Base de dados : LILACS
Pesquisa : D01.625.400.100.875 [Categoria DeCS]
Referências encontradas : 5 [refinar]
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Id: lil-683234
Autor: Dube, Praveen N; Alavandi, Shwetha; Hosetti, Basaling B.
Título: Effect of exposure to sublethal concentrations of sodium cyanide on the carbohydrate metabolism of the Indian Major Carp Labeo rohita (Hamilton, 1822)
Fonte: Pesqui. vet. bras = Braz. j. vet. res;33(7):914-919, jul. 2013. tab.
Idioma: en.
Resumo: Experiments were designed to study in-vivo effects of sodium cyanide on biochemical endpoints in the freshwater fish Labeo rohita. Fish were exposed to two sublethal concentrations (0.106 and 0.064mg/L) for a period of 15 days. Levels of glycogen, pyruvate, lactate and the enzymatic activities of lactate dehydrogenase (LDH), succinate dehydrogenase (SDH), glucose-6-phosphate dehydrogenase (G6PDH), phosphorylase, alkaline phosphatase (ALP), acid phosphatase (AcP) were assessed in different tissues (liver, muscle and gills). Result indicated a steady decrease in glycogen, pyruvate, SDH, ALP and AcP activity with a concomitant increase in the lactate, phosphorylase, LDH and G6PD activity in all selected tissues. The alterations in all the above biochemical parameters were significantly (p<0.05) time and dose dependent. In all the above parameters, liver pointing out the intensity of cyanide intoxication compare to muscle and gills. Study revealed change in the metabolic energy by means of altered metabolic profile of the fish. Further, these observations indicated that even sublethal concentrations of sodium cyanide might not be fully devoid of deleterious influence on metabolism in L. rohita.
Descritores: Cianeto de Sódio/administração & dosagem
Cianeto de Sódio/metabolismo
Cianeto de Sódio/síntese química
Peixes/crescimento & desenvolvimento
Peixes/metabolismo
-Metabolismo
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: lil-461000
Autor: Cádenas Freixas, José Luís; Montero Cruz, Sergio Adrián; De Álvarez Buylla, Elena Roces; Álvarez Buylla de Aldana, Ramón.
Título: Papel del óxido nítrico en la retención de glucosa cerebral post-estimulación de los receptores carotídeos con cianuro de sodio en ratas / The role of the nitric oxide to retain the cerebral glucose post-stimulation of the carotid receptors with sodium cyanide in rats
Fonte: Arch. méd. Camaguey;10(5), sept.-oct. 2006. tab, graf.
Idioma: es.
Resumo: Se realizó un estudio experimental, con el objetivo de medir la acción del óxido nítrico (NO) en la captación de glucosa cerebral, después de la estimulación con cianuro de sodio (NaCN-5µg/100g) de los receptores del cuerpo carotídeo (RCC). Los experimentos se realizaron en ratas (280-310g) anestesiadas, mantenidas con respiración artificial a una temperatura de 25°C. Los protocolos fueron el control I, la perfusión en cisterna magna (CM) de líquido cefalorraquídeo artificial-LCRa (5 µL/30 s), el control II, la ERC en forma simultánea con la perfusión de LCRa, la perfusión de un donador de NO (nitroglicerina) (NG-3µg/5µL de LCRa) en CM, la ERC en forma simultánea con NG en CM, la perfusión de un inhibidor de NO (L-NAME) (250µg/5µL de LCRa), la ERC en forma simultánea con L-NAME en CM. Los resultados obtenidos indican que la combinación de NG con ERC no altera la retención de glucosa cerebral, mientras que en los controles, la NG sola aumentó la retención cerebral de glucosa. Por el contrario, el L-NAME en combinación con ERC aumentó la captación de glucosa cerebral e indicó que el óxido nítrico desempeña un papel modulador en la respuesta hiperglucemiante en los estados de hipoxia
Descritores: Glucose Oxidase
Sistema Nervoso
Óxido Nítrico
Ratos
Cianeto de Sódio
-Ensaios Clínicos Fase I como Assunto
Limites: Ratos
Animais
Responsável: CU1.3 - CPICM - Centro Provincial de Información de Ciencias Médicas


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Id: lil-228537
Autor: Iturriaga, R.
Título: Acetate enhances the chemosensory response to hypoxia in the cat carotid body in vitro in the absence of CO2-HCO3-
Fonte: Biol. Res;29(2):237-43, 1996.
Idioma: en.
