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Id: lil-672868
Autor: Alleyne, T; Mohan, N; Adogwa, A.
T韙ulo: Elevated ferric, calcium and magnesium ions in the brain induce protein aggregation in brain mitochondria / El aumento de iones f茅rricos, calcio y magnesio en el cerebro induce la agregaci贸n de prote铆nas en las mitocondrias del cerebro
Fonte: West Indian med. j;61(2):122-127, Mar. 2012. ilus, graf.
Idioma: en.
Resumo: OBJECTIVE: Alzheimer s disease and Parkinson s disease are two of several neurodegenerative disorders that affect the elderly. Although their aetiology remains uncertain, studies suggest that elevated aluminium or other metal ions in the brain directly influence the development of the histological abnormalities normally associated with these diseases; other investigations suggest that metal-ion-induced-dysfunction of mitochondria might be a critical factor. METHODS: In this study, the impact of elevated aluminum (Al3+), ferric (Fe3+), calcium (Ca2+) and magnesium (Mg2+) ions on brain histology and on the protein composition of brain mitochondria were evaluated. Rabbits were injected intra-cerebrally with 1.4% solutions of either aluminium chloride (AlCl3), ferric chloride (FeCl2), calcium chloride (CaCl2) or magnesium chloride (MgCl2) and sacrificed 10 days later. RESULTS: Histological analysis revealed that Al3+ but not the other ions induced neurofibrillary degeneration within the midbrain and medulla. Alternatively, SDS-PAGE revealed that Fe3+, Ca2+ and Mg2+ but not Al3+ induced alterations to the distribution of brain mitochondrial proteins. Both Fe3+ and Ca2+ triggered decreased concentration of three low molecular weight proteins (~7-14 kd) but Ca precipitated their total absence. Both ions led to increased concentration of a high molecular weight protein (~ 110 kd). In contrast, Mg2+ led to the total absence of the protein of lowest molecular weight (~7 kd) and increased concentration of a ~36 kd protein. CONCLUSION: These results suggest that elevation of some metal ions in the brain induces protein aggregation with the nature of the aggregation being highly ion dependent. The results also point toward major differences between the histopathological effect of Al3+ and other ions.

OBJETIVO: La enfermedad de Alzheimer y la enfermedad de Parkinson son dos de los varios trastornos neurodegenerativos que afectan al anciano. Aunque su etiologia sigue siendo incierta, los estudios sugieren que el aumento de los iones de aluminio, influyen directamente sobre el desarrollo de las anormalidades histol贸gicas asociadas normalmente con estas enfermedades. Otras investigaciones sugieren que la disfunci贸n de las mitocondrias, inducida por iones met谩licos, pudiera ser un factor critico. M脡TODOS: Este estudio eval煤a el impacto del aumento de los iones de aluminio (Al3+), los iones f茅rricos (Fe3+), y los iones de calcio (Ca2+) y magnesio (Mg2+) sobre la histologia del cerebro y la composici贸n proteica de las mitocondrias del cerebro. Un n煤mero de conejos recibieron inyecciones intracerebrales de soluciones al 1.4% de soluciones de cloruro de aluminio (AlCl3), cloruro ferroso (FeCl3), cloruro de calcio (CaCl2), o cloruro de magnesio (MgCl2), y fueron sacrificados despu茅s de 10 d铆as. RESULTADOS: El an谩lisis histol贸gico revel贸 que el Al3+ indujo una degeneraci贸n neurofibrilar dentro del mesenc茅falo y la m茅dula, Sin embargo, esto no ocurri贸 con los otros iones. Alternativamente, la t茅cnica de electroforesis SDS-PAGE revel贸 que los iones Fe3+, Ca2+ y Mg2+, a diferencia del i贸n Al3+, induc铆an alteraciones de la distribuci贸n de las prote铆nas mitocondriales cerebrales. Tanto el Fe3+ como el Ca2+ desencadenaron una disminuci贸n de la concentraci贸n de tres prote铆nas de bajo peso molecular (~7-14 kd) pero Ca2+ precipit贸 su ausencia total. Ambos iones condujeron a un aumento de una prote铆na de peso molecular alto (~ 110 kd). En cambio, Mg2+ llev贸 a la ausencia total de la prote铆na de m谩s bajo peso molecular (~7 kd) y al aumento de la concentraci贸n de una prote铆na de ~36 kd. CONCLUSI脫N: Estos resultados parecen sugerir que la elevaci贸n de algunos iones de metal en el cerebro induce la agregaci贸n de la prote铆na, siendo la naturaleza de la agregaci贸n altamente dependiente de los iones. Los resultados tambi茅n apuntan a grandes diferencias entre el efecto histopatol贸gico del Al3+ y otros iones.
Descritores: Enc閒alo/metabolismo
Cloreto de C醠cio/farmacologia
Cloretos/farmacologia
Compostos F閞ricos/farmacologia
Cloreto de Magn閟io/farmacologia
Prote韓as Mitocondriais/metabolismo
-Compostos de Alum韓io/farmacologia
Enc閒alo/ultraestrutura
Eletroforese em Gel de Poliacrilamida
Prote韓as Mitocondriais/efeitos dos f醨macos
Limites: Animais
Coelhos
Respons醰el: BR1.1 - BIREME


