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Id: lil-675675
Autor: Brazilian Journal of Medical and Biological Research; Serafim, K.R.; Kishi, M.S.; Canto-de-Souza, A.; Mattioli, R..
Título: H1 but not H2 histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;46(5):440-446, maio 2013. tab, graf.
Idioma: en.
Projeto: FAPESP and CNPq.
Resumo: This study investigated the role of H1 and H2 receptors in anxiety and the retrieval of emotional memory using a Trial 1/Trial 2 (T1/T2) protocol in an elevated plus-maze (EPM). Tests were performed on 2 consecutive days, designated T1 and T2. Before T1, the mice received intraperitoneal injections of saline (SAL), 20 mg/kg zolantidine (ZOL, an H2 receptor antagonist), or 8.0 or 16 mg/kg chlorpheniramine (CPA, an H1 receptor antagonist). After 40 min, they were subjected to the EPM test. In T2 (24 h later), each group was subdivided into two additional groups, and the animals from each group were re-injected with SAL or one of the drugs. In T1, the Student t-test showed no difference between the SAL and ZOL or 8 mg/kg CPA groups with respect to the percentages of open arm entries (%OAE) and open arm time (%OAT). However, administration of CPA at the highest dose of 16 mg/kg decreased %OAE and %OAT, but not locomotor activity, indicating anxiogenic-like behavior. Emotional memory, as revealed by a reduction in open arm exploration between the two trials, was observed in all experimental groups, indicating that ZOL and 8 mg/kg CPA did not affect emotional memory, whereas CPA at the highest dose affected acquisition and consolidation, but not retrieval of memory. Taken together, these results suggest that H1 receptor, but not H2, is implicated in anxiety-like behavior and in emotional memory acquisition and consolidation deficits in mice subjected to EPM testing.
Descritores: Ansiedade/induzido quimicamente
Benzotiazóis/farmacologia
Clorfeniramina/farmacologia
Antagonistas dos Receptores Histamínicos H1/farmacologia
/farmacologia
HISTAMINE HTEMEFOS ANTAGONISTS/farmacologia
Transtornos da Memória/induzido quimicamente
Fenoxipropanolaminas/farmacologia
Piperidinas/farmacologia
Receptores Histamínicos H1/efeitos dos fármacos
-Aprendizagem em Labirinto
Microinjeções
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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