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Zaia, Alexandre Augusto
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Id: biblio-1278594
Autor: Pelepenko, Lauter Eston; Saavedra, Flávia; Antunes, Thiago Bessa Marconato; Bombarda, Gabriela Fernanda; Gomes, Brenda Paula Figueiredo de Almeida; Zaia, Alexandre Augusto; Marciano, Marina Angélica.
Título: Investigation of a modified hydraulic calcium silicate-based material - Bio-C Pulpo
Fonte: Braz. oral res. (Online);35:e077, 2021. tab, graf.
Idioma: en.
Projeto: State of São Paulo Research Foundation; . State of São Paulo Research Foundation; . State of São Paulo Research Foundation; . State of São Paulo Research Foundation.
Resumo: Abstract This study evaluated the physicochemical, biological, and antimicrobial properties of a new hydraulic calcium silicate-based modified material, and compared it with MTA Repair HP and MTA Angelus. The materials were assessed regarding color luminosity (L), color change, radiopacity, setting time, and ISO 6876:2012 linear flow. Volumetric filling and volume change were evaluated using microcomputed-tomography (µCT). Chemical characterization after 28 days in Hank's Balanced Salt Solution (HBSS) and pH analysis were also assessed. Biological characterization of cytotoxicity and microbiological assessment were also undertaken. Shapiro-Wilk, ANOVA, Levene and post hoc analyses with Bonferroni correction were performed, adopting a 5% significance level (p <0.05). Bio-C Pulpo exhibited the highest L values after 90 days. All tested materials demonstrated color change during the analyses, and had radiopacity above 5 mm Al. MTA Repair HP set faster than Bio-C Pulpo, whereas the latter had the highest linear flow. MTA Repair HP had the highest volumetric filling in µCT analysis. Bio-C Pulpo showed the highest alkalinity during all tested periods, and the highest volumetric loss (above 9%), in comparison with MTA Repair HP and MTA Angelus. Bio-C Pulpo did not form calcium hydroxide after hydration. MTA Repair HP demonstrated the highest cytocompatibility, and Bio-C Pulpo, the highest cytotoxicity. No inhibition halos were observed for any material, and similar higher turbidity values were seen after direct contact. Composition additives used in Bio-C Pulpo modified its properties, and both the absence of calcium hydroxide deposition after hydration, and the related cytotoxicity of this material are of particular concern.
Descritores: Materiais Restauradores do Canal Radicular/toxicidade
Compostos de Alumínio/toxicidade
-Óxidos/toxicidade
Teste de Materiais
Cálcio
Silicatos/toxicidade
Compostos de Cálcio/toxicidade
Combinação de Medicamentos
Responsável: BR1.1 - BIREME


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Id: biblio-1285724
Autor: Caldas, Nathália Lima; Prado, Marina Carvalho; Carvalho, Nancy Kudsi; Senna, Plinio Mendes; Silva, Emmanuel João Nogueira Leal da.
Título: Cytotoxicity, and antimicrobial and physicochemical properties of sealers incorporated with Uncaria tomentosa
Fonte: Braz. oral res. (Online);35:e086, 2021. tab, graf.
Idioma: en.
Resumo: Abstract This study evaluated the cytotoxicity, the antimicrobial and physicochemical properties of root canal sealers incorporated with phytotherapic Uncaria tomentosa (UT). Unmodified AH Plus (Dentsply, DeTrey, Germany) and MTA Fillapex (Angelus, Londrina, Brazil) were used as controls. UT was incorporated into AH Plus and MTA Fillapex, at concentrations of 2% and 5% of the total weight of these sealers (w/w). Flowability, setting time, and solubility were evaluated following ISO requirements. The pH values were measured at periods of 12, 24, 48 hours, and 7 days. The antimicrobial activity of the sealers against Enterococcus faecalis was analyzed by both direct contact tests in freshly prepared sealers, and after 7 days. The cytotoxicity of the samples was evaluated by the MTT assay, to check Balb/c 3T3 cell viability. The statistical analysis was performed by one-way ANOVA and Tukey's test (p < 0.05). The incorporation of UT was associated with a decrease in flow, for both sealers, an increase in AH Plus setting time, increase in MTA Fillapex pH values, and solubility (after 14 days), for both sealers (p < 0.05). Regarding the antibacterial evaluation, bacterial reduction was reported after incorporation of UT into both AH Plus and MTA Fillapex, up to 7 days after handling of the material (P<0.05). UT incorporation decreased the cytotoxic effects of both AH Plus and MTA Fillapex sealers in a way directly proportional to their respective concentrations (p < 0.05). In conclusion, UT can be added to both sealers to reduce their cytotoxicity, and improve their antibacterial effects, without compromising their original physicochemical properties.
