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Id: biblio-900296
Autor: Alegre, O; Yévenes, I; Parada, J; Maggiolo, S; Fernández, E.
Título: Determination of residual parachloroaniline produced by endodontic treatment after the use of 5% sodium hypochlorite and 2% chlorhexidine combined: an ex-vivo study
Fonte: Rev. clín. periodoncia implantol. rehabil. oral (Impr.);10(3):145-148, dic. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT: Aim: The objective of this work was to determine the concentrations of irrigating solutions and the residual content of parachloroaniline (PCA) formed after endodontic irrigation, using 5% NaOCl, 0.9% NaCl, 10% EDTA and 2% CHX 2%. Methodology Twenty premolars were used and 13 samples were collected per tooth from each of the treatment phases. Samples of: NaOCl, EDTA, CHX and PCA were quantified by UV and visible spectrophotometry. Results: Sodium hypochlorite decreased its concentration from 3.8% to 3.4% in phases 1 to 4. In phases 5, 6 and 7, residual NaOCl was measured with concentrations of 0.007%, 0.003% and 0.001% %. The concentration of EDTA decreased to 8.85% in phase 8. In phases 9, 10 and 11, irrigated with serum, EDTA was quantified with concentrations of 0.013% to 0.002% and NaOCl values of 0.0011% to 0, 0006%. In phases 12 and 13, CHX concentrations were 1.850% and 1.812% and PCA values were 0.0005% and 0.0007%. PCA formation occurred in presence of 2% CHX and residual NaClO and was detected colorimetrically in phases 12 and 13. Conclusions. During endodontic irrigation the concentration of 5% NaOCl decreases significantly in the first four phases and the concentrations of EDTA and CHX also decrease. There is PCA training in the last stages of the procedure.
Descritores: Irrigantes do Canal Radicular/química
Hipoclorito de Sódio/química
Clorexidina/química
Compostos de Anilina/análise
-Irrigantes do Canal Radicular/administração & dosagem
Hipoclorito de Sódio/administração & dosagem
Espectrofotometria
Clorexidina/administração & dosagem
Ácido Edético/química
Interações Medicamentosas
Endodontia
Limites: Seres Humanos
Responsável: CL58.1 - Biblioteca


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Id: lil-771673
Autor: Onetto, Daniela; Correa, Verónica; Araya, Pilar; Yévenes, Ismael; Neira, Miguel.
Título: Efecto del ultrasonido endodóntico sobre clorhexidina al 2 por ciento en la formación de paracloroanilina: estudio in vitro / Effect of endodontic ultrasound on 2 percent chlorhexidine in the formation of parachloraniline: in vitro study
Fonte: Rev. clín. periodoncia implantol. rehabil. oral (Impr.);8(3):185-191, dic. 2015. ilus.
Idioma: es.
Projeto: Universidad de Chile. Facultad de Odontología. FIOUCH.
Resumo: Introducción: La clorhexidina (CHX) en solución acuosa se hidroliza generando paracloroanilina (PCA), proceso acelerado por el aumento de temperatura y pH. El uso de ultrasonido endodóntico (USE), basado en fenómenos de oscilación, cavitación, microcorriente acústica, genera calor afectando la CHX. Objetivo Identificar y cuantificar in vitro cambios fisicoquímicos, temperatura y pH, y la cantidad de PCA formada con el uso de ultrasonido endodóntico sobre soluciones de CHX al 2 por ciento. Materiales y métodos La CHX 2 por ciento se activó durante 30, 60, 90 y 120 seg con USE a 24.500 Hz, midiendo antes y después de activación: pH, temperatura y cantidad de PCA, leyendo a 375 nm en curva de calibración de estándares de PCA y formación, registrando el espectro de absorción mediante espectrofotómetro UV-visible. Resultados El USE aumentó la temperatura en 1 °C independiente del tiempo de aplicación y acidificó la solución de CHX 2 por ciento, sin variaciones significativas en pH y temperatura. No se observó coloración ni formación de precipitado en muestras activadas por USE a los diferentes tiempos. Las muestras no presentaron valores medibles de PCA a 375 nm. Los espectros de absorción de CHX 2 por ciento y activadas por USE por más de 60 seg presentaron curvas espectrales, peaks y valores de absorbancia diferentes. Conclusiones El USE aumenta la temperatura y acidifica la solución de la CHX en todos los tiempos de aplicación. No se detectó presencia de PCA por espectrofotometría visible. Muestras activadas por USE por 60 seg o más presentan espectros de absorción diferentes a las muestras sin activar. Diferencias en los espectros de absorción entre CHX activadas con USE y con CHX sin activar indicarían degradación de la CHX y posible presencia de PCA.

