Base de dados : LILACS
Pesquisa : D02.033.100 [Categoria DeCS]
Referências encontradas : 4 [refinar]
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Almeida, Mauro Vieira de
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Id: biblio-889147
Autor: Caneschi, César Augusto; Almeida, Angelina Maria de; Martins, Francislene Juliana; Hyaric, Mireille Le; Oliveira, Manoel Marques Evangelista; Macedo, Gilson Costa; Almeida, Mauro Vieira de; Raposo, Nádia Rezende Barbosa.
Título: In vitro antifungal activity of organic compounds derived from amino alcohols against onychomycosis
Fonte: Braz. j. microbiol;48(3):476-482, July-Sept. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Onychomycosis is a fungal infection of the nail caused by high densities of filamentous fungi and yeasts. Treatment for this illness is long-term, and recurrences are frequently detected. This study evaluated in vitro antifungal activities of 12 organic compounds derived from amino alcohols against standard fungal strains, such as Trichophyton rubrum CCT 5507 URM 1666, Trichophyton mentagrophytes ATCC 11481, and Candida albicans ATCC 10231. The antifungal compounds were synthesized from p-hydroxybenzaldehyde (4a-4f) and p-hydroxybenzoic acid (9a-9f). Minimum inhibitory concentrations and minimum fungicidal concentrations were determined according to Clinical and Laboratory Standards Institute protocols M38-A2, M27-A3, and M27-S4. The amine series 4b-4e, mainly 4c and 4e compounds, were effective against filamentous fungi and yeast (MIC from 7.8 to 312 µg/mL). On the other hand, the amide series (9a-9f) did not present inhibitory effect against fungi, except amide 9c, which demonstrated activity only against C. albicans. This allowed us to infer that the presence of amine group and intermediate carbon number (8C-11C) in its aliphatic side chain seems to be important for antifungal activity. Although these compounds present cytotoxic activity on macrophages J774, our results suggest that these aromatic compounds might constitute potential as leader molecules in the development of more effective and less toxic analogs that could have considerable implications for future therapies of onychomycosis.
Descritores: Amino Álcoois/farmacologia
Antifúngicos/farmacologia
Fungos/efeitos dos fármacos
Onicomicose/microbiologia
-Amino Álcoois/síntese química
Antifúngicos/síntese química
Avaliação Pré-Clínica de Medicamentos
Fungos/classificação
Fungos/fisiologia
Testes de Sensibilidade Microbiana
Onicomicose/tratamento farmacológico
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Almeida, Mauro Vieira de
Romanha, Alvaro José
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Id: lil-711731
Autor: Sales Júnior, Policarpo Ademar; Rezende Júnior, Celso Oliveira; Le Hyaric, Mireille; Almeida, Mauro Vieira de; Romanha, Alvaro José.
Título: The in vitro activity of fatty diamines and amino alcohols against mixed amastigote and trypomastigote Trypanosoma cruzi forms
Fonte: Mem. Inst. Oswaldo Cruz;109(3):362-364, 06/2014. graf.
Idioma: en.
Resumo: Four diamines and three amino alcohols derived from 1-decanol, 1-dodecanol and 1,2-dodecanediol were evaluated in an in vitro assay against a mixture of trypomastigote and intracellular amastigote forms of Trypanosoma cruzi. Two of these compounds (6 and 7) showed better activity against both proliferative stages of T. cruzi than the positive control benznidazole, three were of similar potency (1, 2 and 5) and two were less active (3 and 4).
Descritores: Amino Álcoois/farmacologia
Diaminas/farmacologia
Tripanossomicidas/farmacologia
Trypanosoma cruzi/efeitos dos fármacos
-Relação Dose-Resposta a Droga
Testes de Sensibilidade Parasitária
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-528076
Autor: OR Júnior, Celso; Le Hyaric, Mireille; Costa, Cristiane F da; Corrêa, Taís A; Taveira, Aline F; Araújo, Débora P; Reis, Elaine FC; Lourenço, Maria Cristina S; Vicente, Felipe RC; Almeida, Mauro V de.
Título: Preparation and antitubercular activity of lipophilic diamines and amino alcohols
Fonte: Mem. Inst. Oswaldo Cruz;104(5):703-705, Aug. 2009. ilus, tab.
Idioma: en.
Resumo: A series of diamines and amino alcohols derived from 1-dodecanol, 1-tetradecanol, 1,2-dodecanediol and 1,2-tetradecanediol were synthesized and tested for their antitubercular activity. Compounds 3, 8 and 9 were found to be the most active (MIC of 6.25 µg/mL). Nine other compounds displayed activity against Mycobacterium tuberculosis, with a MIC of 12.5 µg/mL.
Descritores: Amino Álcoois/farmacologia
Antituberculosos/farmacologia
Diaminas/farmacologia
Mycobacterium tuberculosis/efeitos dos fármacos
-Amino Álcoois/síntese química
Antituberculosos/química
Diaminas/síntese química
Testes de Sensibilidade Microbiana
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Madeira, Maria de Fátima
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Id: lil-502296
Autor: Ferrarini, Stela R; Graebin, Cedric S; Limberger, Jones; Canto, Rômulo F. S; Dias, Daiane O; Rosa, Ricardo G da; Madeira, Maria de Fátima; Eifler-Lima, Vera L.
Título: Synthesis of limonene β-amino alcohol derivatives in support of new antileishmanial therapies
Fonte: Mem. Inst. Oswaldo Cruz;103(8):773-777, Dec. 2008. ilus, tab.
Idioma: en.
Projeto: CAPES/MEC; . CNPq; . MCT/CNPq.
Resumo: A series of seven limonene β-amino alcohol derivatives has been regioselectively synthesised in moderate to good yields. Two of these compounds were found to be significantly effective against in vitro cultures of the Leishmania (Viannia) braziliensis promastigote form in the micromolar range. The activities found for 3b and 3f were about 100-fold more potent than the standard drug, Pentamidine, in the same test, while limonene did not display any activity. This is the first report of antileishmanial activity by limonene β-amino alcohol derivatives.
Descritores: Amino Álcoois/síntese química
Antiprotozoários/síntese química
Cicloexenos/química
Leishmania braziliensis/efeitos dos fármacos
Terpenos/química
-Amino Álcoois/farmacologia
Amino Álcoois/toxicidade
Antiprotozoários/farmacologia
Antiprotozoários/toxicidade
Cicloexenos/farmacologia
Cicloexenos/toxicidade
Estrutura Molecular
Testes de Sensibilidade Parasitária
Relação Estrutura-Atividade
Terpenos/farmacologia
Terpenos/toxicidade
Limites: Animais
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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