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Id: biblio-1104063
Autor: Trendafilova, Antoaneta; Kutova, Nikolina; Ozek, Gulmira; Todorova, Milka; Yur, Suleyman; Ozek, Temel; Dimitrov, Dimitar.
Título: Phenolic profile and antioxidant, acetylcholinesterase, and tyrosinase inhibitor activities of Jurinea tzar-ferdinandii Davidov, an endemic plant of the Balkans / Perfil fenólico y actividad antioxidante, acetilcolinesterasa e inhibidora de tirosinasa de Jurinea tzar-ferdinandii Davidov, planta endémica de los Balcanes
Fonte: Bol. latinoam. Caribe plantas med. aromát;19(2):161-166, mar. 2020. tab, ilus.
Idioma: en.
Projeto: Bulgarian Academy of Sciences; . TUBITAK.
Resumo: The methanol extract of the Balkan endemic species Jurinea tzar-ferdinandii Davidov demonstrated weak antioxidant activity against DPPH• and ABTS+• and low inhibitory potential against acetylcholinesterase (8.3% Inh.) and tyrosinase (IC50 = 208 ± 8 µg/mL) enzymes. Phytochemical investigation of the extract led to isolation and identification of apigenin, luteolin, apigenin-7-O-glucoside, apigenin-4'-O-glucoside, apigenin-7-O-gentiobioside, luteolin-4'-O-glucoside, rutin, narcissin, chlorogenic and 1,5-dicaffeoylquinic acid. With exception of apigenin and rutin, all isolated compounds are reported for the first time in the representatives of genus Jurinea. The distribution of flavonoids was discussed from chemotaxonomic point of view.

El extracto de metanol de la especie endémica de los Balcanes Jurinea tzar-ferdinandii Davidov demostró una actividad antioxidante débil contra DPPH• y ABTS+• y un bajo potencial inhibidor contra las enzimas acetilcolinesterasa (8.3% Inh.) tirosinasa (IC50 = 208 ± 8 µg/mL). La investigación fitoquímica del extracto condujo al aislamiento e identificación de apigenina, luteolina, apigenina-7-Oglucósido, apigenina-4'-O-glucósido, apigenina-7-O-gentiobiósido, luteolina-4'-O-glucósido, rutina, narcissin, clorogénico y ácido 1,5- dicafeoilquinico. Con excepción de la apigenina y la rutina, todos los compuestos aislados se informan por primera vez en el género Jurinea. La distribución de flavonoides se discute desde el punto de vista quimiotaxonómico.
Descritores: Asteraceae/química
Antioxidantes/farmacologia
Antioxidantes/química
-Fenóis/análise
Flavonoides/análise
Inibidores da Colinesterase
Monofenol Mono-Oxigenase/antagonistas & inibidores
Metanol
Península Balcânica
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1053200
Autor: Guerrero, Karlo; Arancibia, Alejandra; Caceres, Manuel; Aroca, German.
Título: Release of formaldehyde during the biofiltration of methanol vapors in a peat biofilter inoculated with Pichia pastoris GS115
Fonte: Electron. j. biotechnol;40:10-16, July. 2019. tab, ilus, graf.
Idioma: en.
Projeto: National Comission for Science and Technology (CONICYT) Chile.
Resumo: Background: Methanol can be effectively removed from air by biofiltration. However, formaldehyde is one of the first metabolic intermediates in the consumption of methanol in methylotrophic microorganisms, and it can be released out of the cell constituting a secondary emission. Results: The total removal of methanol was achieved up to input loads of 263 g m−3 h−1 and the maximum elimination capacity of the system was obtained at an empty bed residence times of 90 s and reached 330 g m− 3 h−1 at an input methanol load of 414 g m−3 h−1 and 80% of removal efficiency. Formaldehyde was detected inside the biofilter when the input methanol load was above 212 g m−3 h−1 . Biomass in the filter bed was able to degrade the formaldehyde generated, but with the increase of the methanol input load, the unconsumed formaldehyde was released outside the biofilter. The maximum concentration registered at the output of the system was 3.98 g m−3 when the methanol load was 672 g m−3 h−1 in an empty bed residence times of 60 s. Conclusions: Formaldehyde is produced inside a biofilter when methanol is treated in a biofiltration system inoculated with Pichia pastoris. Biomass present in the reactor is capable of degrading the formaldehyde generated as the concentration of methanol decreases. However, high methanol loads can lead to the generation and release of formaldehyde into the environment
Descritores: Pichia/metabolismo
Metanol/metabolismo
Formaldeído/metabolismo
-Biomassa
Poluentes Atmosféricos
Meio Ambiente
Filtração
Responsável: CL1.1 - Biblioteca Central


