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Id: biblio-840857
Autor: Tokgöz, Hüsnü; Taş, Selim; Giray, Özlem; Yalçınkaya, Soner; Tokgöz, Özlem; Koca, Cemile; Savaş, Murat; Erel, Özcan.
Título: The change in serum Thiol/Disulphide homeostasis after transrectal ultrasound guided prostate biopsy
Fonte: Int. braz. j. urol;43(3):455-461, May.-June 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objectives The aim of this prospective clinical study was to investigate variations in a novel oxidative stress marker (thiol/disulphide homeostasis) in men who underwent transrectal ultrasound guided prostate biopsy (TRUSB). Materials and Methods A total of 22 men undergoing TRUSB of the prostate were enrolled in the study. Patients with abnormal digital rectal examination and/or total prostate specific antigen (PSA) over 4ng/mL underwent TRUSB with 12 cores. Serum samples were obtained before and just after the procedure to evaluate the possible changes in thiol/disulphide homeostasis. Mean age, total PSA and free PSA, prostate volume and histopathological data were also recorded. Results Mean age of the study population was 65.05±8.89 years. Significant decreases in native and total thiol levels were documented after the biopsy procedure. However, serum disulphide levels and disulphide/native thiol, disulphide/total thiol and native/total thiol ratios did not significantly change after TRUSB. No correlation was observed between oxidative parameters and total PSA and free PSA levels, prostate volume and histopathology of the prostate. However, mean patient age was significantly correlated with mean native and total thiol levels. Conclusion Significant decreases in serum native and total thiol levels related to the prostate biopsy procedure suggest that TRUSB causes acute oxidative stress in the human body. Since our trial is the first in the current literature to investigate these oxidative stress markers in urology practice, additional studies are warranted.
Descritores: Neoplasias da Próstata/metabolismo
Neoplasias da Próstata/diagnóstico por imagem
Compostos de Sulfidrila/metabolismo
Ultrassonografia
Antígeno Prostático Específico/metabolismo
Estresse Oxidativo
Dissulfetos/metabolismo
-Próstata/patologia
Biópsia
Biomarcadores
Estudos Prospectivos
Exame Retal Digital
Aspiração por Agulha Fina Guiada por Ultrassom Endoscópico
Biópsia Guiada por Imagem
Limites: Humanos
Masculino
Idoso
Responsável: BR1.1 - BIREME


  2 / 22 LILACS  
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Id: biblio-1012326
Autor: Solakhan, Mehmet; Çiçek, Hülya; Orhan, Nuri; Yildirim, Mustafa.
Título: Role of native thiol, total thiol and dynamic Disulphide in diagnosis of patient with prostate cancer and prostatitis
Fonte: Int. braz. j. urol;45(3):495-502, May-June 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT Background: Our study investigates whether Native Thiol, Total Thiol and disulphide levels measured in serum of patients with prostate cancer and prostatitis and of healthy subjects, have any role in differential diagnosis. Materials and Methods: Patients followed up for histopathologically verified diagnosis of prostate cancer and prostatitis in 2016-2017 at the Medicalpark Gaziantep Hospital Urology Clinic were included in the study. Native Thiol (NT), Total Thiol (TT), Dynamic Disulphide (DD) levels in serum were measured by a novel automated method. Results: NT, TT, DD, NT / TT ratios, DD / TT ratio and DD / NT ratio were measured as 118.4 ± 36.8μmoL / L, 150.3 ± 45.3μmoL / L, 15.9 ± 7μmoL / L, 78.8 ± 7μmoL / L, 10.5 ± 3.5μmoL / L, 13.8 ± 5.8μmoL / L respectively in patients with prostate cancer; as 116.4 ± 40.5μmoL / L, 147.5 ± 50.1μmoL / L, 15.5 ± 8.7μmoL / L, 79.7 ± 9μmoL / L, 10.1 ± 4.5μmoL / L, 13.5 ± 7.2μmoL / L in patients with prostatitis and as 144.1 ± 21.2μmoL / L, 191 ± 32.3μmoL / L, 23.4 ± 10.1μmoL / L, 76.1 ± 98.3μmoL / L, 11.9 ± 4.1μmoL / L, 16.4 ± 6.9μmoL / L in healthy subjects. Significant difference was detected between groups of NT, TT and DD levels (p = 0.008, p = 0.001, p = 0.002). No significant difference was detected in terms of the NT / TT, DD / TT and DD / NT rates (p = 0.222, p = 0.222, p = 0.222). Conclusions: Serum NT, TT, DD levels in patients with prostatitis and prostate cancer were found significantly lower compared to the control group. This indicates that just as inflammation, prostate cancer also increases oxidative stress on tissues.
