC (8%, 19%); GNLY rs10180391 (SNP) from the CC (41%, 44%), CT (42%, % 41), TT (17%, 15%). STUDY LIMITATIONS: The study only included Turkish patients. CONCLUSION: Our findings showed that GNLY rs7908 CC genotype and C allele had a protective effect against psoriasis and decreased the disease severity (according to PASI score), whereas rs10180391 SNP did not show any effective role in psoriasis pathogenesis.
Descritores: Polimorfismo Genético/genética
Psoríase/genética
Antígenos de Diferenciação de Linfócitos T/genética
-Psoríase/etiologia
Índice de Gravidade de Doença
Estudos de Casos e Controles
Expressão Gênica
Substâncias Protetoras
Alelos
Genótipo
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Responsável: BR1.1 - BIREME



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