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Id: lil-568268
Autor: Oscanoa, Patricia E; Sierra, Luis M; Miyahira, Juan.
Título: Características clínicas y evolución de los pacientes con intoxicación por metanol atendidos en un hospital general / Clinical characteristics and outcome of patients with methanol poisoning treated in a general hospital
Fonte: Rev. méd. hered;21(2):70-76, abr.-jun. 2010. tab.
Idioma: es.
Resumo: Objetivo: Describir las características clínicas y la evolución de los pacientes con intoxicación por metanol. Material y métodos: Estudio descriptivo, transversal, retrospectivo, tipo serie de casos en pacientes con diagnóstico de intoxicación por metanol, atendidos en el Hospital Nacional Cayetano Heredia entre el 2004 y 2008. Resultados: Se encontraron 8 pacientes (6 varones y 2 mujeres) atendidos por intoxicación por metanol, 6 sobrevivieron. En todos los casos la vía de ingreso fue oral, 7 en forma accidental; 4 de los pacientes tenía antecedentes de dependencia alcohólica y 3 de depresión. Al ingreso, 7 presentaron alteración del nivel de conciencia, 7 visión borrosa y 4 vómitos y los niveles de metanol sérico estuvieron entre 67 a 93 mg/dL. Todos los pacientes presentaron acidosis metabólica con anión gap elevado. Los pacientes fallecidos tuvieron pH menor de 7,0. La principal complicación fue neumonía aspirativa. Conclusiones: Debido al escaso número de casos no podemos llegar a conclusiones; sin embargo, podemos decir que la intoxicación por metanol generalmente se produce por ingesta accidental, debido al consumo de licores adulterados en varones adultos de limitados recursos económicos, los síntomas más frecuentes de presentación son la alteración de la conciencia y la visión borrosa, y aparentemente el riesgo de muerte está relacionado con la severidad de la acidosis metabólica.

Objective: To describe clinical characteristics and evolution of patients with methanol poisoning. Methods: A descriptive, transversal, retrospective study, case series report of patients with methanol poisoning at the Hospital Nacional Cayetano Heredia between 2004 and 2008. Results: We found 8 patients (6 men and 2 women) with methanol poisoning, 6 survived. In all cases pathway entrance was oral, 7 were accidental; 4 patients were alcoholics and 3 had depression. At admission, 7 had consciousness disorder, 7 blurred vision, 4 vomits and serum methanol levels were between 67-93 mg/dl. All patients had metabolic acidosis with elevated anion gap. The main complication was aspiration pneumonia. Conclusions: Due to the small number of cases we can reach conclusions, but we can say methanol poisoning is usually caused by accidental ingestion, mainly from adulterated liquor consumption by adult men with limited economic resources, most common symptoms are consciousness disorder and blurred vision, and apparently risk of death is related to severity of metabolic acidosis.
Descritores: Acidose
Intoxicação Alcoólica
Metanol/envenenamento
Metanol/toxicidade
-Epidemiologia Descritiva
Estudos Retrospectivos
Estudos Transversais
Relatos de Casos
Peru
Limites: Humanos
Masculino
Feminino
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: lil-713355
Autor: Valdivia-Infantas, Melinda; Medina-Santander, Boris; Arana-Retamozo, Rubén; Llamoca-Palomino, Verónica; Vásquez-Gil, Aymeth.
Título: Intoxicación por metanol con hemorragia e isquemia de los ganglios basales: reporte de dos casos / Methanol intoxication with hemorrhage and ischemia of the basal ganglia: report of two cases
Fonte: Rev. Soc. Peru. Med. Interna;26(1):26-31, ene.-mar. 2013. tab, ilus.
Idioma: es.
Resumo: Se presentan los casos de dos pacientes con historia de alcoholismo crónico que se intoxicaron con metanol y que presentaron ceguera, acidosis metabólica severa, insuficiencia renal aguda y hemorragia en los ganglios basales en un caso e isquemia en el otro.

