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Id: biblio-949949
Autor: Amorim, Gustavo Moreira; Corbellini, João Paulo Niemeyer; Quintella, Danielle Carvalho; Cuzzi, Tullia; Ramos-e-Silva, Márcia.
Título: Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides
Fonte: An. bras. dermatol;93(5):680-685, Sept.-Oct. 2018. tab.
Idioma: en.
Resumo: Abstract: Background: Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed. Objective: To evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF. Methods: This is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death. Results: One hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk. Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR: 1.2 / p = 0.004 / 95%CI: 1.0 - 1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification. Study Limitations: Small sample and its retrospective analysis. Conclusions: Since CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use.
Descritores: Neoplasias Cutâneas/patologia
Micose Fungoide/patologia
-Prognóstico
Neoplasias Cutâneas/mortalidade
Brasil/epidemiologia
Estudos Transversais
Taxa de Sobrevida
Estudos Retrospectivos
Seguimentos
Linfoma Cutâneo de Células T/mortalidade
Linfoma Cutâneo de Células T/patologia
Micose Fungoide/mortalidade
Síndrome de Sézary/patologia
Progressão da Doença
Estadiamento de Neoplasias
Limites: Seres Humanos
Masculino
Meia-Idade
Tipo de Publ: Estudo Observacional
Responsável: BR1.1 - BIREME


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Id: biblio-949930
Autor: Borges, Isabela Bruna Pires; Silva, Marilda Guimarães; Shinjo, Samuel Katsuyuki.
Título: Prevalence and reactivity of anti-melanoma differentiation-associated gene 5 (anti-MDA-5) autoantibody in Brazilian patients with dermatomyositis
Fonte: An. bras. dermatol;93(4):517-523, July-Aug. 2018. tab.
Idioma: en.
Projeto: FAPESP.
Resumo: Abstract: Background: There have been no studies to date on the frequency and reactivity of aanti-melanoma differentiation-associated gene 5 (anti-MDA-5) in samples from the Brazilian population with dermatomyositis. Objectives: To analyze this autoantibody in the Brazilian population. Methods: This was a single-center cross-sectional study in which 131 consecutive adult patients (109 dermatomyositis and 22 clinically amyopathic dermatomyositis) with active disease were evaluated from 2000 to 2016. Analysis of the anti-MDA-5 autoantibody was performed by ELISA. Results: The presence of this autoantibody was observed in 14.7% and 22.7% of patients with dermatomyositis and clinically amyopathic dermatomyositis, respectively. In the case of dermatomyositis, the autoantibody was associated less frequently with Raynaud's phenomenon and periungual hyperemia (P<0.05). In clinically amyopathic dermatomyositis, the presence of this autoantibody was not associated statistically with any demographic, clinical, laboratory, or imaging characteristics. Study limitations: The cross-sectional study design did not allow establishing a temporal correlation between anti-MDA-5 autoantibody and various study variables. In addition, pulmonary function tests were not performed in the patients. Conclusions: The frequency of anti-MDA-5 autoantibody was comparable to that of other populations with dermatomyositis, but with a different reactivity than described in the literature. In addition, there was a phenotypic variability between our patients with clinically amyopathic dermatomyositis and those described in the literature. Further studies are needed to confirm the current study's findings and elucidate this autoantibody's reactivity in Brazilians with idiopathic inflammatory myopathies.
Descritores: Autoanticorpos/sangue
Dermatomiosite/imunologia
Helicase IFIH1 Induzida por Interferon/imunologia
-Autoanticorpos/imunologia
Índice de Gravidade de Doença
Ensaio de Imunoadsorção Enzimática
Estudos Transversais
Estatísticas não Paramétricas
Progressão da Doença
Dermatomiosite/complicações
Dermatomiosite/sangue
Helicase IFIH1 Induzida por Interferon/sangue
Limites: Seres Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-1038300
Autor: Germano, Andressa; Cardili, Leonardo; Carapeto, Fernando Cintra Lopes; Landman, Gilles.
Título: BRAFV600E and KIT immunoexpression in early-stage melanoma
Fonte: An. bras. dermatol;94(4):458-460, July-Aug. 2019. tab, graf.
Idioma: en.
