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Texto completo SciELO Brasil
Camargo, Zoilo Pires de
Moreira, Jose Luciano Bezerra
Rocha, Marcos Fábio Gadelha
Sidrim, José Júlio Costa
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Id: biblio-828189
Autor: Brilhante, Raimunda Sâmia Nogueira; Caetano, Érica Pacheco; Lima, Rita Amanda Chaves de; Marques, Francisca Jakelyne de Farias; Castelo-Branco, Débora de Souza Collares Maia; Melo, Charlline Vládia Silva de; Guedes, Glaucia Morgana de Melo; Oliveira, Jonathas Sales de; Camargo, Zoilo Pires de; Moreira, José Luciano Bezerra; Monteiro, André Jalles; Bandeira, Tereza de Jesus Pinheiro Gomes; Cordeiro, Rossana de Aguiar; Rocha, Marcos Fábio Gadelha; Sidrim, José Júlio Costa.
Título: Terpinen-4-ol, tyrosol, and ß-lapachone as potential antifungals against dimorphic fungi
Fonte: Braz. j. microbiol;47(4):917-924, Oct.-Dec. 2016. tab, graf.
Idioma: en.
Projeto: CNPq; . CAPES.
Resumo: Abstract This study aimed to evaluate the in vitro antifungal activity of terpinen-4-ol, tyrosol, and β-lapachone against strains of Coccidioides posadasii in filamentous phase (n = 22) and Histoplasma capsulatum in both filamentous (n = 40) and yeast phases (n = 13), using the broth dilution methods as described by the Clinical and Laboratory Standards Institute, to determine the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of these compounds. The mechanisms of action of these compounds were also investigated by analyzing their effect on cell membrane permeability and ergosterol synthesis. The MIC and MFCf these compounds against C. posadasii, mycelial H. capsulatum, and yeast-like H. capsulatum, were in the following ranges: 350-5720 µg/mL, 20-2860 µg/mL, and 40-1420 µg/mL, respectively for terpinen-4-ol; 250-4000 µg/mL, 30-2000 µg/mL, and 10-1000 µg/mL, respectively, for tyrosol; and 0.48-7.8 µg/mL, 0.25-16 µg/mL, and 0.125-4 µg/mL, respectively for β-lapachone. These compounds showed a decrease in MIC when the samples were subjected to osmotic stress, suggesting that the compounds acted on the fungal membrane. All the compounds were able to reduce the ergosterol content of the fungal strains. Finally, tyrosol was able to cause a leakage of intracellular molecules.
Descritores: Álcool Feniletílico/análogos & derivados
Terpenos/farmacologia
Naftoquinonas/farmacologia
Fungos/efeitos dos fármacos
Antifúngicos/farmacologia
-Pressão Osmótica
Álcool Feniletílico/farmacologia
Testes de Sensibilidade Microbiana
Permeabilidade da Membrana Celular/efeitos dos fármacos
Ergosterol/metabolismo
Fungos/classificação
Fungos/metabolismo
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
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Id: biblio-893194
Autor: Turgut, Fethiye Gülden; Özevren, Hüseyin; Yildirim, M; Deveci, E.
Título: Effects of caffeic acid phenethyl ester on retinal damage after traumatic brain injury / Efectos del ester fenetílico del ácido cafeico en el daño de la retina después de una lesion cerebral traumática
Fonte: Int. j. morphol;36(1):97-103, Mar. 2018. tab, graf.
Idioma: en.
Resumo: SUMMARY: Head trauma damages the optic nerve visual function and visual acuity.Effects of head trauma on the retina was investigated with biochemical, histological and immunohistochemical respects.The study was conducted on 30 rats with three groups: group 1 was control group (n=10). Second group was head-traumatized group (n=10) and last group was head-traumatized+Caffeic acid phenethyl ester (CAPE, i.p. 20ml/kg/day). Upon head was traumatized, CAPE was applied to trauma+CAPE group and then for the following four days. At the end of 5th day, rats were anesthetized with ketamine hydroxide and then blood samples were taken for biochemical analysis. MDA and GSH-Px values were compared. After blood sample, total eyes of rats were dissected for histopathological and immunohistochemical analysis. In trauma group, degeneration in retinal photoreceptor cells, disintegrity and in inner and outer nuclear layers, hypertrophy in ganglion cells, and hemorrhage in blood vessels were observed. In the group treated with CAPE, lesser degeneration in photoreceptor cells, regular appearances of inner and outer nuclear layers, mild hemorrhage in blood vessels of ganglionic cell layer were observed. The apoptotic changes caused by trauma seen in photoreceptor and ganglionic cells were decreased and cellular organization was preserved due to CAPE treatment. CAPE was thought to induce healing process on traumatic damages.

