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Pesquisa : D02.047.122 [Categoria DeCS]
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Id: biblio-1349507
Autor: Hussain, Zulfia; Khan, Junaid Ali; Arshad, Muhammad Imran; Muhammad, Faqir; Abbas, Rao Zahid.
Título: Comparative characterization of cinnamon, cinnamaldehyde and kaempferol for phytochemical, antioxidant and pharmacological properties using acetaminophen-induced oxidative stress mouse model / Caracterización comparativa de canela, cinamaldehído y kaempferol para propiedades fitoquímicas, antioxidantes y farmacológicas utilizando el modelo de ratón con estrés oxidativo inducido por acetaminofeno
Fonte: Bol. latinoam. Caribe plantas med. aromát;20(4):339-350, jul. 2021. ilus, tab.
Idioma: en.
Resumo: This study was aimed to explore the comparative efficacy of cinnamon bark extract, cinnamaldehyde and kaempferol against acetaminophen (APAP)-induced oxidative stress. Cinnamon bark extract, cinnamaldehyde and kaempferol were utilized or in-vivo analysis. From the results of in-vitro screening tests, cinnamon ethanolic extract was selected for in-vivo study in mouse model. For this, Balb/c albino mice were treated with cinnamon ethanolic extract (200 mg/kg), cinnamaldehyde (10 mg/kg) and kaempferol (10 mg/kg) orally for 14 days followed by single intraperitoneal administration of APAP during 8 hours. Blood and organ samples were collected for biochemical and histopathological analysis. The results showed that cinnamon bark ethanolic extract, cinnamaldehyde and kaempferol ameliorated APAP-induced oxidative stress and organ toxicity in mice. In conclusion, cinnamaldehyde and kaempferol possess comparable antioxidant potential even at 20-times less dose as compared to cinnamon bark ethanolic extract suggesting therapeutic potential in oxidative stress-related disorders.

Este estudio tuvo como objetivo explorar la eficacia comparativa del extracto de corteza de canela, cinamaldehído y kaempferol contra el estrés oxidativo inducido por acetaminofén (APAP). Se utilizaron extracto de corteza de canela, cinamaldehído y kaempferol para el análisis in vivo. De los resultados de las pruebas de detección in vitro, se seleccionó el extracto etanólico de canela para estudio in vivo en modelo de ratón. Para ello, los ratones albinos Balb/c fueron tratados con extracto etanólico de canela (200 mg/kg), cinamaldehído (10 mg/kg) y kaempferol (10 mg/kg) por vía oral durante 14 días, seguido de la administración intraperitoneal única de APAP durante 8 horas. Se recogieron muestras de sangre y órganos para análisis bioquímicos e histopatológicos. Los resultados mostraron que el extracto etanólico de la corteza de canela, el cinamaldehído y el kaempferol mejoraron el estrés oxidativo inducido por APAP y la toxicidad orgánica en ratones. En conclusión, el cinamaldehído y el kaempferol poseen un potencial antioxidante comparable, incluso a una dosis 20 veces menor en comparación con el extracto etanólico de la corteza de canela, lo que sugiere un potencial terapéutico en los trastornos relacionados con el estrés oxidativo.
Descritores: Acroleína/análogos & derivados
Extratos Vegetais/administração & dosagem
Cinnamomum zeylanicum/química
Estresse Oxidativo/efeitos dos fármacos
Quempferóis/química
Antioxidantes/administração & dosagem
-Acroleína/química
Cromatografia Líquida de Alta Pressão
Modelos Animais de Doenças
Compostos Fitoquímicos
Rim/efeitos dos fármacos
Rim/patologia
Fígado/efeitos dos fármacos
Fígado/patologia
Acetaminofen/toxicidade
Camundongos Endogâmicos BALB C
Limites: Animais
Camundongos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1040068
Autor: Onder, Alev; Yilmaz-Oral, Didem; Jerkovic, Igor; Akdemir, Alp Ozgur; Gur, Serap.
