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Pesquisa : D01.045 [Categoria DeCS]
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Id: biblio-973685
Autor: Barrón Balderas, Alejandro; Robledo Aceves, Mireya; Coello Ramírez, Pedro; García Rodríguez, Elizabeth; Barriga Marín, Javier A.
Título: Hallazgos endoscópicos en el tubo digestivo secundarios a la ingesta de cáusticos en niños atendidos en el Departamento de Urgencias / Endoscopic findings of the digestive tract secondary to caustic ingestion in children seen at the Emergency Department
Fonte: Arch. argent. pediatr;116(6):409-414, dic. 2018. ilus, tab.
Idioma: en; es.
Resumo: Antecedentes. La ingesta de sustancias cáusticas en pediatría constituye una causa frecuente de atención médica en Urgencias. El uso indiscriminado de limpiadores químicos y la facilidad de adquisición son factores determinantes para estas lesiones. Población y métodos. Estudio descriptivo analítico. Se incluyeron niños < 16 años, entre enero de 1998 y diciembre de 2017. Se identificó el agente químico cáustico ingerido por el niño como ácido o alcalino. Se realizó una endoscopía digestiva para tipificar el grado de quemadura. Se comparó el grado de quemadura con el tipo de cáustico; por medio de la prueba de chi² o exacta de Fisher, se consideró significativo el valor de P < 0,05. Resultados. Ingresaron 133 niños en Urgencias por ingesta de cáusticos. El agente cáustico fue ácido en el 41 % y alcalino en el 59 %. El agente ácido más frecuente fue el ácido muriático (36,8 %), mientras que el alcalino fue la sosa (soda) cáustica (41,4 %). La quemadura del esófago fue más frecuente en la ingesta de sosa en comparación con otros cáusticos (p= 0,001), mientras que la quemadura del estómago (p= 0,001) y del duodeno (p= 0,002) fue estadísticamente significativa en la ingesta de ácido muriático. El grupo de edad que más frecuentemente ingirió algún cáustico (93,2 %) fueron los menores de 5 años. Conclusiones. El cáustico ingerido con mayor frecuencia fue un agente alcalino, que provocó quemadura esofágica, mientras que un agente ácido provocó quemaduras en el estómago y el duodeno evidenciadas por endoscopía.

Background. Caustic ingestion in pediatrics is a common cause of visits to the Emergency Department. An indiscriminate use of cleaning chemicals and an easy access to them are determining factors for these injuries. Population and methods. Descriptive, analytical study. Children aged < 16 years hospitalized between January 1998 and December 2017 were included. The ingested caustic substance was identified as acid or alkaline. A gastrointestinal endoscopy was done to establish the burn grade. The grade of the burn was compared to the type of caustic substance using the χ² test or the Fisher's exact test; a P value < 0.05 was considered significant. Results. A total of 133 children were admitted to the Emergency Department due to caustic ingestion. The caustic agent was acid in 41 % of cases and alkaline, in 59 %. The most common acid caustic substance was muriatic acid (36.8 %) and the most common alkaline caustic agent was caustic soda (41.4 %). An esophageal burn was the most common consequence of caustic soda ingestion compared to other caustic agents (p = 0.001), whereas muriatic acid ingestion was the most statistically significant cause of stomach burn (p = 0.001) and duodenal burn (p = 0.002). The age group that most commonly ingested some caustic agent (93.2 %) corresponded to children younger than 5 years. Conclusions. The most common type of ingested caustic agent was alkaline, which caused esophageal burn; whereas, the ingestion of an acid caustic substance caused stomach and duodenal burns, as evidenced by endoscopy.
Descritores: Queimaduras Químicas/diagnóstico
Cáusticos/envenenamento
Endoscopia Gastrointestinal/métodos
Trato Gastrointestinal/lesões
-Estômago/lesões
Ácidos/envenenamento
Queimaduras Químicas/etiologia
Queimaduras Químicas/epidemiologia
Epidemiologia Descritiva
Fatores Etários
Duodeno/lesões
Álcalis/envenenamento
Serviço Hospitalar de Emergência
Esôfago/lesões
Limites: Seres Humanos
Lactente
Pré-Escolar
Criança
Adolescente
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: lil-735403
Autor: Mejías Sánchez, Yoerquis; Morales Suárez, Ileana; Perera Vandrell, Sebastián.
