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Id: biblio-1002175
Autor: Carvalho, Eduardo G. B; Machado-Júnior, Almiro J; Pauna, Henrique F; Nicola, Ester M. D; Altemani, Albina M. A. M; Crespo, Agricio N.
Título: The Effect of Fibroblast Growth Factors in Grafted Fascia into the Vocal Fold of Rabbits
Fonte: Int. arch. otorhinolaryngol. (Impr.);23(1):60-64, Jan.-Mar. 2019. tab, graf.
Idioma: en.
Resumo: Abstract Introduction The human larynx is a very important organ for communication. Many conditions lead to scarring of the vocal folds, decreasing voice quality. Objective We aimed to determine whether fibroblast growth factors (FGFs) may influence tissue integration of grafted fascia into the vocal folds of an animal model. Methods This is an experimental animal study with 12 adult rabbits that were submitted to a grafting fragment obtained from superficial cervical fascia into the vocal fold lamina propria, bilaterally. The right vocal fold was injected with FGFs. The animals were sacrificed after 1 month or 12 months, depending on the group they were assigned to, and a histological analysis of their vocal folds was performed.We analyzed the histological changes (such as the presence of fibrosis and neovascularization) induced by the acute or chronic inflammatory reactions. Results The FGFs induced acute inflammatory changes in all animals after 1 month of the initial experiment. The presence of FGFs triggered more fibrosis than the expected due to the surgical procedure itself when compared with the control side of all animals after 12 months of the initial experiment. Conclusions Fibroblast growth factors alone do not represent a good therapeutic option in phonosurgery, since we observed higher levels of fibrosis in the vocal fold lamina propria. Further studies combining more substances may be necessary to elucidate the best option to be used in this kind of surgery. (AU)
Descritores: Prega Vocal/patologia
Fascia Lata/transplante
Fatores de Crescimento de Fibroblastos/farmacologia
-Coelhos
Fibrose/etiologia
Doenças da Laringe/congênito
Inflamação/induzido quimicamente
Neovascularização Patológica/etiologia
Limites: Animais
Responsável: BR66.1 - Divisão de Biblioteca e Documentação


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Id: biblio-877285
Autor: Bond, Marina Macedo Kuenzer; Silva, Rafael Ozorio Alves da; Targino, Decarthon Vitor Dantas; Castro, Fernando Panchano; Scharf, Renato; Gomes, Manoella de Macedo; Almeida, Mariana Brito de; Mateos, Juan Carlos Pachón.
Título: Papel da ressonância magnética nuclear cardíaca na terapia de ressincronização cardíaca / Role of cardiac magnetic resonance imaging in cardiac resynchronization therapy
Fonte: RELAMPA, Rev. Lat.-Am. Marcapasso Arritm;30(3):f:104-l:113, jul.-set. 2017. graf, tab, ilus.
Idioma: pt.
Resumo: A insuficiência cardíaca é um importante problema de saúde pública. As modificações cardíacas estruturais que surgem com o processo de cronificação da insuficiência cardíaca levam a anormalidades na contração miocárdica e à dessincronização ventricular. A terapia de ressincronização cardíaca busca o tratamento dessa dessincronia. Neste trabalho é feita revisão bibliográfica que busca evidenciar o papel da ressonância magnética nuclear cardíaca na terapia de ressincronização cardíaca. Apesar de ainda não existir um grande estudo randomizado comparando os métodos complementares disponíveis, a análise da literatura médica sugere que a ressonância magnética nuclear cardíaca venha a ter papel crucial na obtenção de melhores resultados da terapia de ressincronização cardíaca, principalmente após o surgimento dos novos ressincronizadores compatíveis. A qualidade da imagem capturada, com melhor caracterização da estrutura tecidual miocárdica, localização das áreas de fibrose, e mensuração mais acurada dos volumes ventriculares e índices funcionais, associado ao fato de ser um método menos dependente de operador, sem emissão de radiação ionizante, e que utiliza contrastes menos nefrotóxicos, a coloca como um dos melhores métodos complementares para avaliar selecionar candidatos, guiar o implante dos cabos-eletrodos e avaliar a resposta individual ao tratamento. No contexto da insuficiência cardíaca e da terapia de ressincronização cardíaca, a classe médica pode ter certeza e segurança em optar pela ressonância magnética nuclear cardíaca como método adequado e confiável para avaliação e acompanhamento de seus pacientes

