Base de dados : LILACS
Pesquisa : D01.928 [Categoria DeCS]
Referências encontradas : 3 [refinar]
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Id: biblio-975668
Autor: Polat, Emre Can; Besiroglu, Huseyin; Ozcan, Levent; Otunctemur, Alper; Eruyar, Ahmet Tugrul; Somay, Adnan; Ozbay, Nurver; Cekmen, Mustafa; Eraldemir, Ceyla; Ozbek, Emin.
Título: Beneficial effects of Oltipraz, nuclear factor - erythroid - 2 - related factor 2 (Nrf2), on renal damage in unilateral ureteral obstruction rat model
Fonte: Int. braz. j. urol;44(6):1243-1251, Nov.-Dec. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Introduction: We investigated whether Oltipraz (OPZ) attenuated renal fibrosis in a unilateral ureteral obstruction (UUO) rat model. Materials and Methods: We randomly divided 32 rats into four groups, each consisting of eight animals as follows: Rats in group 1 underwent a sham operation and received no treatment. Rats in group 2 underwent a sham operation and received OPZ. Rats in group 3 underwent unilateral ureteral ligation and received no treatment. Group 4 rats were subjected to unilateral ureteral ligation plus OPZ administration. Transforming growth factor beta-1 (TGF-β1), E-cadherin, nitric oxide (NO) and hydroxyproline levels were measured. Histopathological and immunohistochemical examinations were carried out. Results: TGF-β1, NO and E-cadherin levels in the UUO group were significantly higher than the sham group and these values were significantly different in treated groups compared to the UUO group. In rats treated with UUO + OPZ, despite the presence of mild tubular degeneration and less severe tubular necrosis, glomeruli maintained a better morphology when compared to the UUO group. Expressions of α-SMA in immunohistochemistry showed that the staining positivity decreased in the tubules of the OPZ-treated group. Conclusions: While the precise mechanism of action remains unknown, our results demonstrated that OPZ exerted a protective role in the UUO-mediated renal fibrosis rat model highlighting a promising therapeutic potency of Nrf2-activators for alleviating the detrimental effects of unilateral obstruction in kidneys.
Descritores: Pirazinas/uso terapêutico
Obstrução Ureteral/complicações
Fator 2 Relacionado a NF-E2/uso terapêutico
Nefropatias/tratamento farmacológico
-Tionas
Tiofenos
Obstrução Ureteral/patologia
Obstrução Ureteral/tratamento farmacológico
Fibrose/etiologia
Fibrose/tratamento farmacológico
Imuno-Histoquímica
Caderinas/sangue
Ratos Wistar
Modelos Animais de Doenças
Fator de Crescimento Transformador beta1/sangue
Hidroxiprolina/sangue
Nefropatias/etiologia
Nefropatias/patologia
Óxido Nítrico/sangue
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-742970
Autor: Cruz, Lucinéia Claudia de Toni Aquino da; Serra, Otacília Pereira; Leal-Santos, Fábio Alexandre; Ribeiro, Ana Lucia Maria; Slhessarenko, Renata Dezengrini; Santos, Marina Atanaka dos.
Título: Natural transovarial transmission of dengue virus 4 in Aedes aegypti from Cuiabá, State of Mato Grosso, Brazil
Fonte: Rev. Soc. Bras. Med. Trop;48(1):18-25, jan-feb/2015. tab, graf.
Idioma: en.
Resumo: INTRODUCTION: Dengue is the most prevalent arboviral disease in tropical areas. In Mato Grosso, outbreaks are reported every year, but studies on dengue in this state are scarce. METHODS: Natural transovarial infection of Aedes aegypti by a flavivirus was investigated in the Jardim Industriário neighborhood of Cuiabá, Mato Grosso. Eggs were collected with ovitraps during the dry, intermediate, and rainy seasons of 2012. After the eggs hatched and the larvae developed to adulthood, mosquitoes (n = 758) were identified and allocated to pools of 1-10 specimens according to the collection location, sex, and climatic period. After RNA extraction, multiplex semi-nested RT-PCR was performed to detect the four dengue virus (DENV) serotypes, yellow fever virus, West Nile virus and Saint Louis encephalitis virus. RESULTS: DENV-4 was the only flavivirus detected, and it was found in 8/50 pools (16.0%). Three of the positive pools contained females, and five contained males. Their nucleotide sequences presented 96-100% similarity with DENV-4 genotype II strains from Manaus, Amazonas. The minimum infection rate was 10.5 per 1000 specimens, and the maximum likelihood estimator of the infection rate was 11.6 (95% confidence interval: 4.8; 23.3). CONCLUSIONS: This study provides the first evidence of natural transovarial infection by DENV-4 in Ae. Aegypti in Mato Grosso, suggesting that this type of infection might serve as a mechanism of virus maintenance during interepidemic periods in Cuiabá, a city where dengue epidemics are reported every year. These results emphasize the need for efficient vector population control measures to prevent arbovirus outbreaks in the state. .