Descritores: Neoplasias da Próstata/sangue
Prostatite/sangue
Compostos de Sulfidrila/sangue
Dissulfetos/sangue
-Neoplasias da Próstata/diagnóstico
Prostatite/diagnóstico
Valores de Referência
Biomarcadores Tumorais/sangue
Estudos de Casos e Controles
Reprodutibilidade dos Testes
Estudos Retrospectivos
Fatores de Risco
Análise de Variância
Estatísticas não Paramétricas
Medição de Risco
Estresse Oxidativo/fisiologia
Diagnóstico Diferencial
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Idoso
Responsável: BR1.1 - BIREME


  3 / 22 LILACS  
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Id: biblio-1020487
Autor: Ozgunay, Seyda Efsun; Ozsin, Kadir Kaan; Ustundag, Yasemin; Karasu, Derya; Ozyaprak, Buket; Balcı, Burak; Erel, Ozcan; Yavuz, Senol.
Título: The effect of continuous ventilation on thiol-disulphide homeostasis and albumin-adjusted ischemia-modified albumin during cardiopulmonary bypass
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);34(4):436-443, July-Aug. 2019. tab, graf.
Idioma: en.
Resumo: Abstract Objective: To investigate the effect of continuous lung ventilation with low tidal volume on oxidation parameters, such as thiol/disulphide homeostasis and albumin-adjusted ischemia-modified albumin (AAIMA), during cardiopulmonary bypass (CBP) in coronary artery bypass grafting (CABG). Methods: Seventy-four patients who underwent elective CABG with CPB were included in the study. Blood samples were taken in the preoperative period, 10 minutes after CPB, and six and 24 hours postoperatively. Patients were assigned to the continuous ventilation group (Group 1, n=37) and the non-ventilated group (Group 2, n=37). The clinical characteristics, thiol/disulphide homeostasis, ischemia-modified albumin (IMA), and AAIMA levels of the patients were compared. Results: A significant difference was found between the groups regarding native thiol, total thiol, and IMA levels at the postoperative 24th hour (P=0.030, P=0.031, and P=0.004, respectively). There was no difference between the groups in terms of AAIMA. AAIMA levels returned to preoperative levels in Groups 1 and 2, at the 6th and 24th postoperative hours, respectively. Length of hospital stay was significantly shorter in Group 1 (P<0.001) than in Group 2. Conclusion: Continuous ventilation during CPB caused an increase in native and total thiol levels, an earlier return of AAIMA levels, and shorter hospital stay. Continuous ventilation may reduce the negative effects of CPB on myocardium (Table 2, Figure 1, and Reference 31).
Descritores: Respiração Artificial
Compostos de Sulfidrila/sangue
Albumina Sérica/análise
Ponte Cardiopulmonar/efeitos adversos
Dissulfetos/sangue
-Complicações Pós-Operatórias/prevenção & controle
Biomarcadores/sangue
Ponte Cardiopulmonar/métodos
Ponte de Artéria Coronária
Método Duplo-Cego
Estudos Prospectivos
Lesão Pulmonar/etiologia
Albumina Sérica Humana
Homeostase/fisiologia
Antioxidantes
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


  4 / 22 LILACS  
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Id: biblio-888132
Autor: Aktaş, Serdar; Sağdık, Hacı Murat; Tetikoğlu, Mehmet; Aktaş, Hatice; Özcura, Fatih; Uçar, Fatma; Alışık, Murat; Ergin, Merve.