Descritores: Materiais Restauradores do Canal Radicular/toxicidade
Unha-de-Gato
-Óxidos
Teste de Materiais
Silicatos
Compostos de Cálcio
Combinação de Medicamentos
Resinas Epóxi/toxicidade
Antibacterianos/toxicidade
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-1283651
Autor: Yamaguchi, Klenicy KL; Pedrosa, Tatiana do Nascimento; Vasconcellos, Marne Carvalho de; Lima, Emerson Silva; Veiga-Junior, Valdir F.
Título: Ocotea (Lauraceae) Amazonian essential oils chemical composition and their tyrosinase inhibition to use in cosmetics / Ocotea (Lauraceae) composición química de aceites esenciales amazónicos y su inhibición de la tirosinasa para usar en cosméticos
Fonte: Bol. latinoam. Caribe plantas med. aromát;19(5):519-526, 2020. tab.
Idioma: en.
Resumo: This study presents analyses on the chemistry, biology, pharmacology and chromatography of essential oils extracted from three species of the Ocotea genus: O. minor, O. ceanothifolia and O. leucoxylon. Leaves and stems, as well as the bark of O. minor, were processed using a modified Clevenger apparatus. Seven essential oils were obtained and analyzed using GC-FID and GC-MS, and their chemical compositions were determined. Assays of cytotoxicity, antioxidant and free radical scavenging activity, as well as tyrosinase and elastase inhibition were performed. In total, 25 constituents were identified, the principal being sesquiterpenes, such as spathulenol caryophyllene and its oxide. The oils did not present cytotoxicity using a hemolytic model, but also did not show antioxidant activity in the DPPH assay. Essential oil from stems of O. ceanothifolia, rich in spathulenol and caryophyllene oxide, demonstrated the capacity to inhibit 49.08% of tyrosinase activity at a concentration of 100 µg/mL. This research contributes to the chemical profile analysis of the three species of Ocoteathrough chemical investigations and biological activity, which are reported for the first time here in this study.

Este trabajo realiza un estudio químico, biológico, farmacológico y cromatográfico de aceites esenciales extraídos de tres especies del género Ocotea: O. minor, O. ceanothifoliay O. leucoxylon. Las hojas y tallos, así como la corteza de O. minor, se procesaron utilizando un aparato Clevenger modificado. Se obtuvieron siete aceites esenciales y se analizaron usando GC-FID y GC-MS, y se determinaron sus composiciones químicas. Se realizaron ensayos de citotoxicidad, actividad antioxidante y de atrapamiento de radicales libres, así como inhibición de tirosinasa y elastasa. En total, se identificaron 25 componentes, siendo los principales sesquiterpenos, como el spathulenol cariofileno y su óxido. Los aceites no presentaron citotoxicidad en un modelo hemolítico y tampoco mostraron actividad antioxidante en el ensayo con DPPH. El aceite esencial de tallos de O. ceanothifolia, rico en espatulenol y óxido de cariofileno, mostró capacidad para inhibir el 49.08% de la actividad de tirosinasa a una concentración de 100 µg/mL. Esta investigación contribuye al análisis del perfil químico de las tres especies de Ocotea a través de investigaciones químicas y actividad biológica la cual se informan por primera vez.
Descritores: Óleos Voláteis/farmacologia
Monofenol Mono-Oxigenase/antagonistas & inibidores
Ocotea/química
-Óxidos/análise
Sesquiterpenos/análise
Óleos Voláteis/química
Sequestradores de Radicais Livres
Lauraceae/química
Indústria Cosmética
Ionização de Chama
Cromatografia Gasosa-Espectrometria de Massas
Responsável: CL1.1 - Biblioteca Central


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Id: lil-613893
Autor: Gehrke, Sergio Alexandre; Cabrera Colasso, José; Santos, Miriam dos; Dedavid, Berenice Anina; Del Fabro, Massimo; Tascheri, Silvio.
Título: Observación in vitro e in vivo de implantes arenados por micropartículas de óxido de titanio / An in vitro and in vivo observation of implants sandblasted with titanium oxide microparticles
Fonte: Actas odontol;8(2):27-34, dic. 2011.