Resumo: Abstract: Melanoma is widely known as the most lethal skin cancer. Specific tumor-related mortality can be significantly reduced if diagnosis and treatment are properly performed during initial phases of the disease. The current search for biomarkers in early-stage melanomas is a high-priority challenge for physicians and researchers. We aimed to assess the immunoexpression of BRAFV600E and KIT in a case series consisting of 44 early-stage melanomas. Formalin-fixed paraffin-embedded samples were systematically evaluated using a semi-quantitative method based on scores of percentage and intensity for immunostained tumor cells. We observed significant concordance between BRAFV600E and KIT immunoexpression in thin invasive melanomas. Our findings corroborate previous evidence showing abnormal expression of proteins associated with MAPK intracellular signaling pathway in early-stage melanomas.
Descritores: Neoplasias Cutâneas/patologia
Proteínas Proto-Oncogênicas c-kit/análise
Proteínas Proto-Oncogênicas B-raf/análise
Melanoma/patologia
-Imuno-Histoquímica
Estudos Retrospectivos
Progressão da Doença
Proteínas Proto-Oncogênicas c-kit/genética
Proteínas Quinases Ativadas por Mitógeno/análise
Proteínas Proto-Oncogênicas B-raf/genética
Mutação
Estadiamento de Neoplasias
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: lil-749672
Autor: Adriano, André Ricardo; Quiroz, Carlos Daniel; Acosta, Martha Liliana; Jeunon, Thiago; Bonini, Flávia.
Título: Milker's nodule - Case report
Fonte: An. bras. dermatol;90(3):407-410, May-Jun/2015. tab, graf.
Idioma: en.
Resumo: Abstract Milker's nodule is an occupational viral skin disease of universal distribution, caused by the Paravaccinia virus and that occurs in individuals who deal with dairy cattle herds. We describe a case acquired due to lack of use of PPE (Personal Protective Equipment) and perform a literature review.
Descritores: Dermatopatias Virais/patologia
Infecções por Poxviridae/patologia
Dermatoses da Mão/patologia
Doenças Profissionais/patologia
-Biópsia
Vírus da Pseudovaríola das Vacas
Progressão da Doença
Limites: Seres Humanos
Animais
Feminino
Meia-Idade
Bovinos
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: lil-703537
Autor: Santos, Guida; Sousa, Lourdes; Fernandes, Teresa; Joao, Alexandre.
Título: Case for diagnosis
Fonte: An. bras. dermatol;89(1):173-174, Jan-Feb/2014. graf.
Idioma: en.
Resumo: Cutaneous involvement associated to multiple myeloma varies from 5 to 10% of cases and is infrequently recognized. Cutaneous metastatic plasmacitomas are rare. We present the case of a 72-year-old man with multiple myeloma in complete remission since 2 years ago with cutaneous tumors on the trunk and face. A cutaneous biopsy was consistent with plasmacytoma. The patient was treated with melphalan, prednisolone and radiotherapy. Despite optimal therapeutic response of the lesions, the disease progressed, with the appearance of new extra-cutaneous plasmocytomas. The cutaneous metastatic plasmocytomas were the first sign of progression of the disease.
Descritores: Plasmocitoma/secundário
Neoplasias Cutâneas/secundário
Mieloma Múltiplo/patologia
-Pele/patologia
Biópsia
Medula Óssea/patologia
Imuno-Histoquímica
Progressão da Doença
Limites: Seres Humanos
Masculino
Idoso
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-827663
Autor: Baracho, Nilo César do Vale; Kangussu, Lucas Miranda; Prestes, Thiago Ruiz Rodrigues; Silveira, Kátia Daniela da; Pereira, Regina Maria; Rocha, Natália Pessoa; Silva, Ana Cristina Simões e.
Título: Characterization of an experimental model of progressive renal disease in rats
Fonte: Acta cir. bras;31(11):744-752, Nov. 2016. tab, graf.
Idioma: en.
Projeto: FAPEMIG; . CNPq.
