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Pesquisa : D01.029.260.340 [Categoria DeCS]
Referências encontradas : 22 [refinar]
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Id: biblio-1024839
Autor: Aguirre, Alberto; Bernal, Pamela; Maureira, Daniela; Ramos, Nicolás; Vásquez, Javier; Urrutia, Homero; Gentina, Juan Carlos; Aroca, Germán.
Título: Biofiltration of trimethylamine in biotrickling filter inoculated with Aminobacter aminovorans
Fonte: Electron. j. biotechnol;33:63-67, May. 2018. ilus, graf, tab.
Idioma: en.
Projeto: FONDECYT.
Resumo: Background: Trimethylamine (TMA) is the main responsible for the odor associated with rotting fish and other annoying odors generated in many industrial activities. Biofiltration has proved to be efficient for treating odorous gaseous emissions. The main objective of this work was to determine the removal capacity of TMA of a biotrickling filter inoculated with Aminobacter aminovorans and to evaluate the effect of H2S on its performance. Results: The maximumspecific growth rate ofA. aminovorans in a liquid culture was 0.15 h -1 , witha TMAto biomass yield of 0.10 (g g -1) and a specific consumption rate of 0.062 g·g-1·h-1 . The initial specific consumption rate of TMA was highly influenced by the presence of H2S in liquid culture at concentrations of 20 and 69 ppm in heading space oftheflasks.ABTF inoculatedwithA. aminovorans showedremoval efficiencieshigher than98%ina range ofloading rate of 0.2 to 8 g·m-3·h-1 at empty bed residence time (EBRT) of 85 and 180 s. No effect on the elimination capacity and efficiency was detected when H2S was added at 20 and 50 ppm to the inlet gaseous emission, though the fraction of A. aminovorans measured by qPCR in the biofilm decreased. Conclusions:Abiotrickling filter inoculated with A. aminovorans can remove efficiently the TMA in a gaseous stream. The elimination capacity of TMA can be negatively affected by H2S, but its effect is not notorious when it is forming part of a biofilm, due to its high specific consumption rate of TMA.
Descritores: Alphaproteobacteria/metabolismo
Sulfeto de Hidrogênio
Metilaminas/metabolismo
-Desodorização/métodos
Reatores Biológicos
Filtração
Peixes
Responsável: CL1.1 - Biblioteca Central


  2 / 22 LILACS  
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Id: biblio-896317
Autor: Wang, Zhiyong; Fang, Mignxing; Guo, Jianying; Yang, Yong; Tian, Fengjun.
Título: The analysis on the expression of gasotransmitters in early trauma patients
Fonte: Rev. Assoc. Med. Bras. (1992);63(11):988-993, Nov. 2017. tab, graf.
Idioma: en.
Resumo: Summary Objective: Nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) were endogenously-generated molecules gas. They owned important biological activity and participated in many pathophysiological processes. This study aimed to examine the levels of three gasotransmitters in the early phase of trauma patients. Method: Blood samples were collected from 60 trauma patients and ten healthy volunteers. Concentration of serum iNOS and HO-1 were analyzed by enzyme linked immunosorbent assay and plasma H2S was determined by colorimetric method. Meanwhile, the occurrence of multiple organ dysfunction syndrome (MODS) was also monitored. Results: The levels of iNOS, HO-1 and endogenous H2S in the patients group were significantly different from the healthy control group, and the difference was more obvious with the increase of ISS score. iNOS levels were positively correlated with ISS scores and blood lactic acid values, and HO-1 and endogenous H2S were negatively correlated with ISS scores and blood lactic acid values. Of 60 trauma patients, eight (13.33%) developed MODS. The level of iNOS in the MODS group was higher than that in non-MODS group, while HO-1 and H2S were significant lower in the MODS group. Conclusion: The three gasotransmitters participated in systemic inflammatory responses during early trauma and could be used as important indicators for trauma severity. Their measurements were meaningful for evaluating the severity and prognosis of trauma.
Descritores: Ferimentos e Lesões/sangue
Monóxido de Carbono/sangue
Gasotransmissores/sangue
Sulfeto de Hidrogênio/sangue
Óxido Nítrico/sangue
-Ensaio de Imunoadsorção Enzimática
Biomarcadores/sangue
Estudos de Casos e Controles
Índices de Gravidade do Trauma
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