Introduction: Chlorhexidine (CHX) in aqueous solution is hydrolysed to p-chloroaniline (PCA), a process accelerated by increasing temperature and pH. Using endodontic ultrasound based on oscillation phenomena, cavitation, and acoustic microstreaming generates heat, affecting the CHX. Objective The aim of this in vitro study was to identify and quantify the physical-chemical changes, temperature and pH, and the amount of PCA formed by increasing the temperature of 2 percent CHX by endodontic ultrasound. Materials and methods Samples of 2 percent CHX were activated for 30, 60, 90, and 120 seconds with endodontic ultrasound 24,500 Hz. The pH and temperature were measured before and after activation, as well as the formation and amount of PCA, by reading and recording the result obtained from a standard calibration curve reading at 375 nm in a UV-visible light spectrophotometer. Results Independent of time, ultrasound increased the temperature of 2 percent CHX by 1 °C and acidified the solution. No significant changes were recorded in pH and temperature. No staining or precipitates were observed in samples ultrasonically activated at different times. Samples read at 375 nm showed no measurable PCA values. Absorption spectra of 2 percent CHX and 2 percent CHX activated for more than 60 seconds showed different spectral curves, peaks, and absorbance values. Conclusions Ultrasound increased the temperature and acidified the solution of CHX for all application times. No PCA was detected by visible spectrophotometry. Absorption spectra of 2 percent CHX activated with ultrasound at different times differs from 2 percent CHX without activation. These differences indicate degradation of CHX and possible presence of PCA.
Descritores: Clorexidina/química
Compostos de Anilina/química
Ultrassom
-Desinfetantes/química
Concentração de Íons de Hidrogênio
Técnicas In Vitro
Espectrofotometria
Temperatura Ambiente
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
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Id: lil-748233
Autor: Mercimek, Hatice Aysun; Dincer, Sadik; Guzeldag, Gulcihan; Ozsavli, Aysenur; Matyar, Fatih; Arkut, Afet; Kayis, Fikret; Ozdenefe, Melis Sumengen.
Título: Degradation of 2,4,6-trinitrotoluene by P. aeruginosa and characterization of some metabolites
Fonte: Braz. j. microbiol;46(1):103-111, 05/2015. graf.
Idioma: en.
Resumo: Degradation of 2,4,6-trinitrotoluene (TNT), a nitroaromatic explosive found in the soil and ground water, was investigated using Pseudomonas aeruginosa in in vitro experiments. Biodegradable abilitiy of this bacteria was performed with 50 and 75 mg L−1 TNT concentrations in a defined liquid medium for 96 h time period. Treatment of TNT in supernatant samples taken at 0, 6, 12, 24, 48, 72 and 96 h from agitated vessels was followed by reverse-phase high-performance liquid chromatography (HPLC). In cultures supplemented with 50 and 75 mgL−1 TNT, after 96 h of incubation 46% and 59% reduction were detected respectively. Two metabolites as degradation intermediates with nitrite release into the medium, 2,4-dinitrotoluene (2,4-DNT) and 4-aminodinitrotoluene (4-ADNT), were elucidated by thin layer chromatography (TLC) and gas chromatography-mass spectrometry (GC-MS). These findings clearly indicate that Pseudomonas aeruginosa can be used in bioremediation of TNT contaminated sites.
Descritores: Redes e Vias Metabólicas
Pseudomonas aeruginosa/metabolismo
Trinitrotolueno/metabolismo
-Compostos de Anilina/análise
Biotransformação
Cromatografia Líquida de Alta Pressão
Cromatografia em Camada Delgada
Meios de Cultura
Dinitrobenzenos/análise
Cromatografia Gasosa-Espectrometria de Massas
Fatores de Tempo
Responsável: BR1.1 - BIREME


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Id: lil-746547
Autor: LOPES, José Fernando Scarelli; PINTO, João Henrique Nogueira; LOPES, Monica Moraes Waldemarin; MAZOTTINI, Reinaldo; SOARES, Simone.
Título: Interrelationship between implant and orthognathic surgery for the rehabilitation of edentulous cleft palate patients: a case report
Fonte: J. appl. oral sci;23(2):224-229, Mar-Apr/2015. graf.
Idioma: en.
