Base de dados : LILACS
Pesquisa : D02.092.471.739 [Categoria DeCS]
Referências encontradas : 17 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 2 ir para página        

  1 / 17 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Id: lil-246052
Autor: Savino, E. A; Varela, A.
Título: Influence of moderate cooling (37§C-25§C) on the reactivity of isolated rat tail artery
Fonte: Acta physiol. pharmacol. ther. latinoam;49(3):141-8, 1999. tab, graf.
Idioma: en.
Resumo: The aim of the investigation was to examine the effects of cooling on the tail artery regarding the scarceness of such studies in spite of the essential thermoregulatory role played by this vessel. Segments of the proximal portion were suspended isometrically in medium containig 1.25 mM Ca. Lowering the temperature to 25 degrees Celsius increased the sensitivity and maximum strength of the adrenaline concentration-effect curves. These changes were reversed by warming to 37 degrees Celsius. Cocaine attenuated the increase of sensitivity without changing the increase of the maximum response. Either the sensitivity and strength of the responses to phenylephrine and serotomin were increased by cooling. Clonidine evoked weak contractions in 18 out of 38 experiments. After cooling, the responses persisted only in 7 arteries and the strength was almost halved. Responses to field eletric stimulation at 25 degrees Celsius exhibited a pronounced increase of strength and a small increase of sensitivity. -log Kb for prazosin against adrenaline was encreased by cooling (8.7 and 9.1 at 37 degrees Celsius and 25 degrees Celsius C, P<0.01). After partial receptor inactivation using phenoxybenzamine, the dissociation-constant (KA) indicated a moderate affinity for phenylephrine that was not changed by cooling (4.1 and 4.2 x 10(-6) at 37 degrees Celsius respectively). Receptor reserve and occupancy at EC(50) also remained unchanged at 25 degrees Celsius. It can be concluded that: 1) cooling increases the tail artery reactivity, partly as a consequence of the inhibition of adrenergic neuronal uptake; 2) responsiveness to alpha 2-agonists is not in volved in the effects of cooling whereas the role of alpha 1-adrenoceptor could not be properly clarified; 3) cooling may facilitate some steps of the contractile activation beyond the agonist-receptor interaction.
Descritores: Agonistas alfa-Adrenérgicos/farmacologia
Artérias/fisiologia
Temperatura Baixa
Sequestradores de Radicais Livres/farmacologia
Serotonina/farmacologia
Cauda/irrigação sanguínea
-Artérias/efeitos dos fármacos
Clonidina/farmacologia
Estimulação Elétrica
Epinefrina/farmacologia
Fenoxibenzamina/farmacologia
Fenilefrina/farmacologia
Prazosina/farmacologia
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