Título: Evaluation of relaxant responses properties of cinnamon essential oil and its major component, cinnamaldehyde on human and rat corpus cavernosum
Fonte: Int. braz. j. urol;45(5):1033-1042, Sept.-Dec. 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT Cinnamomum cassia (Cinnamon) is a well-known traditional medicine with therapeutic benefits for centuries. We evaluated the effects of cinnamon essential oil (CEO) and its main component cinnamaldehyde (CA) on human corpus cavernosum (HCC) and rat CC. The essential oil of cinnamon was analyzed for the confirmation of the oil profile. HCC specimens from patients undergoing penile prosthesis surgery (age 48-69 years) were utilized for functional studies. In addition, erectile responses in anesthetized control and diabetic rats were evaluated in vivo after intracavernosal injection of CEO and CA, and rat CC strips were placed in organ baths. After precontraction with phenylephrine (10µM), relaxant responses to CEO and CA were investigated. CA (96.9%) was found as the major component. The maximum relaxation responses to CEO and CA were 96.4±3.5% and 96.0±5.0% in HCC and 97.5±5.5% and 96.8±4.8% in rat CC, respectively. There was no difference between control and diabetic rats in relaxation responses to CEO and CA. The relaxant responses obtained with essential oil and CA were not attenuated in the presence of nitric oxide synthase (NOS) inhibitor, and soluble guanylate cyclase inhibitor (sGS) in CC. In vivo, erectile responses in diabetic rats were lower than in control rats, which was restored after intracavernosal injection of CEO and CA. CEO and CA improved erectile function and relaxation of isolated strips of rat CC and HCC by a NO/cGMP-independent mechanism. Further investigations are warranted to fully elucidate the restorative effects of CEO and CA on diabetic erectile dysfunction.
Descritores: Pênis/efeitos dos fármacos
Acroleína/análogos & derivados
Óleos Voláteis/farmacologia
Cinnamomum zeylanicum/química
Relaxamento Muscular/efeitos dos fármacos
-Pênis/fisiopatologia
Fenilefrina/farmacologia
Vasoconstritores/farmacologia
Acroleína/farmacologia
Ereção Peniana/efeitos dos fármacos
Ereção Peniana/fisiologia
Reprodutibilidade dos Testes
Análise de Variância
Ratos Sprague-Dawley
Inibidores da Fosfodiesterase 5/farmacologia
Citrato de Sildenafila/farmacologia
Disfunção Erétil/fisiopatologia
Disfunção Erétil/tratamento farmacológico
Pessoa de Meia-Idade
Relaxamento Muscular/fisiologia
Limites: Humanos
Animais
Masculino
Idoso
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-1051317
Autor: Chen, Peng-Cheng; Zhang, Hui; Zheng, Pu.
Título: Direct biodegradation of eugenol to coniferyl aldehyde and other higher value-added products by Gibberella fujikuroi ZH-34
Fonte: Electron. j. biotechnol;38:32-39, Mar. 2019. ilus, graf, tab.
Idioma: en.
Projeto: National Natural Science Foundation of China.
Resumo: BACKGROUND: Eugenol is an economically favorable substrate for the microbial biotransformation of aromatic compounds. Coniferyl aldehyde is one kind of aromatic compound that is widely used in condiment and medical industries; it is also an important raw material for producing other valuable products such as vanillin and protocatechuic acid. However, in most eugenol biotransformation processes, only a trace amount of coniferyl aldehyde is detected, thus making these processes economically unattractive. As a result, an investigation of new strains with the capability of producing more coniferyl aldehyde from eugenol is required. RESULTS: We screened a novel strain of Gibberella fujikuroi, labeled as ZH-34, which was capable of transforming eugenol to coniferyl aldehyde. The metabolic pathway was analyzed by high-performance liquid chromatography­mass spectrometry and transformation kinetics. The culture medium and biotransformation conditions were optimized. At a 6 h time interval of eugenol fed-batch strategy, 3.76 ± 0.22 g/L coniferyl aldehyde was obtained, with the corresponding yield of 57.3%. CONCLUSIONS: This work improves the yield of coniferyl aldehyde with a biotechnological approach. Moreover, the fed-batch strategy offers possibility for controlling the target product and accumulating different metabolites
Descritores: Acroleína/análogos & derivados
Eugenol/metabolismo
Biotransformação
Gibberella/metabolismo
-Biodegradação Ambiental
Acroleína/metabolismo
Biotecnologia
Cromatografia Líquida de Alta Pressão
Recursos Renováveis
Técnicas de Cultura Celular por Lotes
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Saúde Pública
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Id: lil-733338
Autor: Laureano-Eugenio, Jorge; Mejía-Mendoza, Martha Leticia; Villaseñor-Farías, Martha; Gil-Hernández, Elisa.