Resumo: ABSTRACT PURPOSE: To characterize an experimental model of progressive renal disease induced by different degrees of nephrectomy in rats. METHODS: Eighty male Wistar rats were divided into four experimental groups (n=20/group): sham surgery (control group), progressive degrees of nephrectomy leading to mild uremia (group 1), moderate uremia (group 2) and severe uremia (group 3). Ten animals of each group were followed for two or four weeks. At the end, blood and 24-hour urine samples were collected to determine renal function parameters. Urine output and water and food intake were daily monitored. RESULTS: In rats of group 1, serum levels of creatinine and urea and microalbuminuria were increased, while reduced creatinine clearance (p<0.05, compared with control group), without changing blood pressure. Animals of group 2 had more accentuated alterations: increases in urinary output, blood pressure, serum concentrations of urea, creatinine, sodium, potassium, and in microalbuminuria, and reduction of creatinine clearance (p<0.05). Group 3 exhibited even more increased serum concentrations of urea, creatinine, sodium and potassium, blood pressure and microalbuminuria, and decreased creatinine clearance (p<0.05) in comparison with control group and unilateral nephrectomy. CONCLUSION: Progressive nephrectomy in rats seems to be useful to study the physiopathology of chronic kidney disease and its mechanisms of progression.
Descritores: Uremia/metabolismo
Rim/fisiopatologia
Falência Renal Crônica/fisiopatologia
Nefrectomia/efeitos adversos
-Ureia/sangue
Uremia/etiologia
Índice de Gravidade de Doença
Ratos Wistar
Progressão da Doença
Creatinina/sangue
Albuminúria/sangue
Modelos Animais de Doenças
Pressão Arterial/fisiologia
Taxa de Filtração Glomerular/fisiologia
Falência Renal Crônica/patologia
Nefrectomia/métodos
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-745887
Autor: Calado, Bruno Nagel; Maron, Paulo Eduardo Goulart; Vedovato, Bruno César; Barrese, Tomas Zecchini; Fernandes, Roni de Carvalho; Perez, Marjo Deninson Cardenuto.
Título: Small cell carcinoma of the bladder / Carcinoma de células pequenas de bexiga
Fonte: Einstein (Säo Paulo);13(1):114-116, Jan-Mar/2015. graf.
Idioma: en.
Resumo: Small cell carcinoma of the urinary bladder is an extremely aggressive and rare tumor. Even though small cell carcinoma most commonly arises from the lungs there are several reports of small cell carcinoma in extrapulmonary sites. Due to its low frequency there is no well-established management for this disease. We report the case of a 61 year-old man with small cell carcinoma of the bladder who underwent radical cystectomy following neoadjuvant chemotherapy. We also reviewed the literature for the optimal treatment strategy.

O carcinoma de células pequenas da bexiga urinária é um tumor extremamente agressivo e raro. Apesar desses tumores terem como sítio principal o pulmão, existem diversos relatos de carcinoma de pequenas células extrapulmonares. Pela baixa frequência, ainda não existe um tratamento bem estabelecido para essa neoplasia. Relatamos o caso de um homem de 61 anos de idade com carcinoma de células pequenas da bexiga urinária que foi submetido à quimioterapia neoadjuvante seguida de cistectomia radical. Fazemos ainda revisão na literatura em busca dos métodos de maior sucesso para o tratamento.
Descritores: Neoplasias da Bexiga Urinária/patologia
Carcinoma de Células Pequenas/patologia
-Neoplasias da Bexiga Urinária/cirurgia
Evolução Fatal
Carcinoma de Células Pequenas/cirurgia
Progressão da Doença
Limites: Seres Humanos
Masculino
Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-950019
Autor: Caviedes Bottner, Paola; Córdova Fernández, Tamara; Larraín Valenzuela, Marcos; Cruces Romero, Pablo.
Título: Miocardiopatía dilatada e insuficiencia cardíaca grave: Puesta al día para el médico pediatra / Dilated cardiomyopathy and severe heart failure: An update for pediatricians
Fonte: Arch. argent. pediatr;116(3):421-428, jun. 2018. tab.
Idioma: en; es.