Idioma: es.
Resumo: El objetivo de este estudio fue la observación in vitro y in vivo de implantes arenados con partículas de TiO. La observación in vitro fue hecha con la obtención de imágenes en MEB y evaluación de las características morfológicas. Para las evaluaciones invivo fueron utilizados seis conejos New Zeland, adultos, con peso medio de 3,5kg obtenidos en el Bioterio de la Universidad Federal de Santa María. Fueron utilizados 24 implantes cilíndricos de hexágono interno fabricados por la empresa ImplacilMaterial odontológico (Implantes DeBortoli), arenados por TiO. Un marcador de crecimiento óseo de fluorescencia, Calceina, fue inyectada subcutáneamente en dos diferentes intervalos de tiempo, para evaluar la cantidad de deposición de calcio en elhueso en los períodos de la segunda a cuarta semana, correspondiendo a el Grupo experimental 1 (exp1) con 3 animales; y de la sexta a octava semana, correspondiendo a el Grupo experimental 2 (exp2) con 3 animales. Las muestras fueron cortadasobteniéndose 3 cortes de cada implante, utilizando uno para cada técnica histológica: microscopía de luz, de fluorescencia y de barrido, donde fueron analizadas y comparadas las áreas de contacto entre hueso/implante en tiempos de 30 y 60 días. Losresultados demostraron que la superficie propuesta promueve una estimulación ósea muy efectiva en los tiempos estudiados. Los implantes presentaron grandes áreas de hueso corticalizado y una característica de hueso lamelar. La deposición de calcioocurre con más intensidad después de los 30 días de la implantación. De esta manera se concluye que la superficie presentada por los implantes DeBortoli arenados por partículas de TiO tienen una buena capacidad óseo-conductora, promoviendo un adecuado crecimiento y corticalización del hueso.

The aim of this study was the observation in vitro and in vivo implants sandblasted with particles of TiO. The in vitro observation was made with imaging in SEM and evaluation of morphological characteristics. Six adult New Zealand rabbits with average weight of 3.5 kg obtained from the Bioterio of the Federal University of Santa Maria were used for in vivo evaluations. Were used 24 cylindrical implants with internal hex manufactured by the company Implacil Dental Material (Implants DeBortoli) sandblasted to TiO. A marker of bone growth of fluorescence, calcein was injected subcutaneously at two different time intervals to assess the calcium deposition in the bone in the period from second to fourth week, corresponding to the experimental group 1 (exp1) with 3 animals, and from sixth to eighth week, corresponding to the experimental group 2 (exp2) with 3 animals. Thesamples obtained were cut 3 slices of each implant using a histological technique for each: light microscopy, fluorescence and scanning, which were analyzed and compared the contact areas between bone/implant times of 30 days and 60 days. The resultsdemonstrate that the proposed surface promotes bone stimulation very effectively in the times studied. Implants of bone presented large areas corticalized and a feature of lamellar bone. Calcium deposition occurs with more intensity after 30 days ofimplantation. Thus we conclude that the implant surface by DeBortoli sandblasted with particles of TiO have good boneconductive capacity, promoting proper growth and bone corticalization.
Descritores: Teste de Materiais
Implantes Dentários
Materiais Biocompatíveis
-Implantação Dentária Endo-Óssea
Osseointegração
Titânio
Óxidos
Limites: Coelhos
Responsável: UY108.1 - Biblioteca Central Universidad Católica del Uruguay


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Id: biblio-950847
Autor: Faisal, Mohammad; Saquib, Quaiser; Alatar, Abdulrahman A; Al-Khedhairy, Abdulaziz A; Ahmed, Mukhtar; Ansari, Sabiha M; Alwathnani, Hend A; Dwivedi, Sourabh; Musarrat, Javed; Praveen, Shelly.
Título: Cobalt oxide nanoparticles aggravate DNA damage and cell death in eggplant via mitochondrial swelling and NO signaling pathway
Fonte: Biol. Res;49:1-13, 2016. ilus, graf.
Idioma: en.
Projeto: National Plan for Science, Technology and Innovation; . King Abdul Aziz City for Science and Technology.