It is presented two patients with chronic consumption of alcohol that were intoxicated with methanol and that presented blindness, severe metabolic acidosis, acute renal failure and basal ganglia hemorrhage in one and ischemia in the other.
Descritores: Alcoolismo
Cetose
Hemorragia Cerebral
Intoxicação Alcoólica
Isquemia Encefálica
Metanol
Limites: Humanos
Masculino
Adulto
Adulto Jovem
Tipo de Publ: Relatos de Casos
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: lil-677693
Autor: Huamán, S; Hurtado, H; Kong, V; León, C; León, D; Lister, P; Miñano, Karla; Orrego, F; Santillán, L; Sánchez, M; Vargas, E; Castañeda, Benjamín; Ibañez, Lucy.
Título: Estudio toxicológico y teratogénico del extracto metanólico de cinnamomun zeylanicum (canela) / Toxicológico and teratogénico study of the metanólico extract of cinnamomun zeylanicum (cinnamon)
Fonte: Horiz. méd. (Impresa);3(1/2):69-78, dic. 2003. ilus, tab, graf.
Idioma: es.
Resumo: Se realizó el estudio fitoquímico, toxicológico agudo y citotóxico del cinnamomum zeylanicum (canela). Para la determinación de la DL50 se utilizaron 30 ratones albinos, cuyos pesos oscilaron entre 25 y 30 gr., siguiendo el método de Probits. Igualmente se determinó la concentración letal media (CL-50) en artemia salina. La actividad citotóxica y teratogénica fue evaluada en huevos de Tetrapygus Níger (erizo de mar). Nos permite concluir, siguiendo los criterios de William, que el extracto metanólico de la canela es ligeramente tóxico y posee efecto citotóxico frente al erizo de mar, no evidenciándose efecto teratogénico, a las dosis empleadas.

We have performed a Phytochemic. Toxicologic and Cytotoxic study, of Cinamomum zeylanicum (canela) in laboratory. We have determinated the letal 50-doses (DLSO) in mice, the letal middle concentration (CL_50) in Artemia salina and the cytotoxic and teratogenic effect on Tetrapygus niger eggs (sea Hedgehog). We may conclude following the William Criterions that the metanolic extract of canela is lightly toxic and it has cytotoxic effects on sea Hedgehog at the doses studied.
Descritores: Artemia
Cinnamomum zeylanicum/toxicidade
Citotoxinas
Ouriços-do-Mar
Extratos Vegetais/toxicidade
Metanol/toxicidade
Testes de Toxicidade/métodos
Limites: Masculino
Animais
Feminino
Camundongos
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: lil-332860
Autor: Trafani, Arnaldo; Conrado, José Geraldo Lupato.
Título: Um dia de festa. E de intoxicaçäo e mortes por metanol / A party day. And deaths intoxication by metanol
Fonte: In: Marques, Maria Cristina; Diniz, Elizeu; Carvalho, Marisa Lima; Pereira, Sheila Duarte. Casos e fatos da vigilância sanitária sobre a saúde da sociedade. Säo Paulo, SOBRAVIME, 2002. p.275-284, ilus.
Idioma: pt.
Descritores: Envenenamento
Metanol
Bebidas Alcoólicas
-Vigilância Sanitária
Responsável: BR91.2 - Centro de Documentação
BR91.2; WA672, M357c, 2002


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Id: lil-130445
Autor: Säo Paulo (Estado). Secretaria da Saúde. Centro de Vigilância Sanitária.
Título: IVT - Informativo da Vigilância Toxicológica / IVT - Toxicologic surveillance informative.
Fonte: Säo Paulo; Säo Paulo (Estado). Secretaria da Saúde. Centro de Vigilância Sanitária; 1993. 12 p.
Idioma: pt.
Descritores: Toxicologia
Vigilância Sanitária
-Envenenamento
Técnicas de Laboratório Clínico
Metanol/envenenamento
Limites: Humanos
Responsável: BR91.2 - Centro de Documentação
BR91.2; 1438, Cx.V3