Título: Dynamic thiol/disulfide homeostasis in patients with age-related macular degeneration / Homeostase dinâmica de tiol/dissulfureto em pacientes com degeneração macular relacionada à idade
Fonte: Arq. bras. oftalmol;80(4):234-237, July-Aug. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Purpose: We evaluated dynamic thiol/disulfide homeostasis (TDH), malondialdehyde (MDA) levels, and catalase (CAT) activity in patients with age-related macular degeneration (AMD). All analyzes were conducted on plasma samples. Methods: Thirty-two patients with AMD and 38 age-matched healthy controls were included. Native thiol, total thiol, and disulfide levels and TDH status were determined using a novel, automated assay. MDA levels and CAT activity were determined. Percentages were compared using the chi-squared test. The Student's t-test and Mann-Whitney U-test were used to compare quantitative variables. Results: Native thiol levels were significantly lower (p=0.004) in patients with AMD (272.02 ± 52.41 µmol/l) than in healthy individuals (307.82 ± 47.18 µmol/l), whereas disulfide levels were significantly higher (p<0.001) in patients with AMD than in controls (21.64 ± 5.59 vs. 14.48 ± 5.37 µmol/L). Dynamic TDH was also significantly lower (p<0.001) in patients with AMD than in controls (13.41 ± 4.3 vs. 25.41 ± 14.52 µmol/l). No significant differences were evident in total thiol or MDA levels. Mean CAT activity was significantly higher (p=0.043) in patients with AMD compared with controls (0.035 vs. 0.018 k/ml). Conclusions: The antioxidant/oxidant balance demonstrated by dynamic TDH is shifted to the oxidative side in patients with AMD.

RESUMO Objetivo: Avaliar a homeostase dinâmica de tiol/dissulfureto e os níveis de malon dialdeído (MDA) e catalase (CAT) em pacientes com degeneração macular relacionada à idade (DMRI). Todas as análises foram realizadas em amostras de plasma. Métodos: Foram incluídos 32 pacientes com degeneração macular relacionada à idade e 38 controles saudáveis de idade similar. Os níveis de tiol, tiol total, dissulfureto e estado de homeostase de tiol/dissulfureto foram determinados utilizando um novo ensaio automatizado. Os níveis de atividade de MDA e CAT foram também determinados. As porcentagens foram comparadas pelo teste do qui-quadrado. O teste t de Student e o teste U de Mann Whitney foram utilizados para comparar variáveis quantitativas. Resultados: Os níveis de tiol nativo foram significativamente menores (p=0,004) nos pacientes com degeneração macular relacionada à idade (272,02 ± 52,41 µmol/l) do que nos indivíduos saudáveis (307,82 ± 47,18 µmol/l), enquan to os dissulfetos foram significativamente maiores em pacientes com degeneração macular relacionada à idade (21,64 ± 5,59 µmol/l versus 14,48 ± 5,37 µmol/l, respectivamente, p<0,001). A homeostase dinâmica de tiol/dissulfureto também foi significativamente menor nos pacientes com degeneração macular re la cionada à idade (13,41 ± 4,3 µmol/l) versus os controles (versus 25,41 ± 14,52 µmol/l, p<0,001). Não foram observadas diferenças significativas nos níveis de tiol total ou MDA. A atividade média de CAT foi significativamente mais elevada (p=0,043) em doentes com degeneração macular relacionada à idade (0,035 k/ml vs. 0,018 k/ml). Conclusões: O equilíbrio antioxidante/oxidante demonstrado pela homeostase dinâmica de tiol/dissulfeto é deslocado para o lado oxidativo em pacientes com de generação macular relacionada à idade.
Descritores: Compostos de Sulfidrila/sangue
Catalase/metabolismo
Dissulfetos/sangue
Degeneração Macular/sangue
Malondialdeído/sangue
Antioxidantes
-Biomarcadores/sangue
Estudos de Casos e Controles
Fatores Etários
Estresse Oxidativo/fisiologia
Homeostase
Limites: Humanos
Masculino
Feminino
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


  5 / 22 LILACS  
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Id: biblio-886876
Autor: RECH, VIRGINIA C; MEZZOMO, NATHANA J; ATHAYDES, GENARO A; FEKSA, LUCIANE R; FIGUEIREDO, VANDRÉ C; KESSLER, ADRIANA; FRANCESCHI, ITIANE D DE; WANNMACHER, CLOVIS M D.
Título: Thiol/disulfide status regulates the activity of thiol-containing kinases related to energy homeostasis in rat kidney
Fonte: An. acad. bras. ciênc;90(1):99-108, Mar. 2018. graf.
Idioma: en.