Resumo: BACKGROUND: Despite manifold benefits of nanoparticles (NPs), less information on the risks of NPs to human health and environment has been studied. Cobalt oxide nanoparticles (Co3O4-NPs) have been reported to cause toxicity in several organisms. In this study, we have investigated the role of Co3O4-NPs in inducing phytotoxicity, cellular DNA damage and apoptosis in eggplant (Solanum melongena L. cv. Violetta lunga 2). To the best of our knowledge, this is the first report on Co3O4-NPs showing phytotoxicity in eggplant. RESULTS: The data revealed that eggplant seeds treated with Co3O4-NPs for 2 h at a concentration of 1.0 mg/ml retarded root length by 81.5 % upon 7 days incubation in a moist chamber. Ultrastructural analysis by transmission electron microscopy (TEM) demonstrated the uptake and translocation of Co3O4-NPs into the cytoplasm. Intracellular presence of Co3O4-NPs triggered subcellular changes such as degeneration of mitochondrial cristae, abundance of peroxisomes and excessive vacuolization. Flow cytometric analysis of Co3O4-NPs (1.0 mg/ml) treated root protoplasts revealed 157, 282 and 178 % increase in reactive oxygen species (ROS), membrane potential (APm) and nitric oxide (NO), respectively. Besides, the esterase activity in treated protoplasts was also found compromised. About 2.4-fold greater level of DNA damage, as compared to untreated control was observed in Comet assay, and 73.2 % of Co3O4-NPs treated cells appeared apoptotic in flow cytometry based cell cycle analysis. CONCLUSION: This study demonstrate the phytotoxic potential of Co3O4-NPs in terms of reduction in seed germination, root growth, greater level of DNA and mitochondrial damage, oxidative stress and cell death in eggplant. The data generated from this study will provide a strong background to draw attention on Co3O4-NPs environmental hazards to vegetable crops.
Descritores: Óxidos/toxicidade
Dano ao DNA/efeitos dos fármacos
Morte Celular/efeitos dos fármacos
Cobalto/toxicidade
Solanum melongena/efeitos dos fármacos
Nanopartículas/toxicidade
Dilatação Mitocondrial/efeitos dos fármacos
Óxido Nítrico/metabolismo
-Óxidos/metabolismo
Análise de Variância
Espécies Reativas de Oxigênio/metabolismo
Cobalto/metabolismo
Ensaio Cometa
Solanum melongena/metabolismo
Microscopia Eletrônica de Transmissão
Nanopartículas/metabolismo
Citometria de Fluxo
Dilatação Mitocondrial/fisiologia
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950904
Autor: Xiong, Xilin; Li, Yang; Liu, Ling; Qi, Kai; Chen, Yueqin; Fang, Jianpei; Zhang, Chi.
Título: Arsenic trioxide induces cell cycle arrest and affects Trk receptor expression in human neuroblastoma SK-N-SH cells
Fonte: Biol. Res;51:18, 2018. tab, graf.
Idioma: en.
Projeto: Guangdong Science and Technology Department.
Resumo: BACKGROUND: Arsenic trioxide (As2O3), a drug that has been used in China for approximately two thousand years, induces cell death in a variety of cancer cell types, including neuroblastoma (NB). The tyrosine kinase receptor (Trk) family comprises three members, namely TrkA, TrkB and TrkC. Various studies have confirmed that TrkA and TrkC expression is associated with a good prognosis in NB, while TrkB overexpression can lead to tumor cell growth and invasive metastasis. Previous studies have shown that As2O3 can inhibit the growth and proliferation of a human NB cell line and can also affect the N-Myc mRNA expression. It remains unclear whether As2O3 regulates Trks for the purposes of treating NB. METHODS: The aim of the present study was to investigate the effect of As2O3 on Trk expression in NB cell lines and its potential therapeutic efficacy. SK-N-SH cells were grown with increasing doses of As2O3 at different time points. We cultured SK-N-SH cells, which were treated with increasing doses of As2O3 at different time points. Trk expression in the NB samples was quantified by immunohistochemistry, and the cell cycle was analyzed by flow cytometry. TrkA, TrkB and TrkC mRNA expression was evaluated by real-time PCR analysis. RESULTS: Immunohistochemical and real-time PCR analyses indicated that TrkA and TrkC were over-expressed in NB, and specifically during stages 1, 2 and 4S of the disease progression. TrkB expression was increased in stage 3 and 4 NB. As2O3significantly arrested SK-N-SH cells in the G2/M phase. In addition, TrkA, TrkB and TrkC expression levels were significantly upregulated by higher concentrations of As2O3 treatment, notably in the 48-h treatment period. Our findings suggested that to achieve the maximum effect and appropriate regulation of Trk expression in NB stages 1, 2 and 4S, As2O3 treatment should be at relatively higher concentrations for longer delivery times;however, for NB stages 3 and 4, an appropriate concentration and infusion time for As2O3 must be carefully determined. CONCLUSION: The present findings suggested that As2O3 induced Trk expression in SK-N-SH cells to varying degrees and may be a promising adjuvant to current treatments for NB due to its apoptotic effects.
