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Pesquisa : D02.033.100.291.630 [Categoria DeCS]
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Fotocópia
Solé, Dirceu
Id: lil-127768
Autor: Solé, Dirceu; Villalba, Silvia R; Sestelo, Mariestela R; Scalabrin, Deolinda M. F; Soares, Francisco J. P; Naspitz, Charles K.
Título: Maximum bronchodilator effect of pirbuterol and procaterol administered as sprays with and without an aerochamber
Fonte: Rev. paul. med;111(3):397-402, May-June 1993. tab.
Idioma: en.
Resumo: Objective of the study: To determine the maximal bronchodilator dose of procaterol and pirbuterol administered by inhalation with an without an aerochamber (Aerocâmera) to children with acute brinchial asthma attacks. Type of study: Prospective. 18 children (6-15 years of age) with acute bronchial asthma attacks (FEV1 < 80 per cents of the predicted value) received pirbuterol (N = 10) or procaterol (N = 8) by metered-dose inhaler, one puff every 5 minutes, for a total of five doses. During another acute attack, the same patient received the same medication with the aid of a spacer (Aerocâmera). Clinical evaluation and pulmonary function tests were performed 5 minutes after each inhaled dose. Results: For both drugs, maximal bronchodilation was obtained after the second dose. No significant side effects were observed even after procaterol doses of 50 µg or pirbuterol doses of 1000 µg. The results were unaffected by the use of the spacer. Conclusions: The doses that induced maximal bronchodilation were 400 µg pirbuterol and 20 µg procaterol Although the spacer did not change the results, it is a valuable aid for patients who have difficulty in using the metered-dose inhaler (M.D.I.)
Descritores: Asma/tratamento farmacológico
Etanolaminas/administração & dosagem
Procaterol/administração & dosagem
-Administração por Inalação
Etanolaminas/uso terapêutico
Procaterol/uso terapêutico
Estudos Retrospectivos
Espirometria
Fatores de Tempo
Limites: Seres Humanos
Masculino
Criança
Adolescente
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME



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