  2 / 17 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-212408
Autor: Oliveira, M. A; Prado, W. A.
Título: Antinociception induced by stimulating amygdaloid nuclei in rats: changes produced by systemically administered antagonists
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;31(5):681-90, May 1998. ilus.
Idioma: en.
Resumo: The antinociceptive effects of stimulating the medial (ME) and central (CE) nuclei of the amygdala in rats were evaluated by the changes in the latency for the tail withdrawal reflex to noxious heating of the skin. A 30-s period of sine-wave stimulation of the ME or CE produced a significant and short increase in the duration of tail flick latency. A 15-s period of stimulation was ineffective. Repeated stimulation of these nuclei at 48-h intervals produced progressively smaller effects. The antinociception evoked from the ME was significantly reduced by the previous systemic administration of naloxone, methysergide, atropine, phenoxybenzamine, and propranolol, but not by mecamylamine, all given at the dose of 1.0 mg/kg. Previous systemic administration of naloxone, atropine, and propranolol, but not methysergide, phenoxy-benzamine, or mecamylamine, was effective against the effects of stimulating the CE. We conclude that the antinociceptive effects of stimulating the ME involve at least opioid, serotonergic, adrenergic, and muscarinic cholinergic descending mechanisms. The effects of stimulating the CE involve at least opioid, beta-adrenergic, and muscarinic cholinergic descending mechanisms.
Descritores: Antagonistas Adrenérgicos alfa/farmacologia
Antagonistas Adrenérgicos beta/farmacologia
Tonsila do Cerebelo/efeitos dos fármacos
Analgesia
Atropina/farmacologia
Bloqueadores Ganglionares/farmacologia
Mecamilamina/farmacologia
Metisergida/farmacologia
Antagonistas Muscarínicos/farmacologia
Naloxona/farmacologia
Antagonistas de Entorpecentes/farmacologia
Fenoxibenzamina/farmacologia
Propranolol/farmacologia
Antagonistas da Serotonina/farmacologia
-Análise de Variância
Estimulação Elétrica
Eletrodos Implantados
Ratos Wistar
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  3 / 17 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Id: lil-188212
Autor: Gutierrez, Maria Christina; Oliveira, Bernardino Correia de; Henriques, Jodélia Lima Martins; Guimaräes, Aroldo Antunes; Peixoto, Humberto da Silva; Gazzola, Helena Mussi; Dimetz, Trude.
Título: Manifestaçöes clínicas e laboratoriais de 11 pacientes com feocromocitoma / Clinical and laboratorial manifestations of 11 patients with pheochromocytoma
Fonte: J. bras. med;64(4):12, 16, 17, passin, abr. 1993. tab.
Idioma: pt.
Descritores: Neoplasias das Glândulas Suprarrenais/diagnóstico
Feocromocitoma/diagnóstico
-Neoplasias das Glândulas Suprarrenais/sangue
Neoplasias das Glândulas Suprarrenais/cirurgia
Hipertensão
Fenoxibenzamina/uso terapêutico
Feocromocitoma/sangue
Feocromocitoma/cirurgia
Complicações Pós-Operatórias
Cuidados Pré-Operatórios
Sensibilidade e Especificidade
Limites: Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


  4 / 17 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Id: lil-187218
Autor: Franco, A. C. J; Prado, W. A.
Título: Antinociceptive effects of stimulation of discrete sites in the rat hypothalamus: evidence for the participation of the lateral hypothalamus area in descending pain suppression mechanisms
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;29(11):1531-41, Nov. 1996. ilus, graf.
Idioma: en.
Resumo: The sites in the rat hypothalamus where microinjection of morphine 5 mug/0.5 mul) or electrical stimulation depresses the tail withdrawal reflex to noxious heating of the skin were examined. Among other hypothalamic sites found to be sensitive to morphine or to an electrical stimulus, the posterior part of the lateral hypothalamic area (LHA) was the only portion of the hypothalamus that was strongly sensitive to both manipulations. A 15-sec period of 35-muA sine-wave stimulation of the LHA significantly increased the latency of the tail reflex for periods up to 30 min. The effects of intraperitoneal administration of antagonists to opioids (naloxone), 5-hydroxytryptamine (methysergide), noradrenaline (phenoxybenzarnine), dopamine (haloperidol and acetylcholine (atropine and mecamylamine) on the antinociceptive effects of LHA stimulation were also examined. Naloxone, methysergide, and atropine (all given at doses of 0.5 and 1.0 mg/kg attenuated the effects of LHA stimulation in a dose-dependent manner. Phenoxybenzamine, but not haloperidol (both at the dose of 1.0 mg/kg), was also effective but dose-dependent curves could not be constructed. Mecamylamine (1.0 mg/kg) reduced the duration but no the peak effect of stimulating the LHA. We conclude that antagonism at the level of opioid, serotonergic, adrenergic, and muscarinic cholinergic receptors, but not dopamine or nicotinic cholinergic receptors reduces the antinociceptive effects of LHA stimulation. This may imply that antinociception evoked from the LHA depends on the activation of descending pathways that relay in the mesencephalic periaqueductal gray matter and then in the nucleus raphe magnus and/or nucleus reticularis paragigantocellularis.
Descritores: Analgesia
Haloperidol/farmacologia
Região Hipotalâmica Lateral/fisiologia
Mecamilamina/farmacologia
Dor/fisiopatologia
Fenoxibenzamina/farmacologia
-Estimulação Elétrica
Região Hipotalâmica Lateral/anatomia & histologia
Morfina/administração & dosagem
Ratos Wistar
Limites: Ratos
Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  5 / 17 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Id: lil-177003
Autor: Castillo, Carlos; Ibarra, Maximiliano; Márquez, Angel J; Villalobos Molina, Rafael; Hong, Enrique.
Título: Vascular effects of ipsapirone are related with subtypes of alpha 1-adrenergic receptors
Fonte: Arch. med. res;24(2):161-8, jun. 1993. ilus, tab.
Idioma: en.
Resumo: The aim of this study was to provide further evidence about the participation of Ó1-adrenoceptors in the vascular responses elicited by impsapirone. This 5-HT 1A agonist displayed vasodilator activity only when aortic rings were precontracted by Ó-adrenergic compounds. The relaxant effect was particulary evident when rings were precontracted with methoxamine (selective Ó1A-adrenergic agonist).On the other hand, ipsapirone but chloroethylclonidine (selective Ó1B-adrenergic antagonist), clearly displaced norepinephrine and methoxaminevasocontractile concentration-response curves to the right. Fanally, ipsapirone protected the Ó-adrenoceptors from the irreversible blockade provoked by phenoxybenzamine, as judged by thenorepinephrine contraction and stimulated phosphatidylinositil labeling. Accordingly the relaxant effect elicited by ipsapirone in aortic rings precontracted with Ó-adrenergic agonists and the protective action against blockade by phenoxybenzamine shown by this agent are proof of its ability to occupy Ó1-adrenoceptors. Specifically, Ó1A-adrenergic receptors seem to be involved in ipsapirone vascular effects, since this agent selectively relaxed aortic preparation precontracted with methoxamine and unlike chloroethylclonidine, clearly inhibited the contractile effect of this agonist. In summary, the present findings can be explained by accepting that ipsapirone may act as an antagonist at Ó1A-adrenoceptors
Descritores: Norepinefrina/farmacologia
Fenoxibenzamina/farmacologia
Receptores Adrenérgicos alfa/farmacologia
Limites: Animais
Coelhos
Responsável: MX1.1 - CENIDSP - Centro de Información para Decisiones en Salud Pública


