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Id: lil-538337
Autor: Oliveira, Carlos Alberto Rodrigues de; Friedmann, Antonio Américo; Habib, Ricardo.
Título: O eletrocardiograma em outras situações de grande impacto clínico / The electrocardiogram in great impact clinical setting
Fonte: Rev. Soc. Cardiol. Estado de Säo Paulo;19(3):362-377, jul.-set. 2009. ilus.
Idioma: pt.
Resumo: Apesar de ter completado 100 anos de existência, o eletrocardiograma ainda é o primeiro exame complementar solicitado para avaliação cardiológica de um paciente. A incorporação de modernos recursos da eletrônica e da informática desenvolveu muito os eletrocardiográfos, mas as bases do registro do sinal elétrico emitido pelo coração permanecem as mesmas. Entretanto, ao longo do século XX, os conhecimentos adquiridos a partir do eletrocardiograma não permaneceram estáticos. A eletrofisiologia clínica contribuiu muito para elucidar os mecanismos das arritmias cardíacas. O reconhecimento de novas doenças diagnosticáveis apenas pelo eletrocardiograma, como as síndromes do QT longo e de Brugada, causadas por modificações genéticas dos canais iônicos, transformou o eletrocardiograma em mensageiro molecular das células do coração. No infarto agudo do miocárdio, estudos baseados em evidências...
Descritores: Bradicardia/prevenção & controle
Hipocalcemia/diagnóstico
Hipotireoidismo/prevenção & controle
Síndrome de Brugada/diagnóstico
-Antiarrítmicos/efeitos adversos
Eletrocardiografia Ambulatorial
Potássio/efeitos adversos
Potássio/sangue
Sódio/sangue
Limites: Humanos
Masculino
Responsável: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt


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Id: lil-761819
Autor: Santana, Dalvinea Carvalho; Bittencourt, Ester Dias; Weber, Márcia Lopes.
Título: Análise comparativa do teor de sódio presente em salgadinhos industrializados com os requerimentos para o consumo diário / Comparative analysis of sodium in industrialised snacks with requirementsfor the daily consuption
Fonte: Rev. Soc. Cardiol. Estado de Säo Paulo;24(1,Supl.A):33-38, jan.-mar.2014.
Idioma: pt.
Resumo: A população brasileira apresenta um padrão alimentar rico emsal, açúcar e gorduras. Paralelo a isto, observa-se o aumento noconsumo de salgadinhos industrializados em escala mundial,em crianças e em adultos. O objetivo deste estudo foi identificaro teor de sódio em salgadinhos industrializados e compará-locom seus requerimentos para consumo diário. A amostra foicomposta de 10 marcas de salgadinhos industrializados. Foramconsiderados os teores de sódio por porção apresentados nainformação nutricional das embalagens e, a partir deles, foramcalculados o teor de sódio para a quantidade total de produtona embalagem e na porção, padronizada em 25 g. O teor desódio foi comparado, por porção e por embalagem, com seusrequerimentos para consumo diário, considerando-se valores deingestão adequada (AI) e nível de ingestão máximo tolerável(UL). As marcas foram comparadas em relação ao teor de sódiona porção e no conteúdo total da embalagem, ao percentualde valor diário recomendado para sódio por porção, e aopreço. Foram calculados média, desvio padrão e coeficientede variação (CV) para as variáveis, e a relação entre preço eteor de sódio foi analisada por meio do teste de correlação dePearson. O preço e o teor de sódio dos produtos apresentaramCV muito alto, e não foi observada correlação significanteentre preço e teor de sódio. O teor de sódio no conteúdo totalda embalagem ultrapassou os requerimentos de AI e UL emuma das marcas em estudo, e não excedeu os requerimentospor porção em nenhuma delas...

The Brazilian population has a high eating pattern in salt,sugar and fat. Parallel to this, there is a worldwide increase ofmanufactured snack foods consumption in children and adults.The aim of this study was to identify the sodium content inprocessed snacks and compare it with its requirements for dailyconsumption. The sample was composed of 10 industrializedsalty snacks. The content of sodium per serving shown in thepackage's nutrition facts was used to calculate the total sodiumcontent of the package and in a 25 g standardized portion. Thesodium content was compared, per serving and per package, withits requirements for daily consumption, considering values foradequate intake (AI) and tolerable upper intake level (UL). Thesodium content in a portion and in the package was comparedto the percentage of the recommended daily value for sodiumper serving. A possible correlation between price and sodiumcontent was also investigated. We calculated mean ± standarddeviation and coefficient of variation (CV) for the variables. Therelationship between price and sodium content was analyzed usingthe Pearson's correlation. The price and the sodium content of theproducts presented a very high CV, and there was no significantcorrelation between price and sodium content. One of the saltysnacks of the study exceeded the requirements of AI and UL fortotal sodium content of the package, but none of them exceed therequirements for a portion...