Resumo: ABSTRACT Considering that thiol-containing enzymes like kinases are critical for several metabolic pathways and energy homeostasis, we investigated the effects of cystine dimethyl ester and/or cysteamine administration on kinases crucial for energy metabolism in the kidney of Wistar rats. Animals were injected twice a day with 1.6 µmol/g body weight cystine dimethyl ester and/or 0.26 µmol/g body weight cysteamine from the 16th to the 20th postpartum day and euthanized after 12 hours. Pyruvate kinase, adenylate kinase, creatine kinase activities and thiol/disulfide ratio were determined. Cystine dimethyl ester administration reduced thiol/disulfide ratio and inhibited the kinases activities. Cysteamine administration increased the thiol/disulfide ratio and co-administration with cystine dimethyl ester prevented the inhibition of the enzymes. Regression between the thiol/disulfide ratio, and the kinases activities were significant. These results suggest that redox status may regulate energy metabolism in the rat kidney. If thiol-containing enzymes inhibition and oxidative stress occur in patients with cystinosis, it is possible that lysosomal cystine depletion may not be the only beneficial effect of cysteamine administration, but also its antioxidant and thiol-protector effect.
Descritores: Compostos de Sulfidrila
Cisteamina/farmacologia
Cistina/análogos & derivados
Dissulfetos
Homeostase/efeitos dos fármacos
Rim/efeitos dos fármacos
-Adenilato Quinase/análise
Adenilato Quinase/efeitos dos fármacos
Reprodutibilidade dos Testes
Ratos Wistar
Creatina Quinase/análise
Creatina Quinase/efeitos dos fármacos
Cistina/farmacologia
Eliminadores de Cistina/farmacologia
Limites: Animais
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


  6 / 22 LILACS  
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Id: biblio-1001185
Autor: Ayar, Ganime; Sahin, Sanliay; Men Atmaca, Yasemin; Uysal Yazici, Mutlu; Neselioglu, Salim; Erel, Ozcan.
Título: La homeostasis de tiol/disulfuro es un indicador del estrés oxidativo en los niños críticamente enfermos con sepsis / Thiol-disulphide homeostasis is an oxidative stress indicator in critically ill children with sepsis
Fonte: Arch. argent. pediatr;117(3):143-148, jun. 2019. ilus, tab.
Idioma: en; es.
Resumo: Objetivo. Evaluar un novedoso marcador del estrés oxidativo (la homeostasis de tiol /disulfuro) en la sepsis pediátrica y determinar sus efectos sobre el pronóstico de esta afección. Métodos. En el estudio, se incluyeron pacientes con diagnóstico de sepsis y controles sanos. Se midieron las concentraciones de tiol total, tiol nativo, disulfuro, disulfuro /tiol total, disulfuro /tiol nativo y tiol nativo/tiol total en los grupos con sepsis y de referencia. Se compararon los parámetros entre los supervivientes y los no supervivientes del grupo con sepsis. Se midieron las concentraciones de hemoglobina, leucocitos, trombocitos, lactato y proteína C-reactiva en los pacientes con sepsis al momento del diagnóstico. Se utilizaron el puntaje de riesgo de mortalidad pediátrico (Pediatric Risk of Mortality, PRISM) y el puntaje de disfunción orgánica (Pediatric Logistic Organ Dysfunction, PELOD) para estimar la gravedad de la enfermedad. Resultados. En el grupo con sepsis se incluyó a 38 pacientes y en el de referencia, a 40 niños sanos. Las concentraciones plasmáticas de tiol en los pacientes con sepsis fueron significativamente inferiores que las del grupo de referencia (p < 0,001). Conclusión. La homeostasis de tiol/disulfuro fue anormal en los niños con sepsis en la unidad de cuidados intensivos pediátricos.

The aim of this study is to evaluate a novel oxidative stress marker (thiol-disulphide homeostasis) in paediatric sepsis and to determine their effects on the prognosis of sepsis. Patients diagnosed with sepsis (n= 38) and healthy controls (n= 40) were incorporated in the study. Total thiol, native thiol, disulphide, disulphide/total thiol, disulphide/native thiol, and native thiol /total thiol levels were measured in the sepsis and control groups. Additionally, the parameters were compared between survivors and non-survivors in the sepsis group. The levels of hemoglobin, white blood cell, platelet, lactate, and C-reactive protein were measured in patients with sepsis at diagnosis. The paediatric risk of mortality and paediatric logistic organ dysfunction scores of the patients were used to estimate the disease severity. The plasma thiol levels of the patients with sepsis were significantly lower than the control group (p < 0.001). This study showed that thiol/disulphide homeostasis is abnormal in children with sepsis in Paediatric Intensive Care Unit.