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Id: biblio-1087710
Autor: Guerrero, Karlo; Arancibia, Alejandra; Caceres, Manuel; Aroca, German.
Título: Release of formaldehyde during the biofiltration of methanol vapors in a peat biofilter inoculated with Pichia pastoris GS115
Fonte: Electron. j. biotechnol;44:58-59, Mar. 2020. ilus.
Idioma: en.
Resumo: BACKGROUND: Methanol can be effectively removed from air by biofiltration (Shareefdeen et al., 1993; Babbitt et al., 2009 [1,2]). However, formaldehyde is one of the first metabolic intermediates in the consumption of methanol in methylotrophic microorganisms (Negruta et al., 2010 [3]), and it can be released out of the cell constituting a secondary emission. RESULTS: The total removal of methanol was achieved up to input loads of 263 g m−3 h−1 and the maximum elimination capacity of the system was obtained at an empty bed residence times of 90 s and reached 330 g m−3 h−1 at an input methanol load of 414 g m−3 h−1 and 80% of removal efficiency. Formaldehyde was detected inside the biofilter when the input methanol load was above 212 g m−3 h−1 . Biomass in the filter bed was able to degrade the formaldehyde generated, but with the increase of the methanol input load, the unconsumed formaldehyde was released outside the biofilter. The maximum concentration registered at the output of the system was 3.98 g m−3 when the methanol load was 672 g m−3 h−1 in an empty bed residence times of 60 s. CONCLUSIONS: Formaldehyde is produced inside a biofilter when methanol is treated in a biofiltration system inoculated with Pichia pastoris. Biomass present in the reactor is capable of degrading the formaldehyde generated as the concentration of methanol decreases. However, high methanol loads can lead to the generation and release of formaldehyde into the environment.
Descritores: Pichia/química
Metanol/química
Formaldeído/análise
-Volatilização
Filtros Biológicos
Biomassa
Reatores Biológicos
Meio Ambiente
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
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Id: biblio-949367
Autor: Karaoğlan, Esen Sezen; Albayrak, Abdulmecit; Kutlu, Zerrin; Bayır, Yasin.
Título: Gastroprotective and antioxidant effects of Eremurus spectabilis Bieb. methanol extract and its isolated component isoorientin on indomethacin induced gastric ulcers in rats
Fonte: Acta cir. bras;33(7):609-618, July 2018. graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the gastroprotective effect of methanol extract of E. spectabilis and its major component isoorientin. Methods: Effects of isoorientin and methanol extract of E. spectabilis were investigated in indomethacin-induced gastric damage model on rats. Famotidine was used as the standard antiulcer drug. Numerical density of ulcer areas and oxidative status were determined on stomach tissues of rats. Results: All doses of isoorientin and methanol extract decreased MDA level and increased SOD activity and GSH levels in the stomach tissue of rats. When numerical density of ulcer areas were analized, the 500 mg/kg dose of methanol extract (84%) exhibited a similar effect to 20 mg/kg dose of standart drug famotidine (87%). Conclusions: The gastroprotective effects of E. spectabilis and its major constituent isoorientin in rats for the first time. Detailed analyses suggested that potential antioxidant activity of both plant extract and isoorientin mediates the gastroprotective effect.
Descritores: Úlcera Gástrica/tratamento farmacológico
Extratos Vegetais/farmacologia
Luteolina/farmacologia
Metanol/farmacologia
Xanthorrhoeaceae/química
Antiulcerosos/farmacologia
Antioxidantes/farmacologia
-Úlcera Gástrica/patologia
Superóxido Dismutase/análise
Superóxido Dismutase/efeitos dos fármacos
Índice de Gravidade de Doença
Indometacina
Reprodutibilidade dos Testes
Resultado do Tratamento
Ratos Wistar
Relação Dose-Resposta a Droga
Glutationa/análise
Glutationa/efeitos dos fármacos
Malondialdeído/análise
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-974294
Autor: Zepeda, Andrea B; Figueroa, Carolina A; Pessoa, Adalberto; Farías, Jorge G.
Título: Free fatty acids reduce metabolic stress and favor a stable production of heterologous proteins in Pichia pastoris
Fonte: Braz. j. microbiol;49(4):856-864, Oct.-Dec. 2018. graf.
Idioma: en.
Projeto: FAPESP.
Resumo: ABSTRACT The growth of yeasts in culture media can be affected by many factors. For example, methanol can be metabolized by other pathways to produce ethanol, which acts as an inhibitor of the heterologous protein production pathway; oxygen concentration can generate aerobic or anaerobic environments and affects the fermentation rate; and temperature affects the central carbon metabolism and stress response protein folding. The main goal of this study was determine the implication of free fatty acids on the production of heterologous proteins in different culture conditions in cultures of Pichia pastoris. We evaluated cell viability using propidium iodide by flow cytometry and thiobarbituric acid reactive substances to measure cell membrane damage. The results indicate that the use of low temperatures and low methanol concentrations favors the decrease in lipid peroxidation in the transition phase from glycerol to methanol. In addition, a temperature of 14 ºC + 1%M provided the most stable viability. By contrast, the temperature of 18 ºC + 1.5%M favored the production of a higher antibody fragment concentration. In summary, these results demonstrate that the decrease in lipid peroxidation is related to an increased production of free fatty acids.
Descritores: Pichia/metabolismo
Ácidos Graxos não Esterificados/metabolismo
-Pichia/crescimento & desenvolvimento
Pichia/genética
Temperatura
Proteínas Recombinantes/genética
Meios de Cultura/metabolismo
Meios de Cultura/química
Metanol/metabolismo
Fermentação
Glicerol/metabolismo
Responsável: BR1.1 - BIREME



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