Título: Bases legales y proyecciones de desarrollo de la metrología en el Sistema Nacional de Salud / Legal basis and development projection of metrology in the national health care system
Fonte: Rev. cuba. salud pública;41(1):172-177, ene.-mar. 2015.
Idioma: es.
Resumo: La metrología es una ciencia de amplia aplicación en los servicios de salud puesto que garantiza la objetividad, confiabilidad, trazabilidad y uniformidad de las mediciones. Es propósito de este informe presentar las bases legales de la metrología en Cuba y sus perspectivas de desarrollo en el Sistema Nacional de Salud. Se realizó una búsqueda acerca de la pertinencia de esta ciencia y de las proyecciones del Ministerio de Salud Pública para su desarrollo. En Cuba, la metrología está refrendada en los Lineamientos de la Política Económica y Social del Partido y la Revolución y soportada legalmente. En el sector de la salud, el aseguramiento metrológico lo apoya, fundamentalmente, el Servicio Nacional de Metrología y la red de servicios de electromedicina, que dentro de sus funciones tiene la de reparar y calibrar equipos e instrumentos de medición. La existencia de las nuevas tecnologías y los requerimientos del Sistema conllevan a la implementación, por parte del Ministerio de Salud Pública, de un conjunto de acciones dirigidas al desarrollo de la metrología, entre ellas, la formación y superación de los recursos humanos, el desarrollo de las inversiones, la utilización de los resultados de la ciencia, el control y las alianzas estratégicas. Todos son elementos claves para garantizar las actividades de aseguramiento metrológico que demanda el Sistema Nacional de Salud y contribuir, desde esa óptica, al progreso de la salud pública, al mejoramiento de la calidad de los servicios y a la satisfacción de la población.

Metrology is science of great application in health care services since it assures objectivity, reliability, traceability and uniformity of measurements. The objective of the present report was to present the legal bases of metrology in Cuba and its development prospects in the Cuban health care system. A search was made on the relevance of this science and the projections of the Ministry of Public Health for its advancement. Metrology is included in the Guidelines of the Economic and Social Policy of the Party and the Revolution and is legally endorsed in Cuba. The National Service of Metrology and the medical equipment maintenance and repair service are the ones that render the metrological assurance in the health care sector. One of their functions is to repair and calibrate measurement tools and equipment. The new technologies and the requirements of the national health care system lead to the implementation of a set of actions by the Ministry of Public Health towards the development of metrology such as formation and upgrading of human resources, investment plans, utilization of the scientific results, control and strategic alliances. All of these are key elements to guarantee the metrological assurance activities that the health system demands, thus contributing to the advance of the public health, the improvement of the service quality and the satisfaction of the population.
Descritores: Medidas, Métodos e Teorias
Álcalis
Limites: Seres Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: lil-775128
Autor: Alrumman, Sulaiman A..
Título: Enzymatic saccharification and fermentation of cellulosic date palm wastes to glucose and lactic acid
Fonte: Braz. j. microbiol;47(1):110-119, Jan.-Mar. 2016. tab, graf.
Idioma: en.
Resumo: Abstract The bioconversion of cellulosic wastes into high-value bio-products by saccharification and fermentation processes is an important step that can reduce the environmental pollution caused by agricultural wastes. In this study, enzymatic saccharification of treated and untreated date palm cellulosic wastes by the cellulases from Geobacillus stearothermophilus was optimized. The alkaline pre-treatment of the date palm wastes was found to be effective in increasing the saccharification percentage. The maximum rate of saccharification was found at a substrate concentration of 4% and enzyme concentration of 30 FPU/g of substrate. The optimum pH and temperature for the bioconversions were 5.0 and 50 °C, respectively, after 24 h of incubation, with a yield of 31.56 mg/mL of glucose at a saccharification degree of 71.03%. The saccharification was increased to 94.88% by removal of the hydrolysate after 24 h by using a two-step hydrolysis. Significant lactic acid production (27.8 mg/mL) was obtained by separate saccharification and fermentation after 72 h of incubation. The results indicate that production of fermentable sugar and lactic acid is feasible and may reduce environmental pollution by using date palm wastes as a cheap substrate.