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Texto completo SciELO Brasil
Texto completo
Id: lil-605880
Autor: Noritomi, Danilo Teixeira; Pereira, Adriano Jos; Bugano, Diogo Diniz Gomes; Rehder, Paulo Sergio; Silva, Eli閦er.
T韙ulo: Impact of Plasma-Lyte pH 7.4 on acid-base status and hemodynamics in a model of controlled hemorrhagic shock
Fonte: Clinics;66(11):1969-1974, 2011. ilus, tab.
Idioma: en.
Resumo: OBJECTIVE: Intravenous infusion of crystalloid solutions is a cornerstone of the treatment of hemorrhagic shock. However, crystalloid solutions can have variable metabolic acid-base effects, perpetuating or even aggravating shock-induced metabolic acidosis. The aim of this study was to compare, in a controlled volume-driven porcine model of hemorrhagic shock, the effects of three different crystalloid solutions on the hemodynamics and acid-base balance. METHODS: Controlled hemorrhagic shock (40 percent of the total blood volume was removed) was induced in 18 animals, which were then treated with normal saline (0.9 percent NaCl), Lactated Ringer's Solution or Plasma-Lyte pH 7.4, in a blinded fashion (n = 6 for each group). Using a predefined protocol, the animals received three times the volume of blood removed. RESULTS: The three different crystalloid infusions were equally capable of reversing the hemorrhage-induced low cardiac output and anuria. The Lactated Ringer's Solution and Plasma-Lyte pH 7.4 infusions resulted in an increased standard base excess and a decreased serum chloride level, whereas treatment with normal saline resulted in a decreased standard base excess and an increased serum chloride level. The Plasma-Lyte pH 7.4 infusions did not change the level of the unmeasured anions. CONCLUSION: Although the three tested crystalloid solutions were equally able to attenuate the hemodynamic and tissue perfusion disturbances, only the normal saline induced hyperchloremia and metabolic acidosis.
Descritores: Equil韇rio 羉ido-Base/efeitos dos f醨macos
Hemodin鈓ica/efeitos dos f醨macos
Solu珲es Isot鬾icas/efeitos adversos
Choque Hemorr醙ico/tratamento farmacol骻ico
-Modelos Animais de Doen鏰s
M閠odos Epidemiol骻icos
Gluconatos/efeitos adversos
Concentra玢o de 蚾ns de Hidrog阯io
Solu珲es Isot鬾icas/classifica玢o
Cloreto de Magn閟io/efeitos adversos
Cloreto de Pot醩sio/efeitos adversos
Su韓os
Choque Hemorr醙ico/induzido quimicamente
Acetato de S骴io/efeitos adversos
Cloreto de S骴io/efeitos adversos
Limites: Animais
Masculino
Tipo de Publ: Estudo Comparativo
Respons醰el: BR1.1 - BIREME