  3 / 22 LILACS  
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Id: biblio-1038781
Autor: Nevoral, Jan; Zalmanova, Tereza; Hoskova, Kristyna; Stiavnicka, Miriam; Hosek, Petr; Petelak, Ales; Petr, Jaroslav.
Título: Involvement of K+ATP and Ca2+ channels in hydrogen sulfide-suppressed ageing of porcine oocytes
Fonte: Biol. Res;51:38, 2018. graf.
Idioma: en.
Projeto: National Agency of Agriculture Sciences; . Czech Ministry of Agriculture; . Charles University Research Fund; . Ministry of Education, Youth and Sports of the Czech Republic.
Resumo: BACKGROUND: Hydrogen sulfide has been shown to improve the quality of oocytes destined for in vitro fertilization. Although hydrogen sulfide is capable of modulating ion channel activity in somatic cells, the role of hydrogen sulfide in gametes and embryos remains unknown. Our observations confirmed the hypothesis that the KATP and L-type Ca2+ ion channels play roles in porcine oocyte ageing and revealed a plausible contribution of hydrogen sulfide to the modulation of ion channel activity. RESULTS: We confirmed the benefits of the activation and suppression of the KATP and L-type Ca2+ ion channels, respectively, for the preservation of oocyte quality. CONCLUSIONS: Our experiments identified hydrogen sulfide as promoting the desired ion channel activity, with the capacity to protect porcine oocytes against cell death. Further experiments are needed to determine the exact mechanism of hydrogen sulfide in gametes and embryos.
Descritores: Oócitos/efeitos dos fármacos
Canais de Cálcio/fisiologia
Senescência Celular/fisiologia
Canais de Potássio Cálcio-Ativados/fisiologia
Sulfeto de Hidrogênio/farmacologia
-Oócitos/metabolismo
Fenótipo
Suínos
Bloqueadores dos Canais de Cálcio/farmacologia
Verapamil/farmacologia
Canais de Cálcio/efeitos dos fármacos
Transdução de Sinais/efeitos dos fármacos
Trifosfato de Adenosina
Canais de Potássio Cálcio-Ativados/efeitos dos fármacos
Minoxidil/farmacologia
Limites: Animais
Feminino
Responsável: CL1.1 - Biblioteca Central


  4 / 22 LILACS  
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Id: lil-742066
Autor: Eid, Letícia Palota; Soriano, Renato Nery; Batalhão, Marcelo Eduardo; Balderrama, Lais Palotta; Carnio, Evelin Capellari.
Título: Pharmacotherapy and analysis of gaseous mediators in hypertensive patients / Farmacoterapia y análisis de mediadores gaseosos en pacientes hipertensos / Farmacoterapia e análise de mediadores gasosos em pacientes hipertensos
Fonte: Rev. Esc. Enferm. USP;49(1):69-75, Jan-Feb/2015. graf.
Idioma: en.
Resumo: OBJECTIVE To evaluate the effect of using antihypertensive classes of drugs of the calcium channel antagonists and inhibitors of angiotensin-converting enzyme in plasma concentrations of hydrogen sulfide and nitric oxide in patients with hypertension. METHODS Cross-sectional study with quantitative approach conducted with hypertensive patients in use of antihypertensive classes of drugs: angiotensin-converting enzyme inhibitors or calcium channel antagonists. RESULTS It was found that the concentration of plasma nitric oxide was significantly higher in hypertensive patients that were in use of angiotensin-converting enzyme inhibitors (p<0.03) and the hydrogen sulphide concentration was significantly higher in hypertensive plasma in use of calcium channel antagonists (p<0.002). CONCLUSION The findings suggest that these medications have as additional action mechanism the improvement of endothelial dysfunction by elevate plasma levels of vasodilatory substances. .

