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| Id: |
lil-256614
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| Autor: |
Thielemann, Lilian E; Videla, Ramón A; Videla, Rodrigo; Videla, Luis A. |
| Título: |
Changes in antioxidant enzyme activities and lipid peroxidation related to bromoethylamine-induced renal cytotoxicity |
| Fonte: |
Arch. med. res;30(1):14-8, ene.-feb. 1999. graf.
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| Idioma: |
en.
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| Resumo: |
Background. The effect of bromoethylamine (BEA) administration on lipid peroxidation and on the activieties of antioxidant enzymes was studied. Methods. Adult rats received BEA at 1.2 mmol/kg, a dose that produces renal papillary necrosis. Lipid peroxidation assessed by maximal rate in MDA formation, the activities of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the levels of non-protein sulfhydryls (NPSH) were measured in renal cortex and papilla of control and BEA-treated animals. Results. After BEA treatment, an increment in lipid peroxidation in papilla and cortex was found after 1.5 and 24 hours of treatment. Catalase activity decreased in both regions, but earlier cortex. Conclusion. These data suggest some role of oxidative stress in the mechanism of BEAinduced papillary necrosis
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| Descritores: |
Antioxidantes/metabolismo
Catalase/metabolismo
Etilaminas/toxicidade
Glutationa Peroxidase/metabolismo
Necrose Papilar Renal/induzido quimicamente
Superóxido Dismutase/metabolismo
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-Córtex Renal/enzimologia
Medula Renal/enzimologia
Necrose Papilar Renal/enzimologia
Malondialdeído/análise
Especificidade de Órgãos
Estresse Oxidativo
Ratos Sprague-Dawley
Compostos de Sulfidrila/análise
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| Limites: |
Animais
Feminino
Ratos
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| Tipo de Publ: |
Estudo Comparativo
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| Responsável: |
MX1.1 - CENIDSP - Centro de Información para Decisiones en Salud Pública
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