Descritores: Compostos de Sulfidrila
Sepse
Estresse Oxidativo
Dissulfetos
Homeostase
Limites: Humanos
Recém-Nascido
Lactente
Pré-Escolar
Criança
Adolescente
Tipo de Publ: Relatório Técnico
Responsável: AR94.1 - Centro de Información Pediatrica


  7 / 22 LILACS  
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Id: biblio-837687
Autor: Ozturk, Barcin; Kurtoglu, Tunay; Durmaz, Selim; Kozaci, Leyla Didem; Abacigil, Filiz; Ertugrul, Bulent; Erel, Ozcan.
Título: The effects of ozone on bacterial growth and thiol-disulphide homeostasis in vascular graft infection caused by MRSA in rats
Fonte: Acta cir. bras;32(3):219-228, Mar. 2017. tab, graf.
Idioma: en.
Projeto: Adnan Menderes University.
Resumo: Abstract: Purpose: To investigate the microbiological, inflammatory and oxidant effects of adjuvant ozone administration in experimental rat vascular graft infection model which has not been previously investigated. Methods: Forty adult Wistar rats were divided into Sham, Control, Vancomycin, Ozone, Vancomycin+Ozone groups. Grafts were inoculated with Methicillin-resistant Staphylococcus aureus (MRSA) strain and implanted subcutaneously. Rats were treated intraperitoneally with ozone and /or intramuscularly with vancomycin for 10 days. Grafts were evaluated by quantitative bacterial cultures. Blood samples were harvested for determination of thiol-disulphide and cytokine profiles. Results: There was no significant difference in bacterial counts between Control and Ozone Groups. In the Ozone Group median colony count was significantly higher than the Vancomycin and Vancomycin+Ozone Groups. Total thiol and disulphide levels increased and disulphide/native thiol and disulphide/total thiol ratios decreased in Ozone Group significantly. Albumin levels decreased significantly in Vancomycin and Vancomycin+Ozone Groups compared to the Sham Group. IL-1 and TNF-alpha levels significantly increased in infected rats. Decreased levels of VEGF due to infection reversed by ozone therapy in control and vancomycin groups. Conclusions: We didn't observe any benefit of the agent on MRSA elimination in our model. Likewise, effects of ozone on thiol-disulphide homeostasis and inflammatory cytokines were contradictory.
Descritores: Oxidantes Fotoquímicos/farmacologia
Ozônio/farmacologia
Infecções Estafilocócicas/tratamento farmacológico
Dissulfetos/sangue
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Enxerto Vascular
-Valores de Referência
Fatores de Tempo
Doenças Vasculares/microbiologia
Albumina Sérica/análise
Vancomicina/farmacologia
Contagem de Colônia Microbiana
Distribuição Aleatória
Reprodutibilidade dos Testes
Citocinas/sangue
Resultado do Tratamento
Ratos Wistar
Transplantes/microbiologia
Staphylococcus aureus Resistente à Meticilina/crescimento & desenvolvimento
Homeostase/efeitos dos fármacos
Antibacterianos/farmacologia
Limites: Animais
Masculino
Tipo de Publ: Estudo de Validação
Responsável: BR1.1 - BIREME


  8 / 22 LILACS  
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Id: biblio-1008980
Autor: Tang, Feng; Chen, Daiwen; Yu, Bing; Luo, Yuheng; Zheng, Ping; Mao, Xiangbing; Yu, Jie; He, Jun.
Título: Improving the thermostability of Trichoderma reesei xylanase 2 by introducing disulfide bonds
Fonte: Electron. j. biotechnol;26:52-59, Mar. 2017. ilus, tab, graf.
Idioma: en.
Projeto: Fok Ying Tung Education Foundation; . "Prominent Young Scientist Fund" of Sichuan Province.
