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Id: lil-781351
Autor: Sittart, José Alexandre de Souza; Costa, Adilson da; Mulinari-Brenner, Fabiane; Follador, Ivonise; Azulay-Abulafia, Luna; Castro, Lia Cândida Miranda de.
Título: Multicenter study for efficacy and safety evaluation of a fixeddose combination gel with adapalen 01% and benzoyl peroxide 2 5% (Epiduo® for the treatment of acne vulgaris in Brazilian population
Fonte: An. bras. dermatol;90(6,supl.1):1-16, Nov.-Dec. 2015. tab, graf.
Idioma: en.
Resumo: Abstract: BACKGROUND: The current options for the treatment of acne vulgaris present many mechanisms of action. For several times, dermatologists try topical agents combinations, looking for better results. OBJECTIVES: To evaluate the efficacy, tolerability and safety of a topical, fixed-dose combination of adapalene 0.1% and benzoyl peroxide 2.5% gel for the treatment of acne vulgaris in the Brazilian population. METHODS: This is a multicenter, open-label and interventionist study. Patients applied 1.0 g of the fixed-dose combination of adapalene 0.1% and benzoyl peroxide 2.5% gel on the face, once daily at bedtime, during 12 weeks. Lesions were counted in all of the appointments, and the degree of acne severity, overall improvement, tolerability and safety were evaluated in each visit. RESULTS: From 79 recruited patients, 73 concluded the study. There was significant, fast and progressive reduction of non-inflammatory, inflammatory and total number of lesions. At the end of the study, 75.3% of patients had a reduction of >50% in non-inflammatory lesions, 69.9% in inflammatory lesions and 78.1% in total number of lesions. Of the 73 patients, 71.2% had good to excellent response and 87.6% had satisfactory to good response. In the first week of treatment, erythema, burning, scaling and dryness of the skin were frequent complaints, but, from second week on, these signals and symptoms have reduced. CONCLUSION: The fixed-dose combination of adapalene 0.1% and benzoyl peroxide 2.5% gel is effective, safe, well tolerated and apparently improves patient compliance with the treatment.
Descritores: Acne Vulgar/tratamento farmacológico
Fármacos Dermatológicos/administração & dosagem
Combinação Adapaleno e Peróxido de Benzoil/administração & dosagem
-Fatores de Tempo
Índice de Gravidade de Doença
Brasil
Anti-Inflamatórios não Esteroides/administração & dosagem
Reprodutibilidade dos Testes
Resultado do Tratamento
Satisfação do Paciente
Acne Vulgar/patologia
Estatísticas não Paramétricas
Relação Dose-Resposta a Droga
Limites: Masculino
Feminino
Criança
Adolescente
Adulto
Adulto Jovem
Tipo de Publ: Estudo Multicêntrico
Estudo de Avaliação
Responsável: BR1.1 - BIREME



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