Descritores: Celulases/metabolismo
Celulose/metabolismo
Geobacillus stearothermophilus/enzimologia
Glucose/metabolismo
Resíduos Industriais
Ácido Láctico/metabolismo
Phoeniceae/metabolismo
-Álcalis
Biotransformação
Fermentação
Concentração de Íons de Hidrogênio
Phoeniceae/efeitos dos fármacos
Temperatura Ambiente
Responsável: BR1.1 - BIREME


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Id: lil-775115
Autor: Luvielmo, Márcia de Mello; Borges, Caroline Dellinghausen; Toyama, Daniela de Oliveira; Vendruscolo, Claire Tondo; Scamparini, Adilma Regina Pippa.
Título: Structure of xanthan gum and cell ultrastructure at different times of alkali stress
Fonte: Braz. j. microbiol;47(1):102-109, Jan.-Mar. 2016. graf.
Idioma: en.
Resumo: Abstract The effect of alkali stress on the yield, viscosity, gum structure, and cell ultrastructure of xanthan gum was evaluated at the end of fermentation process of xanthan production by Xanthomonas campestris pv. manihotis 280-95. Although greater xanthan production was observed after a 24 h-alkali stress process, a lower viscosity was observed when compared to the alkali stress-free gum, regardless of the alkali stress time. However, this outcome is not conclusive as further studies on gum purification are required to remove excess sodium, verify the efficiency loss and the consequent increase in the polymer viscosity. Alkali stress altered the structure of xanthan gum from a polygon-like shape to a star-like form. At the end of the fermentation, early structural changes in the bacterium were observed. After alkali stress, marked structural differences were observed in the cells. A more vacuolated cytoplasm and discontinuities in the membrane cells evidenced the cell lysis. Xanthan was observed in the form of concentric circles instead of agglomerates as observed prior to the alkali stress.
Descritores: Álcalis/toxicidade
Polissacarídeos Bacterianos/química
Polissacarídeos Bacterianos/metabolismo
Estresse Fisiológico
Xanthomonas campestris/metabolismo
Xanthomonas campestris/ultraestrutura
-Membrana Celular/ultraestrutura
Citoplasma/ultraestrutura
Organelas/ultraestrutura
Xanthomonas campestris/efeitos dos fármacos
Responsável: BR1.1 - BIREME


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Id: lil-741276
Autor: Colavolpe, María Belén; Mejía, Santiago Jaramillo; Albertó, Edgardo.
Título: Efficiency of treatments for controlling Trichoderma spp during spawning in cultivation of lignicolous mushrooms
Fonte: Braz. j. microbiol;45(4):1263-1270, Oct.-Dec. 2014. ilus, tab.
Idioma: en.
Resumo: Trichoderma spp is the cause of the green mold disease in mushroom cultivation production. Many disinfection treatments are commonly applied to lignocellulose substrates to prevent contamination. Mushroom growers are usually worried about the contaminations that may occur after these treatments during handling or spawning. The aim of this paper is to estimate the growth of the green mold Trichoderma sp on lignocellulose substrates after different disinfection treatments to know which of them is more effective to avoid contamination during spawning phase. Three different treatments were assayed: sterilization (121 ºC), immersion in hot water (60 and 80 ºC), and immersion in alkalinized water. Wheat straw, wheat seeds and Eucalyptus or Populus sawdust were used separately as substrates. After the disinfection treatments, bagged substrates were sprayed with 3 mL of suspension of conidia of Trichoderma sp (10(5) conidia/mL) and then separately spawned with Pleurotus ostreatus or Gymnopilus pampeanus. The growth of Trichoderma sp was evaluated based on a qualitative scale. Trichoderma sp could not grow on non-sterilized substrates. Immersions in hot water treatments and immersion in alkalinized water were also unfavorable treatments for its growth. Co- cultivation with mushrooms favored Trichoderma sp growth. Mushroom cultivation disinfection treatments of lignocellulose substrates influence on the growth of Trichoderma sp when contaminations occur during spawning phase. The immersion in hot water at 60 ºC for 30 min or in alkalinized water for 36 h, are treatments which better reduced the contaminations with Trichoderma sp during spawning phase for the cultivation of lignicolous species.