Resumo: A 43-year-old woman with a unilateral cleft lip and palate, presenting a totally edentulous maxilla and mandible with marked maxillomandibular discrepancy, attended the Prosthodontics section of the Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo for treatment. She could not close her mouth and was dissatisfied with her complete dentures. Treatment planning comprised placement of six implants in the maxilla, four in the mandible followed by prostheses installation and orthognathic surgery. The mandibular full arch prosthesis guided the occlusion for orthognathic positioning of the maxilla. The maxillary complete prosthesis was designed to assist the orthognathic surgery with a provisional prosthesis (no metal framework), allowing reverse treatment planning. Maxillary and mandibular realignment was performed. Three months later, a relapse in the position of the maxilla was observed, which was offset with a new maxillary prosthesis. This isa complex interdisciplinary treatment and two-year follow-up is presented and discussed. It should be considered that this type of treatment could also be applied in non-cleft patients.
Descritores: Compostos de Anilina
Encéfalo/irrigação sanguínea
Encéfalo/patologia
Angiopatia Amiloide Cerebral/complicações
Angiopatia Amiloide Cerebral/diagnóstico
Hemorragia Cerebral/complicações
Tomografia por Emissão de Pósitrons/métodos
Tiazóis
-Hemorragia Cerebral/diagnóstico
Limites: Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-744702
Autor: Sedrez, Juliana Adami; Rosa, Maria Izabel Zaniratti da; Noll, Matias; Medeiros, Fernanda da Silva; Candotti, Claudia Tarragô.
Título: Risk factors associated with structural postural changes in the spinal column of children and adolescents / Fatores de risco associados a alterações posturais estruturais da coluna vertebral em crianças e adolescentes
Fonte: Rev. paul. pediatr;33(1):72-81, Jan-Mar/2015. tab, graf.
Idioma: en.
Resumo: OBJECTIVE: To investigate the association between behavioral risk factors, specifically postural habits, with the presence of structural changes in the spinal column of children and adolescents. METHODS: 59 students were evaluated through the self-reporting Back Pain and Body Posture Evaluation Instrument and spinal panoramic radiographic examination. Spine curvatures were classified based on Cobb angles, as normal or altered in the saggital plane and as normal or scoliotic in the frontal plane. Data were analyzed using SPSS 18.0, based on descriptive statistics and chi-square association test (a=0,05). RESULTS: The prevalence of postural changes was 79.7% (n=47), of which 47.5% (n=28) showed frontal plane changes and 61% (n=36) sagital plane changes. Significant association was found between the presence of thoracic kyphosis and female gender, practice of physical exercises only once or twice a week, sleep time greater than 10 hours, inadequate postures when sitting on a seat and sitting down to write, and how school supplies are carried. Lumbar lordosis was associated with the inadequate way of carrying the school backpack (asymmetric); and scoliosis was associated wuth the practice of competitive sports and sleep time greater than 10 hours. CONCLUSIONS: Lifestyle may be associated with postural changes. It is important to develop health policies in order to reduce the prevalence of postural changes, by decreasing the associated risk factors. .

OBJETIVO: Verificar se existe associação de fatores de risco comportamentais, especificamente hábitos posturais, com a presença de alteração postural estrutural na coluna vertebral de crianças e adolescentes. MÉTODOS: Foram avaliados 59 crianças e adolescentes, que responderam ao questionário auto-aplicável Back Pain and Body Posture Evaluation Instrument e fizeram o exame radiográfico panorâmico da coluna vertebral. De acordo com o ângulo de Cobb, as curvaturas sagitais da coluna vertebral foram classificadas como normais ou alteradas e, no plano frontal, como escolioses ou normais. Os dados foram analisados no SPSS 18.0, a partir de estatística descritiva e do teste de associação qui-quadrado (a=0,05). RESULTADOS: A prevalência de alterações posturais foi de 79,7% (n=47), 47,5% (n=28) apresentavam alteração no plano frontal e 61% (n=36) no sagital. Foi encontrada associação entre cifose torácica e sexo feminino, prática de exercício físico apenas uma ou duas vezes na semana, tempo de sono superior a 10 horas, posturas inadequadas para sentar no banco e sentar para escrever e o meio de transporte do material escolar. Para lordose lombar, observou-se associação com o transporte da mochila escolar de modo inadequado (assimétrico). Houve associação significativa entre a presença de escoliose com a prática de esporte competitivo e o tempo de sono superior a 10 horas. CONCLUSÕES: Hábitos de vida podem estar associados a alterações posturais, é importante o desenvolvimento políticas de saúde a fim de reduzir a prevalência de alterações posturais por meio da redução dos fatores de risco associados. .
