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Waitzberg, Dan Linetzky
Texto completo
Id: lil-72737
Autor: Waitzberg, Dan Linetzky; Gonçalves, Ernesto Lima; Duarte, Alberto José da Silva; Faintuch, Joel; Rocha, Carla Lee; Bevilacqua, Lucí Rezende.
Título: Modificaçäo da resposta cutânea ao teste de hipersensibilidade tardia em desnutriçäo e câncer: estudo experimental / Skin response in delayed hypersensibilitty in malnutrition and cancer: experimental study
Fonte: Acta oncol. bras;9(1):54-62, jan.-abr. 1989. tab, ilus.
Idioma: pt.
Resumo: O tumor maligno é capaz de interferir com os valores do peso da carcaça, da albumina sérica e dos testes de hipersensibilidade, o mesmo acontecendo com a desnutriçäo. Procurando distinguir os efeitos dos dois fenômenos, ratos Wistar adultos foram submetidos a diferentes manipulaçöes nutricionais em associaçäo com o implante de células de carcinomassarcoma de Walker 256 (TU). Seis grupos de animais normais com resposta positiva ao Keyhole Limpet hemocyanin (KLH) foram estudados. Três grupos de ratos portadores de tumor foram submetidos a diferentes esquemas nutricionais: dieta aprotéica antes e depois do implante tumoral (grupo DDT); dieta aprotéica antes do implante, seguindo-se dieta normal (grupo DNT); dieta normal ao longo de todo o experimento (grupo NNT). Grupos controles sem tumor receberam os mesmos tratamentos nutricionais, constituindo os grupos DDC, DNC e NNC. O peso corpóreo dos ratos e da massa tumoral em evoluçäo foram determinados diariamente; os testes KLH foram realizados periodicamente e a albumina sérica foi dosada no dia do sacrifício dos animais. Os resultados indicam que o tumor maligno produz acentuadas modificaçöes na resposta imunológica; a desnutriçäo é responsável por anergia e perda de peso . Quando ambas as condiçöes estäo presentes, ocorrem pertubaçöes mais acentuadas. A realimentaçäo (grupos DNC e DNT) foi capaz de restabelecer o peso corpóreo e a resposta ao KLK, tanto nos ratos normais, quanto nos portadores de tumor, mas prejuízo subseqüente ocorreu em ratos portadores do tumor, depois da primeira semana de desenvolvimento tumoral. Conclui-se que o câncer potencializa os efeitos da desnutriçäo sobre o peso corpóreo e a resposta imunológica, com recuperaçäo temporária após adequada realimentaçäo
Descritores: Peso Corporal
Carcinoma 256 de Walker/induzido quimicamente
Estado Nutricional
Hipersensibilidade Tardia
Transtornos Nutricionais
Modelos Animais de Doenças
Testes Cutâneos
Limites: Animais
Masculino
Ratos
Responsável: BR440.1 - Biblioteca Geraldo Matos de Sá . Hospital do Câncer I


  2 / 2351 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: biblio-886699
Autor: DAMAZIO, LOUYSE S; SILVEIRA, FLÁVIA R; CANEVER, LARA; CASTRO, ADALBERTO A DE; ESTRELA, JADNE M; BUDNI, JOSIANE; ZUGNO, ALEXANDRA I.
Título: The preventive effects of ascorbic acid supplementation on locomotor and acetylcholinesterase activity in an animal model of schizophrenia induced by ketamine
Fonte: An. acad. bras. ciênc;89(2):1133-1141, Apr.-June 2017. graf.
Idioma: en.
Resumo: ABSTRACT Studies have shown that schizophrenic patients seem to have nutritional deficiencies. Ascorbic acid (AA) has an important antioxidant effect and neuromodulatory properties. The aim of this study was to evaluate the effects of AA on locomotor activity and the acetylcholinesterase activity (AChE) in an animal model of schizophrenia (SZ). Rats were supplemented with AA (0.1, 1, or 10 mg/kg), or water for 14 days (gavage). Between the 9th and 15th days, the animals received Ketamine (Ket) (25 mg/kg) or saline (i.p). After the last administration (30 min) rats were subjected to the behavioral test. Brain structures were dissected for biochemical analysis. There was a significant increase in the locomotor activity in Ket treated. AA prevented the hyperlocomotion induced by ket. Ket also showed an increase of AChE activity within the prefrontal cortex and striatum prevented by AA. Our data indicates an effect for AA in preventing alterations induced by Ket in an animal model of SZ, suggesting that it may be an adjuvant approach for the development of new therapeutic strategies within this psychiatric disorder.