Descritores: Agaricales/crescimento & desenvolvimento
Desinfecção/métodos
Trichoderma/crescimento & desenvolvimento
-Álcalis/metabolismo
Anti-Infecciosos/metabolismo
Eucalyptus/microbiologia
Temperatura Alta
Populus/microbiologia
Temperatura Ambiente
Trichoderma/efeitos dos fármacos
Trichoderma/efeitos da radiação
Triticum/microbiologia
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-732581
Autor: GORDAN, Valeria Veiga; McEDWARD, Deborah Landry; OTTENGA, Marc Edward; GARVAN, Cynthia Wilson; HARRIS, Pearl Ann.
Título: Alkali production in the mouth and its relationship with certain patient's characteristics
Fonte: J. appl. oral sci;22(6):560-568, Nov-Dec/2014. tab, graf.
Idioma: en.
Projeto: NIH-NIDCR.
Resumo: Objectives To assess the relationships among alkali production, diet, oral health behaviors, and oral hygiene. Methods Data from 52 subjects including demographics, diet, and oral hygiene scores were analyzed against the level of arginine and urea enzymes in plaque and saliva samples. An oral habit survey was completed that included: use of tobacco (TB), alcohol (AH), sugary drinks (SD), and diet. Alkali production through arginine deiminase (ADS) and urease activities were measured in smooth-surface supragingival dental plaque and un stimulated saliva samples from all subjects. ADS and urease activities were measured by quantification of the ammonia generated from the incubation of plaque or saliva samples. Spearman correlations were used to compute all associations. Results Participants in the lowest SES (Socio-economic status) group had the habit of consuming sugary drinks the most and had the highest rate of tobacco use. Males consumed significantly more alcohol than females. No significant relationship was found between age or gender and alkali production. Higher rates of sugary drink consumption and tobacco use were significantly related to lower alkali production. Conclusion The study showed a relationship between alkali production and oral hygiene, diet, and certain oral health behaviors. Poor oral hygiene was significantly associated with age, lower SES, tobacco use, and alcohol, and sugary drinks consumption. Clinical relevance Certain oral health behaviors have an impact on oral hygiene and on alkali production; it is important to address these factors with patients as a strategy for caries control. .
Descritores: Álcalis/análise
Comportamento Alimentar
Boca/química
Higiene Bucal
-Fatores Etários
Consumo de Bebidas Alcoólicas/efeitos adversos
Álcalis/metabolismo
Carboidratos/efeitos adversos
Cárie Dentária/etiologia
Cárie Dentária/prevenção & controle
Hidrolases/análise
Hidrolases/metabolismo
Fatores de Risco
Fatores Socioeconômicos
Estatísticas não Paramétricas
Saliva/química
Fumar/efeitos adversos
Urease/análise
Urease/metabolismo
Limites: Adulto
Feminino
Seres Humanos
Masculino
Adulto Jovem
Tipo de Publ: Research Support, N.I.H., Extramural
Responsável: BR1.1 - BIREME


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Id: lil-711711
Autor: REYES, Evelyn; MARTIN, Javier; MONCADA, Gustavo; NEIRA, Miguel; PALMA, Patricia; GORDAN, Valeria; OYARZO, Juan Fernando; YEVENES, Ismael.
Título: Caries-free subjects have high levels of urease and arginine deiminase activity
Fonte: J. appl. oral sci;22(3):235-240, May-Jun/2014. tab.
Idioma: en.
Projeto: FONIS.