Descritores: Alimentos Industrializados
Dieta Hipossódica/métodos
Ingestão de Alimentos/fisiologia
Ciências da Nutrição/educação
Sódio/administração & dosagem
Sódio/análise
-Estudos Transversais/métodos
Prevalência
Limites: Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Pessoa de Meia-Idade
Responsável: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt


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Id: biblio-1136695
Autor: Porto, Aline Silva; Martins, Haysla Xavier; Faria, Carolina Perim de; Molina, Maria del Carmen Bisi.
Título: Impact of the mHealth strategy in sodium consumption markers: AvaliaSal study / Impacto da estratégia mHealth em marcadores do consumo de sódio: estudo AvaliaSal
Fonte: Rev. Nutr. (Online);33:e200026, 2020. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective Evaluate the effectiveness of mHealth strategy on sodium consumption markers. Methods Intervention study carried out with 175 adults (20-59 years), from an educational institution of Vitória, Espírito Santo State. Participants were made aware through posters, oral approach and electronic media. Anthropometric, hemodynamic, socioeconomic, health, and dietary practices data was collected in two stages. After the first assessment, participants were randomized into two groups: Intervention Group and Control Group. The Intervention Group included 21 electronic messages and 3 videos on healthy eating focusing on the goal to reduce sodium intake for 3 months. Behavioral changes were assessed using the Generalized Estimation Equation (p-value <0.05). Results At baseline, no significant differences in socioeconomic, anthropometric and health variables, and eating practices between groups were observed. The stock broth cube was the most used ready processed seasoning. After the intervention, a reduction in the use of stock broth was observed only in the intervention group (β=0.615; p=0.016). In addition, 73% of the intervention group participants reported that the messages were clear, 67% reported that they were useful, and 48% stated they followed the guidelines. Conclusion There was a reduction in the frequency of use of stock broth cubes, demonstrating the potential effect of the m-Health strategy on sodium consumption markers in individuals without a hypertension medical diagnosis.

RESUMO Objetivo Avaliar a efetividade da estratégia mHealth sobre marcadores do consumo de sódio. Métodos Estudo de intervenção realizado com 175 adultos (20-59 anos), vinculados a uma instituição de ensino de Vitória, no Estado do Espirito Santo. Os participantes foram contatados por através da exposição a de um pôster, de abordagem oral e mídia eletrônica. Dados antropométricos, hemodinâmicos, socioeconômicos, de saúde e práticas alimentares foram coletados em dois momentos. Os participantes foram randomizados em dois grupos: Grupo de Intervenção e Grupo de Controle. Durante a intervenção, que durou três meses, os participantes receberam 21 mensagens eletrônicas e assistiram a três vídeos sobre alimentação saudável, com foco na redução do consumo de sódio. Mudanças foram avaliadas por Equação de Estimativa Generalizada e adoção de valor de p<0,05. Resultados Na linha de base, não foram observadas diferenças significativas em relação às variáveis antropométricas, socioeconômicas, de saúde e práticas alimentares entre os grupos. Caldo pronto foi o condimento industrializado mais utilizado pelos participantes durante o estudo. Foi observada uma redução do uso de caldo pronto apenas no Grupo de Intervenção (β=0,615; p=0,016). Além disso, 73% do Gruo de Intervenção relataram que as mensagens foram claras; 67% afirmaram que as mensagens foram úteis e 48% disseram que seguiram as orientações. Conclusão Foi observada uma redução da frequência do uso de caldo pronto, demonstrando potencial da estratégia m-Health sobre marcadores do consumo de sódio em participantes sem diagnóstico de hipertensão.
Descritores: Sódio
Ingestão de Alimentos
Alimentos Industrializados
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR13.3 - Biblioteca das Faculdades de Odontologia e Nutrição


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Id: biblio-1282985
Autor: Ramos Flores, Yris Eugenia(edt).
Título: Contenido de sodio en productos alimenticios preenvasados y comercializados en El Salvador / Sodium content in products prepackaged food and marketed in El Salvador
Fonte: Alerta (San Salvador);4(3):142-135, jul. 29, 2021. graf, tab.
Idioma: es.