Descritores: Acetilcolinesterase/análise
Acetilcolinesterase/efeitos dos fármacos
Ácido Ascórbico/farmacologia
Esquizofrenia/enzimologia
Locomoção/efeitos dos fármacos
Antioxidantes/farmacologia
-Acetilcolinesterase/fisiologia
Esquizofrenia/prevenção & controle
Antagonistas de Aminoácidos Excitatórios
Suplementos Nutricionais
Corpo Estriado/efeitos dos fármacos
Corpo Estriado/enzimologia
Modelos Animais de Doenças
Hipocampo/efeitos dos fármacos
Hipocampo/enzimologia
Ketamina
Locomoção/fisiologia
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


  3 / 2351 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: biblio-886724
Autor: NEVES, GILDA; BORSOI, MILENE; ANTONIO, CAMILA B; PRANKE, MARIANA A; BETTI, ANDRESA H; RATES, STELA M K.
Título: Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects
Fonte: An. acad. bras. ciênc;89(3):1655-1669, July-Sept. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Immobility time in the forced swimming has been described as analogous to emotional blunting or apathy and has been used for characterizing schizophrenia animal models. Several clinical studies support the use of NMDA receptor antagonists to model schizophrenia in rodents. Some works describe the effects of ketamine on immobility behavior but there is variability in the experimental design used leading to controversial results. In this study, we evaluated the effects of repeated administration of ketamine sub-anesthetic doses in forced swimming, locomotion in response to novelty and novel object recognition, aiming a broader evaluation of the usefulness of this experimental approach for modeling schizophrenia in mice. Ketamine (30 mg/kg/day i.p. for 14 days) induced a not persistent decrease in immobility time, detected 24h but not 72h after treatment. This same administration protocol induced a deficit in novel object recognition. No change was observed in mice locomotion. Our results confirm that repeated administration of sub-anesthetic doses of ketamine is useful in modeling schizophrenia-related behavioral changes in mice. However, the immobility time during forced swimming does not seem to be a good endpoint to evaluate the modeling of negative symptoms in NMDAR antagonist animal models of schizophrenia.
Descritores: Esquizofrenia/fisiopatologia
Natação/fisiologia
Comportamento Animal/efeitos dos fármacos
Modelos Animais de Doenças
Ketamina/farmacologia
Anestésicos Dissociativos/farmacologia
-Esquizofrenia/induzido quimicamente
Comportamento Animal/fisiologia
Imobilização/fisiologia
Atividade Motora/efeitos dos fármacos
Atividade Motora/fisiologia
Limites: Animais
Masculino
Coelhos
Responsável: BR1.1 - BIREME


  4 / 2351 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: biblio-886764
Autor: AGUIAR, RAQUEL R DE; VALE, DANIELA F; SILVA, RENATO M DA; MUNIZ, YOLANDA P; ANTUNES, FERNANDA; LOGULLO, CARLOS; OLIVEIRA, ANDRÉ L A; ALMEIDA, ADRIANA J E.
Título: A possible relationship between gluconeogenesis and glycogen metabolism in rabbits during myocardial ischemia
Fonte: An. acad. bras. ciênc;89(3):1683-1690, July-Sept. 2017. graf.
Idioma: en.
Resumo: ABSTRACT Ischemia is responsible for many metabolic abnormalities in the heart, causing changes in organ function. One of modifications occurring in the ischemic cell is changing from aerobic to anaerobic metabolism. This change causes the predominance of the use of carbohydrates as an energy substrate instead of lipids. In this case, the glycogen is essential to the maintenance of heart energy intake, being an important reserve to resist the stress caused by hypoxia, using glycolysis and lactic acid fermentation. In order to study the glucose anaerobic pathways utilization and understand the metabolic adaptations, New Zealand white rabbits were subjected to ischemia caused by Inflow occlusion technique. The animals were monitored during surgery by pH and lactate levels. Transcription analysis of the pyruvate kinase, lactate dehydrogenase and phosphoenolpyruvate carboxykinase enzymes were performed by qRT-PCR, and glycogen quantification was determined enzymatically. Pyruvate kinase transcription increased during ischemia, followed by glycogen consumption content. The gluconeogenesis increased in control and ischemia moments, suggesting a relationship between gluconeogenesis and glycogen metabolism. This result shows the significant contribution of these substrates in the organ energy supply and demonstrates the capacity of the heart to adapt the metabolism after this injury, sustaining the homeostasis during short-term myocardial ischemia.