OBJETIVO Evaluar el efecto del uso de antihipertensivos pertenecientes a las clases medicamentosas antagonistas de canales de calcio e inhibidores de la enzima convertidora de angiotensina en las concentraciones plasmáticas de ácido sulfhídrico y óxido nítrico en portadores de hipertensión arterial sistémica. MÉTODO Estudio transversal con abordaje cuantitativo realizado con hipertensos que toman antihipertensivos de las clases de inhibidores de la enzima convertidora de angiotensina o antagonistas de los canales de calcio. RESULTADOS Se verificó que la concentración de óxido nítrico plasmático fue significativamente mayor en hipertensos que estaban usando inhibidores de la enzima convertidora de angiotensina (p<0.03) y que la concentración de ácido sulfhídrico plasmático fue significativamente mayor en hipertensos en uso de antagonistas de los canales de calcio (p<0.002). CONCLUSIÓN Los hallazgos sugieren que dichos fármacos tienen como mecanismo de acción adicional la mejora de la disfunción endotelial al elevar los niveles plasmáticos de sustancias vasodilatadoras. .

OBJETIVO Avaliar o efeito do uso de anti-hipertensivos pertencentes às classes medicamentosas antagonistas de canais de cálcio e inibidores da enzima conversora de angiotensina nas concentrações plasmáticas de ácido sulfídrico e óxido nítrico em portadores de hipertensão arterial sistêmica. MÉTODO Estudo transversal com abordagem quantitativa realizado com hipertensos em uso de anti-hipertensivos das classes inibidores da enzima conversora de angiotensina ou antagonistas dos canais de cálcio. RESULTADOS Verificou-se que a concentração de óxido nítrico plasmático foi significativamente maior em hipertensos que estavam em uso de inibidores da enzima conversora de angiotensina (p<0.03) e que a concentração de ácido sulfídrico plasmático foi significativamente maior em hipertensos em uso de antagonistas dos canais de cálcio (p<0.002). CONCLUSÃO Os achados sugerem que essas medicações possuem como mecanismo de ação adicional a melhora da disfunção endotelial por elevar os níveis plasmáticos de substâncias vasodilatadoras. .
Descritores: Inibidores da Enzima Conversora de Angiotensina/uso terapêutico
Anti-Hipertensivos/uso terapêutico
Bloqueadores dos Canais de Cálcio/uso terapêutico
Sulfeto de Hidrogênio/sangue
Hipertensão/sangue
Hipertensão/tratamento farmacológico
Óxido Nítrico/sangue
-Estudos Transversais
Limites: Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