Heart failure is an important public healthcare problem. Structural heart changes resulting from chronic heart failure lead to abnormalities in myocardial contraction and ventricular dyssynchrony. Cardiac resynchronization therapy attempts to treat this dyssynchrony. This is a literature review that seeks to determine the role of cardiac magnetic resonance imaging in cardiac resynchronization therapy. Although there are no large randomized trials comparing the complementary methods available, a medical literature review suggests that cardiac magnetic resonance imaging plays a crucial role in obtaining the best results of cardiac resynchronization therapy, especially after the appearance of the new resynchronizers. The quality of the image captured with the best characterization of myocardial tissue structure, location of areas of fibrosis, and a more accurate measurement of ventricular volumes and functional indices, in addition to the fact that it is less operator dependent without ionizing radiation emition, which uses less nephrotoxic contrasts, turns it as one of the best complementary methods to evaluate, select candidates, guide electrode implantation and evaluate the individual response to treatment. In the context of heart failure and cardiac resynchronization therapy, doctors can be sure and confident in choosing cardiac magnetic resonance imaging as an adequate and reliable method for the evaluation and follow-up of their patients
Descritores: Diagnóstico por Imagem
Espectroscopia de Ressonância Magnética/métodos
Terapia de Ressincronização Cardíaca/métodos
Insuficiência Cardíaca
-Volume Sistólico
Fibrose
Literatura de Revisão como Assunto
Ecocardiografia/métodos
Saúde Pública
Desfibriladores Implantáveis
Eletrocardiografia/métodos
Ventrículos do Coração
Miocárdio
Limites: Seres Humanos
Masculino
Feminino
Responsável: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt


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Texto completo SciELO Brasil
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Id: biblio-1012673
Autor: Issa, Yasmine Amr; El Achy, Samar Nabil; Mady, Rasha Fadly.
Título: Cannabinoid receptor-1 antagonism: a new perspective on treating a murine schistosomal liver fibrosis model
Fonte: Mem. Inst. Oswaldo Cruz;114:e190062, 2019. tab, graf.
Idioma: en.
Resumo: BACKGROUND Formation of schistosomal granulomata surrounding the ova can result in schistosomiasis-associated liver fibrosis (SSLF). The current standard of treatment is praziquantel (PZQ), which cannot effectively reverse SSLF. The role of the cannabinoid (CB) receptor family in liver fibrosis has recently been highlighted. OBJECTIVES This study aimed to assess the therapeutic effect of CB1 receptor antagonism in reversing SSLF in a murine model of Schistosoma mansoni infection. METHODS One hundred male Swiss albino mice were divided equally into five groups: healthy uninfected control (group I), infected control (group II), PZQ treated (group III), rimonabant (RIM) (SR141716, a CB1 receptor antagonist)-treated (group IV) and group V was treated with combined PZQ and RIM. Liver sections were obtained for histopathological examination, alpha-1 smooth muscle actin (α-SMA) immunostaining and assessment of CB1 receptor expression using real-time polymerase chain reaction (RT-PCR). FINDINGS The most effective reduction in fibrotic marker levels and granuloma load was achieved by combined treatment with PZQ+RIM (group V): CB1 receptor expression (H = 26.612, p < 0.001), number of α-SMA-positive cells (F = 57.086, p < 0.001), % hepatic portal fibrosis (F = 42.849, p < 0.001) and number of granulomata (F = 69.088, p < 0.001). MAIN CONCLUSIONS Combining PZQ with CB1 receptor antagonists yielded the best results in reversing SSLF. To our knowledge, this is the first study to test this regimen in S. mansoni infection.
Descritores: Fibrose/diagnóstico
Tifo Endêmico Transmitido por Pulgas/transmissão
Fígado/fisiopatologia
-Receptores de Canabinoides
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Antunes, Sérgio Luiz Gomes
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Id: biblio-1012667
Autor: Antunes, Sérgio Luiz Gomes; Jardim, Márcia Rodrigues; Vital, Robson Teixeira; Pascarelli, Bernardo Miguel de Oliveira; Nery, José Augusto da Costa; Amadeu, Thaís Porto; Sales, Anna Maria; da Costa, Eduardo Alves Freire; Sarno, Euzenir Nunes.
Título: Fibrosis: a distinguishing feature in the pathology of neural leprosy
Fonte: Mem. Inst. Oswaldo Cruz;114:e190056, 2019. tab, graf.
Idioma: en.
Resumo: BACKGROUND Fibrosis in the peripheral nerve is the end stage of leprous neuropathy and the cause of the resulting permanent neural function impairments. Preventive measures to avoid this irreversible pathological state are a relief strategy for leprosy sufferers. OBJECTIVES The present study describes the frequency of fibrosis along with its characterisation and pathogenic development. METHODS Six-hundred-and-thirteen nerve samples were sorted from 278 neural leprosy (NL) and 335 non-leprosy neuropathy patients (ON). The total number of samples was histologically examined by routine staining methods (haematoxylin-eosin, Wade staining and Gomori's trichrome) and fibrosis was evaluated via semi-quantitative estimation. FINDINGS Fibrosis was most frequent in the NL group (33% against 0.4% in ON) while fibrosis in association with endoneurial microfasciculation was found in 38 (41.3%) of the NL samples in the examination of semithin sections. Pericytic activation in the perivascular environment was confirmed to be the source of the fibroblasts and perineurial cells delimiting microfascicles. End-stage fibrosis in leprosy displays an arrangement of microfascicles devoid of neural components (i.e., Schwann cells and axons) lined by an intermediate phenotype of fibroblastic-perineurial cells filled with bundles of collagen fibres. MAIN CONCLUSIONS The present study underscores that fibrosis is frequently the severe end stage of neural leprosy NL pathogeny after analysing the notably distinct development of fibrosis within the neural environment.
Descritores: Fibrose/diagnóstico
Fibrose/terapia
-Hanseníase Tuberculoide/diagnóstico
Hanseníase Tuberculoide/prevenção & controle
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-1003636
Autor: Fernández, J. Rodrigo; Ocaranza, María Paz; Herrera, Sebastián; Vega, Julián; Salinas, Manuel; Contreras-Briceño, Felipe; Llevaneras, Silvana; Jalil, Jorge E; Yañez, Fernando; Godoy, Paz; Córdova, Samuel; Chiong, Mario; Muñoz, Mario; Lavandero, Sergio; Castro, Pablo; Gabrielli, Luigi.
Título: Biomarcadores de fibrosis y función ventricular derecha en maratonistas con distinto grado de entrenamiento: estudio en la maratón de Santiago / Fibrosis and right ventricular function biomarkers in marathon runners: a study at the Santiago, Chile marathon
Fonte: Rev. chil. cardiol;38(1):37-45, abr. 2019. tab, graf.
Idioma: es.
Projeto: Fondecyt; . Fondap.
Resumo: Resumen: Introducción: Atletas altamente entrenados muestran cambios cardíacos estructurales como adaptación a la sobrecarga, producto del ejercicio repetitivo y extenuante. Se han evidenciado elevación de biomarcadores de remodelado y fibrosis miocárdica posterior al ejercicio intenso en atletas. Sin embargo, el comportamiento de estos biomarcadores según el nivel de entrenamiento previo no se ha evaluado. Objetivo: Investigar biomarcadores de fibrosis y función ventricular derecha en maratonistas con distinto nivel de entrenamiento previo. Métodos: Se incluyeron 36 maratonistas hombres, sanos, que completaron 42 km en la maratón de Santiago. Se dividieron según entrenamiento previo en dos grupos, Grupo 1 (G1): ≥100 km/semana y Grupo 2 (G2): <100 km/semana. Se realizó ecocardiografía transtorácica y se evaluaron niveles plasmáticos de galectina-3 y del propéptido amino terminal del procolágeno tipo III (PIIINP) en la semana previa a la carrera e inmediatamente posterior a ésta. Resultados: Posterior a la maratón, la función sistólica del ventrículo derecho disminuyó en el grupo G2 junto con un aumento significativo de los niveles plasmáticos de PIIIPNP (61±16 a 94±24 ng/mL, p=0,01). Estos cambios no se observaron en el grupo G1 (65 ± 11 a 90±29 ng/mL, p=0,10). Los niveles plasmáticos de galectina-3 aumentaron significativamente en ambos grupos posterior al ejercicio (6,8±2,2 a 19,7±4,9 ng/mL, p 0,012 y 6,0±1,1 a 19,4 ± 5,9 ng/mL, p 0,01) en los grupos G1 y G2, respectivamente). Conclusiones: Atletas con menor grado de entrenamiento, presentan posterior a una maratón un significativo aumento de productos de degradación del colágeno (PIIIPNP) asociado a disminución de la función del ventrículo derecho. Los niveles de galectina-3 plasmática aumentan significativamente en ambos grupos post-esfuerzo independiente del entrenamiento previo.