Resumo: Introducción. La dieta actual de la población se caracteriza por la sustitución de alimentos naturales por productos alimenticios procesados, formulados industrialmente con ingredientes que contienen sodio. Objetivo. Clasificar el contenido de sodio en productos alimenticios preenvasados comercializados en El Salvador, según el perfil de nutrientes de la Organización Panamericana de la Salud y las metas regionales para formulación industrial. Metodología. Diseño transversal descriptivo, se analizaron las etiquetas nutricionales de 1016 productos de siete categorías, registrados en el Sistema de Información en Salud Ambiental. Para la clasificación del contenido de sodio se aplicaron fórmulas según el perfil de nutrientes: alto en sodio ≥1 miligramo de sodio por caloría. Para la clasificación según metas regionales: cuando el contenido de sodio en 100 gramos de producto es > a la meta establecida. Resultados. Según el perfil de nutrientes, el 52% de los productos tiene alto contenido de sodio. Según metas regionales, el 24% está formulado por arriba de las metas, esto refleja diferencias entre las valoraciones de contenido de sodio por categoría. Conclusión. Más de la mitad los productos alimenticios preenvasados comercializados en El Salvador son clasificados como altos en sodio, según el perfil de nutrientes. Una cuarta parte de estos están formulados con sodio por encima de las metas regionales, mostrando que las metas son más flexibles en la valoración de contenido máximo de sodio para la formulación industrial en relación con la valoración de contenido alto en sodio para consumo humano

Introduction. The current diet of the population is characterized by the substitution of natural foods for processed food products, industrially formulated with ingredients that contain sodium. Target. Classify the sodium content in prepackaged food products marketed in El Salvador, according to the nutrient profile of the Pan American Health Organization and the regional goals for industrial formulation. Methodology. Descriptive cross-sectional design, the nutritional labels of 1016 products from seven categories, registered in the Environmental Health Information System, were analyzed. For the classification of sodium content, formulas were applied according to the nutrient profile: high in sodium ≥1 milligram of sodium per calorie. For classification according to regional goals: when the sodium content in 100 grams of product is> the established goal. Results. According to the nutrient profile, 52% of the products are high in sodium. According to regional goals, 24% is formulated above the goals, this reflects differences between the valuations of sodium content by category. Conclution. More than half of the prepackaged food products marketed in El Salvador are classified as high in sodium, according to the nutrient profile. A quarter of these are formulated with sodium above the regional goals, showing that the goals are more flexible in the assessment of maximum sodium content for industrial formulation in relation to the assessment of high sodium content for human consumption
Descritores: Sódio
Alimentos
-Nutrientes
Dieta
Rotulagem de Alimentos
Responsável: SV2 - Departamento de Gobernanza y Gestión del Conocimiento


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Id: biblio-1279403
Autor: Estrada-Gómez, Sebastian; Vargas-Muñoz, Leidy Johana; Saldarriaga-Córdoba, Monica Maria; Meijden, Arie van der.
Título: MS/MS analysis of four scorpion venoms from Colombia: a descriptive approach
Fonte: J. venom. anim. toxins incl. trop. dis;27:e20200173, 2021. tab, graf.
Idioma: en.
Projeto: UdeA; . FEDER.
Resumo: Background: Scorpions are widely known for the neurotoxic effects of their venoms, which contain peptides affecting ionic channels. Although Colombia is recognized for its scorpion diversity, only a few studies are available describing the venom content. Methods: In this descriptive study, we analyzed the MS/MS sequence, electrophoretic and chromatographic profile linked to a bioinformatics analysis of the scorpions Chactas reticulatus (Chactidae), Opisthacanthus elatus (Hormuridae), Centruroides edwardsii (Buthidae) and Tityus asthenes (Buthidae) from Colombia. Results: Each scorpion showed a specific electrophoretic and chromatographic profile. The electrophoretic profiles indicate the presence of high molecular mass compounds in all venoms, with a predominance of low molecular mass compounds in the Buthidae species. Chromatographic profiles showed a similar pattern as the electrophoretic profiles. From the MS/MS analysis of the chromatographic collected fractions, we obtained internal peptide sequences corresponding to proteins reported in scorpions from the respective family of the analyzed samples. Some of these proteins correspond to neurotoxins affecting ionic channels, antimicrobial peptides and metalloproteinase-like fragments. In the venom of Tityus asthenes, the MSn analysis allowed the detection of two toxins affecting sodium channels covering 50% and 84% of the sequence respectively, showing 100% sequence similarity. Two sequences from Tityus asthenes showed sequence similarity with a phospholipase from Opisthacanthus cayaporum indicating the presence of this type of toxin in this species for the first time. One sequence matching a hypothetical secreted protein from Hottentotta judaicus was found in three of the studied venoms. We found that this protein is common in the Buthidae family whereas it has been reported in other families - such as Scorpionidae - and may be part of the evolutionary puzzle of venoms in these arachnids. Conclusion: Buthidae venoms from Colombia can be considered an important source of peptides similar to toxins affecting ionic channels. An interesting predicted antimicrobial peptide was detected in three of the analyzed venoms.(AU)
Descritores: Venenos de Escorpião
Sódio/análise
Biologia Computacional
Neurotoxinas
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-1279407
Autor: Yang, Manyi; Li, Yubin; Liu, Longfei; Zhou, Maojun.