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Texto completo SciELO Brasil
Texto completo
Id: lil-304672
Autor: Prado, W. A; Machado Filho, E. B.
T韙ulo: Antinociceptive potency of aminoglycoside antibiotics and magnesium chloride: a comparative study on models of phasic and incisional pain in rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. m閐. biol;35(3):395-403, Mar. 2002. ilus.
Idioma: en.
Projeto: FAPESP.
Resumo: A close relationship exists between calcium concentration in the central nervous system and nociceptive processing. Aminoglycoside antibiotics and magnesium interact with N- and P/Q-type voltage-operated calcium channels. In the present study we compare the antinociceptive potency of intrathecal administration of aminoglycoside antibiotics and magnesium chloride in the tail-flick test and on incisional pain in rats, taken as models of phasic and persistent post-surgical pain, respectively. The order of potency in the tail-flick test was gentamicin (ED50 = 3.34 鎔; confidence limits 2.65 and 4.2) > streptomycin (5.68 鎔; 3.76 and 8.57) = neomycin (9.22 鎔; 6.98 and 12.17) > magnesium (19.49 鎔; 11.46 and 33.13). The order of potency to reduce incisional pain was gentamicin (ED50 = 2.06 鎔; confidence limits 1.46 and 2.9) > streptomycin (47.86 鎔; 26.3 and 87.1) = neomycin (83.17 鎔; 51.6 and 133.9). The dose-response curves for each test did not deviate significantly from parallelism. We conclude that neomycin and streptomycin are more potent against phasic pain than against persistent pain, whereas gentamicin is equipotent against both types of pain. Magnesium was less potent than the antibiotics and effective in the tail-flick test only
Descritores: Analg閟icos
Antibacterianos
Cloreto de Magn閟io
Dor
Medi玢o da Dor
-Antibacterianos
Modelos Animais de Doen鏰s
Rela玢o Dose-Resposta a Droga
Gentamicinas
Inje珲es Espinhais
Cloreto de Magn閟io
Neomicina
Dor
Ratos Wistar
Limites: Animais
Masculino
Ratos
Tipo de Publ: Estudo Comparativo
Respons醰el: BR1.1 - BIREME


  4 / 10 LILACS  
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Milani, H
Texto completo
Id: lil-252280
Autor: Milani, H; Lepri, E. R; Giordani, F; Favero-Filho, L. A.
T韙ulo: Magnesium chloride alone or in combination with diazepam fails to prevent hippocampal damage following transient forebrain ischemia
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. m閐. biol;32(10):1285-93, Oct. 1999. graf.
Idioma: en.
Resumo: In the central nervous system, magnesium ion (Mg2+) acts as an endogenous modulator of N-methyl-D-aspartate (NMDA)-coupled calcium channels, and may play a major role in the pathomechanisms of ischemic brain damage. In the present study, we investigated the effects of magnesium chloride (MgCl2, 2.5, 5.0 or 7.5 mmol/kg), either alone or in combination with diazepam (DZ), on ischemia-induced hippocampal cell death. Male Wistar rats (250-300 g) were subjected to transient forebrain ischemia for 15 min using the 4-vessel occlusion model. MgCl2 was applied systemically (sc) in single (1x, 2 h post-ischemia) or multiple doses (4x, 1, 2, 24 and 48 h post-ischemia). DZ was always given twice, at 1 and 2 h post-ischemia. Thus, ischemia-subjected rats were assigned to one of the following treatments: vehicle (0.1 ml/kg, N = 34), DZ (10 mg/kg, N = 24), MgCl2 (2.5 mmol/kg, N = 10), MgCl2 (5.0 mmol/kg, N = 17), MgCl2 (7.5 mmol/kg, N = 9) or MgCl2 (5 mmol/kg) + DZ (10 mg/kg, N = 14). Seven days after ischemia the brains were analyzed histologically. Fifteen minutes of ischemia caused massive pyramidal cell loss in the subiculum (90.3 percent) and CA1 (88.4 percent) sectors of the hippocampus, vehicle vs sham). Compared to the vehicle-treated group, all pharmacological treatments failed to attenuate the ischemia-induced death of both subiculum (lesion: 86.7-93.4 percent) and CA1 (lesion: 85.5-91.2 percent) pyramidal cells. Both DZ alone and DZ + MgCl2 reduced rectal temperature significantly. No animaldeath was observed after drug treatment. These data indicate that exogenous magnesium, when administered systemically post-ischemia even in different multiple dose schedules, alone or with diazepam, is not useful against the histopathological effects of transient global cerebral ischemia in rats
Descritores: Diazepam/uso terap陁tico
Hipocampo/les鮡s
Ataque Isqu阭ico Transit髍io/tratamento farmacol骻ico
Cloreto de Magn閟io/uso terap陁tico
F醨macos Neuroprotetores/uso terap陁tico
Prosenc閒alo
-An醠ise de Vari鈔cia
Esquema de Medica玢o
Quimioterapia Combinada
Hipocampo/patologia
Ratos Wistar
Limites: Animais
Ratos
Masculino
Respons醰el: BR1.1 - BIREME