Resumo: Objectives: This study investigated the relationship between urease and arginine deiminase system (ADS) activities and dental caries through a cross-sectional study. Material and Methods: Urease and ADS activities were measured in saliva and plaque samples from 10 caries-free subjects and 13 caries-active. Urease activity was obtained from the ammonia produced by incubation of plaque and saliva samples in urea. ADS activity was obtained from the ammonia generated by the arginine-HCl and Tris-maleate buffer. Specific activity was defined as micromoles of ammonia per minute per milligram of protein. Shapiro-Wilk statistical test was used to analyze the distribution of the data, and Mann-Whitney test was used to determine the significance of the data. Results: The specific urease activity in saliva and plaque was significantly higher in individuals with low DMFT scores. ADS activity in saliva (6.050 vs 1.350, p=0.0154) and plaque (8.830 vs 1.210, p=0.025) was also higher in individuals with low DMFT scores. Conclusions: Caries-free subjects had a higher ammonia generation activity by urease and arginine deiminase system for both saliva and plaque samples than low caries-active subjects. High levels of alkali production in oral environment were related to caries-free subjects. .
Descritores: Cárie Dentária/enzimologia
Placa Dentária/enzimologia
Hidrolases/análise
Saliva/enzimologia
Urease/análise
-Álcalis/metabolismo
Amônia/análise
Estudos de Casos e Controles
Estudos Transversais
Índice CPO
Placa Dentária/química
Valores de Referência
Fatores de Risco
Estatísticas não Paramétricas
Saliva/química
Limites: Feminino
Seres Humanos
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Weckwerth, Paulo Henrique
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Id: lil-697642
Autor: Weckwerth, Paulo Henrique; Zapata, Ronald Ordinola; Vivan, Rodrigo Ricci; Tanomaru Filho, Mario; Maliza, Amanda Garcia Alves; Duarte, Marco Antonio Hungaro.
Título: In Vitro Alkaline pH Resistance of Enterococcus faecalis
Fonte: Braz. dent. j;24(5):474-476, Sep-Oct/2013.
Idioma: en.
Resumo: Enterococcus faecalis is a bacterial species often found in root canals with failed endodontic treatment. Alkaline pastes are widely used in Endodontics because of their biocompatibility and antimicrobial activity, but this microorganism can resist alkalinity. The purpose of this study was to evaluate in vitro the alkaline pH resistance of E. faecalis for different periods up to 14 days. Samples were obtained from the oral cavity of 150 patients from the Endodontic clinic. The pH of the experimental tubes (n=84) was first adjusted with 6M NaOH to pH values of 9.5, 10.5, 11.5 and 12.5 (21 tubes per pH). Twenty clinical isolates and the ATCC 29212 strain were tested. The 5 positive controls and experimental tubes of each pH were inoculated with 10 µL of bacterial suspension and incubated at 36 °C for 24, 48 and 72 h, 7 and 14 days. For each period, the turbidity of the medium was visually compared with a 0.5 McFarland standard. The presence of the microorganism was confirmed by seeding on M-Enterococcus agar. Four tubes containing BHI broth adjusted to the tested pHs were incubated for 14 days to verify if pH changes occurred. The pH of inoculated BHI broth was also measured on day 14 to determine if the microorganism acidified the medium. The growth of all E. faecalis strains occurred at pH 9.5 to 11.5 in all periods. Although turbidity was not observed at pH 12.5, there was growth of 13 and 2 strains at 24 and 48 h, respectively, on M-Enterococcus agar. No tube showed growth at pH 12.5 after 72 h. It was concluded that E. faecalis can survive in highly alkaline pH, and some clinical isolates require 72 h at pH 12.5 to be killed.