  5 / 22 LILACS  
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Id: biblio-839247
Autor: Zhang, HT; Zhang, T; Chai, M; Sun, JJ; Yu, XY; Liu, CZ; Huang, CC.
Título: Effect of tobacco smoke on hydrogen sulfide-induced rat thoracic aorta relaxation
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(2):e5592, 2017. graf.
Idioma: en.
Projeto: Air Logistics Scientific Research Fund.
Resumo: Levels of hydrogen sulfide (H2S), a gaseous signaling molecule, are reduced in the serum of individuals who smoke. We hypothesized that tobacco smoke influenced smooth muscle relaxation by decreasing H2S levels and this effect could also influence expression of cystathionine γ-lyase (CSE) and sulfonylurea receptor-2 (SUR-2). The aim of this study was to explore the effect of tobacco smoke on H2S-mediated rat thoracic aorta relaxation and its possible mechanism. Thirty-two Sprague-Dawley rats were divided into four groups: control (C) group, short-term smoker (SS) group, mid-term smoker (MS) group, and long-term smoker (LS) group. H2S concentrations in serum, action of H2S on rat aortic vascular relaxation, and expression of CSE and SUR-2 in thoracic aortic smooth muscle were measured. Although there was no significant difference in H2S between the C and the SS groups, concentration of H2S was significantly reduced in both the LS and MS groups compared to control (P<0.01). Furthermore, H2S was significantly lower in the LS than in the MS group (P<0.05). Rat aortic vascular relaxation was lower in all three treatment groups compared to the control, with the most significant decrease observed in the LS group (P<0.05 compared to the MS group). Expression of CSE and SUR-2 was reduced in the LS and MS groups compared to control (P<0.05), with the lowest levels observed in the LS group (P<0.05). Therefore, tobacco smoke reduced expression of CSE and SUR-2 in rat thoracic aorta, which may inhibit H2S production and vascular dilation.
Descritores: Aorta Torácica/efeitos dos fármacos
Endotélio Vascular/efeitos dos fármacos
Sulfeto de Hidrogênio
Poluição por Fumaça de Tabaco
-Modelos Animais
Ratos Sprague-Dawley
Fatores de Tempo
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  6 / 22 LILACS  
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Id: lil-775120
Autor: Šuranská, Hana; Vránová, Dana; Omelková, Jiřina.
Título: Isolation, identification and characterization of regional indigenous Saccharomyces cerevisiae strains
Fonte: Braz. j. microbiol;47(1):181-190, Jan.-Mar. 2016. tab, graf.
Idioma: en.
Projeto: MŠMT ČR.
Resumo: Abstract In the present work we isolated and identified various indigenous Saccharomyces cerevisiae strains and screened them for the selected oenological properties. These S. cerevisiae strains were isolated from berries and spontaneously fermented musts. The grape berries (Sauvignon blanc and Pinot noir) were grown under the integrated and organic mode of farming in the South Moravia (Czech Republic) wine region. Modern genotyping techniques such as PCR-fingerprinting and interdelta PCR typing were employed to differentiate among indigenous S. cerevisiae strains. This combination of the methods provides a rapid and relatively simple approach for identification of yeast of S. cerevisiae at strain level. In total, 120 isolates were identified and grouped by molecular approaches and 45 of the representative strains were tested for selected important oenological properties including ethanol, sulfur dioxide and osmotic stress tolerance, intensity of flocculation and desirable enzymatic activities. Their ability to produce and utilize acetic/malic acid was examined as well; in addition, H2S production as an undesirable property was screened. The oenological characteristics of indigenous isolates were compared to a commercially available S. cerevisiae BS6 strain, which is commonly used as the starter culture. Finally, some indigenous strains coming from organically treated grape berries were chosen for their promising oenological properties and these strains will be used as the starter culture, because application of a selected indigenous S. cerevisiae strain can enhance the regional character of the wines.
Descritores: Saccharomyces cerevisiae/classificação
Saccharomyces cerevisiae/isolamento & purificação
Vitis/microbiologia
-Ácido Acético/metabolismo
Aderência Bacteriana
República Tcheca
Impressões Digitais de DNA
Tolerância a Medicamentos
Etanol/toxicidade
Sulfeto de Hidrogênio/metabolismo
Tipagem Molecular
Técnicas de Tipagem Micológica
Malatos/metabolismo
Pressão Osmótica
Reação em Cadeia da Polimerase
Estresse Fisiológico
Saccharomyces cerevisiae/genética
Saccharomyces cerevisiae/fisiologia
Dióxido de Enxofre/toxicidade
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


