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Id: lil-217523
Autor: Cazzulo, Berta M. Franke de; Bernacchi, Adriana; Esteva, Monica I; Ruiz, Andres M; Castro, José A; Cazzulo, Juan J.
Título: Trypanocidal effect of SKF525A, proadifen, on different developmental forms of Trypanosoma cruzi
Fonte: Medicina (B.Aires);58(4):415-8, 1998. ilus, tab.
Idioma: en.
Resumo: SKF525A, an inhibitor and inducer of cytochrome P450, was tested on different developmental stages of Trypanosoma cruzi. Growth, motility and structure of epimastigotes, motility and infectivity of trypomastigotes, and infectivity of trypomastigotes to Vero cells in culture were abolished by the drug at 10-100 muM concentration. When blood from infected mice was treated with the drug, and used to infect 8 day-old-mice, no parasites were observed at 0.6-1 mM, and all animals survived. Blood cell morphology was well preserved, and the sleeping time of pentobarbital-treated mice inoculated with the same amount of drug was not increased. The present results suggest that SKF525A or other related inhibitors of cytochrome P450 coned be tested as an additive for blood sterilization in blood banks.
Descritores: Inibidores Enzimáticos/farmacologia
Proadifeno/farmacologia
Tripanossomicidas/farmacologia
Trypanosoma cruzi/efeitos dos fármacos
-Células Cultivadas
Sistema Enzimático do Citocromo P-450/efeitos dos fármacos
Camundongos Endogâmicos BALB C
Pentobarbital/farmacologia
Fatores de Tempo
Trypanosoma cruzi/enzimologia
Trypanosoma cruzi/ultraestrutura
Células Vero/efeitos dos fármacos
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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