  5 / 10 LILACS  
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Id: lil-239086
Autor: Kohan, Abraham I.
T韙ulo: Fisiolog韆 de la hemaf閞esis en el procedimiento de vol鷐enes est醤dar y grandes vol鷐enes / Physiology of apheresis in procedure with standard and big volume removal
Fonte: Rev. argent. transfus;24(3):135-9, jul.-sept. 1998. ilus, tab.
Idioma: es.
Confer阯cia: Apresentado em: Jornadas de Hemaf閞esis de la Asociaci髇 Argentina de Hemoterapia e Inmunohematolog韆, Buenos Aires, 23-24 oct. 1998.
Descritores: Adsor玢o
Troca Plasm醫ica/m閠odos
Plasmaferese/hist髍ia
Plasmaferese/m閠odos
Volume Plasm醫ico/fisiologia
-Precipita玢o Qu韒ica
Sulfato de Dextrana
Cloreto de Magn閟io
Limites: Humanos
Respons醰el: AR1.1 - Biblioteca Rafael Herrera Vegas


  6 / 10 LILACS  
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Id: lil-226361
Autor: Teruel L髉ez, Emelina; Hern醤dez, Hugo.
T韙ulo: Efectos del pH y la concentraci髇 i髇ica sobre la infecciosidad del virus de la encefalitis equina venezolana / Effecs of pH and ionic concentration on VEE virus infection
Fonte: Invest. cl韓;36((Sup 2)):293-8, nov. 1995. tab.
Idioma: es.
Resumo: El virus de la EEV a una temperatura de 37篊 sufre alteraciones en su nivel de infecciosidad, que var韆n seg鷑 la concentraci髇 de la soluci髇 empleada. En buffer citrato 100 mM a pH 3,4 y 5, hay p閞dida notable de la infecciosidad viral; cuando se usan concentraciones de 5 y 10 mM, a los mismos pH, no se observa ninguna variaci髇 en su nivel de infecciosidad. En presencia de soluciones dilu韉as de cloruro de magnesio pH 4 y a 77篊, el virus es estable en su nivel de infecciosidad; lo que no se observa en las soluciones de elevada concentraci髇 (1 2 M). Cuando se emplea una soluci髇 de MgSO4, no ocurre ninguna variaci髇 del nivel de infecciosidad del virus tratado en las mismas condiciones
Descritores: V韗us da Encefalite/patogenicidade
Infec珲es/complica珲es
Cloreto de Magn閟io/uso terap陁tico
Limites: Animais
Camundongos
Respons醰el: VE1.1 - Biblioteca Humberto Garcia Arocha