Descritores: Óxidos/farmacologia
Arsenicais/farmacologia
Glicoproteínas de Membrana/efeitos dos fármacos
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Receptor trkB/efeitos dos fármacos
Proliferação de Células/efeitos dos fármacos
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Neuroblastoma/metabolismo
-Glicoproteínas de Membrana/metabolismo
Receptor trkB/metabolismo
Linhagem Celular Tumoral/efeitos dos fármacos
Linhagem Celular Tumoral/metabolismo
Trióxido de Arsênio
Neuroblastoma/patologia
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1147548
Autor: Barbosa, Jamila.
Título: Formulação de sal de ervas como promotor da redução de sódio em hambúrguer: avaliação sensorial e efeitos na formação de óxidos de colesterol / Formulation of herbal salt as a promoter of sodium reduction in beef burger: sensory evaluation and effects on the formation of cholesterol oxides.
Fonte: São Paulo; s.n; 2020. 98 p.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Saúde Pública para obtenção do grau de Mestre.
Resumo: Introdução - A carne é um elemento central na alimentação, entretanto, diferentes condições podem levar a formação de produtos da oxidação do colesterol (POCs). Também os efeitos do excesso de sódio na pressão arterial estão bem documentados. Assim, o uso de sal de ervas poderia reduzir o teor de sódio e a formação de POCs. Objetivo - Avaliar os efeitos de diferentes concentrações de sal de ervas na aceitação da redução de sódio e na proteção contra a oxidação lipídica em hambúrguer. Material e Métodos - Os hambúrgueres foram adicionados de dois níveis de sal (0,60% e 1,90%) e dois níveis de orégano, alecrim e manjericão (0,36% e 0,72%). Aos controles FC1 (0,60% de sal) e FC2 (1,90% de sal), foram adicionadas duas concentrações de ervas, compondo as formulações F3 (0,60% de sal e 0,36% de ervas), F4 (1,90% de sal e 0,36% de ervas), F5 (0,60% de sal e 0,72% de ervas) e F6 (1,90% de sal e 0,72% de ervas). A aceitação sensorial foi realizada por escala hedônica e de intensidade do sabor. A cor e textura foram avaliadas por análises instrumentais. Foi realizada a caracterização físico-química das amostras cruas e grelhadas. A avaliação da oxidação lipídica foi realizada logo após o preparo e após 30, 60 e 90 dias de congelamento. Foram determinados os compostos fenólicos totais e a capacidade antioxidante das ervas. Resultados - Todas as formulações foram aceitas, sendo FC2, F3 e F4 as mais aceitas. No atributo sabor, F3 obteve média maior que FC2, indicando maior aceitação do sabor após adição de sal de ervas, em comparação a adição isolada de sal no teor regularmente consumido. A cor obteve médias de aceitação maiores para os controles. A análise instrumental da dureza não apresentou variações, porém pela avaliação sensorial as ervas auxiliaram na maciez. A maioria das formulações foram consideradas com salinidade e condimentação ideal. A retenção de umidade após a cocção foi maior com o uso de ervas. Os teores de fenólicos totais no orégano foi de 16,46 ± 0,25 mg EAG/g, no alecrim de 17,80 ± 0,18 mg EAG/g e no manjericão 3,24 ± 0,34 mg EAG/g. O uso de ervas não inibiu a oxidação lipídica durante a cocção e após, o armazenamento, a inibição ocorreu no teor reduzido de sal (F3 e F5 com 21% e 16%, respectivamente, em 30 dias e 54% e 59%, respectivamente, em 60 dias) e, em 90 dias, apenas F3 apresentou inibição de 22%. Os teores de colesterol variaram entre 35,25 ± 5,34 a 87,13 ± 8,05 mg/100g de amostra seca e a concentração de POCs totais foi de 68,19 ± 2,89 a 123,68 ± 4,51 µg/g de amostra seca. As formulações com ervas não apresentaram menores teores de POCs que os controles. Conclusão - Todas as formulações foram aceitas em todos os atributos, com maior aceitação a formulação adicionada de teor de sal reduzido e do menor teor de ervas, sendo também a formulação com menor oxidação e redução de sal de 40%. A adição de ervas não apresentou efeito sinérgico contra a formação de POCs.