Descritores: Cinesina/metabolismo
Biossíntese de Proteínas
-Linhagem Celular
Centrifugação com Gradiente de Concentração
Técnicas de Silenciamento de Genes
Imunoprecipitação
Interfase
Cinesina/antagonistas & inibidores
Cinesina/genética
Microtúbulos/metabolismo
Iniciação Traducional da Cadeia Peptídica
Ligação Proteica
Pirimidinas/farmacologia
Interferência de RNA
Ribossomos/metabolismo
Tionas/farmacologia
Limites: Animais
Humanos
Camundongos
Tipo de Publ: Research Support, N.I.H., Extramural
Responsável: BR1.1 - BIREME


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Machado, Rosangela Zacarias
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Id: lil-731251
Autor: Sousa, Keyla Carstens Marques de; Herrera, Heitor Miraglia; Domingos, Iara Helena; Campos, João Bosco Vilela; Santos, Isabela Maria Campanelli dos; Neves, Haroldo Henrique; Machado, Rosangela Zacarias; André, Marcos Rogério.
Título: Serological detection of Toxoplasma gondii, Leishmania infantum and Neospora caninum in cats from an area endemic for leishmaniasis in Brazil / Detecção sorológica de Toxoplasma gondii, Leishmania infantum e Neospora caninum em gatos de uma área endêmica para leishmaniose no Brasil
Fonte: Rev. bras. parasitol. vet;23(4):449-455, Oct-Dec/2014. tab.
Idioma: en.
Projeto: FAPESP (São Paulo Research Foundation).
Resumo: An investigation was made into the occurrence of antibodies to Toxoplasma gondii, Leishmania infantum and Neospora caninum in 151 domestic cats, based on the indirect fluorescent antibody test (IFAT). Serum samples were collected from 151 domestic cats (65 free-roaming and 86 domiciled cats; 55 males and 96 females) in Campo Grande, Mato Grosso do Sul, Brazil between January and April 2013. IgG antibodies to T. gondii, L. infantum and N. caninum were found, respectively, in 49 (32.5%), 34 (22.5%) and 10 (6.6%) sampled cats. A positive correlation was found between T. gondii and N. caninum, T. gondii and L. infantum, and N. caninum and L. infantum (p <0.05) infections. Also, a significant interaction was identified between gender and area of activity on the probability of T. gondii (p = 0.0324) infection. However, no significant interaction was observed between gender and area of activity on infections by either N. caninum or L. infantum. This study showed that cats from an area endemic for visceral leishmaniasis in Brazil are exposed to three different protozoans, two of which are causal agents of important zoonosis.

O presente estudo teve como objetivo investigar a ocorrência de anticorpos anti-Toxoplasma gondii, Leishmania infantum e Neospora caninum, em 151 gatos, por meio da Reação de Imunofluorescência Indireta (RIFI). Entre os meses de janeiro e abril de 2013, amostras de soro foram coletadas de 151 gatos domésticos (65 gatos errantes e 86 gatos domiciliados; 55 machos e 96 fêmeas), de Campo Grande, Mato Grosso do Sul, Brasil. Anticorpos IgG anti-T. gondii, anti-L. infantum e anti-N. caninum foram encontrados em 49 (32,5%), 34 (22,5%) e 10 (6,6%) gatos amostrados, respectivamente. Verificou-se uma associação estatisticamente significativa entre as infecções por T. gondii e N. caninum, T. gondii e L. infantum e N. caninum e Leishmania infantum (p <0,05). Além disso, foi observada uma interação significativa entre sexo, área de atividade na probabilidade de infecção por T. gondii (p = 0,0324). No entanto, não foi observada interação significativa entre sexo e área de atividade nas infecções por N. caninum e L. infantum. Este estudo mostrou que os gatos de uma área endêmica brasileira para leishmaniose visceral são expostos a três diferentes protozoários, sendo dois deles importantes agentes zoonóticos.
Descritores: Aldeídos/química
Fatores Biológicos/síntese química
-Oxazóis/química
Estereoisomerismo
Esparteína/química
Tionas/química
Titânio/química
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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