  6 / 17 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Id: lil-167908
Autor: Camargo Neves, Maria do Carmo Longo; Pelá, Irene Rosemir.
Título: Efeitos do propranolol e da fenoxibenzimina sobre a resposta febril induzida pelo lipopolissacarídeo de E. coli, em coelhos / Effects of propranolol and phenoxibenzamine on the febrile response induced in rabbits by lipopolysaccharide from E. coli
Fonte: Rev. ciênc. farm;14:67-73, 1992. ilus.
Idioma: pt.
Resumo: Drogas bloqueadoras de receptores Alfa e Beta adrenérgicos, como a fenoxibenzamina e o propranolol, produziram reduçäo estatisticamente significante da resposta febril induzida pelo lipopolissacarídeo de E. coli (LPS) em coelhos. Os presentes resultados sugerem que receptores Alfa e Beta adrenérgicos poderäo estar envolvidos nessa resposta febril
Descritores: Regulação da Temperatura Corporal
Escherichia coli
Febre/induzido quimicamente
Febre/fisiopatologia
Lipopolissacarídeos
Fenoxibenzamina/farmacologia
Pirogênios/fisiologia
Propranolol/farmacologia
-Receptores Adrenérgicos alfa
Receptores Adrenérgicos beta
Limites: Animais
Masculino
Coelhos
Responsável: BR33.1 - Divisão Técnica de Biblioteca e Documentação


  7 / 17 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Id: lil-138343
Autor: Nardi, Aguinaldo C.
Título: Alfa-bloqueadores no tratamento / Alpha-blockers in the treatment of benign prostatic hyperplasia
Fonte: J. bras. urol;19(5):324-5, dez. 1993. tab.
Idioma: pt.
Descritores: Indoramina/uso terapêutico
Fenoxibenzamina/uso terapêutico
Prazosina/uso terapêutico
Hiperplasia Prostática/terapia
Responsável: BR13.1 - NDC - Núcleo de Documentação