Introduction - Meat is central element in the diet; however, different conditions can lead to the formation of cholesterol oxidation products (COPs). The effects of excess sodium on blood pressure are also well documented. Thus, the use of herbal salt could reduce the sodium content and the formation of POCs. Objective - To evaluate the effects of different concentrations of herbal salt on the acceptance of sodium reduction and protection against lipid oxidation in hamburgers. Material and Methods - The hamburgers were formulated with two levels of sodium chloride (0.60% and 1.90%) and two levels of herbal mixture (0.36% and 0.72%), composed of oregano, rosemary and basil. To the controls FC1 (0.60% of salt) and FC2 (1.90% of salt), different herbs proportions were added: F3 (0.60% of salt and 0.36% of the herbal mix), F4 (1.90% of the salt and 0.36% of the herbal mix), F5 (0.60% of the salt and 0.72% of the herbal mix) and F6 (1.90% of the salt and 0.72% herbal mix). Sensory acceptance was achieved by hedonic scale and flavor intensity. The color and texture were evaluated by instrumental analyzes. The physical and chemical characterization of raw and grilled samples was carried out. The evaluation of lipid oxidation was performed immediately after preparation and after 30, 60 and 90 days of freezing. The total phenolic compounds and the antioxidant capacity of the herbs were determined. Results - All formulations were accepted, with FC2, F3 and F4 being the most accepted. In the flavor attribute, F3 obtained an average greater than FC2, demonstrating greater acceptance of flavor after adding herbal salt, compared to salt in the content regularly consumed. The color obtains higher acceptance averages for the controls. An instrumental analysis of the hardness does not show variations, however, in the sensorial evaluation the herbs helped in the softness. Most formulations were evaluated with ideal salinity and seasoning. Moisture retention after cooking was greater with the use of herbs. The content of total phenolics in oregano was 16.46 ± 0.25 mg EAG / g, in rosemary 17.80 ± 0.18 mg EAG / g and in basil 3.24 ± 0.34 mg EAG / g. The use of herbs did not inhibit lipid oxidation during cooking and after storage the inhibition occurred reduced salt content (F3 and F5 with 21% and 16%, respectively, in 30 days and 54% and 59%, respectively, in 60 days) and in 60 days only F3 showed 22% inhibition. Cholesterol levels vary between 35.25 ± 5.34 to 87.13 ± 8.05 mg / 100g of dry sample and the concentration of total COPs was 68.19 ± 2.89 to 123.68 ± 4.51 µg / g of dry sample. The herbal formulations has no lower COPs content than controls. Conclusions - All formulations were accepted in all attributes, with preference for the formulation added with reduced salt content and the lowest herbal content, and also the formulation with less oxidation and 40% salt reduction. The addition of herbs has no synergistic effect against the formation of POCs.
Descritores: Óxidos
Sódio
Colesterol
Condimentos
Carne
Responsável: BR67.1 - CIR - Biblioteca - Centro de Informação e Referência


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Id: biblio-1019971
Autor: Lopes, Fabiane Carneiro; Zangirolami, Caio; Mazzi-Chaves, Jardel Francisco; Silva-Sousa, Alice Corrêa; Crozeta, Bruno Monguilhott; Silva-Sousa, Yara Teresinha Corrêa; Sousa-Neto, Manoel Damião.
Título: Effect of sonic and ultrasonic activation on physicochemical properties of root canal sealers
Fonte: J. appl. oral sci;27:e20180556, 2019. tab, graf.
Idioma: en.