Descritores: Traumatismo por Reperfusão Miocárdica/metabolismo
Isquemia Miocárdica/metabolismo
Gluconeogênese/fisiologia
Glicogênio/metabolismo
-Traumatismo por Reperfusão Miocárdica/fisiopatologia
Isquemia Miocárdica/fisiopatologia
Modelos Animais de Doenças
Limites: Animais
Masculino
Coelhos
Responsável: BR1.1 - BIREME


  5 / 2351 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: biblio-886830
Autor: LUCINDA, LEDA M F; AARESTRUP, BEATRIZ J V; REBOREDO, MAYCON M; PAINS, THAIS D A; CHAVES, RAPHAEL Z; REIS, JOÃO E P; LOUZADA, MÁRIO J Q; GUERRA, MARTHA O.
Título: Evaluation of the anti-osteoporotic effect of Ginkgo biloba L. in Wistar rats with glucocorticoid-induced-osteoporosis by bone densitometry using dual-energy x-ray absorptiometry (DEXA) and mechanical testing
Fonte: An. acad. bras. ciênc;89(4):2833-2841, Oct.-Dec. 2017. graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de Minas Gerais.
Resumo: ABSTRACT Evaluate the effect of the extract of Ginkgo biloba in the bone alkaline phosphatase, bone mineral density, in the mechanical properties of the tibia in rats with glucocorticoid-induced-osteoporosis. After osteoporosis induction, the rats were divided into five groups: Osteoporosis; EGb1 (28 mg/Kg); EGb2 (56 mg/Kg); alendronate (0.2 mg/animal) and control. The animals were treated during 20 and 30 days. The control group was compared with the osteoporosis's (Student's t-test), while the other were analyzed by ANOVA test followed by Tukey/Dunnett'T3 (p<0.05). In the osteoporosis group the bone alkaline phosphatase, bone mineral density, the bone stiffness, the maximum load and the resilience were reduced. The bone alkaline phosphatase values increased in the EGb1 and EGb2 groups (30 days). In addition, in the EGb2 and alendronate groups (20 and 30 days) the bone mineral density increased. The extract of Ginkgo biloba restored bone alkaline phosphatase and bone mineral density using dual-energy x-ray absorptiometry.
Descritores: Osteoporose/tratamento farmacológico
Extratos Vegetais/farmacologia
Densidade Óssea/efeitos dos fármacos
-Osteoblastos
Osteoporose/induzido quimicamente
Tíbia
Ratos Wistar
Modelos Animais de Doenças
Fosfatase Alcalina/metabolismo
Glucocorticoides
Limites: Animais
Feminino
Ratos
Responsável: BR1.1 - BIREME


  6 / 2351 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: biblio-886836
Autor: FRANKE, SILVIA I R; MOLZ, PATRÍCIA; MAI, CAMILA; ELLWANGER, JOEL H; ZENKNER, FERNANDA F; HORTA, JORGE A; PRÁ, DANIEL.
Título: High consumption of sucrose induces DNA damage in male Wistar rats
Fonte: An. acad. bras. ciênc;89(4):2657-2662, Oct.-Dec. 2017. tab.
Idioma: en.
Resumo: ABSTRACT The purpose of this study was to determine the effects of the high consumption of sucrose on the levels of DNA damage in blood, hippocampus and bone marrow of rats. Male Wistar rats were treated for 4 months with sucrose (10% for 60 initial days and 34% for the following 60 days) in drinking water, and then, glycemia and glycated hemoglobin (A1C) were measured. Levels of DNA damage in blood and hippocampus were evaluated by the comet assay. The micronucleus test was used to evaluate chromosomal damages in the bone marrow. The sucrose treatment significantly increased (p<0.01) the serum glucose levels (~20%) and A1C (~60%). The level of primary DNA damage was significantly increased (p<0.05) in hippocampal cells (~60%) but not in peripheral blood leukocytes (p>0.05). Additionally, it was observed a significative increase (p<0.05) in the markers of chromosomal breaks/losses in bone marrow, as indicated by the micronucleus test. This is the first study that evaluated DNA damage induced by high sucrose concentration in the hippocampus and bone marrow of rats. Sucrose-induced DNA damage was observed in both tissues. However, the mechanism of sucrose toxicity on DNA remains unknown.