Resumo: Background: Xylanases are considered one of the most important enzymes in many industries. However, their low thermostability hampers their applications in feed pelleting, pulp bleaching, and so on. The main aim of this work was to improve the thermostability of Trichoderma ressei xylanase 2 (Xyn2) by introducing disulfide bonds between the N-terminal and α-helix and the ß-sheet core. Results: In this work, two disulfide bonds were separately introduced in the Xyn2 to connect the N-terminal and α-helix to the ß-sheet core of Xyn2. The two disulfide bonds were introduced by site-directed mutagenesis of the corresponding residues. The half-life of the mutants Xyn2C14­52 (disulfide bond between ß-sheets B2 and B3) and Xyn2C59­149 (disulfide bond between ß-sheets A5 and A6) at 60°C was improved by approximately 2.5- and 1.8-fold compared to that of the wild type Xyn2. In addition, the enzyme's resistance to alkali and acid was enhanced. Conclusion: Our results indicated that the connection of the N-terminal and α-helix to the ß-sheet core is due to the stable structure of the entire protein.
Descritores: Trichoderma/enzimologia
Xilosidases/metabolismo
Dissulfetos/metabolismo
-Espectrometria de Massas
Temperatura
Trichoderma/genética
Trichoderma/metabolismo
Xilanos/metabolismo
Xilosidases/genética
Estabilidade Enzimática
Cinética
Mutagênese Sítio-Dirigida
Concentração de Íons de Hidrogênio
Mutação
Responsável: CL1.1 - Biblioteca Central


  9 / 22 LILACS  
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Id: lil-747142
Autor: Bothe, Carolina; Fernandez, Alejandro; Garcia, Jacinto; Lopez, Montserrat; León, Xavier; Quer, Miquel; Lop, Joan.
Título: Parotid Incidentaloma Identified by Positron Emission/Computed Tomography: When to Consider Diagnoses Other than Warthin Tumor
Fonte: Int. arch. otorhinolaryngol. (Impr.);19(2):112-115, Apr-Jun/2015. tab.
Idioma: en.
Resumo: Introduction Parotid gland incidentalomas (PGIs) are unexpected hypermetabolic foci in the parotid region that can be found when scanning with whole-body positron emission/computed tomography (PET/CT). These deposits are most commonly due to benign lesions such as Warthin tumor. Objective The aim of this study was to determine the prevalence of PGIs identified in PET/CT scans and to assess the role of smoking in their etiology. Methods We retrospectively reviewed all PET/CT scans performed at our center in search of PGIs and identified smoking status and standardized uptake value (SUVmax) in each case. We also analyzed the database of parotidectomies performed in our department in the previous 10 years and focused on the pathologic diagnosis and the presence or absence of smoking in each case. Results Sixteen cases of PGIs were found in 4,250 PET/CT scans, accounting for 0.4% . The average SUVmax was 6.5 (range 2.8 to 16). Cytology was performed in five patients; it was benign in four cases and inconclusive in one case. Thirteen patients had a history of smoking. Of the parotidectomies performed in our center with a diagnosis of Warthin tumor, we identified a history of smoking in 93.8% of those patients. Conclusions The prevalence of PGIs on PET/CT was similar to that reported by other authors. Warthin tumor is frequently diagnosed among PGIs on PET/CT, and it has a strong relationship with smoking. We suggest that a diagnosis other than Warthin tumor should be considered for PGIs in nonsmokers. .
Descritores: Proteínas ADAM/metabolismo
Proteólise
Fator de von Willebrand/química
Fator de von Willebrand/metabolismo
-Sítios de Ligação
Cálcio/metabolismo
Dissulfetos/química
Dissulfetos/metabolismo
HEKABORTION, INCOMPLETEABATTOIRS CELLS
Ligação de Hidrogênio
Modelos Moleculares
Mutagênese Sítio-Dirigida
Ligação Proteica
Estabilidade Proteica
Estrutura Terciária de Proteína
Isoformas de Proteínas/química
Isoformas de Proteínas/metabolismo
Fator de von Willebrand/genética
Limites: Humanos
Responsável: BR1.1 - BIREME


  10 / 22 LILACS  
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Id: lil-736436
Autor: Andrade, Dilma Maria de; Barbosa-Branco, Anadergh.
Título: Sinovite e tenossinovite no Brasil: uma análise dos benefícios auxílio-doença / Synovitis and tenosynovitis in Brazil: analysis of sickness benefit claims
Fonte: Rev. bras. epidemiol;18(1):194-207, Jan-Mar/2015. tab.
Idioma: pt.