Resumo: La miocardiopatía dilatada es la principal causa de insuficiencia cardíaca que lleva a trasplante cardíaco. Su pronóstico es variable y depende de la etiología, la edad de presentación y el grado de insuficiencia cardíaca. El manejo está orientado a minimizar los síntomas y evitar la progresión de la enfermedad; se requiere de una evaluación integral en la pesquisa de comorbilidades y prevención de complicaciones que permitan mejorar la condición general de estos niños y atenuar su pronóstico. A continuación, se realiza una revisión orientada al manejo multidisciplinario que el pediatra debería considerar a la hora de enfrentarse a este tipo de pacientes.

Dilated cardiomyopathy is the main cause of heart failure leading to heart transplant. Its prognosis is variable and depends on the etiology, the patient's age at onset, and the severity. The management of dilated cardiomyopathy is aimed at minimizing symptoms and preventing disease progression; it requires a comprehensive screening for comorbidities and the prevention of complications to improve the overall status of these children and mitigate their prognosis. Here we present a review oriented at the multidisciplinary management that pediatricians should consider when seeing these patients.
Descritores: Cardiomiopatia Dilatada/complicações
Insuficiência Cardíaca/etiologia
-Prognóstico
Índice de Gravidade de Doença
Cardiomiopatia Dilatada/fisiopatologia
Cardiomiopatia Dilatada/terapia
Programas de Rastreamento/métodos
Transplante de Coração/métodos
Idade de Início
Progressão da Doença
Pediatras
Insuficiência Cardíaca/fisiopatologia
Insuficiência Cardíaca/terapia
Limites: Seres Humanos
Criança
Tipo de Publ: Revisão
Responsável: AR94.1 - Centro de Información Pediatrica


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Tilbery, Charles Peter
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Id: biblio-840285
Autor: Domingues, Renan Barros; Fernandes, Gustavo Bruniera Peres; Leite, Fernando Brunale Vilela de Moura; Tilbery, Charles Peter; Thomaz, Rodrigo Barbosa; Silva, Gisele Sampaio; Mangueira, Cristóvão Luis Pitangueira; Soares, Carlos Augusto Senne.
Título: The cerebrospinal fluid in multiple sclerosis: far beyond the bands / O líquido cefalorraquidiano na esclerose múltipla: muito além das bandas
Fonte: Einstein (Säo Paulo);15(1):100-104, Jan.-Mar. 2017.
Idioma: en.
Resumo: ABSTRACT The cerebrospinal fluid analysis has been employed for supporting multiple sclerosis diagnosis and ruling out the differential diagnoses. The most classical findings reflect the inflammatory nature of the disease, including mild pleocytosis, mild protein increase, intrathecal synthesis of immunoglobulin G, and, most typically, the presence of oligoclonal bands. In recent years, new biomarkers have emerged in the context of multiple sclerosis. The search for new biomarkers reflect the need of a better evaluation of disease activity, disease progression, and treatment efficiency. A more refined evaluation of disease and therapy status can contribute to better therapeutic choices, particularly in escalation of therapies. This is very relevant taking into account the availability of a greater number of drugs for multiple sclerosis treatment in recent years. In this review, we critically evaluate the current literature regarding the most important cerebrospinal fluid biomarkers in multiple sclerosis. The determination of biomarkers levels, such as chemokine ligand 13, fetuin A, and mainly light neurofilament has shown promising results in the evaluation of this disease, providing information that along with clinical and neuroimaging data may contribute to better therapeutic decisions.

RESUMO A análise do líquido cefalorraquidiano tem sido empregada para avaliação diagnóstica da esclerose múltipla e a exclusão dos diagnósticos diferenciais. Os achados clássicos refletem a natureza inflamatória da doença, incluindo discreta pleocitose, leve hiperproteinorraquia, aumento da síntese intratecal de imunoglobulina G e, mais tipicamente, a presença de bandas oligoclonais. Nos últimos anos, surgiram novos biomarcadores para esclerose múltipla, e esta busca por marcadores reflete a necessidade de melhor avaliar a atividade e a progressão da doença, bem como a eficácia terapêutica. Uma avaliação mais refinada da atividade da doença e da resposta aos medicamentos pode contribuir para melhores decisões terapêuticas, particularmente no que se refere à troca de medicação. Isto é muito importante nos dias de hoje, quando surgem novas opções medicamentosas. Neste artigo de revisão, avaliamos criticamente a literatura atual referente aos novos marcadores liquóricos na esclerose múltipla. A mensuração destes marcadores, como a quimiocina CXCL13, fetuína A e, principalmente, o neurofilamento de cadeia leve, demonstrou resultados promissores na avaliação da doença, provendo informações que, em conjunto com dados clínicos e de neuroimagem, podem contribuir para melhores decisões terapêuticas.