Resumo: Abstract Objective: To evaluate the effect of ultrasonic and sonic activation on physicochemical properties of AH Plus, MTA Fillapex, ADSeal, GuttaFlow Bioseal, and GuttaFlow 2 sealers. Methodology: Three experimental groups were formed: no activation (NA), ultrasonic activation (UA), and sonic activation (SA). The sealers were manipulated according to the manufacturers' instructions. A 3-mL syringe was adapted to receive 1 mL of sealer. Activation was performed with a 20/.01 ultrasonic insert (20 s/1W) in the UA group. A size 35.04 sonic tip was used (20 s/10,000 cycles/min-1) in the SA group. The molds for physicochemical analysis were filled and evaluated according to ANSI/ADA specification no. 57: setting time (ST), flow (FL), dimensional change (DC), solubility (SB), and radiopacity (RD). Statistical analysis was performed by Kruskal-Wallis, one-way ANOVA, and Tukey's tests (P<0.05). Results: Regarding ST, only AH Plus and GuttaFlow 2 in the NA group met the ANSI/ADA standards. All FL values were greater than 20 mm in diameter, as determined by ANSI/ADA. The tested sealers and protocols did not comply with the ANSI/ADA standards for DC. As for SB, only MTA Fillapex, regardless of the activation protocol, did not follow the ANSI/ADA standards. All of the investigated sealers, regardless of the activation protocol, presented radiographic density higher than 3 mm Al, as proposed by ANSI/ADA. Conclusions: UA and SA promoted changes in the physicochemical properties of the evaluated root canal sealers, mainly in ST and F. Thus, it is important to evaluate the physicochemical properties of endodontic sealers associated with activation techniques prior to clinical application in order to determine whether the properties follow the parameters set by ANSI/ADA, ensuring safety and quality of root canal filling.
Descritores: Óxidos/química
Materiais Restauradores do Canal Radicular/química
Silicatos/química
Compostos de Cálcio/química
Compostos de Alumínio/química
Dimetilpolisiloxanos/química
Resinas Epóxi/química
Ondas Ultrassônicas
Guta-Percha/química
-Valores de Referência
Solubilidade
Propriedades de Superfície
Fatores de Tempo
Teste de Materiais
Reprodutibilidade dos Testes
Análise de Variância
Estatísticas não Paramétricas
Combinação de Medicamentos
Tipo de Publ: Estudo de Avaliação
Responsável: BR28.1 - Serviço de Biblioteca e Documentação Professor Doutor Antônio Gabriel Atta


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Id: biblio-1040226
Autor: Tang, Jing-jing; Shen, Zong-shan; Qin, Wei; Lin, Zhengmei.
Título: A comparison of the sealing abilities between Biodentine and MTA as root-end filling materials and their effects on bone healing in dogs after periradicular surgery
Fonte: J. appl. oral sci;27:e20180693, 2019. graf.
Idioma: en.
Projeto: International Cooperation Project of Science and Technology in Guangdong Province; . National Natural Science Foundation of China.
Resumo: ABSTRACT Objectives: To compare the sealing ability and biocompatibility of Biodentine with mineral trioxide aggregate (MTA) when used as root-end filling materials. Methodology: The Cell Counting Kit-8 (CCK-8) assay was used to compare the cytotoxicity of MTA and Biodentine. Twenty-one extracted teeth with a single canal were immersed in an acidic silver nitrate solution after root-end filling. Then, the volume and depth of silver nitrate that infiltrated the apical portion of the teeth were analyzed using micro-computed tomography (micro-CT). Seventy-two roots from 3 female beagle dogs were randomly distributed into 3 groups and apical surgery was performed. After six months, the volume of the bone defect surrounding these roots was analyzed using micro-CT. Results: Based on the results of the CCK-8 assay, MTA and Biodentine did not show statistically significant differences in cytotoxicity (P>0.05). The volume and the depth of the infiltrated nitrate solution were greater in the MTA group than in the Biodentine group (P<0.05). The volume of the bone defect was larger in the MTA group than in the Biodentine group. However, the difference was not significant (P>0.05). The volumes of the bone defects in the MTA and Biodentine groups were smaller than the group without any filling materials (P<0.05). Conclusions: MTA and Biodentine exhibited comparable cellular biocompatibility. Biodentine showed a superior sealing ability to MTA in root-end filling. Both Biodentine and MTA promoted periradicular bone healing in beagle dog periradicular surgery models.