Resumo: OBJETIVO: Analisar os fatores pessoais associados à prevalência e duração dos benefícios auxílio-doença decorrentes de sinovite e tenossinovite (CID10 M65). MÉTODO: Estudo transversal referente aos benefícios auxílio-doença decorrentes de sinovite e tenossinovite concedidos pelo Instituto Nacional de Seguro Social aos empregados no Brasil em 2008. Dados sobre o ramo de atividade econômica (Classificação Nacional de Atividades Econômicas - CNAE divisão, classe), sexo, idade, espécie e duração dos benefícios foram coletados do Sistema Único de Benefícios. A população corresponde à média mensal dos vínculos empregatícios declarados ao Cadastro Nacional de Informações Sociais. RESULTADOS: Em 2008 foram concedidos 35.601 benefícios auxílio-doença decorrentes de sinovite e tenossinovite, com prevalência de 10,9/10.000 vínculos empregatícios. No conjunto dos benefícios auxílio-doença houve maior razão de prevalência (RP) acidentária (RP 1,2), sendo esta maior em mulheres (RP 3,3), e em trabalhadores com idade acima de 39 anos (RP 1,4). As CNAE 37-Esgoto (55,4) e 60-Atividade de rádio e TV (47,1) apresentaram as maiores prevalências, no entanto, 64-Atividade de serviços financeiros e 6422-Bancos múltiplos caracterizaram mais acidentes de trabalho (RP 3,2 e 3,8, respectivamente) e maior duração (70 e 73 dias, respectivamente). A maior duração de benefício ocorreu entre trabalhadores com idade superior a 39 anos. Tanto a CNAE-divisão 60-Atividade de rádio e TV, quanto a CNAE-classe 6010-Atividade de rádio apresentaram elevadas razões de feminilidade (RP 8,1 e 10,8, respectivamente). CONCLUSÃO: A incapacidade para o trabalho por sinovite e tenossinovite apresenta associação tanto da prevalência quanto da duração com o ramo de atividade, sexo, idade e espécie de benefício (previdenciário/acidentário). .

OBJECTIVE: To analyse the personal and occupational factors associated with the prevalence and duration of sickness benefit claims due to synovitis and tenosynovitis (CID10 M65). METHODS: Cross-sectional study regarding sickness benefit claims due to synovitis and tenosynovitis granted to employees by National Institute of Social Security in Brazil in 2008. Data on economic activity (Economic Activities National Classification - CNAE division, class), sex, age, type and duration of benefits were collected from the Unified Benefit System. The study's population consists of the average monthly employment contracts declared to the National Register of Social Information. RESULTS: In 2008, 35,601 employees were granted sickness benefits due to synovitis and tenosynovitis, with a prevalence of 10.9/10,000 employments. Sickness benefits showed higher prevalence rates (PR) for work-related claims (PR 1,2), mostly made by females (PR 3.3) and by workers older than 39 years (PR 1,4). The CNAE 37-Sewage (55.4) and 60-Broadcasting Activity (47.1) had the highest overall prevalence. However, the 64-Financial service activities, except insurance and pension funding and 6422-Multiple banks with commercial service had the highest rates of work-related claims (RP 3.2 and 3.8, respectively), and the longer duration (70 and 73 days, respectively). Workers older than 39 years had the highest durations of work disability claims. Both the CNAE-division 60-Broadcasting Activity, and the CNAE-class 6010-Radio showed a high activity ratio of females (PR 8.1 and 10.8, respectively). CONCLUSION: The work disability due to synovitis and tenosynovitis presents prevalence and duration associated with economic activity, sex, age and kind of benefit (non work-related and work-related claims). .
Descritores: Globinas/química
Peróxido de Hidrogênio/química
Proteínas do Tecido Nervoso/química
Nitritos/química
-Sequência de Aminoácidos
Sítios de Ligação
Catálise
Cisteína/química
Cisteína/metabolismo
Dissulfetos/química
Dissulfetos/metabolismo
Globinas/metabolismo
Peróxido de Hidrogênio/metabolismo
Cinética
Modelos Moleculares
Dados de Sequência Molecular
Mioglobina/química
Mioglobina/metabolismo
Proteínas do Tecido Nervoso/metabolismo
Nitritos/metabolismo
Oxirredução
Conformação Proteica
Fenol/química
Fenóis/química
Fenilacetatos/química
Espectrometria de Massas em Tandem
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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