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Id: |
lil-256614
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Autor: |
Thielemann, Lilian E; Videla, Ramón A; Videla, Rodrigo; Videla, Luis A. |
Título: |
Changes in antioxidant enzyme activities and lipid peroxidation related to bromoethylamine-induced renal cytotoxicity |
Fonte: |
Arch. med. res;30(1):14-8, ene.-feb. 1999. graf.
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Idioma: |
en.
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Resumo: |
Background. The effect of bromoethylamine (BEA) administration on lipid peroxidation and on the activieties of antioxidant enzymes was studied. Methods. Adult rats received BEA at 1.2 mmol/kg, a dose that produces renal papillary necrosis. Lipid peroxidation assessed by maximal rate in MDA formation, the activities of catalase, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the levels of non-protein sulfhydryls (NPSH) were measured in renal cortex and papilla of control and BEA-treated animals. Results. After BEA treatment, an increment in lipid peroxidation in papilla and cortex was found after 1.5 and 24 hours of treatment. Catalase activity decreased in both regions, but earlier cortex. Conclusion. These data suggest some role of oxidative stress in the mechanism of BEAinduced papillary necrosis
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Descritores: |
Antioxidantes/metabolismo Catalase/metabolismo Etilaminas/toxicidade Glutationa Peroxidase/metabolismo Necrose Papilar Renal/induzido quimicamente Superóxido Dismutase/metabolismo
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-Córtex Renal/enzimologia Medula Renal/enzimologia Necrose Papilar Renal/enzimologia Malondialdeído/análise Especificidade de Órgãos Estresse Oxidativo Ratos Sprague-Dawley Compostos de Sulfidrila/análise
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Limites: |
Animais Feminino Ratos
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Tipo de Publ: |
Estudo Comparativo
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Responsável: |
MX1.1 - CENIDSP - Centro de Información para Decisiones en Salud Pública
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