Abstracts: Introduction: Highly trained athletes show structural cardiac changes as adaptation to overload. Rise in remodeling biomarkers and myocardial fibrosis after intense exercise in athletes has been evidenced; however, the behavior of these biomarkers according to pre-competition training level has not been evaluated. Objective: To evaluate fibrosis biomarkers levels and right ventricle function in marathon runners according to their previous training level, in the period prior to a marathon race and immediately after it. Methods: Thirty-six healthy male marathon runners were included. Subjects were grouped according to their previous training level: Group 1 (G1): ≥100 km/week and Group 2 (G2): <100 km/week. Transthoracic echocardiography along with plasmatic levels of galectin-3 and amino terminal propeptide of type III procollagen (PIIINP) were measured one week previous and immediately after the marathon. Results: Post-effort right ventricle systolic function decreased in G2, together with a significant elevation of PIIIPNP (61±16 to 94±24 ng/mL, p=0.01). These changes were not observed in G1 (from 65±11 to 90±29 ng/mL, p=0.10). Plasma galectin-3 increased significantly in both groups immediately post-exercise (6.8±2.2 to 19.7±4.9 ng/mL, p=0.012, and 6.0±1.1 to 19.4±5.9 ng/mL, p=0.01, in G1 and G2. respectively). Conclusion: Less trained athletes evidenced higher post marathon levels of PIIIPNP which is associated with a decreased global right ventricle function. Plasma galectin-3 levels increased significantly after intense exertion regardless of the intensity of previous training.
Descritores: Fragmentos de Peptídeos/sangue
Corrida
Função Ventricular Esquerda/fisiologia
Função Ventricular Direita/fisiologia
Galectina 3/sangue
-Fibrose/diagnóstico por imagem
Ecocardiografia
Biomarcadores
Método Simples-Cego
Estudos Retrospectivos
Atletas
Limites: Seres Humanos
Masculino
Adulto
Meia-Idade
Tipo de Publ: Ensaio Clínico
Responsável: CL126.2 - Biblioteca Médica Dr. Profesor Hernán Alessandri R.


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Id: biblio-1009702
Autor: Riera, Vanesa; Ruíz, Yelena; González, Anays; Bonaldy, Nayrelis; Agueda, Azacón; Navas, Trina.
Título: Enfermedad por IgG (fibrosis retroperitoneal + "ojo seco") / IgG disease (retroperitoneal fibrosis + "dry eye")
Fonte: Med. interna (Caracas);31(3):[129], 2015. ilus.
Idioma: es.
Descritores: Fibrose/fisiopatologia
Imunoglobulina G/metabolismo
Síndromes do Olho Seco
-Medicina Interna
Limites: Seres Humanos
Feminino
Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: VE1.1 - Biblioteca Humberto Garcia Arocha