Resumo: To determine if intracellular acidosis enhances hypoxic chemoreception in the absence of CO2-HCO3- at pH 7.4, the effects of sodium acetate (30 mM) were studied on the chemosensory responses of the cat carotid body to hypoxic, stagnant and cytotoxic hypoxia. Carotid bodies were perfused and superfused in vitro with Tyrode's solution, free of CO2-HCO3-, buffered with HEPES-NaOH, pH 7.40, at 36.5 +/d- 0.5 degrees C and equilibrated at PO2 of 125 Torr (perfusate) and < 20 Torr (superfusate). In the absence of acetate, hypoxia (PO2 25 Torr), flow interruption and NaCN (0.01-100 micrograms) augmented the chemosensory discharges. However, in the presence of acetate, the half-excitation time of these responses decreased and their amplitude increased. Thus, acetate enhances the chemosensory response to hypoxic, stagnant and cytotoxic hypoxia. It is suggested that that intracellular acidosis induced by acetate contributes to this potentiation by correcting the alkaline pHi caused by the absence of HCO3-(-)HCO2 in the perfusate
Descritores: Acetatos/farmacologia
Bicarbonatos/metabolismo
Dióxido de Carbono/metabolismo
Corpo Carotídeo/metabolismo
Células Quimiorreceptoras/metabolismo
Hipóxia/tratamento farmacológico
Técnicas In Vitro
Cianeto de Sódio/farmacologia
-Corpo Carotídeo/efeitos dos fármacos
Células Quimiorreceptoras/efeitos dos fármacos
Limites: Animais
Gatos
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-161512
Autor: Pelster, B.
Título: Blood acidification in the swimbladder: mechanisms and metabolic pathways
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;28(11/12):1133-8, Nov.-Dec. 1995. ilus, graf.
Idioma: en.
Conferência: Apresentado em: International Symposium on Regulatory Mechanisms of Cardiovascular and Respiratory Function in Vertebrates, Säo Carlos, Sept. 8-13, 1994.
Projeto: Deutsche Forschungsgemeinschaft.
Resumo: The metabolism of gas gland cells of the swimbladder epithelium is specialized for the production of acidic metabolites that are released into the blood stream and provoke an increase in gas partial pressure by reducing the effective gas-carrying capacity of the blood. In a subsequent step this initial increase in gas partial pressure is multiplied by back-diffusion of gas molecules from the venous to the arterial side in the countercurrent system, the rete mirabile. Thus, gas partial pressures of up to several hundred atmospheres can be generated in the swimbladder. Measurements of metabolic end products and analysis of the formation of 14C02 from [1-14(superscription) C] glucose and [6-14(superscription) C] glucose revealed that the acidic metabolises are lactic acid, produced in the glycolytic pathway, and also C02, formed in the pentose phosphate shunt. C02 easily enters the blood stream by diffusion. The release of protons from isolated gas gland cells, however, is highly dependent on the extracellular sodium concentration. This sodium dependence can in part be blocked by addition of amiloride, indicating that a Na+/ H+ exchanger is involved in the release of protons. A significant decrease in the rate of proton secretion in the presence of the carbonic anhydrase inhibitor ethoxzolamide indicates that the second major route for the release of protons includes carbonic anhydrase activity and the diffusion of C02.
Descritores: beta-Galactosidase/biossíntese
Dióxido de Carbono/sangue
Metabolismo Energético
Glucose/metabolismo
Sacos Aéreos/metabolismo
-Ácido Oxâmico/metabolismo
Cianeto de Sódio/metabolismo
Etoxzolamida/farmacologia
Fluoreto de Sódio/metabolismo
Concentração de Íons de Hidrogênio
Sacos Aéreos/irrigação sanguínea
Limites: Seres Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-105190
Autor: Alvarez Buylla, Ramón.
Título: Consumo de glucosa bajo acción de una cocarboxilasa no degradable, utilizando cianuro como estimulante / Consuption of glucose under the action of a non degradable cocaiboxilase using cyamide as stimulant
Fonte: Compend. invest. clin. latinoam;7(2):26-33, oct. 1987. tab, ilus.
Idioma: es.
Resumo: Se determinó la variación del consumo de glucosa, por acción de una cocarboxilasa no degradable en animal sano y en animal intoxicado con cianuro como estimulante, midiendo las alteraciones electrofisiológicas de los quimiorreceptores aórticos y carotídeos. La conclusión fue que la cocarboxilasa no degradable inteviene en el metabolismo de la glucosa favorecendo funcional y notoriamente al músculo cardiaco sometido a la anoxia del cianuro, el cual reproduce masivametne los efectos de la isquemia
Descritores: Isquemia Encefálica/induzido quimicamente
Glucose/metabolismo
Cianeto de Sódio/envenenamento
Tiamina Pirofosfato/farmacologia
Limites: Masculino
Feminino
Responsável: MX1.1 - CENIDSP - Centro de Información para Decisiones en Salud Pública



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