RESUMEN: El trauma craneal daña la función visual del nervio óptico y la agudeza visual. Se investigaron los efectos del traumatismo craneal en la retina con aspectos bioquímicos, histológicos e inmunohistoquímicos. El estudio se realizó en 30 ratas distribuidas en tres grupos: grupo control (n = 10); grupo con traumatismo craneal (n = 10); grupo con traumatismo craneoencefálico + Éster fenetílico de ácido cafeico (CAPE, i.p. 20 ml / kg / día). Sobre la cabeza traumatizada, se aplicó CAPE a trauma + grupo CAPE durante los siguientes cuatro días. Al final del día 5, las ratas se anestesiaron con hidróxido de ketamina y luego se tomaron muestras de sangre para el análisis bioquímico. Se compararon los valores de MDA y GSH-Px. Después de la muestra de sangre, se disecaron los ojos de las ratas para su análisis histopatológico e inmunohistoquímico. En el grupo de traumatismos, se observó degeneración en las células fotorreceptoras retinianas, desintegridad en capas nucleares internas y externas, hipertrofia en células ganglionares y hemorragia en los vasos sanguíneos. En el grupo tratado con CAPE, se observó una menor degeneración en las células fotorreceptoras, apariciones regulares de capas nucleares internas y externas, hemorragia leve en los vasos sanguíneos de la capa de células ganglionares. Los cambios apoptóticos causados por el trauma visto en el fotorreceptor y las células ganglionares disminuyeron y la organización celular se conservó debido al tratamiento con CAPE. Se concluyó que CAPE induce un proceso de curación en daños traumáticos.
Descritores: Ácidos Cafeicos/administração & dosagem
Álcool Feniletílico/administração & dosagem
Doenças Retinianas/tratamento farmacológico
Retina/efeitos dos fármacos
-Lesões Encefálicas Traumáticas/patologia
Glutationa Peroxidase/análise
Imuno-Histoquímica
Malondialdeído/análise
Álcool Feniletílico/análogos & derivados
Ratos Sprague-Dawley
Doenças Retinianas/patologia
Retina/patologia
Limites: Animais
Masculino
Ratos
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Chile
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Id: biblio-840945
Autor: Görkem, Ümit; Togrul, Cihan; Sahin, Izzet; Coskun, Bugra; Ozat, Mustafa; Güngör, Tayfun; Deveci, Engin.
Título: Protective effect of caffeic acid phenethyl ester (CAPE) on ischemia­ reperfusion injury in rat ovary / Efecto protector de ester feniletílico de ácido cafeico (CAPE) en la lesión por isquemia-reperfusión en ovario de rata
Fonte: Int. j. morphol;35(1):141-147, Mar. 2017. ilus.
Idioma: en.
Resumo: The aim of this study was to investigate the effects of caffeic acid phenethyl ester (CAPE) as a prophylactic agent on ischemia/reperfusion (I/R) injury in the rat ovary. A total of 28 Wistar rats were divided into 4 equal groups: (I) sham, (II) ischemia, (III) ischemia + reperfusion, and (IV) IR + CAPE. In groups I and II, ovary torsion was not performed and no drug was administered. In group III, 1 hour of ischemia and 2 hours of reperfusion were performed and no drug was given. Ovarian tissue concentrations of malondialdehyde were significantly higher in the torsion and detorsion groups compared with the sham and Cape groups (P<0.005). The detorsion group showed preantral ovarian follicles and luteal folicules around the blood vessels and positive expression of CD34. In the CAPE group the stromal vascular endothelium with weak expression of CD34 was detected in small areas, and the ovarian follicles and the corpus luteum showed negative expression of CD34. In the study, Biochemical and histopathological results of CAPE treatment was considered to torsion-detorsioned the model showed a protective effect against tissue damage.

El objetivo de este trabajo consistió en investigar los efectos del éster fenetílico del ácido cafeico (EFAC) como agente profiláctico en la lesión por isquemia/reperfusión (I / R) en el ovario de rata. Un total de 28 ratas Wistar se dividieron en 4 grupos iguales: (I) control, (II) isquemia, (III) isquemia + reperfusión, y (IV) IR + EFAC. En los grupos I y II, no se realizó torsión ovárica y no se administró ningún fármaco. En el grupo III, se provocó una hora de isquemia, dos horas de reperfusión y no se administró ningún fármaco. Las concentraciones de malondialdehído en los tejidos ováricos fueron significativamente mayores en los grupos de torsión y de destorsión, en comparación con los grupos sham y de EFAC (P <0,005). El grupo de destorsión mostró folículos ováricos preantrales y folículos lúteos alrededor de los vasos sanguíneos y expresión positiva de CD34. En el grupo EFAC el endotelio vascular estromal con expresión débil de CD34 se detectó en áreas pequeñas, y los folículos ováricos y el cuerpo lúteo mostraron expresión negativa de CD34. En el estudio, fueron considerados los resultados bioquímicos e histopatológicos del tratamiento EFAC en relación a la torsión-destorsión, desarrollando un modelo que mostró un efecto protector contra el daño tisular.
Descritores: Ácidos Cafeicos/farmacologia
Ovário/efeitos dos fármacos
Álcool Feniletílico/farmacologia
Traumatismo por Reperfusão/tratamento farmacológico
Limites: Animais
Feminino
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: lil-691811
Autor: Santos, Jeanine Salles dos.
Título: Avaliação da aspirina e do ácido cafeico fenetil ester sobre o reparo tecidual cutâneo / Assessment of aspirin and caffeic acid phenethyl ester on the cutaneous tissue repair.
Fonte: Rio de Janeiro; s.n; 2012. 75 p. ilus.
Idioma: pt.
Tese: Apresentada a Universidade do Estado do Rio de Janeiro. Instituto de Biologia Roberto Alcântara Gomes para obtenção do grau de Doutor.
Resumo: Numerosos modelos in vitro e in vivo foram desenvolvidos para estudar o reparo de lesões e identificar os mecanismos chave deste processo. Visando avaliar o processo de cicatrização utilizamos um modelo de lesão excisional total e um modelo de queimadura promovida por escaldamento. No estudo utilizando o modelo de lesão excisional total, abordamos o uso da aspirina (um inibidor não seletivo da COX) e seu efeito diferenciado sobre os sexos na cicatrização cutânea de camundongos. Observamos que os grupos fêmea controle e tratado apresentaram contração atrasada comparado aos grupos macho controle e tratado, respectivamente. Entre os grupos fêmea e macho controles, as fêmeas apresentaram menor atividade da mieloperoxidase e menor quantidade de células MIF-positivas do que os machos controle. Já entre os grupos fêmea e macho tratados, foi observado que nas fêmeas tratadas, a atividade da mieloperoxidase e a quantidade de macrófagos F4/80-positivos estavam maiores do que no grupo macho tratado. Ainda entre os grupos tratados, as fêmeas apresentaram menores níveis de hidroxiprolina e maior expressão proteica de vWF e VEGF comparado aos machos. No estudo das lesões causadas por queimadura, avaliamos as propriedades anti- inflamatórias e antioxidantes do ácido cafeico fenetil ester (CAPE) no reparo destas lesões e observamos que em 7, 14, 21 e 70 dias após a queimadura, o grupo queimado+CAPE apresentou menor área lesada, além de menor atividade da mieloperoxidase e dos níveis de nitrito do que o grupo queimado. Também foi observado que no grupo queimado+CAPE a expressão proteica de CD68 e de PECAM-1 estava reduzida comparada ao grupo queimado. Analisando os parâmetros de dano oxidativo foi observado que os níveis de MDA e de proteínas carboniladas estavam menores no grupo queimado+CAPE do que no grupo queimado, tanto no plasma quanto na lesão. Em suma, nosso estudo avaliou o processo de cicatrização de dois modelos de lesão, em roedores de diferentes espécies ...

Several in vitro and in vivo models have been developed to study wound healing and to identify key mechanisms of this process. The most of these studies use animals models to reproduce the human physiology and possible therapeutic treatments. In order to evaluate the wound healing process in different wound models, we use a full-thickness excisional wound model and a burn model promoted by scalding. In the full-thickness excisional wound study, we approach the aspirin use (COX non-selective inhibitor) and its distinct effect on the gender in cutaneous wound healing on mice. It was observed that both female control and treated groups presented smaller wound area than male control and treated groups, respectively. Between female and male control groups, the females presented smaller myeloperoxidase activity and MIF-positive cells than control males. Comparing female and male treated groups it was observed that in female treated group, the myeloperoxidase activity and the F4/80-positive macrophages amount were greater than male treated group. Also between the treated groups, the females presented smaller hydroxyproline levels and greater vWF and VEGF protein expression compared to the males. In study of the burns performed by scalding, it was evaluated the caffeic acid phenethyl ester (CAPE) anti-inflammatory and antioxidant properties on repair of these lesions. It was observed that at 7, 14, 21 and 70 days after burning, the burn+CAPE group presented smaller wound area, beyond smaller myeloperoxidase activity and nitrite levels than burn group. It was also observed that the burn+CAPE group presented smaller CD68 and PECAM-1 protein expression compared to burn group. Analyzing the oxidative damage parameters, it was observed that the MDA and carbonilated proteins levels were greater in the burn group compared to burn+CAPE group. In conclusion, our study evaluated the wound healing process in 2 wound models on distinct rodent species with distinct approaches ...