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Id: biblio-1005027
Autor: Burbano, Raúl; Aldeán, Jorge; Herdoíza, Xavier; Ruíz, Javier; Andrade, María José; Chong, Ricardo; Garcés, Cristina; Armijos, Ximena; Armijos, Cristian.
Título: Elastografía esplénica como predictor de varices esofágicas / Spleen elastography as a predictor of esophageal varices
Fonte: Rev. de la Fed. Ecuat. de Soc. de Radiol;11(2):7-12, dic. 2018.
Idioma: es.
Resumo: El propósito del estudio fue evaluar el rendimiento diagnóstico de la elastografía esplénica y otros métodos no invasivos para detectar varices esofágicas de alto riesgo en pacientes con cirrosis. La verificación de la existencia de varices se realizó con endoscopia digestiva alta que es el gold standard. Se incluyeron 40 pacientes con reciente diagnóstico de cirrosis los cuales fueron evaluados con ecografía Doppler portal, elastografía hepática, elastografía esplénica, endoscopia y que cumplieron con los siguientes criterios: no antecedentes de sangrado digestivo, no tratamiento con betabloqueantes, no trombosis de la porta. Se realizó un estudio transversal, unicéntrico desde abril del 2017 hasta agosto del 2018. Los datos se presentan organizados en tablas de frecuencia. La comparación con el standard incluyo el uso de chi cuadrado y obtuvimos curvas ROC para presentar los datos de sensibilidad y especificidad. La elastografía demostró ser un buen estudio predictivo de la presencia de várices esofágicas (AUC 0,84 ; IC 95%: 0,71 - 0,97), seguido del diámetro del bazo (AUC 0,81 ; IC 95%: 0,66 - 0,96), mientras que el índice de congestividad (AUC 0,46 ; IC 95%: 0,27 - 0,64) y la elastografía hepática (AUC 0,39 ; IC 95%: 0,21 - 0,58) fueron los parámetros con menor precisión, el punto de corte de 3,8 m/seg en la elastografía esplénica fue capaz de identificar las varices de alto riesgo con una sensibilidad del 90,9% . La elastografía esplénica y el diámetro del bazo alcanzaron mayor rendimiento diagnostico en comparación a la elastografía hepática para identificar varices esofágicas de alto riesgo

The purpose of the study was to evaluate the diagnostic performance of splenic elastography and other non-invasive methods to detect high-risk esophageal varices in patients with cirrhosis. Verification of the existence of varicose veins was performed with upper digestive endoscopy, which is the gold standard. Forty patients with a recent diagnosis of cirrhosis were included, who were evaluated with portal Doppler ultrasound, hepatic elastography, splenic elastography, endoscopy and who fulfilled the following criteria: no history of digestive bleeding, no treatment with beta-blockers, no thrombosis of the portal. A cross-sectional, unicentric study was conducted from August 2018 to April 2017. The data are presented organized in frequency tables. The comparison with the standard included the use of chi square and we obtained ROC curves to present the sensitivity and specificity data. Elastography proved to be a good predictive study of the presence of esophageal varices (AUC 0.84, 95% CI: 0.71-0.97), followed by spleen diameter (AUC 0.81, 95% CI: 0.66 - 0.96), while the congestivity index (AUC 0.46, 95% CI: 0.27 - 0.64) and hepatic elastography (AUC 0.39, 95% CI: 0.21) - 0.58) were the parameters with less precision, the cutoff point of 3.8 m / sec in splenic elastography was able to identify high risk varicose veins with a sensitivity of 90.9%. Splenic elastography and spleen diameter achieved a higher diagnostic yield compared to hepatic elastography to identify high risk esophageal varices.
Descritores: Fibrose
Varizes Esofágicas e Gástricas
Técnicas de Imagem por Elasticidade
-Doença Crônica
Diagnóstico
Limites: Seres Humanos
Masculino
Meia-Idade
Tipo de Publ: Estudo Observacional
Responsável: EC166