Descritores: Esclerose Múltipla/líquido cefalorraquidiano
-Filamentos Intermediários
Biomarcadores/líquido cefalorraquidiano
Citocinas/líquido cefalorraquidiano
Progressão da Doença
Proteína Básica da Mielina/líquido cefalorraquidiano
alfa-2-Glicoproteína-HS/líquido cefalorraquidiano
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-1017318
Autor: Cano G, Esaú; Córdova H, Juan Antonio; Guzmán P, Crystell; Muñoz C, Juan.
Título: Prediabetes en estudiantes de 1er año del campus ciencias de la salud de una universidad Mexicana / Prediabetes in 1st year students of the health sciences campus from a Mexican university
Fonte: ARS med. (Santiago, En línea);43(1):5-11, 2018. Tab, Graf.
Idioma: es.
Resumo: Introducción. Dado el aumento dramático de diabetes en el mundo, el objetivo de esta investigación fue analizar los valores de la glucemia en una población universitaria de nuevo ingreso para sustentar estrategias de detección y manejo preventivo de prediabetes y diabetes. Métodos. Estudio observacional, analítico, transversal, no probabilístico. Se analizaron los valores de glucemia en ayunas de 367 estudiantes de nuevo ingreso en 2011, y 430 en 2016 al campus de Ciencias de la Salud de una universidad del sureste de México. Se aplicaron pruebas de tendencia central, comparaciones y proyecciones. Resultados. En la muestra de 2011 hubo prevalencia de 11 por ciento de mujeres y 12,4 por ciento de hombres con glucemia en valores de prediabetes. En la de 2016, hubo 30,3 por ciento de mujeres y 40 por ciento en prediabetes. Hubo diferencia de los promedios de glucemia entre ambas muestras de 5,4 mg/dL (0,3 mmol/L) en mujeres, t = - 4,582 (p = 0,0001) y 10,81 mg/dL (0,6 mmol/L) en hombres, t = - 6,428 (p = 0,0001). No se encontró correlación con masa corporal. Conclusiones. En la muestra de 2016 hubo incremento en la prevalencia de prediabetes y de adultos jóvenes en riesgo de desarrollar diabetes mellitus de tipo 2, por lo que es necesario desarrollar estrategias para mejorar el estilo de vida.(AU)

Introduction. Given the dramatic increase of diabetes in the world, the aim of this research was to analyze the values of blood glucose in a university population again income to support strategies for detection and preventive management of pre-diabetes and diabetes. Methods. Study observational, analytical, transverse, non-probability. The blood glucose values were analyzed in fasting of 367 freshmen students from move income in 2011 and 430 in 2016 to the campus of Health Sciences from a University in the Southeast of Mexico. Testing central tendency, comparisons and projections were applied. Results. In the sample of 2011 there was prevalence of 11 percent of women and 12.4 percent of men with blood glucose values of pre-diabetes. In the 2016 there were 30.3 percent of women and 40 percent in pre-diabetes. There was a difference of blood glucose averages among both samples of 5.4 mg/dL (0.3 mmol/L) in women, t = - 4.582 (p = 0.0001) and 10.81 mg/dL (0.6 mmol/L) in males, t = - 6.428 (p = 0.0001). Correlation with body mass was not found. C Conclusions. In the sample of 2016 there was increase in the prevalence of pre-diabetes and young adults at risk of developing type 2 diabetes mellitus by what is needed to develop strategies to improve lifestyle.(AU)
Descritores: Estado Pré-Diabético
Estudantes de Ciências da Saúde
-Incidência
Progressão da Doença
Diabetes Mellitus
Doenças não Transmissíveis
México
Limites: Seres Humanos
Masculino
Feminino
Adulto
Tipo de Publ: Artigo Clássico
Responsável: CL10.1 - Biblioteca Biomédica



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