Descritores: Óxidos/farmacologia
Tecido Periapical/efeitos dos fármacos
Ligamento Periodontal/efeitos dos fármacos
Materiais Restauradores do Canal Radicular/farmacologia
Tratamento do Canal Radicular/métodos
Cicatrização/efeitos dos fármacos
Silicatos/farmacologia
Compostos de Cálcio/farmacologia
Compostos de Alumínio/farmacologia
-Osteogênese/efeitos dos fármacos
Tecido Periapical/citologia
Tecido Periapical/diagnóstico por imagem
Ligamento Periodontal/diagnóstico por imagem
Fatores de Tempo
Raiz Dentária/cirurgia
Raiz Dentária/efeitos dos fármacos
Raiz Dentária/diagnóstico por imagem
Regeneração Óssea/efeitos dos fármacos
Teste de Materiais
Contagem de Células
Células Cultivadas
Reprodutibilidade dos Testes
Resultado do Tratamento
Combinação de Medicamentos
Microtomografia por Raio-X
Limites: Humanos
Animais
Masculino
Adolescente
Cães
Tipo de Publ: Estudo Comparativo
Responsável: BR28.1 - Serviço de Biblioteca e Documentação Professor Doutor Antônio Gabriel Atta


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Id: biblio-1090666
Autor: Gomez, Felipe; Fuentes, Jorge; Saravia, Diego; Silva, Mónica.
Título: Induction of root development and apical closure in permanent mandibular molar with irreversible pulpitis through total pulpotomy with application of mineral trioxide aggregate / Inducción del termino de desarrollo radicular y cierre apical en molar mandibular permanente con pulpitis irreversible a través de pulpotomía total con aplicación de agregado de trióxido mineral
Fonte: Int. j. odontostomatol. (Print);14(2):144-149, June 2020. graf.
Idioma: en.
Projeto: Universidad de La Frontera.
Resumo: Loss of teeth vitality when root formation is incomplete, results in weaker structures leaving them prone to fractures and unfavourable long-term prognosis. Apexogenesis is currently the treatment of choice in immature teeth and is indicated in vital teeth without pulpal pathologies. The treatment aims to eliminate the causal agent of the damage, and provide the necessary conditions to preserve vitality in the tooth and induce apical root closure. A 6-year-old male patient was treated at the Endodontics Clinic, Universidad de La Frontera upon complaining of acute pain in tooth 30. The tooth presented incomplete root development due to dental caries with pulp exposure and a diagnosis of irreversible symptomatic pulpitis. Total pulpotomy was performed with the application of Mineral Trioxide Aggregate and controlled at 1, 4, 6, 7 and 12 months, achieving root development and apical closure in the permanent molar. The result was comparable with studies that support this therapy in teeth with irreversible pulpitis. This work seeks to contribute to the existing evidence on the management of immature permanent teeth with irreversible pulpitis to induce root development and apical closure, and maintain pulp vitality.

La pérdida de vitalidad en dientes con formación radicular incompleta trae como resultado el debilitamiento de estos, dejándolos propensos a fracturas con un desfavorable pronóstico a largo plazo. Las terapéuticas actuales de regeneración pulpar en dientes inmaduros estan principalmente indicadas en cuadros de pulpitis irreversible y buscan eliminar el agente causal de daño y brindarle al diente las condiciones y estímulos necesarios para preservar vitalidad e inducir el cierre apical radicular. Un paciente de 6 años de edad y de sexo masculino, acude a la Clínica de Especialidad de Endodoncia de la Universidad de la Frontera, consultando por un dolor agudo en diente 4.6 el cual presentaba un desarrollo radicular incompleto producto de una caries con exposición pulpar con diagnóstico de Pulpitis Irreversible Sintomática. Se realiza una pulpotomia total con aplicación de Mineral Trioxide Aggregate y se controla a los 1, 4, 6 y 7 meses obteniendo un interesante resultado comparable con estudios que avalan dicha terapeutica en dientes con pulpitis irreversible. Este trabajo busca contribuir a la evidencia existente sobre el manejo de dientes permanentes inmaduros con cuadros de pulpitis irreversible para inducir el desarrollo radicular, cierre apical y mantener vitalidad pulpar.
Descritores: Óxidos/administração & dosagem
Pulpite/terapia
Pulpotomia/métodos
Silicatos/administração & dosagem
Compostos de Cálcio/administração & dosagem
Compostos de Alumínio/administração & dosagem
-Regeneração
Materiais Restauradores do Canal Radicular
Dentição Permanente
Dente não Vital/terapia
Cárie Dentária
Combinação de Medicamentos
Apexificação
Limites: Humanos
Masculino
Criança
Tipo de Publ: Relatos de Casos
Responsável: CL1.1 - Biblioteca Central



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