Título: A novel proline-rich M-superfamily conotoxin that can simultaneously affect sodium, potassium and calcium currents
Fonte: J. venom. anim. toxins incl. trop. dis;27:e20200164, 2021. tab, graf.
Idioma: en.
Resumo: Background Conotoxins have become a research hotspot in the neuropharmacology field for their high activity and specificity in targeting ion channels and neurotransmitter receptors. There have been reports of a conotoxin acting on two ion channels, but rare reports of a conotoxin acting on three ion channels. Methods Vr3a, a proline-rich M-superfamily conotoxin from a worm-hunting Conus varius, was obtained by solid-phase synthesis and identified by mass spectrometry. The effects of synthesized Vr3a on sodium, potassium and calcium currents were tested on rat DRG cells by patch clamp experiments. The further effects of Vr3a on human Cav1.2 and Cav2.2 currents were tested on HEK293 cells. Results About 10 μM Vr3a has no effects on the peak sodium currents, but can induce a ~10 mV shift in a polarizing direction in the current-voltage relationship. In addition, 10 μM Vr3a can increase 19.61 ± 5.12% of the peak potassium currents and do not induce a shift in the current-voltage relationship. An amount of 10 μM Vr3a can inhibit 31.26% ± 4.53% of the peak calcium currents and do not induce a shift in the current-voltage relationship. The IC50 value of Vr3a on calcium channel currents in rat DRG neurons is 19.28 ± 4.32 μM. Moreover, 10 μM Vr3a can inhibit 15.32% ± 5.41% of the human Cav1.2 currents and 12.86% ± 4.93% of the human Cav2.2 currents. Conclusions Vr3a can simultaneously affect sodium, potassium and calcium currents. This novel triple-target conotoxin Vr3a expands understanding of conotoxin functions.(AU)
Descritores: Prolina/análise
Conotoxinas/análise
-Potássio
Sódio
Cálcio
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-1045622
Autor: Cohall, DH; Scantlebury-Manning, T; Nakhleh, C; Toure, D; James, S; Hall, K.
Título: Predicting 24-hour urinary sodium excretion in Afro-Caribbean Barbadians by comparing urine sodium excretion over different durations versus spot collection / Predicción de la excreción del sodio urinario de 24 horas en Barbadenses Afrocaribeños mediante la comparación de la excreción del sodio en la orina en diferentes periodos de tiempo en contraste con la eecogida al azar
Fonte: West Indian med. j;62(3):181-185, Mar. 2013. ilus.
Idioma: en.
Resumo: AIM: Urinary sodium excretion is used as an assessment tool for salt intake and salt handling. Even though cumbersome, the most reliable and readily used method in clinical and epidemiological studies is the 24-hour urine collection. This study investigates other appropriate means of predicting 24-hour urinary sodium excretion in a sample of Afro-Caribbeans in Barbados by assessing the correlation of actual and estimated urinary sodium excretion between a 24-hour urine collection sample, 12-hour (AM and PM), and spot (AM and PM) urine collections. METHOD: A convenient sample of 30 healthy participants of Afro-Caribbean origin between the ages of 21 and 55 years was recruited for the study. The 24-hour urine samples and anthropometric data were collected as documented in the study's standard clinical procedure. A 24-hour urine sample was collected as two separate 12-hour AM and PM samples. In addition, two spot samples (AM and PM) were taken during each 12-hour sample collection period. Analysis of the urinary sodium and creatinine was done with a Roche/Hitachi Modular System (Roche Diagnostics, IN, USA). SPSS version 19 was used to analyse the data to make inferences. RESULTS: Thirty Afro-Caribbean subjects participated in this study: 16 females and 14 males. The average age and body mass index (BMI) were 38 ± 17 years and 25.32 ± 5.98 kg/m2, respectively. The greatest correlation of the estimated 24-hour sodium excretion to the measured 24-hour sodium excretion was observed in the 12-hour PM sample (Pearson's correlation, r = 0.786, p < 0.001) followed by the 12-hour AM sample (Pearson's correlation, r = 0.774, p < 0.001). The PM spot sample showed a weaker, but still statistically significant correlation to the 24-hour timed sample (Pearson's correlation, r = 0.404, p < 0.045). The AM spot sample showed a very weak and insignificant correlation (Pearson's correlation, r = 0.05, p = 0.807) to the 24-hour timed sample. Similarly to the whole sample, the gender analysis demonstrated that estimated 24-hour sodium excretion in the female's 12-hour PM sample had the greatest correlation (r = 0.819, p < 0.001) to the measured 24- hour sodium excretion, followed by the 12-hour AM (r = 0.793, p = 0.001) and the PM spot samples (r = 0.741, p = 0.02). The correlation between variables is weaker in males compared to the females. CONCLUSION: Overall, this study shows a clear correlation between the estimated 24-hour sodium excretion from the 12-hour timed PM sample and the measured 24-hour sodium excretion. Such findings support the thought of using other alternatives to determine sodium excretion, in view of replacing the cumbersome 24-hour urinary collection with a smaller timed sample. Nonetheless, a more robust and randomized population sample as well as a method to correct for high creatinine variability is required to further enhance the significance of the obtained results.