Enterococcus faecalis é uma espécie bacteriana frequentemente encontrada em canais radiculares com insucesso do tratamento endodôntico. Pastes alcalinas são amplamente utilizada em Endodontia por causa de sua biocompatibilidade e atividade antimicrobiana, porém esse microrganismo pode ser resistente a alcalinidade. Este estudo avaliou in vitro a resistência do E. faecalis ao pH alcalino por diferentes períodos até 14 dias. Amostras foram obtidas da cavidade oral de 150 pacientes da Clínica de Endodontia. O pH dos tubes experimentais (n=84) foram inicialmente ajustados com NaOH 6M a valores de pH 9.5, 10.5, 11.5 e 12.5 (21 tubes per pH). Vinte isolados clínicos e a cepa ATCC 29212 foram testados. Os 5 controles positivos e os tubos experimentais de cada pH foram inoculados com 10 µL de suspensão bacteriana e incubados a 36 °C por 24, 48 e 72 h, 7 e 14 dias. Para cada período, turvação do meio foi compara visualmente com padrão 0.5 da escala de McFarland. A presença de microorganism foi confirmada por semeadura no meio ágar M-Enterococcus. Quatro tubos contendo caldo BHI ajustado aos pHs testados foram incubados por 14 dias para verificar a ocorrência de alterações de pH. O pH do caldo BHI inoculado também foi medido no 14° dia para determinar se o microrganismo acidificou o meio. O crescimento de todas as cepas de E. faecalis ocorreu com pH entre 9.5 e 11.5 em todos os períodos. Embora não tenha sido observada turvação do meio no pH 12.5, houve crescimento de 13 e 2 cepas às 24 e 48 h, respectivamente, no meio ágar M-Enterococcus. Nenhum tube apresentou crescimento bacteriano no pH 12.5 após 72 h. Concluiu-se que o E. faecalis pode sobreviver em pH altamente alcalino, que alguns isolados clínicos requerem 72 h em pH 12.5 para serem eliminados.
Descritores: Álcalis/metabolismo
Enterococcus faecalis/metabolismo
Concentração de Íons de Hidrogênio
-Meios de Cultura
Técnicas In Vitro
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: lil-675668
Autor: Brazilian Dental Journal; Paranhos, Helena de Freitas Oliveira; Peracini, Amanda; Pisani, Marina Xavier; Oliveira, Viviane de Cássia; Souza, Raphael Freitas de; Silva-Lovato, Cláudia Helena.
Título: Color Stability, Surface Roughness and Flexural Strength of an Acrylic Resin Submitted to Simulated Overnight Immersion in Denture Cleansers
Fonte: Braz. dent. j;24(2):152-156, Mar-Apr/2013. tab.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de São Paulo – FAPESP.
Resumo: This study evaluated color stability, surface roughness and flexural strength of acrylic resin specimens after immersion in alkaline peroxide and alkaline hypochlorite, simulating a period of one and a half year of use of overnight immersion. Sixty disc-shaped (16X4 mm) and 80 rectangular specimens (65X10X3.3 mm) were prepared from heat-polymerized acrylic resin (Lucitone 550) and distributed into 4 groups (n=20): C1: without immersion, C2: 8 h immersion in distilled water; AP: 8 h immersion in alkaline peroxide effervescent tablet; SH: 8 h immersion in 0.5% NaOCl solution. Properties were evaluated at baseline and after the immersion. Color data were also calculated according the National Bureau of Standards (NBS). Results were analyzed statistically by ANOVA and Tukey's HSD test (α=0.05). AP (2.34 ± 0.41) caused color alteration significantly higher than C2 (0.39 ± 0.30) and SH (1.73 ± 0.52). The mean ΔE values were classified as indicial for C2 (0.36 ± 0.29) and noticeable for AP (2.12 ± 0.39) and SH (1.59 ± 0.48). SH (0.0195 ± 0.0150) caused significantly higher ΔRa (p=0.000) than the C2 (0.0005 ± 0.0115) and PA (0.0005 ± 0.0157) groups. There was no statistically significant difference (p=0.063) among the solutions for flexural strength (C1: 105.43 ± 14.93, C2: 100.30 ± 12.43, PA: 97.61 ± 11.09, SH: 95.23 ± 10.18). In conclusion, overnight immersion in denture cleansing solutions simulating a year and a half of use did not alter the flexural strength of acrylic resin but caused noticeable color alterations, higher for alkaline peroxide. The 0.5% NaOCl solution caused increase in surface roughness.