Descritores: Compostos de Anilina/farmacologia
Inibidores de Proteínas Quinases/farmacologia
Quinolonas/farmacologia
-ABATTOIRS-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES
Compostos de Anilina/química
Compostos de Anilina/síntese química
Relação Dose-Resposta a Droga
Modelos Moleculares
Estrutura Molecular
Inibidores de Proteínas Quinases/química
Inibidores de Proteínas Quinases/síntese química
Quinolonas/química
Quinolonas/síntese química
Relação Estrutura-Atividade
Limites: Seres Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-744699
Autor: Passos, Darlise Rodrigues dos; Gigante, Denise Petrucci; Maciel, Francine Villela; Matijasevich, Alicia.
Título: Children's eating behavior: comparison between normal and overweight children from a school in Pelotas, Rio Grande do Sul, Brazil / Comportamento alimentar infantil: comparação entre crianças sem e com excesso de peso em uma escola do município de Pelotas, RS
Fonte: Rev. paul. pediatr;33(1):42-49, Jan-Mar/2015. tab, graf.
Idioma: en.
Resumo: OBJECTIVE: To evaluate differences in children's eating behavior in relation to their nutritional status, gender and age. METHODS: Male and female children aged six to ten years were included. They were recruited from a private school in the city of Pelotas, Rio Grande do Sul, southern Brazil, in 2012. Children´s Eating Behaviour Questionnaire (CEBQ) subscales were used to assess eating behaviors: Food Responsiveness (FR), Enjoyment of Food (EF), Desire to Drink (DD), Emotional Overeating (EOE), Emotional Undereating (EUE), Satiety Responsiveness (SR), Food Fussiness (FF) and Slowness in Eating (SE). Age-adjusted body mass index (BMI) z-scores were calculated according to the WHO recommendations to assess nutritional status. RESULTS: The study sample comprised 335 children aged 87.9±10.4 months and 49.3% had normal weight (n=163), 26% were overweight (n=86), 15% were obese (n=50) and 9.7% were severely obese (n=32). Children with excess weight showed higher scores at the CEBQ subscales associated with "food approach" (FR, EF, DD, EOE, p<0.001) and lower scores on two "food avoidance" subscales (SR and SE, p<0.001 and p=0.003, respectively) compared to normal weight children. Differences in the eating behavior related to gender and age were not found. CONCLUSIONS: "Food approach" subscales were positively associated to excess weight in children, but no associations with gender and age were found. .

OBJETIVO: Avaliar diferenças no comportamento alimentar infantil em função do estado nutricional, do sexo e da idade. MÉTODOS: O estudo incluiu crianças na faixa de seis a dez anos, de ambos os sexos, de uma escola privada em Pelotas (RS), em 2012. Para avaliar o comportamento alimentar usaram-se as subescalas do questionário Children's Eating Behaviour Questionnaire (CEBQ): resposta à comida (FR), prazer de comer (EF), desejo de beber (DD), sobreingestão emocional (EOE), subingestão emocional (EUE), resposta à saciedade (SR), seletividade (FF) e ingestão lenta (SE). Avaliou-se o estado nutricional por meio do escore-z do IMC/idade. RESULTADOS: Participaram 335 crianças de 87,9±10,4 meses. Apresentaram eutrofia 49,3% (n=163), sobrepeso 26% (n=86), obesidade 15% (n=50) e obesidade grave 9,7% (n=32). Crianças com excesso de peso tiveram maior pontuação nas subescalas de "interesse pela comida" (FR, EF, DD, EOE, p<0,001) e menor pontuação nas subescalas de "desinteresse pela comida" (SR e SE, p<0,001 e p=0,003, respectivamente), se comparadas com as crianças com peso adequado. Não foram observadas diferenças no comportamento alimentar segundo sexo e idade. CONCLUSÕES: Observou-se que comportamentos alimentares que refletem "interesse pela comida" estão associados positivamente ao excesso de peso, mas não foi encontrada associação com o sexo e a idade da criança. .