  8 / 17 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Id: lil-134660
Autor: Zubin, P; Defagot, C; Taleisnik, S.
Título: Norepinephrine: stimulated activity of hypothalamic adenylate cyclase varies throughout the estrous cycle of the female rat
Fonte: Acta physiol. pharmacol. ther. latinoam;42(3):171-81, 1992. tab, graf.
Idioma: en.
Resumo: The activity of hypothalamic adenylate cyclase was studied throughout the estrous cycle of the female rat. The activity of the enzyme was determined in particulate fractions obtained from hypothalami of rats killed at 10.00 h and 16.00 h of the 4-day estrous cycle. The activity was assayed in the presence of norepinephrine (10(-8) to 10(-3) M) by the capacity to produce adenosine 3',5' cyclic monophosphate. The basal activity of adenylate cyclase was higher in the morning of estrus than at any other time during the cycle. Norepinephrine-stimulated adenylate cyclase activity, as assessed by the apparent affinity (Kd) and apparent maximum effect, varied during the cycle, showing highest affinity, lowest Kd, in the afternoon of proestrus. The highest level of apparent maximum effect was also found in the afternoon of proestrus declining on diestrous day 2, diestrous day 1 and estrus. The norepinephrine stimulated activity was significantly inhibited by phenoxybenzamine, an alpha-blocker, in the morning of diestrus day 1, whereas on the day of diestrus day 2 and proestrus it was inhibited by the beta-adrenoblocker, propranolol. A similar degree of inhibition by alpha- and beta-blockers was observed in the morning of estrus. These results indicate that the hypothalamic adenylate cyclase coupled to adrenergic receptors shows dynamic changes throughout the estrous cycle
Descritores: Adenilil Ciclases/metabolismo
Estro/fisiologia
Hipotálamo/enzimologia
Técnicas In Vitro
Norepinefrina/farmacologia
-Hipotálamo/efeitos dos fármacos
Norepinefrina/antagonistas & inibidores
Fenoxibenzamina/farmacologia
Propranolol/farmacologia
Ratos
Ratos Wistar
Estimulação Química
Limites: Animais
Feminino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  9 / 17 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Id: lil-124779
Autor: Yeyati, Nesmo Levy; Altenberg, Guillermo.
Título: Efectos renales de la dopamina (DM) en perros anestesiados con bloqueo alfa-adrenérgico: (II) probable interrelación con el sistema de las prostagladinas / Effects renal of the dopamine (DM) in dogs anesthetized with alpha-adrenergic block (II) interrlation likely with the prostaglandin systems
Fonte: Rev. nefrol. diál. traspl;(11):5-23, abr. 1985. ilus, tab.
Idioma: es.
Descritores: Antagonistas Adrenérgicos alfa/uso terapêutico
Cães/sangue
Dopamina/fisiologia
Prostaglandinas/fisiologia
-Capacidade de Concentração Renal
Circulação Renal
Cães/fisiologia
Cães/urina
Dopamina/análogos & derivados
Dopamina/antagonistas & inibidores
Indometacina/efeitos adversos
Fenoxibenzamina
Prostaglandinas/biossíntese
Pesquisa
Rim/fisiologia
Limites: Animais
Cães
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco


  10 / 17 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Id: lil-90381
Autor: Calleriza, Fernando; Hiriart, Juan Carlos.
Título: Emergencia hipertensiva por feocromocitoma / Hypertensive emergency caused by pheochromocytoma
Fonte: Paciente crit. (Uruguay);2(1):106-14, 1988. ilus.
Idioma: es.
Descritores: Hipertensão/tratamento farmacológico
Feocromocitoma/terapia
-Catecolaminas/urina
Cuidados Críticos
Hipertensão/etiologia
Nitroprussiato/uso terapêutico
Fenoxibenzamina/uso terapêutico
Fentolamina/uso terapêutico
Feocromocitoma/complicações
Feocromocitoma/diagnóstico
Feocromocitoma/patologia
Cuidados Pré-Operatórios
Propranolol/uso terapêutico
Tomografia Computadorizada por Raios X
Limites: Pessoa de Meia-Idade
Humanos
Feminino
Responsável: UY1.1 - BINAME - Biblioteca Nacional de Medicina



página 1 de 2 ir para página        
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde