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Texto completo SciELO Chile
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Id: biblio-954136
Autor: Núñez-R, Daniela; Balboa-P, Natalia; Quilaqueo-P, Nelson; Alvear-Z, Marysol; Paredes-H, Marco.
Título: Evaluación de la actividad inmunomoduladora de extractos metanólicos y de alcaloides de Berberis darwinii H. (Berberidaceae) / Evaluation of the immunomodulatory activity of methanolic extracts and alkaloids of Berberis darwinii H. (Berberidaceae)
Fonte: Int. j. morphol;36(2):454-459, jun. 2018. graf.
Idioma: es.
Projeto: Departamento de Ciencias Básicas, de Ciencias Químicas y Recursos Naturales y al BIOREN de la Universidad de La Frontera; . CONICYT.
Resumo: Berberis darwinii Hook es una especie que habita el sur de Chile y la Patagonia, utilizada por la etnia mapuche para el tratamiento de procesos inflamatorios, estados febriles y dolor de estomacal. El propósito del siguiente estudio fue evaluar in vitro las propiedades del extracto total y de alcaloides de raíz de B. darwinii sobre viabilidad celular y la translocación del factor nuclear NF-kB en línea celular RAW 264.7. Se observó que los extractos no afectan negativamente la viabilidad en las células e inhibieron la translocación del factor nuclear NF-kB asociado a la modulación de la inflamación solo frente al extracto total. Estos resultados indicarían que B. darwinii podría inhibir algunos mecanismos específicos de la defensa celular al modular la translocación de NF- kB.

Berberis darwinii Hook is a species that inhabits southern Chile and Patagonia, used by the Mapuche ethnic group for the treatment of inflammatory processes, febrile states and stomach pain. The purpose of the following study was to evaluate in vitro the properties of the total extract and alkaloids of the root of B. darwinii on cell viability and the translocation of the nuclear factor NF-kB in cell line RAW 264.7. It was observed that the extracts did not negatively affect the viability in the cells and inhibited the translocation of the nuclear factor NF-kB associated with the modulation of inflammation only against the total extract. These results indicate that B. darwinii could inhibit some specific mechanisms of cell defense by modulating the translocation of NF-kB.
Descritores: Extratos Vegetais/farmacologia
NF-kappa B/efeitos dos fármacos
Berberis
Células RAW 264.7/efeitos dos fármacos
-Sobrevivência Celular/efeitos dos fármacos
Imunofluorescência
Raízes de Plantas
Metanol
Alcaloides/farmacologia
Citometria de Fluxo
Fatores Imunológicos/farmacologia
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1134450
Autor: Haque, Ziaul; Rahman, Asabur; Khan, Zahirul Islam; Hussan, Mohammad Tufazzal; Alam, Mahmudul.
Título: Alcohol-based fixatives can better preserve tissue morphology than formalin / Fijadores a base de alcohol pueden preservar mejor la morfología tisular que la formalina
Fonte: Int. j. morphol;38(5):1371-1375, oct. 2020. tab, graf.
Idioma: en.
Resumo: SUMMARY: Fixation is a crucial step in processing of tissue specimen for preservation of cellular architecture and composition of cells. Alcohol-based fixatives are considered some of the most promising alternatives to formalin. We evaluated the performance of alcohol-based fixatives (EthMeth and methacarn) and formalin as a comparator fixative in the research laboratory. Following 24 hours of fixation, tissue morphology and cellular details of the liver, spleen and brain (cerebral cortex) were evaluated. Morphological characteristics were evaluated by gross observations and analyzing cellular details, tissue architecture and overall staining characteristics (Hematoxylin and Eosin). EthMeth and methacarn fixation gave generally comparable and satisfactory results on the tissue morphology and subsequent identification of tissue characteristics. Particularly, tissues were well preserved and all nuclear as well as cytoplasmic details were clearly visible. However, formalin fixed tissues showed some peculiarity such as improper fixation, mild shrinkage, and alterations of tissue components. These results confirm that alcohol-based fixation is the superior alternative to formalin for preservation of tissue morphology. However, it is required to standardize the formalin-free methods and harmonize diagnosis in the laboratory worldwide.

RESUMEN: La fijación es un paso crucial en el procesamiento de muestras de tejido para preservar la arquitectura celular y la composición de las células. Los fijadores a base de alcohol se consideran algunas de las alternativas más prometedoras a la formalina. Evaluamos el rendimiento de los fijadores a base de alcohol (EthMeth y metacarn) y formalina como fijador comparativo en el laboratorio de investigación. Después de 24 horas de fijación, se observó la morfología del tejido y los detalles celulares del hígado, bazo y corteza cerebral. Se evaluaron las características morfológicas mediante observaciones generales y analizando detalles celulares, arquitectura de tejidos y características generales de tinción (hematoxilina y eosina). La fijación de EthMeth y metacarn dio resultados generalmente comparables y satisfactorios en la morfología del tejido y la posterior identificación de las características del mismo. Particularmente, los tejidos estaban bien conservados y todos los detalles nucleares y citoplasmáticos eran claramente visibles. Sin embargo, los tejidos fijados con formalina mostraron cierta peculiaridad, tal como una fijación inadecuada, la contracción leve y alteraciones de los componentes del tejido. Estos resultados confirman que la fijación a base de alcohol es la mejor alternativa a la formalina, para preservar la morfología del tejido. Sin embargo, es necesario estandarizar los métodos sin formalina y armonizar el diagnóstico en los laboratorios.
Descritores: Fixação de Tecidos/métodos
Álcoois/química
Fixadores
Formaldeído/química
-Clorofórmio/química
Ácido Acético/química
Metanol/química
Tipo de Publ: Estudo Comparativo
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1249336
Autor: Souza, T F G; Pierdoná, T M; Macedo, F S; Aquino, P E A; Rangel, G F P; Duarte, R S; Silva, L M A; Viana, G S B; Alves, A P N N; Montenegro, R C; Wilke, D V; Silveira, E R; Alencar, N M N.
Título: A proline derivative-enriched methanol fraction from Sideroxylon obtusifolium leaves (MFSOL) stimulates human keratinocyte cells and exerts a healing effect in a burn wound model
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;54(9):e10700, 2021. tab, graf.
Idioma: en.
Resumo: It was previously demonstrated that the methanol fraction of Sideroxylon obtusifolium (MFSOL) promoted anti-inflammatory and healing activity in excisional wounds. Thus, the present work investigated the healing effects of MFSOL on human keratinocyte cells (HaCaT) and experimental burn model injuries. HaCaT cells were used to study MFSOL's effect on cell migration and proliferation rates. Female Swiss mice were subjected to a second-degree superficial burn protocol and divided into four treatment groups: Vehicle, 1.0% silver sulfadiazine, and 0.5 or 1.0% MFSOL Cream (CrMFSOL). Samples were collected to quantify the inflammatory mediators, and histological analyses were performed after 3, 7, and 14 days. The results showed that MFSOL (50 μg/mL) stimulated HaCaT cells by increasing proliferation and migration rates. Moreover, 0.5% CrMFSOL attenuated myeloperoxidase (MPO) activity and also stimulated the release of interleukin (IL)-1β and IL-10 after 3 days of treatment. CrMFSOL (0.5%) also enhanced wound contraction, promoted improvement of tissue remodeling, and increased collagen production after 7 days and VEGF release after 14 days. Therefore, MFSOL stimulated human keratinocyte (HaCaT) cells and improved wound healing via modulation of inflammatory mediators of burn injuries.
Descritores: Queimaduras/tratamento farmacológico
Sapotaceae
-Prolina
Queratinócitos
Folhas de Planta
Metanol
Limites: Humanos
Feminino
Responsável: BR1.1 - BIREME


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Id: biblio-1254836
Autor: Pérez-Rodriguez, Saumel; Ramírez, Octavio T; Trujillo-Roldán, Mauricio A; Valdez-Cruz, Norma A.
Título: Comparison of protein precipitation methods for sample preparation prior to proteomic analysis of Chinese hamster ovary cell homogenates
Fonte: Electron. j. biotechnol;48:86-94, nov. 2020. tab, graf, ilus.
Idioma: en.
Projeto: Consejo Nacional de Ciencia y Tecnología CONACyT-México; . Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica, Universidad Nacional Autónoma de México, PAPIIT-UNAM; . Institutional Program of the Instituto de Investigaciones Biomédicas-UNAM.
Resumo: BACKGROUND: Chinese hamster ovary (CHO) cells are the workhorse for obtaining recombinant proteins. Proteomic studies of these cells intend to understand cell biology and obtain more productive and robust cell lines for therapeutic protein production in the pharmaceutical industry. Because of the great importance of precipitation methods for the processing of samples in proteomics, the acetone, methanol-chloroform (M/C), and trichloroacetic acid (TCA)-acetone protocols were compared for CHO cells in terms of protein recovery, band pattern resolution, and presence on SDS-PAGE. RESULTS: Higher recovery and similar band profile with cellular homogenates were obtained using acetone precipitation with ultrasonic bath cycles (104.18 ± 2.67%) or NaOH addition (103.12 ± 5.74%), compared to the other two protocols tested. TCA-acetone precipitates were difficult to solubilize, which negatively influenced recovery percentage (77.91 ± 8.79%) and band presence. M/C with ultrasonic homogenization showed an intermediate recovery between the other two protocols (94.22 ± 4.86%) without affecting protein pattern on SDS-PAGE. These precipitation methods affected the recovery of low MW proteins (< 15 kDa). CONCLUSIONS: These results help in the processing of samples of CHO cells for their proteomic study by means of an easily accessible, fast protocol, with an almost complete recovery of cellular proteins and the capture of the original complexity of the cellular composition. Acetone protocol could be incorporated to sample-preparation workflows in a straightforward manner and can probably be applied to other mammalian cell lines as well.
Descritores: Proteínas Recombinantes
Células CHO
Proteômica/métodos
-Acetona
Precipitação Química
Solubilidade
Ácido Tricloroacético
Separação Celular
Clorofórmio
Técnicas de Cultura de Células
Metanol
Eletroforese em Gel de Poliacrilamida
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1045593
Autor: Sahin, S; Solak, S; Akyol, O; Vatansever, S; Ozyuvaci, E.
Título: Transdermal methyl alcohol intoxication cause of pain relief / Intoxicación transdérmica con alcohol metílico tratando de aliviar un dolor
Fonte: West Indian med. j;62(1):84-86, Jan. 2013. ilus, tab.
Idioma: en.
Resumo: A 60-year old female patient was found comatosed at home and taken to the hospital's Emergency Department by her relatives. It was learnt that she wrapped her knees with spirit-impregnated cotton pad for pain for one week. On physical examination, only a colour change of purple violet on her knees was noted. Metabolic acidosis with increased anion gap was detected by arterial blood analysis. The patient underwent haemodialysis. She was discharged from the hospital with no complaints, alert and rational following five days of follow-up treatment, with the diagnosis of methyl alcohol poisoning.

Una paciente de 60 años de edad fue hallada en estado comatoso en su casa, y trasladada por sus familiares al departamento de emergencias del hospital. Se supo que la paciente había sentido dolor en sus rodillas, y las cubrió con almohadillas de algodón impregnadas de metanol por espacio de una semana. Al realizarse el examen físico, sólo se observó un cambio de color violeta púrpura en sus rodillas. El análisis de sangre arterial reveló acidosis metabólica con hiato iónico elevado. A la paciente se le practicó una hemodiálisis. Fue dada de alta del hospital sin dolencias, consciente, y en su sano juicio, luego de cinco días de seguimiento de su tratamiento, tras de haber sido diagnosticada con envenamiento por alcohol metílico.
Descritores: Acidose/induzido quimicamente
Diálise Renal
Artralgia/tratamento farmacológico
Metanol/efeitos adversos
-Resultado do Tratamento
Metanol/administração & dosagem
Manejo da Dor
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-990033
Autor: Azubuike, Nkiruka C; Okwuosa, Chukwugozie N; Maduakor, Uzoamaka C; Onwukwe, Okechukwu S; Onyemelukwe, Anulika O; Ogu, Cornelius O; Ikele, Ikenna T; Oparah, Chioma L; Akande, Adeniyi.
Título: Effects of methanolic extract of Brassica juncea seeds on biochemical parameters and histological integrity of the heart and liver of albino rats / Efectos del extracto metanólico de las semillas de Brassica juncea sobre los parámetros bioquímicos y la integridad histológica del corazón y el hígado de ratas albinas
Fonte: Int. j. morphol;37(1):237-240, 2019. tab, graf.
Idioma: en.
Resumo: SUMMARY: Brassica juncea (Indian mustard) seeds are consumed in treatment of high blood pressure, headache and prevention of heart disease. The aim of the present study was to investigate the effects of methanol extract of Brassica juncea seeds [BJME] on the heart and liver of adult Albino Wistar rats. A total of 24 albino rats of both sexes were divided into 6 groups [I - VI] of 4 rats per group. Groups I to IV received graded doses of the methanol extract by oral gavage while groups V and VI (controls) received 2 ml/kg body weight of 3 % Tween 80 and water respectively via oral gavage once daily. Treatment lasted for four weeks and the serum levels of aspartate transaminase (AST), alanine transaminase (ALT) and alkaline phosphatase (ALP) were estimated. The animals were sacrificed and the heart and liver tissues were excised for further histological processing for light microscopy. There was significant increase in AST and ALT levels following BJME treatment when compared to the controls. ALP activity did not differ significantly among the treatment and control groups. Histopathological changes consistent with toxic injury were observed in the heart and liver tissues of BJME- treated rats. In conclusion, the results of this study show that sub-acute administration of methanol seed extract of Brassica juncea can exert cardiotoxic and hepatotoxic effects in rats.

RESUMEN: Las semillas de Brassica juncea (mostaza india) se consumen en el tratamiento de la hipertensión arterial, el dolor de cabeza y la prevención de enfermedades del corazón. El objetivo del presente estudio fue investigar los efectos del extracto de metanol de semillas de Brassica juncea [BJME] en el corazón y el hígado de ratas Albino Wistar adultas. Un total de 24 ratas albinas de ambos sexos se dividieron en 6 grupos [I - VI] de 4 ratas por grupo. Los grupos I a IV recibieron dosis del extracto de metanol por sonda oral progresivamente, mientras que los grupos V y VI (control) recibieron 2 ml / kg de peso corporal de 3 % de 80 y agua, respectivamente, por sonda oral una vez al día. El tratamiento duró cuatro semanas y se estimaronlos niveles séricos de aspartato transaminasa (AST), alanina transaminasa (ALT) y fosfatasa alcalina (ALP). Los animales se sacrificaron y fueron analizados los tejidos del corazón y el hígado, para un procesamiento histológico adicional con microscopía óptica. Hubo un aumento significativo en los niveles de AST y ALT después del tratamiento con BJME en comparación con los controles. La actividad de ALP no difirió significativamente entre los grupos de tratamiento y control. Se observaron cambios histopatológicos compatibles con lesiones tóxicas en los tejidos del corazón y el hígado de ratas tratadas con BJME. En conclusión, los resultados de este estudio muestran que la administración subaguda de extracto de semilla de metanol de Brassica juncea puede ejercer efectos cardiotóxicos y hepatotóxicos en ratas.
Descritores: Extratos Vegetais/farmacologia
Metanol/farmacologia
Coração/efeitos dos fármacos
Fígado/efeitos dos fármacos
Mostardeira/química
-Aspartato Aminotransferases/análise
Sementes
Fatores de Tempo
Extratos Vegetais/administração & dosagem
Ratos Wistar
Alanina Transaminase/análise
Metanol/administração & dosagem
Fosfatase Alcalina/análise
Limites: Animais
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950716
Autor: Hung, Tran Manh; Dang, Nguyen Hai; Dat, Nguyen Tien.
Título: Methanol extract from Vietnamese Caesalpinia sappan induces apoptosis in HeLa cells
Fonte: Biol. Res;47:1-5, 2014. ilus, graf, tab.
Idioma: en.
Projeto: Vietnam National Foundation for Science and Technology Development.
Resumo: BACKGROUND: This study evaluated the cytotoxic activity of extracts from Caesalpinia sappan heartwood against multiple cancer cell lines using an MTT cell viability assay. The cell death though induction of apoptosis was as indicated by DNA fragmentation and caspase-3 enzyme activation. RESULTS: A methanol extract from C. sappan (MECS) showed cytotoxic activity against several of the cancer cell lines. The most potent activity exhibited by the MECS was against HeLa cells with an IC50 value of 26.5 ± 3.2 µg/mL. Treatment of HeLa cells with various MECS concentrations resulted in growth inhibition and induction of apoptosis, as indicated by DNA fragmentation and caspase-3 enzyme activation. CONCLUSION: This study is the first report of the anticancer properties of the heartwood of C. sappan native to Vietnam. Our findings demonstrate that C. sappan heartwood may have beneficial applications in the field of anticancer drug discovery.
Descritores: Extratos Vegetais/farmacologia
Apoptose
Caesalpinia/química
Feixe Vascular de Plantas/metabolismo
Antineoplásicos Fitogênicos/farmacologia
-Sais de Tetrazólio
Vietnã
Ensaios de Seleção de Medicamentos Antitumorais/métodos
Células HeLa
Sobrevivência Celular
Concentração Inibidora 50
Citotoxinas/farmacologia
Linhagem Celular Tumoral
Proliferação de Células/efeitos dos fármacos
Metanol
Ativação Enzimática/efeitos dos fármacos
Caspase 3/metabolismo
Fragmentação do DNA
Formazans
Inibidores do Crescimento/farmacologia
Indicadores e Reagentes
Camundongos Endogâmicos C57BL
Antineoplásicos Fitogênicos/isolamento & purificação
Limites: Humanos
Animais
Feminino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950720
Autor: Chaudhuri, Dipankar; Ghate, Nikhil Baban; Deb, Shampa; Panja, Sourav; Sarkar, Rhitajit; Rout, Jayashree; Mandal, Nripendranath.
Título: Assessment of the phytochemical constituents and antioxidant activity of a bloom forming microalgae Euglena tuba
Fonte: Biol. Res;47:1-11, 2014. graf, tab.
Idioma: en.
Resumo: BACKGROUND: Unstable generation of free radicals in the body are responsible for many degenerative diseases. A bloom forming algae Euglena tuba growing abundantly in the aquatic habitats of Cachar district in the state of Assam in North-East India was analysed for its phytochemical contents, antioxidant activity as well as free radical scavenging potentials. RESULTS: Based on the ability of the extract in ABTS•+ radical cation inhibition and Fe3+ reducing power, the obtained results revealed the prominent antioxidant activity of the algae, with high correlation coefficient of its TEAC values to the respective phenolic and flavonoid contents. The extract had shown its scavenging activity for different free radicals and 41.89 ± 0.41 µg/ml, 5.83 ± 0.07 µg/ml, 278.46 ± 15.02 µg/ml and 223.25 ± 4.19 µg/ml were determined as the IC50 values for hydroxyl, superoxide, nitric oxide and hypochlorous acid respectively, which are lower than that of the corresponding reference standards. The phytochemical analysis also revealed that the phenolics, flavonoids, alkaloids, tannins and carbohydrates are present in adequate amount in the extract which was confirmed by HPLC analysis. CONCLUSIONS: The results showed that 70% methanol extract of the algae possesses excellent antioxidant and free radical scavenging properties.
Descritores: Extratos Celulares/química
Sequestradores de Radicais Livres/metabolismo
Substâncias Redutoras/metabolismo
Euglena/química
Antioxidantes/metabolismo
-Oxirredução
Fenóis/análise
Ácido Ascórbico/análise
Taninos/análise
Flavonoides/análise
Peroxidação de Lipídeos/efeitos dos fármacos
Cromanos/metabolismo
Cromatografia Líquida de Alta Pressão
Metanol
Alcaloides/análise
Microalgas
Glucose/análise
Índia
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950753
Autor: Zeb, Anwar; Sadiq, Abdul; Ullah, Farhat; Ahmad, Sajjad; Ayaz, Muhammad.
Título: Phytochemical and toxicological investigations of crude methanolic extracts, subsequent fractions and crude saponins of Isodon rugosus
Fonte: Biol. Res;47:1-6, 2014. tab.
Idioma: en.
Resumo: BACKGROUND: Isodon rugosus is used traditionally in the management of hypertension, rheumatism, tooth-ache and pyrexia. Present study was arranged to investigate I. rugosus for phytoconstituents, phytotoxic and cytotoxic activities to explore its toxicological, pharmacological potentials and to rationalize its ethnomedicinal uses. Briefly, qualitative phytochemical analysis of the plant extracts were carried out for the existence of alkaloids, flavonoids, saponins, oils, glycosides, anthraquinones, terpenoids, sterols and tannins. Plant crude methanolic extract (Ir.Cr), its subsequent fractions; n-hexane (Ir.Hex), chloroform (Ir.Chf), ethyl acetate (Ir.EtAc), aqueous (Ir.Aq) and saponins (Ir.Sp) in different concentrations were tested for phytotoxic and cytotoxic activities using radish seeds and brine shrimps (Artemia salina) respectively. The phytotoxic activity was determined by percent root length inhibition (RLI) and percent seeds germination inhibition (SGI) while the cytotoxicity was obtained with percent lethality of the brine shrimps. RESULTS: Ir.Cr was tested positive for the presence of alkaloids, glycosides, flavonoids, oils, terpenoids, saponins, tannins and anthraquinones. Among different fractions Ir.Sp, Ir.Chf, Ir.EtAc, and Ir.Cr were most effective causing 93.55, 89.32, 81.32 and 58.68% inhibition of seeds in phytotoxicity assay, with IC50 values of 0.1, 0.1, 0.1 and 52 µg/ml respectively. Similarly, among all the tested samples, Ir.Sp exhibited the highest phytotoxic effect causing 91.33% root length inhibition with IC50 of 0.1 µg/ml. Ir.Sp and Ir.Chf were most effective against brine shrimps showing 92.23 and 76.67% lethality with LC50 values of 10 and 12 µg/ml respectively. CONCLUSIONS: It may be inferred from the current investigations that I. rugosus contains different secondary metabolites and is a potential source for the isolation of natural anticancer and herbicidal drug molecules. Different fractions exhibited phytotoxic and cytotoxic activities, thus providing pharmacological basis for ethnomedicinal uses of this plant.
Descritores: Saponinas/análise
Extratos Vegetais/farmacologia
Isodon/química
Fitoterapia
-Artemia/efeitos dos fármacos
Taninos/análise
Terpenos/análise
Flavonoides/análise
Óleos Vegetais/análise
Clorofórmio
Antraquinonas/análise
Raízes de Plantas/crescimento & desenvolvimento
Citotoxinas
Componentes Aéreos da Planta/química
Metanol
Alcaloides/análise
Glicosídeos/análise
Hexanos
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950747
Autor: Khan, Alam; Islam, Md Hedayetul; Islam, Md Ekramul; Al-Bari, Md Abdul Alim; Parvin, Mst Shahnaj; Sayeed, Mohammed Abu; Islam, Md Nurul; Haque, Md Ekramul.
Título: Pesticidal and pest repellency activities of rhizomes of Drynaria quercifolia (J. Smith) against Tribolium castaneum (Herbst)
Fonte: Biol. Res;47:1-6, 2014. ilus, graf, tab.
Idioma: en.
Resumo: BACKGROUND: Tribolium castaneum (Herbst) is a harmful pest of stored grain and flour-based products in tropical and subtropical region. In the present study, rhizome of Drynaria quercifolia (J. Smith) was evaluated for pesticidal and pest repellency activities against T. castaneum, using surface film method and filter paper disc method, respectively. In addition, activity of the isolated compound 3,4-dihydroxybenzoic acid was evaluated against the pest. RESULTS: Chloroform soluble fraction of ethanol extract of rhizome of D. quercifolia showed significant pesticidal activity at doses 0.88 to 1.77 mg/cm² and significant pest repellency activity at doses 0.94 to 0.23 mg/cm². No pesticidal and pest repellency activity was found for petroleum ether, ethyl acetate and methanol soluble fractions of ethanol extract as well as for 3,4-dihydroxybenzoic acid. CONCLUSION: Considering our findings it can be concluded that chloroform soluble fraction of rhizome of D. quercifoliais useful in controlling T. castaneum of stored grain and flour-based products.
Descritores: Praguicidas
Tribolium/efeitos dos fármacos
Controle de Pragas/métodos
Polypodiaceae/química
Rizoma/química
Hidroxibenzoatos/farmacologia
Repelentes de Insetos/farmacologia
-Extratos Vegetais/isolamento & purificação
Extratos Vegetais/química
Clorofórmio
Etanol
Metanol
Alcanos
Hidroxibenzoatos/isolamento & purificação
Dose Letal Mediana
Acetatos
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central



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