  7 / 10 LILACS  
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Id: lil-181478
Autor: Grin, Jaime; Pellizzon, Oscar A; Raynald, Augusto.
T韙ulo: Mecanismos involucrados en el efecto antiarritmico y proarritmico del magnesio / Mechanisms involved in the antiarrhythmic and proarrhythmic effects of magnesium
Fonte: Medicina (B.Aires);56(3):231-40, 1996. tab, graf.
Idioma: es.
Resumo: El objetivo fue analizar en perros, los efectos del MgCl2, y del MgSO4 sobre los mecanismos electrofisiol骻icos que pudieran vincularse con las acciones antiarr韙micas y proarr韙micas de estas soluciones. Se estudiaron previamente los par醡etros farmacocin閠icos del MgCl2 y del MgSO4; ambos mostraron que el Mg plasm醫ico disminuye exponencialmente (constante beta de O,118 O,013 h-l), t 1/2 de eliminaci髇 de 6,02 O,68 h y una Vda de O,259 O,02lxkg-l. Posteriormente se estudiaron dos grupos de animales - Grupo I: dieta normal. Grupo II A: dieta sin Mg + clortalidona + K y Grupo II B: dieta sin Mg + clortalidona + KCI + MgSO4. Se midieron los electrolitos y las variables electrofisiol骻icas por medio de estimulaci髇 ventricular programada. El grupo I mostr que la administraci髇 de MgSO4 endovenoso disminuye el Na, el K y el umbral de fibrilaci髇 ventricular (UFV) y prolonga el per韔do refractaria efectivo ventricular (PREV). El MgCl2 no modifica el UFV, pero prolonga el PREV, el A-H, el QTc y el PQ. El MgSO4 aumenta la excreci髇 de K urinario en forma significativamente mayor que el MgCl2. La administraci髇 de NaCl no alter las variables electrofisiol骻icas pero el NaSO4 disminuy el K plasm醫ico, sin modificar el UFV. El Grupo II A present descenso del K y Mg plasm醫ico, linfocitario y mioc醨dico, disminuci髇 del PREV y del UFV y aumento del QTc. A este grupo se le administro en forma aguda: 1) MgSO4 que provoc mayor descenso del UFV y del K plasm醫ico y aumento del PREV y 2) KCI que aumento el K piasm醫ico y el UFV. El grupo II B no modific los electrolitos ni las variables electrofisiol骻icas. Se concluye que los efectos antiarr韙micos observados en cl韓ica por la administraci髇 de sales de Mg se deber韆n probablemente a la prolongaci髇 del PREV. Sin embargo, la depleci髇 de K inducida por el MgSO4 puede provocar un descenso del UFV, efecto proarr韙mico que se podr韆 evitar utilizando MgCl2.
Descritores: Arritmias Card韆cas
Cora玢o
Eletrofisiologia
Magn閟io/farmacologia
-C醠cio/sangue
C醠cio/farmacologia
Cloreto de Magn閟io/farmacologia
Cloreto de S骴io/farmacologia
Eletr髄itos
Fibrila玢o Ventricular/fisiopatologia
Sulfato de Magn閟io/farmacologia
Magn閟io/sangue
Magn閟io/farmacocin閠ica
Pot醩sio/farmacologia
Pot醩sio/sangue
S骴io/sangue
S骴io/farmacologia
Ventr韈ulos do Cora玢o
Limites: Animais
Masculino
Feminino
C鉫s
Tipo de Publ: Estudo Comparativo
Respons醰el: BR1.1 - BIREME


  8 / 10 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: lil-155814
Autor: Arcanjo, K醫ia Denise Souza; Gomes, Laurecir; Pimentel, Edson Rosa.
T韙ulo: Effect of magnesium chloride and guanidinum chloride on the extraction of components of extracellular matrix from chicken cartilage
Fonte: Mem. Inst. Oswaldo Cruz;89(1):93-7, jan.-mar. 1994. ilus, tab.
Idioma: en.
Resumo: In order to evaluate the effect of chaotropic agents on proteoglycan and non-collagenous proteins, chicken xiphoid cartilage was treated with guanidine-HCI and MgCl2 in different concentrations (1M to 5M), and different periods of time (12, 24, 48 and 72hr). The maximum yield of uronic acid was obtained with 3M MgCl2 (73.3 per cent). Concentrations of 4M and 5M of MgCl2 showed that much less uronic acid was removed, 55.3 per cent and 38.1 respectively. Extraction with 3M MgCl2 and 3M guanidine-HCl resulted better efficiency when performed for 48 hr. Analysis by SDS-PAGE of the extracts obtained with guanidine-HCl and MgCl, in different concentrations pointed out that most components are equally removed with the two solvents, showing that the extraction with MgCl2 is an alternative assay to remove non-collagenous proteins from extracellular matrix
Descritores: Cartilagem/qu韒ica
Cloreto de Magn閟io/farmacologia
Guanidinas/farmacologia
Prote韓as da Matriz Extracelular/isolamento & purifica玢o
-Galinhas
Eletroforese em Gel de Poliacrilamida
Limites: Animais
Respons醰el: BR1.1 - BIREME