Descritores: Compostos de Anilina/farmacologia
Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Descoberta de Drogas
Microtúbulos/efeitos dos fármacos
Neoplasias Experimentais/tratamento farmacológico
Inibidores de Proteínas Quinases/farmacologia
Pirimidinas/farmacologia
Receptores Proteína Tirosina Quinases/antagonistas & inibidores
Água/química
-Compostos de Anilina/química
Compostos de Anilina/síntese química
Antineoplásicos/química
Antineoplásicos/síntese química
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Células HeLa
Camundongos Endogâmicos BALB C
Camundongos Nus
Neoplasias Experimentais/patologia
Inibidores de Proteínas Quinases/química
Inibidores de Proteínas Quinases/síntese química
Pirimidinas/química
Pirimidinas/síntese química
Receptores Proteína Tirosina Quinases/metabolismo
Solubilidade
Relação Estrutura-Atividade
Limites: Animais
Feminino
Seres Humanos
Camundongos
Tipo de Publ: Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Cassiani, Sílvia Helena de Bortoli
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Id: lil-732945
Autor: Cassiani, Silvia Helena De Bortoli.
Título: Strategy for universal access to health and universal health coverage and the contribution of the International Nursing Networks / Estratégia para o acesso universal à saúde e cobertura universal de saúde e a contribuição das Redes Internacionais de Enfermagem / Estrategia para el acceso universal a la salud y cobertura universal de salud y la contribución de las Redes Internacionales de Enfermería
Fonte: Rev. latinoam. enferm;22(6):891-892, 16/12/2014.
Idioma: en.
Descritores: Compostos de Anilina/metabolismo
Benzoquinonas
Lactoperoxidase/metabolismo
Peroxidases/metabolismo
Peróxidos/metabolismo
-Bromo
Radicais Livres
Formaldeído/metabolismo
Concentração de Íons de Hidrogênio
Técnicas In Vitro
Oxirredução
Quinonas/metabolismo
Limites: Animais
Bovinos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-727038
Autor: Rani, Babita; Kumar, Vivek; Singh, Jagvijay; Bisht, Sandeep; Teotia, Priyanku; Sharma, Shivesh; Kela, Ritu.
Título: Bioremediation of dyes by fungi isolated from contaminated dye effluent sites for bio-usability
Fonte: Braz. j. microbiol;45(3):1055-1063, July-Sept. 2014. ilus, graf.
Idioma: en.
Resumo: Biodegradation and detoxification of dyes, Malachite green, Nigrosin and Basic fuchsin have been carried out using two fungal isolates Aspergillus niger, and Phanerochaete chrysosporium, isolated from dye effluent soil. Three methods were selected for biodegradation, viz. agar overlay and liquid media methods; stationary and shaking conditions at 25 °C. Aspergillus niger recorded maximum decolorization of the dye Basic fuchsin (81.85%) followed by Nigrosin (77.47%), Malachite green (72.77%) and dye mixture (33.08%) under shaking condition. Whereas, P. chrysosporium recorded decolorization to the maximum with the Nigrosin (90.15%) followed by Basic fuchsin (89.8%), Malachite green (83.25%) and mixture (78.4%). The selected fungal strains performed better under shaking conditions compared to stationary method; moreover the inoculation of fungus also brought the pH of the dye solutions to neutral from acidic. Seed germination bioassay study exhibited that when inoculated dye solutions were used, seed showed germination while uninoculated dyes inhibited germination even after four days of observation. Similarly, microbial growth was also inhibited by uninoculated dyes. The excellent performance of A. niger and P. chrysporium in the biodegradation of textile dyes of different chemical structures suggests and reinforces the potential of these fungi for environmental decontamination.
Descritores: Aspergillus niger/metabolismo
Biodegradação Ambiental
Biotransformação
Corantes/metabolismo
Phanerochaete/metabolismo
Microbiologia do Solo
-Compostos de Anilina/metabolismo
Aspergillus niger/crescimento & desenvolvimento
Aspergillus niger/isolamento & purificação
Concentração de Íons de Hidrogênio
Resíduos Industriais
Phanerochaete/crescimento & desenvolvimento
Phanerochaete/isolamento & purificação
Corantes de Rosanilina/metabolismo
Temperatura Ambiente
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
Texto completo
Id: lil-510266
Autor: Tyagi, Pradeep; Thomas, Catherine A; Yoshimura, Naoki; Chancellor, Michael B.
Título: Investigations into the presence of functional ß1, ß2 and ß3-adrenoceptors in urothelium and detrusor of human bladder
Fonte: Int. braz. j. urol;35(1):76-83, Jan.-Feb. 2009. ilus, graf, tab.
Idioma: en.