Descritores: Aspirina/uso terapêutico
Cicatrização
Pele/lesões
-Ácidos Cafeicos/farmacologia
Ácidos Cafeicos/uso terapêutico
Álcool Feniletílico/análogos & derivados
Ferimentos e Lesões/tratamento farmacológico
Tecido de Granulação
Queimaduras/tratamento farmacológico
Fatores Sexuais
Limites: Animais
Camundongos
Responsável: BR1365.1 - Biblioteca Biomédica A - CB/A
BR1365.1


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Texto completo SciELO Brasil
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Id: lil-595674
Autor: Korish, Aida Abdelhamid; Arafa, Maha Mohamed.
Título: Propolis derivatives inhibit the systemic inflammatory response and protect hepatic and neuronal cells in acute septic shock
Fonte: Braz. j. infect. dis;15(4):332-338, July-Aug. 2011. ilus, tab.
Idioma: en.
Projeto: College of Medicine Research Center; . King Saud University. College of Medicine Research Center, Faculty of Medicine.
Resumo: BACKGROUND: Severe pathogenic infection triggers excessive release of cytokines as part of the massive inflammatory response associated with septic shock. OBJECTIVES: To investigate the protective effect of caffeic acid phenethye ester (CAPE) against lipopolysaccharide (LPS) induced endotoxemia, hepatic and neuronal damage and the associated systemic inflammatory response (SIR). METHODS: Fifty male Wister rats were divided into: control, LPS, and CAPE+LPS groups. Plasma concentrations of various cytokines, including TNF-α, IL-1α, IL-1β, IL-6, IL-4, IL-10, and sICAM-1 were evaluated. In addition, the histopathological changes in the hepatic and neural cells were assessed. RESULTS: The LPS group showed high inflammatory cytokines and sICAM-1 levels reflecting the presence of SIR. Hepatocyte necrosis, apoptosis, extensive hemorrhage and inflammatory cellular infiltration together with brain astrocytes swelling, early neuron injury and presence of inflammatory foci confirmed the toxic tissue damage. Use of CAPE decreased the inflammatory cytokines and increased the anti-inflammatory cytokines levels. This biochemical evidence of decreased SIR was confirmed histologically by decreased cellular infiltration in the liver and brain tissue which coincides with preserved structure and protection of the liver and brain cells from the toxic effects of LPS. CONCLUSION: The ability of CAPE to alleviate the SIR, hepatic and neuronal cell damage induced by LPS and galactosamine could be attributed to its ability to reverse the imbalance of the pro- and anti-inflammatory cytokines which may lead to the inhibition of adhesion molecules' expression. CAPE is a promising agent that could help in the prophylaxis and treatment of septic shock.
Descritores: Encéfalo/patologia
Ácidos Cafeicos/uso terapêutico
Citocinas/sangue
Endotoxemia/prevenção & controle
Fígado/patologia
Álcool Feniletílico/análogos & derivados
Choque Séptico/prevenção & controle
Síndrome de Resposta Inflamatória Sistêmica/prevenção & controle
-Encéfalo/efeitos dos fármacos
Endotoxemia/sangue
Endotoxemia/induzido quimicamente
Galactosamina/farmacologia
Lipopolissacarídeos/farmacologia
Fígado/efeitos dos fármacos
Álcool Feniletílico/uso terapêutico
Ratos Wistar
Choque Séptico/sangue
Choque Séptico/induzido quimicamente
Choque Séptico/patologia
Síndrome de Resposta Inflamatória Sistêmica/sangue
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-65227
Autor: Banthorpe, Derek V; Branch, Stephanie A; Grey, Thomas J.
Título: Initial stages of the oxidate-catabolism of monoterpenes and 2-phenylethanol in Rosa Damascena cultures
Fonte: Arch. biol. med. exp;21(1):23-41, jun. 1988. tab, ilus.
Idioma: en.
Descritores: Álcool Feniletílico/metabolismo
Terpenos/metabolismo
-Extratos Vegetais/metabolismo
Responsável: CL1.1 - Biblioteca Central



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