Título: Experiencia de trabajo con parteras en Jalisco
Fonte: Salud pública Méx;56(6):571-572, nov.-dic. 2014.
Idioma: es.
Descritores: Transtornos de Fotossensibilidade/etiologia
Extratos Vegetais/efeitos adversos
Resinas Vegetais/efeitos adversos
-1-Propanol/efeitos adversos
Administração Cutânea
Administração Oral
Acroleína/efeitos adversos
Acroleína/análogos & derivados
Bálsamos/efeitos adversos
Benzaldeídos/efeitos adversos
Eugenol/efeitos adversos
Eugenol/análogos & derivados
Aromatizantes/efeitos adversos
Mel/efeitos adversos
Propanóis
Perfumes/efeitos adversos
Própole/efeitos adversos
Limites: Adulto
Feminino
Humanos
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Venezuela
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Id: lil-518701
Autor: Linares-Fernández, Beatriz; Alfieri, Anna B.
Título: Cambios en el óxido nítrico, las prostaglandinas y en la actividad de la mieloperoxidasa, inducidos por la acroleína en vejiga urinaria de rata / Changes in nitric oxide, prostaglandins and mieloperoxidase activity in acrolein-induced cystitis in rats
Fonte: Invest. clín;50(1):23-33, mar. 2009. tab.
Idioma: es.
Resumo: Se estudió el papel de la sustancia P, el óxido nítrico(ON) y las prostaglandinas (PGs) en la cistitis inducida por acroleína(ACR), para lo cual se estudiaron los cambios de las actividades de la óxido nítrico sintasa inducible(iNOS) y de la mieloperoxidasa(MPO) vesicales, así como en los niveles de PGs y de metabolitos del ON. Ratas macho Sprague-Dawley recibieron ACR (5mg/Kg, i.p), más uno de los siguientes tratamientos: Grupo 1: Salina, 0,10mL/100g i.p.; Grupo 2: Win-51.708(WIN), 25mg/Kg i.p.; Grupo 3: S-metilisotiourea(MITU), 35 mg/Kg i.p.; Grupo 4: Rofecoxib(ROF), 20mg/Kg v.o.; Grupo 5: Meloxicam(MEL), 25mg/Kg i.p.; Grupo 6: combinación MITU+ MEL. La mortalidad inducida por ACR fue parcialmente prevenida por WIN (antagonista NK1) y MITU (inhibidor iNOS). En los animales que sobrevivieron a 24 horas de exposición a ACR se encontraron cambios histológicos inflamatorios en vejiga, que se acompañaron de aumentos en la actividad MPO. También se observaron aumentos de nitratos+nitritos y PGs. El WIN no previno ninguno de estos cambios. El ROF y el MEL (inhibidores COX-2) protegieron parcialmente contra la inflamación vesical, mientras que el tratamiento con MITU fue capaz de prevenir estos cambios así como también el aumento de metabolitos del ON. La combinación MITU+MEL produjo una mayor protección contra los efectos inducidos por ACR. Estos resultados indican que el ON producido vía de la iNOS y las PGs producidas por la COX-1/COX-2, desempeñan un papel en la patogénesis de la cistitis por ACR. La ACR podría estimular a la iNOS y a las COX-1/COX-2, induciendo la migración linfocitaria, aumentos de nitratos+nitritos y de PGs.