  9 / 10 LILACS  
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Raw, I
Id: lil-153284
Autor: Costa, M. H. B; Arisi, A. C. M; Matos, C. R. T; Silva, L. V. N; Raw, I.
T韙ulo: Kinetic studies on the membrane form of intestinal alkaline phosphatase
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. m閐. biol;27(12):2859-62, Dec. 1994. tab, graf.
Idioma: en.
Confer阯cia: Apresentado em: Annual Meeting of the Federa玟o de Sociedades de Biologia Experimental, 9, Caxambu, Aug. 24-27, 1994.
Resumo: We have purified different membrane and soluble forms of alkaline phosphatase from human placenta and bovine intestine. The enzymes will be used as markers in immunoconjugates and/or as model for membrane enzyme studies. The membrane formof alkaline phosphatase extracted from bovine intestine was purified on Q-Sepharose and on L-histidyldiazobenzylphosphonic acid-agarose columns to remove phosphodiesterase activity. The purified enzyme had a molecular mass of 61 kDa, Km of 1208 礛, and Vmax 240 祄ol pNP/min when assayed in 1 M diethanolamine, 0.5 mM MgCl2 buffer, pH 9.8, containing 10 to 2250 礛 of pNPP at 37. In the present investigation we studied the effect of salts and inositol derivatives on this enzyme activity, which was found to depend on 0.5 mM Mg2+, and to be fully inhibited by 1.2 mM Hg2+. Vanadate (0.5 mM) and Zn2+ (0.5 mM) reduced the Km value by 43 percent and 84 percent, respectively. Inositol (2 mM) and inositol-2-monophosphate (2 mM) reduced the activity by 23 percent and 17 percent. Inositol-1-monophosphate (0.5 mM) and cyclic-inositol-(1:2)-monophosphate (0.5 mM) enhanced their Km value by at least 30 percent compared to p-nitrophenylphosphate
Descritores: Fosfatase Alcalina/farmacocin閠ica
Inositol/farmacologia
Intestinos/enzimologia
-Cloreto de C醠cio/farmacologia
Cloreto de Magn閟io/farmacologia
Cloreto de Merc鷕io/farmacologia
Inositol/an醠ogos & derivados
Vanadatos/farmacologia
Compostos de Zinco/farmacologia
Limites: Humanos
Animais
Bovinos
Respons醰el: BR1.1 - BIREME


  10 / 10 LILACS  
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Id: lil-87985
Autor: Grin, Jaime J; Raynald, Augusto C; Girolami, Ricardo.
T韙ulo: Magnesio plasm醫ico y umbral de fibrilaci髇 ventricular en perros anestesiados / Plasmatic magnesium and ventricular fibrillation threshold in anesthetized dogs
Fonte: Acta physiol. pharmacol. latinoam;40(2):197-206, abr.-jun. 1990. tab.
Idioma: es.
Resumo: En perros anestesiados con pentobarbital s骴ico se estudi el efecto de la administraci髇 parenteral de soluciones de sulfato y cloruro de magnesio sobre algunas variables electrofisiol骻icas vinculadas a su potencial efecto de la administraci髇 parenteral de soluciones de sulfato y cloruro de magnesio sobre algunas variables electrofisiol骻icas vinculadas a su potencial efecto antiarr韙mico. De los resultados obtenidos se puede concluir que tanto el sulfato como el cloruro de magnesio prolongan el per韔do refractario efectivo ventricular (PREV), efecto probablemente relacionado con la prolongaci髇 del intervalo QTc. La administraci髇 de magnesio prolong el intervalo AH probablemente por bloquear el canal de Ca++. El cloruro de magnesio no modific el umbral de fibrilaci髇 ventricular (UFV), pero el sultato de magnesio lo hizo descender en forma significativa. Este efecto pudo estar relacionado con la disminuci髇 del potasio plasm醫ico inducida por la administraci髇 de sulfato de magnesio y a la elevaci髇 del magnesio plasm醫ico, porque la administraci髇 de sulfato de sodio, que tambi閚 disminuy el K+ plasm醫ico, no modific el UFV. Los efectos antiarr韙micos observados con la aministraciRon de magnesio en pacientes normomagnes閙icos podr韆n ser explicados por una prolongaci髇 del PREV. Sin embargo, la disminuci髇 del UFV observada en los experimentos con sulfato de magnesio constituye un efecto potencialmente peligroso que merece ser investigado
Descritores: Cloreto de Magn閟io/administra玢o & dosagem
Fibrila玢o Ventricular/fisiopatologia
Sulfato de Magn閟io/administra玢o & dosagem
-Cloreto de Magn閟io/farmacocin閠ica
Cloreto de Magn閟io/sangue
Infus鮡s Intravenosas
Sulfato de Magn閟io/sangue
Sulfato de Magn閟io/farmacocin閠ica
Limites: C鉫s
Animais
Masculino
Feminino
Tipo de Publ: Estudo Comparativo
Respons醰el: BR1.1 - BIREME



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