Resumo: Purpose: We investigated the presence of functional ß1, ß2 and ß3-adrenoceptor in urothelium and detrusor muscle of human bladder through in vitro pharmacology of selective ß3 adrenoceptor agonist solabegron. Materials and Methods: Expression of these adrenoceptors in surgically separated human urothelium and detrusor muscle were investigated using RT-PCR. The effects of activating these receptors were studied by determining the relaxation produced by ß-adrenoceptors agonist in pre-contracted human detrusor strips. Results: The results confirmed the presence of mRNA for ß1, ß2 and ß3-adrenoceptor in both human urothelium and detrusor. In an in vitro functional bladder assay, Solabegron and other agonists for ß-adrenoceptors such as procaterol and isoproterenol evoked potent concentration-dependent relaxation of isolated human bladder strips with pD2 values of 8.73 ± 0.19, 5.08 ± 0.48 and 6.28 ± 0.54, respectively. Conclusions: Selective ß3-adrenoceptor agonist may be a potential new treatment for the overactive bladder OAB syndrome. Existence of ß3-adrenoceptor mRNA exists in the urothelium in addition to the detrusor muscle suggest multiple site of actions for the ß3-adrenoceptor in the lower urinary tract.
Descritores: Agonistas Adrenérgicos beta/farmacologia
Compostos de Anilina/farmacologia
Benzoatos
/agonistas
RECEPTORS, ADRENERGIC, BETA-ABATTOIRS/agonistas
Bexiga Urinária/efeitos dos fármacos
Urotélio/efeitos dos fármacos
-Relação Dose-Resposta a Droga
Músculo Liso/efeitos dos fármacos
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Receptores Adrenérgicos beta 1/agonistas
Receptores Adrenérgicos beta 1/genética
/genética
RECEPTORS, ADRENERGIC, BETA-ABATTOIRS/genética
/agonistas
RECEPTORS, ADRENERGIC, BETA-TEMEFOS/agonistas
/genética
RECEPTORS, ADRENERGIC, BETA-TEMEFOS/genética
Bexiga Urinária/metabolismo
Urotélio/metabolismo
Adulto Jovem
Limites: Adolescente
Adulto
Idoso
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
Texto completo
Id: lil-495746
Autor: Paula-Lima, Andréia C; Arriagada, Christian; Toro, Rodrigo; Cárdenas, Ana María; Caviedes, Raúl; Ferreira, Sergio T; Caviedes, Pablo.
Título: Small-molecule aggregation inhibitors reduce excess amyloid in a trisomy 16 mouse cortical cell line
Fonte: Biol. Res;41(2):129-136, 2008. ilus, graf.
Idioma: en.
Projeto: Fondecyt; . Univ. of Chile; . Fondation Jéróme Lejeune, Paris, France (to PC); . Howard Hughes Medical Institute; . Conselho Nacional de Desenvolvimento Científico e Tecnológico; . Fundação de Amparo à Pesquisa do Estado do RJ; . FINEP/CT-Verde Amarelo (to STF).
Resumo: We have previously characterized a number of small molecule organic compounds that prevent the aggregation of the β-amyloid peptide and its neurotoxicity in hippocampal neuronal cultures. We have now evaluated the effects of such compounds on amyloid precursor protein (APP) accumulation in the CTb immortalized cell line derived from the cerebral cortex of a trisomy 16 mouse, an animal model of Down's syndrome. Compared to a non-trisomic cortical cell line (CNh), CTb cells overexpress APP and exhibit slightly elevated resting intracellular Ca2+ levéis ([Ca2+]¡). Here, we show that the compounds 2,4-dinitrophenol, 3-nitrophenol and 4-anisidine decreased intracellular accumulation of APP in CTb cells. Those compounds were non-toxic to the cells, and slightly increased the basal [Ca2+]¡. Results indícate that the compounds tested can be leads for the development of drugs to decrease intracellular vesicular accumulation of APP in trisomic cells.
Descritores: Doença de Alzheimer/metabolismo
Precursor de Proteína beta-Amiloide/antagonistas & inibidores
Compostos de Anilina/farmacologia
Síndrome de Down/metabolismo
Nitrofenóis/farmacologia
/farmacologia
TEMEFOS,ABBREVIATIONS AS TOPIC-DINITROPHENOL/farmacologia
-Precursor de Proteína beta-Amiloide/metabolismo
Linhagem Celular
Córtex Cerebral/citologia
Córtex Cerebral/efeitos dos fármacos
Córtex Cerebral/metabolismo
Modelos Animais de Doenças
Limites: Animais
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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