OBJETIVO: La excreción del sodio en orina se utiliza como una herramienta de evaluación para la ingesta y manejo de la sal. Si bien resulta engorroso, el método más fiable y fácilmente utilizado en los estudios clínicos y epidemiológicos es la recolección de orina de 24 horas. Este estudio investiga otros medios apropiados de predicción de la excreción del sodio urinario de 24 horas en los afrocaribeños en Barbados, evaluando la correlación real y estimada de la excreción del sodio en orina entre una muestra de orina de 24 horas, 12 horas (AM y PM), y recogidas aleatorias (AM y PM). MÉTODO: Una muestra conveniente de 30 participantes sanos de origen afrocaribeño entre las edades de 21 y 55 años, fue reclutada para el estudio. Las muestras de orina de 24 horas y los datos antropométricos, fueron recogidos tal como se documenta en el procedimiento clínico estándar del estudio. Una muestra de orina de 24 horas fue recogida en forma de muestras de 12 horas AM y PM por separado. Además, se tomaron dos muestras (AM y PM) al azar durante cada periodo de recolección de muestras de 12 horas. El análisis del sodio y la creatinina urinarios fue hecho con un Sistema Modular Roche/Hitachi (Roche Diagnostic, IN, USA). La versión 19 de SPSS fue utilizada para analizar los datos para hacer las inferencias. RESULTADOS: Treinta sujetos afrocaribeños participaron en este estudio: 16 mujeres y 14 hombres. La edad media y el índice de masa corporal (IMC) promedio fueron 38 ± 17 años y 25.32 ± 5.98 kg/m², respectivamente. La mayor correlación de la excreción estimada de sodio de 24 horas con la excreción medida de sodio 24 horas, se observó en la muestra de 12 horas PM (correlación de Pearson, r = 0.786, p < 0.001), seguida por la muestra de 12 horas AM (correlación de Pearson, r = 0.774, p < 0.001). La muestra aleatoria PM mostró una correlación más débil, pero de todos modos estadísticamente significativa con respecto a la muestra cronometrada de 24 horas (correlación de Pearson, r = 0.404, p < 0.045). La muestra aleatoria AM mostró una correlación muy débil y estadísticamente no significativa (correlación de Pearson, r = 0. 05, p = 0.807) con respecto a la muestra cronometrada de 24 horas. De modo similar a la muestra en su totalidad, el análisis de género demostró que la excreción de sodio estimada de 24 horas en la muestra PM de 12 horas de las mujeres, tenía la mayor correlación (r = 0819, p < 0.001) con respecto a la excreción de sodio medida de 24 horas, seguida por las muestras de 12 horas AM (r = 0.793, p = 0.001) y las muestras PM al azar (r = 0.741, p = 0.02). La correlación entre las variables es más débil en los varones en comparación con las hembras. CONCLUSIÓN: En general, este estudio muestra una clara correlación entre la excreción de sodio estimada de 24 horas a partir de la muestra PM cronometrada de 12 horas, y la excreción de sodio medida de 24 horas. Estos hallazgos respaldan la idea de utilizar otras alternativas para determinar la excreción de sodio, teniendo en la mira el reemplazar la engorrosa recogida de orina de 24 horas por una muestra recogida en un tiempo menor. No obstante, una muestra de población más sólida y aleatoria, así como un método para corregir la variabilidad de la creatinina alta, son necesarios para mejorar aún más la importancia de los resultados obtenidos.