  7 / 22 LILACS  
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Id: lil-769773
Autor: Dursun, Murat; Otunctemur, Alper; Ozbek, Emin; Sahin, Suleyman; Besiroglu, Huseyin; Ozsoy, Ozgur Doga; Cekmen, Mustafa; Somay, Adnan; Ozbay, Nurver.
Título: Protective effect of hydrogen sulfide on renal injury in the experimental unilateral ureteral obstruction
Fonte: Int. braz. j. urol;41(6):1185-1193, Nov.-Dec. 2015. tab, graf.
Idioma: en.
Resumo: Introduction/Objective: Ureteral obstruction is a common pathology and causes kidney fibrosis and dysfunction at late period. In this present study, we investigated the antifibrotic and antiinflammatory effects of hydrogen sulfide on kidney damage after unilateral ureteral obstruction (UUO) in rats. Materials and Methods: 24 rats were divided into four groups. Group 1 was control, group 2 was sham, group 3 included rats with UUO and group 4 rats with UUO which were given sodium hydrogen sulfide (NaHS)-exogenous donor of hydrogen sulfide (intraperitoneally 56μmoL/kg/day). After 14 days, rats were killed and their kidneys were taken and blood analysis was performed. Tubular necrosis, mononuclear cell infiltration and interstitial fibrosis were determined histopathologically in a part of the kidneys; nitric oxide (NO), malondialdehyde (MDA) and reduced glutathione (GSH) levels were determined in the other part of the kidneys. Urea-creatinine levels were investigated by blood analysis. Statistical analyses were made by the Chi-square test and one-way analysis of variance (ANOVA). Results: There was no significantly difference for urea-creatinine levels among groups. Pathologically, there was serious tubular necrosis and fibrosis in group 3 and there was significantly decreasing of tubular necrosis and fibrosis in group 4 (p<0.005). Also, there was significantly increase of NO and MDA levels and decrease of GSH levels in group 3 compared to other groups (p<0.005). Conclusions: hydrogen sulfide prevents kidney damage with antioxidant and antiinflammatory effect.
Descritores: Anti-Inflamatórios/farmacologia
Sulfeto de Hidrogênio/farmacologia
Insuficiência Renal/prevenção & controle
Obstrução Ureteral/prevenção & controle
-Anti-Inflamatórios/uso terapêutico
Creatinina/sangue
Modelos Animais de Doenças
Fibrose
Glutationa/análise
Sulfeto de Hidrogênio/uso terapêutico
Rim/patologia
Malondialdeído/análise
Óxido Nítrico/análise
Estresse Oxidativo
Distribuição Aleatória
Ratos Wistar
Reprodutibilidade dos Testes
Insuficiência Renal/etiologia
Insuficiência Renal/patologia
Fatores de Tempo
Ureia/sangue
Obstrução Ureteral/complicações
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


  8 / 22 LILACS  
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Id: lil-763539
Autor: Lozano, Fernando; Rodríguez Almada, Hugo.
Título: Intoxicación por gases y vapores / Poisoning by gases and vapors
Fonte: In: Rodríguez Almada, Hugo; Abilleira, Doris; Bazán, Natalia; Bengochea, Milka; Borges, Freddy; Cano, Jacqueline; Coitinho, Cecilia; Gamero, Sylvia; Imbert, María; Lozano, Fernanda; Maglia Canzani, Daniel; Mederos Catalano, Domingo; Mesa Figueras, Guillermo; Rabotti, Claudio; Rodríguez Estula, Geraldine; Rodríguez Machado, María Noel; Roó, Rafael; Sarkissian May, Paula; Tidball-Binz, Morris; Verdú Pascual, Fernando. Patología forense. Montevideo, Oficina del Libro Fefmur, 2013. p.467-519.
Idioma: es.
Descritores: Autopsia
Intoxicação por Gás
Intoxicação por Monóxido de Carbono/classificação
Intoxicação por Monóxido de Carbono/etiologia
Sulfeto de Hidrogênio/classificação
Sulfeto de Hidrogênio/efeitos adversos
Sulfeto de Hidrogênio/toxicidade
Limites: Humanos
Masculino
Feminino
Responsável: UY1.1 - BINAME - Biblioteca Nacional de Medicina
UY1.1; 34G, ROD; UY1.1; W700, ROD


