Base de dados : LILACS
Pesquisa : D01.625.400.100.750 [Categoria DeCS]
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Machado, B. H
Mauad, H
Colombari, E
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Id: lil-191391
Autor: Machado, B. H; Mauad, H; Chianca Junior, D. A; Haibara, A. S; Colombari, E.
Título: Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;30(4):533-43, Apr. 1997.
Idioma: en.
Conferência: Apresentado em: International Symposium Neuroendocrine Control of Body Fluid Homeostasis, Ribeiräo Preto, Aug. 17-20, 1996.
Resumo: The nucleus tractus solitarii (NTS) receives afferent projections from the arterial baroreceptors, carotid chemoreceptors and cardiopulmonary receptors and as a function of this information produces autonomic adjustments in order to maintain arterial blood pressure within a narrow range of variation.The activation of each of these cardiovascular afferents produces a specific autonomic response by the excitation of neuronal projections from the NTS to the ventrolateral areas of the medulla (nucleus ambiguus, caudal and rostral ventrolateral medulla). The neurotransmitters at the NTS level as well as the excitatory amino acid (EAA) receptors involved in the processing of the autonomic responses in the NTS, although extensively studied, remain to be completely elucidated. In the present review we discuss the role of the EAA L-glutamate and its different receptor subtypes in the processing of the cardiovascular reflexes in the NTS. The data presented in this review related to the neurotransmission in the NTS are based on experimental evidence obtained in our laboratory in unanesthetized rats. The two major conclusions of the present review are that a) the excitation of the cardiovagal component by cardiovascular relfex activation (chemo- and Bezold-Jarisch reflexes) or by L-glutamatae microinjection into the NTS is mediated by N-methyl-D-aspartate (NMDA) receptors, and b) the sympatho-excitatory componente of the chemoreflex and the pressor response to L-glutamate microinjected into the NTS are not affected by an NMDA receptor antagonist, suggesting that the sympatho-excitatory component of these responses is mediated by non-NMDA receptors.
Descritores: Sistema Cardiovascular/efeitos dos fármacos
Células Quimiorreceptoras/fisiologia
Ácido Glutâmico/farmacologia
Glicina/farmacologia
Cianeto de Potássio/farmacologia
Pressorreceptores/fisiologia
Receptores de Glutamato/efeitos dos fármacos
Reflexo/fisiologia
Serotonina/farmacologia
Núcleo Solitário/fisiologia
-Células Quimiorreceptoras/efeitos dos fármacos
Pressorreceptores/efeitos dos fármacos
Limites: Ratos
Animais
Tipo de Publ: Revisão
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  2 / 2 LILACS  
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Vasquez, E. C
Mauad, H
Cabral, A. M
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Id: lil-191390
Autor: Vasquez, E. C; Meyrelles, S. S; Mauad, H; Cabral, A. M.
Título: Neural reflex regulation of arterial pressure in pathophysiological conditions: interplay among the baroreflex, the cardiopulmonary reflexes and the chemoreflex
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;30(4):521-32, Apr. 1997. ilus, graf.
Idioma: en.
Conferência: Apresentado em: International Symposium Neuroendocrine Control of Body Fluid Homeostasis, Ribeiräo Preto, Aug. 17-20, 1996.
Resumo: The maintenance of arterial pressure at levels adequate to perfuse the tissues is a basic requirement for the constancy of the internal environment and survival.The objective of the present review was to provide information about the basic relfex mechanisms that are responsible for the moment-to-moment regulation of the cardiovascular system. We demonstrate that this control is largely provided by the action of arterial and non-arterial reflexes that detect and correct changes in arterial pressure (baroreflex), blood volume or chemical composition (mechano-and chemosensitive cardiopulmonary reflexes), and changes in bloodgas composition (chemoreceptor reflex). The importance of the integration of these cardiovascular reflexes is well understood and it is clear that processing mainly occurs in the nucleus tractus solitarii, although the mechanism is poorly understood.There are several indications that the interactions of baroreflex, chemoreflex and Bezold-Jarisch reflex inputs, and the central nervous system control the activity of autonomic preganglionic neurons through parallel afferent and efferent pathways to achieve cardiovascular homeostasis. It is surprising that so little appears in the literature about the integration of these neural reflexes in cardiovascular function. Thus, our purpose was to review the interplay between peripheral neural reflex mechanisms of arterial blood pressure and blood volume regulation in physiological and pathophysiological states. Special emphasis is placed on the experimental model or arterial hypertension induced by N-nitro-L-arginine methyl ester (L-NAME) in which the interplay of these three reflexes is demonstrable.
Descritores: Barorreflexo/fisiologia
Pressão Sanguínea/fisiologia
Células Quimiorreceptoras/fisiopatologia
Cisteína/farmacologia
Hipertensão/fisiopatologia
Infarto do Miocárdio/fisiopatologia
Cianeto de Potássio/farmacologia
Pressorreceptores/fisiopatologia
Serotonina/farmacologia
-Células Quimiorreceptoras/efeitos dos fármacos
Hipertensão/tratamento farmacológico
Patologia
Pressorreceptores/efeitos dos fármacos
Limites: Coelhos
Ratos
Animais
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME



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