To investigate the role of substance P(sP), nitric oxide (ON) and prostaglandins (PGs) in acrolein(ACR)-induced cystitis, we studied the changes induced by ACR on bladder inducible nitric oxide synthase(iNOS) and mieloperoxidase(MPO) activities, along with PGs and NO metabolites levels. Sprague-Dawley male rats received i.p. ACR (5mg/Kg) plus one of the following treatments: Group 1: saline 0.10 mL/100g i.p.; Group 2: Win-51.708 (WIN) 25mg/Kg i.p.; Group 3: S-metilisothiourea(MITU) 35mg/Kg i.p.; Group 4: Rofecoxib(ROF) 20mg/Kg o.p.; Group 5: Meloxicam(MEL) 25mg/Kg i.p.; Group 6: combination MITU+MEL. ACR-induced mortality was partially prevented by WIN (NK1 antagonist) and MITU (iNOS inhibitor). Animals that survived after 24h of ACR exposure, had histological inflammatory changes in bladder along with increased MPO activity. There was augmentation of nitrates+nitrites and of PGs. WIN didn't prevent any of these effects. ROF and MEL (COX-2 inhibitors) partially protected against bladder inflammation; MITU pre-treatment was able to prevent these changes and those of NO metabolites levels. The MITU+MEL combination produced the highest protection against ACR-induced damage. These results suggest that NO produced via iNOS and PGs produced by COX-1/COX-2, have an important role in the pathogenesis of cystitis induced by ACR. ACR could stimulate iNOS and COX-1/COX-2, producing lymphocyte migration and increases of NO and PGs.
Descritores: Acroleína
Óxido Nítrico
Oxigenases
Peroxidase
Prostaglandinas
Bexiga Urinária
Limites: Animais
Ratos
Tipo de Publ: Estudo Comparativo
Responsável: VE1.1 - Biblioteca Humberto Garcia Arocha


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Brito, G. A. C
Cunha, F. Q
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Id: lil-437822
Autor: Batista, C. K. L. P; Brito, G. A. C; Souza, M. L. P; Leitão, B. T. A; Cunha, F. Q; Ribeiro, R. A.
Título: A model of hemorrhagic cystitis induced with acrolein in mice
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;39(11):1475-1481, Nov. 2006. graf, tab.
Idioma: en.
Resumo: Acrolein is a urinary metabolite of cyclophosphamide and ifosfamide, which has been reported to be the causative agent of hemorrhagic cystitis induced by these compounds. A direct cytotoxic effect of acrolein, however, has not yet been demonstrated. In the present study, the effects of intravesical injection of acrolein and mesna, the classical acrolein chemical inhibitor, were evaluated. Male Swiss mice weighing 25 to 35 g (N = 6 per group) received saline or acrolein (25, 75, 225 æg) intravesically 3, 6, 12, and 24 h before sacrifice for evaluation of bladder wet weight, macroscopic and histopathological changes by Gray's criteria, and 3 and 24 h for assessment of increase in vascular permeability. In other animals, mesna was administered intravesically (2 mg) or systemically (80 mg/kg) 1 h before acrolein. Intravesical administration of acrolein induced a dose- and time-dependent increase in vascular permeability and bladder wet weight (within 3 h: 2.2- and 21-fold increases in bladder wet weight and Evans blue dye exuded, respectively, at doses of 75 æg/bladder), as confirmed by Gray's criteria. Pretreatment with mesna (2-mercaptoethanesulfonic acid), which interacts with acrolein resulting in an inactive compound, inhibited all changes induced by acrolein. Our results are the first demonstration that intravesical administration of acrolein induces hemorrhagic cystitis. This model of acrolein-induced hemorrhagic cystitis in mice may be an important tool for the evaluation of the mechanism by which acrolein induces bladder lesion, as well as for investigation of new uroprotective drugs.
Descritores: Acroleína/toxicidade
Cistite/induzido quimicamente
Edema/induzido quimicamente
Hemorragia/induzido quimicamente
Bexiga Urinária/efeitos dos fármacos
-Acroleína/administração & dosagem
Acroleína/antagonistas & inibidores
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Mesna/farmacologia
Substâncias Protetoras/farmacologia
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-243624
Autor: Programa Internacional de Seguridad de las Sustancias Químicas (PISSQ).
Título: Acroleína / Acroleina.
Fonte: Metepec; Organización Panamericana de la Salud. Centro Panamericano de Ecología Humana y Salud; 1993. 28 p. ilus, tab. (OPS. Guía para la Salud y la Seguridad, 27).
Idioma: es.
Descritores: Acroleína
Contaminação Química
Substâncias Tóxicas
-Poluição do Ar
Saúde Pública
Medição de Risco
Responsável: CR3.1 - CRID - Centro Regional de Información sobre Desastres para América Latina y el Caribe
CR3.1, DES



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