Descritores: Sódio/urina
Creatinina/urina
Rim/metabolismo
-Sódio/metabolismo
Fatores de Tempo
Barbados
Creatinina/metabolismo
Grupo com Ancestrais do Continente Africano
Coleta de Urina/métodos
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: biblio-1045780
Autor: Cohall, DH; Scantlebury-Manning, T; Rafie, C; James, S; Hall, K.
Título: Dietary potassium intake and renal handling, and their impact on the cardiovascular health of normotensive Afro-Caribbeans / Ingesta dietética de potasio y manejo renal, y su impacto en la salud cardiovascular de los normotensos Afrocaribeños
Fonte: West Indian med. j;63(1):13-19, Jan. 2014. tab.
Idioma: en.
Resumo: OBJECTIVE: Recent nutritional profiles of dietary intake have indicated a shift from the ancient diet to the Western diet. The ancient diet provided high potassium and low sodium intake, which in turn led to sodium conservation and potassium excretion. This change in the dietary intake is expected to affect potassium and sodium handling in the kidneys. Numerous studies have been done to emphasize the importance of sodium handling by the kidneys and its impact on cardiovascular health . This study will investigate potassium intake and handling, and its impact on the cardiovascular health of a sample of normotensive Afro-Caribbeans by the possible modulation of the renin angiotensin aldosterone system (RAAS). METHODS: A sample of 51 normotensive Afro-Caribbean participants was recruited for the study. Participants were observed over a two-day period in which they were given a 24-hour ambulatory blood pressure monitor and a container to collect blood pressure data and a 24-hour urine sample. Anthropometric measurements were noted. Urinary electrolytes and supine plasma renin activity (PRA) were determined from the 24-hour urine collection and a blood sample. Dietary potassium intake was estimated based on dietary intake observations, and calculated based on the urinary potassium excretion. SPSS version 19 was used to analyse the data to make inferences. RESULTS: The daily potassium intake was observed to be 2.95 g/day and measured intake from the urinary potassium was between 4.95 and 7.32 g/day. Urinary potassium excretion was 3.66 (± 1.40) g/day. The urinary potassium excretion in the Afro-Caribbean sample in Barbados was higher than the other population samples. The averaged PRA of the participants (supine) was 0.778 (± 1.072) ng/mL/hour. The averaged nocturnal systolic blood pressure dip of the participants was 5.97 (± 4.324) %. There was no significant correlation between urinary potassium excretion, blood pressure, nocturnal systolic blood pressure dip and PRA. CONCLUSIONS: The Afro-Caribbean sample has an inadequate daily potassium intake based on the observed intake and recommended values, with a high urinary excretion of the electrolyte compared to other values in the literature. This high potassium excretion could have been partly due to low plasma renin activity levels in the study participants. As a possible consequence, an increase in the nocturnal peripheral resistance is a likely cause for the diminished systolic dip. The lack of correlations between dietary potassium excretion and the blood pressure parameters does not allow any firm inference of the electrolyte's handling and its impact on cardiovascular health in the normotensive Afro-Caribbean participants. However, further research is needed to get a more accurate daily potassium intake value, and a more statistically robust sample to assess whether potassium handling and blood pressure would be affected by a change in potassium intake.