Resumo O estudo avaliou a alteração de cor, rugosidade de superfície e força de flexão de espécimes de resina acrílica após imersão em peróxido alcalino e hipoclorito alcalino, simulando um ano e meio de uso seguindo a imersão noturna. Sessenta espécimes circulares (16 X 4 mm) e oitenta retangulares (65 X 10 X 3,3 mm) de resina acrílica termopolimerizável (Lucitone 550) foram distribuídos em 4 grupos (n=20): C1: sem imersão, C2: 8 h de imersão em água destilada; PA: 8 h de imersão em pastilhas efervescentes de peróxido alcalino; HS: 8 h de imersão em hipoclorito de sódio a 0,5%. As propriedades foram avaliadas antes e após as imersões. Os dados de alteração de cor também foram calculados de acordo com o National Bureau of Standards (NBS). Os dados foram analisados estatisticamente pelo teste ANOVA e Tukey HSD (α=0,05). O PA (2,34 ± 0,41) causou alteração de cor significativamente maior que C2 (0,39 ± 0,30) e SH (1,73 ± 0,2). A média ΔE foi classificada como indicial para C2 (0,36 ± 0,29) e perceptível para PA (2,12 ± 0,39) e HS (1,59 ± 0,48). HS (0,0195 ± 0,0150) causou significantemente maior ΔRa (p=0) do que os demais (C2: 0,0005 ± 0,0115 e PA: 0,0005 ± 0,0157). Não houve diferença estatisticamente significante (p=0,063) entre as soluções para a resistência à flexão (C1: 105,43 ± 14,93; C2: 100,30 ± 12,43, PA: 97,61 ± 11,09, HS: 95,23 ± 10,18). A imersão noturna em soluções higienizadores de próteses simulando um ano e meio de uso não alterou a resistência à flexão da resina acrílica, porém causou alterações perceptíveis de cor, sendo maiores com o peróxido alcalino. O hipoclorito de sódio a 0,5% ...
Descritores: Resinas Acrílicas/química
Bases de Dentadura
Materiais Dentários/química
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Limites: Seres Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-662135
Autor: Marín, Gustavo Roberto; Majek, Elena.
Título: Lesión renal aguda secundaria a lisis tumoral inducida por esteroides en una adolescente con leucemia linfoblástica aguda: Rol de la alcalinización urinaria y diálisis peritoneal / Acute kidney injury secondary to steroid-induced tumor lysis in an adolescent with acute lymphoblastic leukemia: Role of urinary alkalinisation and peritoneal dialysis
Fonte: Arch. argent. pediatr;110(6):e118-e122, dic. 2012. ilus, tab.
Idioma: es.
Resumo: Una adolescente con leucemia linfoblástica aguda desarrolló un síndrome de lisis tumoral precoz y grave con lesión renal aguda luego de una dosis única y baja de esteroides. La disfunción renal se atribuyó primariamente a una nefropatía por fosfato con nefrocalcinosis debido a elevaciones extremas de este componente en sangre. La alcalinización urinaria probablemente contribuyó a su patogenia. Se utilizó diálisis peritoneal con resolución de la nefrocalcinosis y normalización de la depuración de creatinina.

An adolescent with acute lymphoblastic leukemia developed an early and severe tumor lysis syndrome with acute kidney injury after a low and single dose of steroids. Renal dysfunction was attributed primarily to phosphate nephropathy with nephrocalcinosis due to extreme elevations of phosphate in blood. Urinary alkalinization probably contributed to this development. We used peritoneal dialysis with resolution of nephrocalcinosis and normalization of creatinine clearance.
Descritores: Lesão Renal Aguda/etiologia
Lesão Renal Aguda/terapia
Diálise Peritoneal
Leucemia-Linfoma Linfoblástico de Células Precursoras/complicações
Síndrome de Lise Tumoral/complicações
-Lesão Renal Aguda/urina
Álcalis/urina
Glucocorticoides/efeitos adversos
Metilprednisolona/efeitos adversos
Leucemia-Linfoma Linfoblástico de Células Precursoras/tratamento farmacológico
Síndrome de Lise Tumoral/etiologia
Limites: Adolescente
Criança
Feminino
Seres Humanos
Tipo de Publ: Relatos de Casos
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas



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