  9 / 22 LILACS  
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Id: lil-759754
Autor: Medeiros, Jand-Venes Rolim.
Título: Efeitos gastroprotetor e procinético do sulfeto de hidrogênio (H2S) em camundongos [manuscrito]: papel dos Neurônios Aferentes Sensíveis à Capsaicina, Receptores de Vanilóides do tipo 1 (TRPV1) e Canais de K ATP-Dependentes (KATP) / Gastroprotective effects and prokinetic hydrogen sulfide (H2S) in mice [manuscript]: role of Afferent Neurons sensitive to capsaicin, vanilloid receptors type 1 (TRPV1) and Channel K ATP-Dependent (KATP).
Fonte: Fortaleza; s.n; 2009.
Idioma: pt.
Tese: Apresentada a Universidade Federal do Ceará para obtenção do grau de Doutor.
Resumo: Recentemente, foi demonstrado que o H2S está envolvido em inúmeras funções fisiológicas e patológicas, sendo produzido em muitos tecidos de mamíferos. OBJETIVOS: Avaliar o papel do H2S na defesa da mucosa e no controle da motilidade gástrica em camundongos, bem como estudar a participação dos canais de KATP, dos neurônios sensoriais sensíveis à capsaicina e dos receptores TRPV1 neste efeito. MÉTODOS: Camundongos Swiss foram pré-tratados com L-cisteína (25, 50 ou 100 mg/kg, v.o), NaHS (75, 150 ou 300 µmol/kg, v.o) ou Lawesson´s (3, 9, 27 ou 81 µmol/kg, v.o). Trinta minutos depois, o etanol 50% (0,5ml/25g, v.o) foi administrado. Depois de 1 h, os animais foram sacrificados e os estômagos abertos para determinação da área da lesão usando planimetria computadorizada. Além disso, fragmentos de tecidos foram removidos para análise microscópica e dosagem de glutationa e malondialdeído. Para o estudo do esvaziamento gástrico, outro grupo experimental foi tratado, por gavagem, com as mesmas doses de L-cisteína, NaHS ou Lawesson´s, decorridos 30 min os animais receberam uma solução glicosada (5%) contendo vermelho de fenol (0,75 mg/ml) em cada animal. Após 10, 20 ou 30 min os animais foram sacrificados e o esvaziamento gástrico foi avaliado por técnica de espectrofotometria. Em outro grupo experimental os animais foram pré-tratados com glibenclamida (3 e 10 mg/Kg, v.o.) ou capsazepina (10 mg/kg, i.p). Após 1h, foram administrados a L-cisteína (50 mg/kg) ou os doadores de H2S (NaHS 150 µmol/kg ou o reagente de Lawesson´s 27µmol/kg, v.o). Trinta minutos depois, o etanol 50% foi administrado para avaliação da lesão gástrica e solução de vermelho de fenol foi administrada para avaliar o esvaziamento gástrico conforme descrito anteriormente...
Descritores: Etanol
Sulfeto de Hidrogênio
Gastropatias
Limites: Animais
Camundongos
Responsável: BR6.1 - BCS - Biblioteca de Ciências da Saúde


  10 / 22 LILACS  
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Id: lil-755866
Autor: Vaitheeswari, S.; Sriram, R.; Brindha, P.; Kurian, Gino A..
Título: Studying inhibition of calcium oxalate stone formation: an in vitro approach for screening hydrogen sulfide and its metabolites
Fonte: Int. braz. j. urol;41(3):503-510, May-June 2015. ilus.
Idioma: en.
Resumo: ABSTRACTPurpose:

Calcium oxalate urolithiasis is one of the most common urinary tract diseases and is of high prevalence. The present study proposes to evaluate the antilithiatic property of hydrogen sulfide and its metabolites like thiosulfate & sulfate in an in vitro model.

Materials and Methods:

The antilithiatic activity of sodium hydrogen sulfide (NaSH), sodium thiosulfate (Na2S2O3) and sodium sulfate (Na2SO4) on the kinetics of calcium oxalate crystal formation was investigated both in physiological buffer and in urine from normal and recurrent stone forming volunteers. The stones were characterized by optical and spectroscopic techniques.

Results:

The stones were characterized to be monoclinic, prismatic and bipyramidal habit which is of calcium monohydrate and dihydrate nature. The FTIR displayed fingerprint corresponding to calcium oxalate in the control while in NaSH treated, S=O vibrations were visible in the spectrum. The order of percentage inhibition was NaSH>Na2S2O3>Na2SO4.

Conclusion:

Our study indicates that sodium hydrogen sulfide and its metabolite thiosulfate are inhibitors of calcium oxalate stone agglomeration which makes them unstable both in physiological buffer and in urine. This effect is attributed to pH changes and complexing of calcium by S2O32-and SO42- moiety produced by the test compounds.

.
Descritores: Oxalato de Cálcio/metabolismo
Sulfeto de Hidrogênio/química
Sulfeto de Hidrogênio/metabolismo
Urolitíase/metabolismo
Urolitíase/prevenção & controle
-Análise de Variância
Estudos de Casos e Controles
Oxalato de Cálcio/química
Reprodutibilidade dos Testes
Espectroscopia de Infravermelho com Transformada de Fourier
Urina/química
Limites: Adulto
Feminino
Humanos
Masculino
Responsável: BR1.1 - BIREME



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