OBJETIVO: Los perfiles nutricionales recientes de ingesta dietética han indicado un cambio de la dieta antigua a la dieta occidental. La dieta antigua ofrecía un consumo alto de potasio frente a un consumo bajo de sodio, lo que a su vez llevaba a la conservación del sodio y a la excreción del potasio. Se espera que este cambio en la ingesta dietética afecte el manejo del potasio y el sodio en los riñones. Se han realizado numerosos estudios con el fin de enfatizar la importancia del manejo del sodio por los riñones y su impacto en la salud cardiovascular. Este estudio investigará la ingesta y manejo del potasio, y su impacto en la salud cardiovascular de una muestra de normotensos afrocaribeños mediante la posible modulación del sistema renina-angiotensina-aldosterona (SRAA). MÉTODOS: Una muestra de 51 participantes normotensos afrocaribeños fue reclutada para el estudio. Los participantes fueron puestos bajo observación por un período de dos días, en los que recibieron un monitor ambulatorio para registrar la presión arterial por 24 horas, y un recipiente para recoger los datos de la presión arterial, y una muestra de orina de 24 horas. Se observaron las mediciones antropométricas. Los electrolitos urinarios y la actividad de renina plasmática (ARP) en posición supina, se determinaron a partir de la orina de 24 horas y una muestra de sangre. La ingesta dietética de potasio fue estimada en base a las observaciones hechas de la ingesta dietética, y se calculó a partir de la excreción del potasio urinario. La versión 19 del SPSS fue utilizada para analizar los datos y hacer inferencias. RESULTADOS: Se observó una ingestión diaria de potasio de 2.95 g/día, y la ingestión medida a partir del potasio urinario estuvo entre 4.95 y 7,32 g/día. La excreción del potasio urinario fue 3.66 (± 1.40) g/día. La excreción del potasio urinario en la muestra afrocaribeña en Barbados fue mayor que en las otras poblaciones. La actividad ARP promedio (supina) de los participantes fue 0.778 (± 1.072) ng/mL/hora. La caída nocturna promedio de la presión arterial sistólica de los participantes fue (± 4.324) 5.97%. No hubo ninguna correlación significativa entre la excreción del potasio urinario, la presión arterial, la caída nocturna de la presión arterial sistólica, y la actividad ARP. CONCLUSIONES: Partiendo de la base del consumo observado y los valores recomendados, la muestra afrocaribeña presenta una ingesta diaria inadecuada de potasio, con una alta excreción urinaria de electrólito, en comparación con otros valores en la literatura. Esta elevada excreción de potasio podría haberse debido en parte a niveles bajos de actividad de renina plasmática en los participantes del estudio. Una posible consecuencia es el aumento de la resistencia periférica nocturna como causa probable del descenso sistólico. La falta de correlación entre los parámetros de la presión arterial y la excreción de potasio dietético no permite ninguna inferencia sólida del manejo del electrólito y su impacto sobre la salud cardiovascular en los normotensos afrocaribeños participantes. Sin embargo, es necesario investigar más a fin de obtener un valor más exacto de la ingesta diaria de potasio y una muestra estadísticamente más sólida para evaluar si el manejo del potasio y la presión arterial podrían ser afectados por un cambio en la ingesta de potasio.
Descritores: Potássio/urina
Sistema Renina-Angiotensina/efeitos dos fármacos
Sódio/urina
Doenças Cardiovasculares/etiologia
Potássio na Dieta
Recomendações Nutricionais
-Fatores de Risco
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-1156326
Autor: Pérez-Riveros, Erika D; Rey R, Margarita; Mendoza De Molano, Belén; Robayo, Juan Carlos; Solano-Mariño, Jaime; García-Duperly, Rafael; Gómez, Andrés; Pinto-Carta, Renzo; Ardila, Gerardo; De la Hoz-Valle, José; Sierra-Arango, Fernando.
Título: No inferioridad entre dos agentes de bajo volumen (picosulfato de sodio/citrato de magnesio frente al sulfato de sodio/potasio/magnesio) en la preparación del colon para procedimientos diagnósticos: estudio observacional / Non-inferiority between two low-volume agents (sodium picosulfate/magnesium citrate vs. sodium sulfate/potassium/magnesium) to prepare the bowel for diagnostic procedures: an observational study
Fonte: Rev. colomb. gastroenterol;35(4):436-446, dic. 2020. tab, graf.
Idioma: es.
Resumo: Resumen Introducción: el cáncer colorrectal es un problema de salud pública; sin embargo, la detección temprana reduce su morbimortalidad. La colonoscopia es el procedimiento de elección para detectar lesiones premalignas y el éxito depende de una limpieza adecuada. El objetivo es evaluar el desempeño de dos preparaciones de bajo volumen empleados en un hospital de alto nivel. Materiales y métodos: estudio prospectivo en adultos que asistieran a colonoscopia en la Fundación Santa Fe de Bogotá, Colombia. Las preparaciones se evaluaron con la escala de Boston, con puntaje ≥ 6 puntos para una limpieza adecuada. Se realizó un análisis de regresión logística para establecer la efectividad de los medicamentos con un cálculo de no inferioridad del 3 %-5 %. Resultados: 598 pacientes fueron evaluados. El 49 % (293) fue expuesto al picosulfato de sodio/citrato de magnesio y el 51 % (305) fue expuesto al sulfato de sodio/potasio/magnesio. Con un promedio de Boston de 6,98 ± 1,86 (78 % con puntaje de Boston ≥ 6) y 7,39 ± 1,83 (83 %), respectivamente (p = 0,649). Según el análisis de la presencia y frecuencia de síntomas no deseados, el picosulfato fue mejor tolerado (p < 0,001). Conclusiones: los estudios de preparación intestinal en pacientes de un escenario real son muy escasos. Los medicamentos de bajo volumen obtuvieron una efectividad global y por segmento de colon similar, confirmando la no-inferioridad; el picosulfato de sodio/citrato de magnesio fue mejor tolerado. Un estudio de costo-efectividad podría definir esto según las necesidades de la población de estudio.