Descritores: Medula Óssea/efeitos dos fármacos
Dano ao DNA
Hipocampo/efeitos dos fármacos
-Medula Óssea/patologia
Testes para Micronúcleos
Ratos Wistar
Sacarose na Dieta/efeitos adversos
Ensaio Cometa
Diabetes Mellitus Tipo 2/complicações
Modelos Animais de Doenças
Hipocampo/patologia
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  7 / 2351 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: biblio-886841
Autor: CORRÊA, ADRIANO S; ALMEIDA, VINÍCIUS L DE; LOPES, BEATRIZ M V; FRANCO, ADEMIR; MATOS, FELIPE R DE; QUINTANS-JÚNIOR, LUCINDO J; RODE, SIGMAR M; PARANHOS, LUIZ R.
Título: The influence of non-steroidal anti-inflammatory drugs and paracetamol used for pain control of orthodontic tooth movement: a systematic review
Fonte: An. acad. bras. ciênc;89(4):2851-2863, Oct.-Dec. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT The present study aimed to perform a systematic literature review to determine if there is a non-steroidal anti-inflammatory drug (NSAID) that interferes less within tooth movement. This research was performed according to the PRISMA statement. Articles were searched in eight electronic databases (PubMed, Scopus, Embase, Web of Science, LILACS, SciELO, Google Scholar, and Open Grey). Only experimental studies on male Wistar rats were selected, which included experiments related to the influence of NSAIDs on orthodontic movement. Studies in animals with pathological conditions, literature review articles, letters to the editor and/or editorials, case reports, abstracts, books, and book chapters were excluded. Each of the steps of this systematic literature review was performed by two examiners independently. Results: the total sample consisted of 505 articles, from which 6 studies were eligible after a qualitative analysis. From the drugs assessed, paracetamol was unanimous for not interfering within orthodontic movement when compared to the control group. However, drugs such as aspirin, ibuprofen, sodium diclofenac, and selective cyclooxygenase-2 inhibitors caused a reduction in tooth movement when compared to the control group. Conclusion: paracetamol could be considered the drug of choice for pain relief because it interferes less within tooth movement.
Descritores: Técnicas de Movimentação Dentária/efeitos adversos
Anti-Inflamatórios não Esteroides/farmacologia
Ibuprofeno/farmacologia
Analgésicos não Entorpecentes/farmacologia
Dor Processual/tratamento farmacológico
Acetaminofen/farmacologia
-Ratos Wistar
Modelos Animais de Doenças
Limites: Animais
Ratos
Tipo de Publ: Revisão
Revisão Sistemática
Responsável: BR1.1 - BIREME


  8 / 2351 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: biblio-886850
Autor: ZENI, ANA LÚCIA B; MOREIRA, TATIANNE D; DALMAGRO, ANA PAULA; CAMARGO, ANDERSON; BINI, LARISSA A; SIMIONATTO, EDÉSIO L; SCHARF, DILAMARA R.
Título: Evaluation of phenolic compounds and lipid-lowering effect of Morus nigra leaves extract
Fonte: An. acad. bras. ciênc;89(4):2805-2815, Oct.-Dec. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Morus nigra L. (Moraceae) is a tree known as black mulberry and the leaves are used in folk medicine in the treatment of diabetes, high cholesterol and menopause symptoms. The aim of this study was to evaluate the M. nigra leaves phytochemical profile in different extractions and the hypolipidemic effect of the infusion comparing to the fenofibrate. Morus nigra infusion (MN) showed higher amounts of phenolics and flavonoids (83.85 mg/g and 79.96 µg/g, respectively), as well as antioxidant activity (83.85%) than decoction or hydromethanolic extracts. Although, decoction showed the best result for ascorbic acid (4.35 mg/100 g) than hydromethanolic or infusion (2.51 or 2.13 mg/100 g, respectively). The phenolic acids gallic, chlorogenic and caffeic and the flavonoids quercetin, rutin and catechin were found in the M. nigra extracts. Hyperlipidemic rats treated with 100, 200 or 400 mg/kg of MN decreased serum cholesterol, triglycerides and normalized lipoproteins. Furthermore, MN inhibited lipid peroxidation in liver, kidney and brain of hyperlipidemic rats. This study provides evidence that M. nigra leaves extracts are rich in polyphenols, mainly chlorogenic acid, which normalized hyperlipidemic disturbance. The results suggest a potential therapeutic effect of the M. nigra leaves infusion on dislipidemic condition and related oxidative stress.