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Id: biblio-913769
Autor: Nascimento, Marco Antonio de Jesus; Palomares Filho, Gilmar; Andrade, Marcel Lima; Reis, André Augusto de Vasconcelos Ouro; Baiao, Kennia M. Rocha; Nascimento, Tereza Virgínia Silva Bezerra do; Santos, Márcio Bezerra; Pacheco, Maurício Soares.
Título: Correlation among three non-invasive methods (APRI, FIB-4 and Transient elastography) to evaluate liver function and stiffness in patients with viral hepatitis c or schistosomiasis mansoni
Fonte: Rev. patol. trop;47(2):100-110, jun. 2018. tab, graf.
Idioma: en.
Resumo: Both chronic viral hepatitis and schistosomiasis are potentially serious causes of liver fibrosis. Several studies suggest, however, that hepatic fibrosis may be reversible, which highlights the importance, not only of early diagnosis, but, above all, observing this while monitoring the disease. This study aimed to evaluate the correlation between three non-invasive methods for classification of hepatic fibrosis in patients with viral hepatitis or schistosomiasis. The sample consisted of 45 patients with chronic hepatitis with HCV and 17 with schistosomiasis. Medical records were analyzed for data collection related to sex, body mass index (BMI) and laboratory testing for biochemical markers. The evaluation was carried out by means of the following hepatic diagnostic methods: APRI, FIB-4 and Transient Elastography (Fibroscan), and the subsequent correlation analysis by Spearman test (r). There was a predominance of males among patients with HCV (64.4%). HCV patients also presented the highest average age (54.8 years) and high levels of AST and ALT. Positive correlation was noted between APRI and FIB-4 results in patients of both groups; positive correlation between APRI and Transient Elastography in patients with HCV; and positive correlation between FIB-4 and Elastography in patients with HCV or schistosomiasis. Our data suggest that the non-invasive methods for diagnosis and monitoring of hepatic fibrosis present a high degree of acceptance, especially in patients with HCV.
Descritores: Esquistossomose mansoni
Fibrose
Técnicas de Imagem por Elasticidade
Hepatite Viral Humana
Hepatopatias
Responsável: BR15.1 - Biblioteca de Ciências Biomédicas


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Id: lil-289227
Autor: Botero, A; Cuarterolo, M. L; Gonzáles Penna, H; Cohen Arazi, J.
Título: Cirrosis-hipoxemia / Diagnosis: cirrhosis-hypoxemia
Fonte: Med. infant;2(4):265-266, dic. 1995.
Idioma: es.
Descritores: Fibrose/diagnóstico
Hipóxia
-Argentina
Limites: Seres Humanos
Feminino
Adolescente
Tipo de Publ: Relatos de Casos
Conferência Clínica
Responsável: AR305.1 - SID - Servicio de Información y Documentación


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Id: biblio-995627
Autor: Núcleo de Telessaúde da Universidade Federal do Rio Grande do Sul.
Título: TeleCondutas: hepatite B / TeleGuides: Hepatitis B.
Fonte: Porto Alegre; Universidade Federal do Rio Grande do Sul. Telessaúde; 2017.
Idioma: pt.
Resumo: As hepatite virais apresentam forma clínicas diversas, desde infecções assintomáticas até quadros de hepatopatia avançada, como cirrose e hepatocarcinoma. A equipe da atenção primária deve investigar pessoas com sinais e sintomas comuns da infecção, bem como assintomáticos que fazem parte do grupo de risco. Esta guia apresenta informação que orienta a conduta para casos de hepatite B no contexto da Atenção Primária à Saúde, incluindo: forma de transmissão, quadro clínico, suspeita ou diagnóstico de cirrose, diagnóstico de hepatite b, avaliação sorológica da hepatite b, avaliação de paciente com hepatite b aguda, avaliação de paciente com hepatite b crônica, rastreamento, vacina para hepatite b, encaminhamento para serviço especializado.
Descritores: Hepatite B/diagnóstico
Hepatite B/patologia
Hepatite B/terapia
Hepatite B/transmissão
-Atenção Primária à Saúde
Encaminhamento e Consulta
Fibrose
Interferons/uso terapêutico
Vacinas contra Hepatite B
Tenofovir/uso terapêutico
Antígenos E da Hepatite B/sangue
Limites: Seres Humanos
Tipo de Publ: Guia de Prática Clínica
Responsável: BR1.1 - BIREME



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