Abstract Introduction: Colorectal cancer is a public health problem; however, early detection reduces morbidity and mortality. Colonoscopy is the procedure of choice for detecting precancerous lesions, and success depends on proper bowel cleansing. Objective: To evaluate the performance of two low-volume agents used in a high-level hospital. Materials and methods: Prospective study in adults who underwent colonoscopy at the Fundación Santa Fe in Bogotá, Colombia. Preparations were evaluated using the Boston Bowel Preparation Scale. A score ≥6 points indicated adequate preparation. A logistic regression analysis was carried out to establish the effectiveness of the medicines with a non-inferiority ratio of 3-5%. Results: 598 patients were evaluated. 49% (293) received sodium picosulfate/magnesium citrate and 51% (305) received sodium sulfate/potassium/magnesium, with an average Boston score of 6.98±1.86 (78% Boston ≥6) and 7.39±1.83 (83%), respectively (p=0.649). According to the analysis of the presence and frequency of unwanted symptoms, picosulfate was better tolerated (p < 0.001). Conclusions: Bowel preparation studies in patients from a real-life scenario are scarce. Low-volume agents had similar overall and segmental effectiveness in the colon, confirming non-inferiority; sodium picosulfate/magnesium citrate was better tolerated. A cost-effectiveness study could establish the best option according to the needs of the study population.
Descritores: Pacientes
Preparações Farmacêuticas
Neoplasias Colorretais
Estudos Prospectivos
Colonoscopia
-Potássio
Sódio
Efetividade
Ácido Cítrico
Custos e Análise de Custo
Preparativos para Desastre
Magnésio
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Estudo Observacional
Responsável: CO354 - Sociedad Colombiana de Gastroenterología


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Id: lil-785740
Autor: Oguz, Ural; Takci, Zennure; Oguz, Isil Deniz; Resorlu, Berkan; Balta, Ilknur; Unsal, Ali.
Título: Are patients with lichen planus really prone to urolithiasis? Lichen planus and urolithiasis
Fonte: Int. braz. j. urol;42(3):571-577tab.
Idioma: en.
Resumo: ABSTRACT Purpose to investigate whether patients with lichen planus (LP) are really prone to urolithiasis or not. Patients and Methods We performed a prospective analysis of 40 patients diagnosed with lichen planus (LP) (group I), and 40 volunteers did not have LP before (group II). Participants were all checked for urolithiasis by radiological investigations. Blood samples were analyzed for biochemistry parameters including calcium and uric acid. 24-h urine samples were analyzed to investigate oxalate, citrate calcium, uric acid, magnesium, sodium and creatinine. Results Men/women ratio and mean age were similar between group I and II (p>0.05). A presence or history of urolithiasis was detected in 8 (20%) and 2 (%5) patients in group I and II, respectively (p<0.05). Hypocitraturia was the most common anomaly with 35% (n:14) in group I. The rate of hypocitraturia in group II was 12.5% (n:5) and the difference was statistically significantly different (p=0.036). In group I, hyperuricosuria and hyperoxaluria followed with rates of 27.5% (n:11) and 25% (n:10), respectively. The rate of hyperuricosuria and hyperoxaluria were both 5% (n:2) in group II and the differences were significant (p<0.05). Hyperuricemia was another important finding in the patients with LP. It was detected in 13 (32.5%) patients in group I and in 1 (2.5%) participant in group II (p=0.001). Conclusion According to our results, metabolic disorders of urolithiasis were highly detected in the patients with LP. However, similar to the etiology of LP, the exact reasons for these metabolic abnormalities in LP remain a mystery.
Descritores: Urolitíase/etiologia
Líquen Plano/complicações
-Oxalatos/urina
Valores de Referência
Sódio/urina
Ácido Úrico/urina
Ácido Úrico/sangue
Estudos de Casos e Controles
Cálcio/sangue
Estudos Prospectivos
Fatores de Risco
Urinálise
Citrato de Cálcio/urina
Creatinina/urina
Urolitíase/urina
Líquen Plano/urina
Magnésio/urina
Doenças Metabólicas/complicações
Doenças Metabólicas/urina
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adulto
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME



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