Descritores: Fenóis/farmacologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
Morus/química
Lipídeos/sangue
-Fenóis/isolamento & purificação
Ácido Ascórbico/farmacologia
Flavonoides/farmacologia
Ratos Wistar
Modelos Animais de Doenças
Antioxidantes/farmacologia
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  9 / 2351 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: biblio-886919
Autor: SOUSA-NETO, BENEDITO P; GOMES, BRUNO S; CUNHA, FRANCISCO V M; ARCANJO, DANIEL D R; GUTIERREZ, STANLEY J C; SOUZA, MARIA F V; ALMEIDA, FERNANDA R C; OLIVEIRA, FRANCISCO A.
Título: Antiedematogenic activity of the indole derivative N-salicyloyltryptamine in animal models
Fonte: An. acad. bras. ciênc;90(1):185-194, Mar. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT The N-salicyloyltryptamine (NST) is an indole derivative compound analogue to the alkaloid N-benzoyltryptamine. In the present study, the antiedematogenic activity of NST was investigated in animal models. Firstly, the acute toxicity for NST was assessed according to the OECD Guideline no. 423. The potential NST-induced antiedematogenic activity was evaluated by carrageenan-induced paw edema in rats, as well as by dextran-, compound 48/80-, histamine-, serotonin-, capsaicine-, and prostaglandin E2-induced paw edema in mice. The effect of NST on compound 48/80-induced ex vivo mast cell degranulation on mice mesenteric bed was investigated. No death or alteration of behavioral parameters was observed after administration of NST (2000 mg/kg, i.p.) during the observation time of 14 days. The NST (100 and 200 mg/kg, i.p.) inhibited the carrageenan-induced edema from the 1st to the 5th hour (**p<0.01; ***p<0.001). The edematogenic activity induced by dextran, compound 48/80, histamine, serotonin, capsaicin, and prostaglandin E2 was inhibited by NST (100 mg/kg, i.p.) throughout the observation period (**p<0.01; ***p<0.001). The pretreatment with NST (50, 100 or 200 mg/kg, i.p) attenuates the compound 48/80-induced mast cell degranulation (**p<0.01; ***p<0.001). Thus, the inhibition of both mast cell degranulation and release of endogenous mediators are probably involved in the NST-induced antiedematogenic effect.
Descritores: Triptaminas/farmacologia
Salicilatos/farmacologia
Edema/tratamento farmacológico
Anti-Inflamatórios/farmacologia
-Peptídeos/efeitos dos fármacos
Fatores de Tempo
Carragenina
Triptaminas/toxicidade
Salicilatos/toxicidade
Ratos Wistar
Mediadores da Inflamação
Modelos Animais de Doenças
Edema/induzido quimicamente
Membro Posterior
Anti-Inflamatórios/toxicidade
Limites: Animais
Masculino
Feminino
Ratos
Responsável: BR1.1 - BIREME


  10 / 2351 LILACS  
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Id: biblio-1118535
Autor: Montes-Angeles, Claudia Daniela; Gutierrez-Castañeda, Nadia; Sosa, Christian; Jiménez, Juan; Miranda, Florencio; Pérez-Martinez, Isaac Obed.
Título: Multidimensional study of orofacial chronic neuropathic pain: an experimental study in rats
Fonte: J. oral res. (Impresa);6(10):270-275, oct. 31, 2017. graf.
Idioma: en.
Resumo: Orofacial neuropathic chronic pain (NCP) is frequently attributed to lesions caused by orofacial surgeries and dental treatments. there are many experimental models available to study orofacial NCP, however, many are extremely painful for the animal due to the amplitude of the innervated region. a previously proposed mental nerve constriction model, mNC, was used in this project. forty wistar rats were randomly divided into two groups: one group included rats with mNC (n=20), and another rats with sham lesions (n=20). through the use of the fixed ratio program and the progressive program, a decrease of motivation for a sweet substance, caused by the lesion, was evaluated. the possibility of alterations in cognitive learning and adaptation abilities was also assessed using the go/no-go behavioral task. the mNC group showed low induced and spontaneously evoked pain responses, as well as a decrease in the motivation for sucrose, a sign of anhedonia. this decrease does not depend on taste processing. finally, although no alterations in the learning-memory process were observed, the mNC group did show alterations when adapting to a new rule.
Descritores: Comportamento Animal/fisiologia
Dor Facial/etiologia
Traumatismos do Nervo Trigêmeo/complicações
Dor Crônica/etiologia
-Sacarose
Ratos Wistar
Modelos Animais de Doenças
Comportamento Exploratório/fisiologia
Neuralgia
Limites: Animais
Ratos
Responsável: CL30.1 - Biblioteca



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