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Id: biblio-839425
Autor: Santos, Paula; Silva, Lilian Eslaine Costa Mendes da; Leão, Ricardo Maurício.
Título: Specific immediate early gene expression induced by high doses of salicylate in the cochlear nucleus and inferior colliculus of the rat / Expressão específica de genes precoces imediatos induzida por doses elevadas de salicilato no núcleo coclear e colículo inferior de rato
Fonte: Braz. j. otorhinolaryngol. (Impr.);83(2):155-161, Mar.-Apr. 2017. graf.
Idioma: en.
Resumo: Abstract Introduction: Salicylate at high doses induces tinnitus in humans and experimental animals. However, the mechanisms and loci of action of salicylate in inducing tinnitus are still not well known. The expression of Immediate Early Genes (IEG) is traditionally associated with long-term neuronal modifications but it is still not clear how and where IEGs are activated in animal models of tinnitus. Objectives: Here we investigated the expression of c-fos and Egr-1, two IEGs, in the Dorsal Cochlear Nucleus (DCN), the Inferior Colliculus (IC), and the Posterior Ventral Cochlear Nucleus (pVCN) of rats. Methods: Rats were treated with doses known to induce tinnitus in rats (300 mg/kg i.p. daily, for 3 days), and c-fos and Egr-1 protein expressions were analyzed using western blot and immunocytochemistry. Results: After administration of salicylate, c-fos protein expression increased significantly in the DCN, pVCN and IC when assayed by western blot. Immunohistochemistry staining showed a more intense labeling of c-fos in the DCN, pVCN and IC and a significant increase in c-fos positive nuclei in the pVCN and IC. We did not detect increased Egr-1 expression in any of these areas. Conclusion: Our data show that a high dose of salicylate activates neurons in the DCN, pVCN and IC. The expression of these genes by high doses of salicylate strongly suggests that plastic changes in these areas are involved in the genesis of tinnitus.

Resumo Introdução: Salicilato em doses elevadas induz zumbido nos seres humanos e em animais experimentais. No entanto, os mecanismos e loci de ação do salicilato na indução de zumbido ainda não são bem conhecidos. A expressão dos genes precoces imediatos (GPIs) está tradicionalmente associada a alterações neuronais em longo prazo, mas ainda não está claro como e onde os GPIs são ativados em modelos animais de zumbido. Objetivos: No presente estudo investigamos a expressão de c-fos e Egr-1, dois GPIs, no núcleo coclear dorsal (NCD), colículo inferior (CI) e núcleo coclear ventral posterior (NCVp) de ratos. Métodos: Os ratos foram tratados com doses que, conhecidamente, induzem zumbido em ratos (300 mg/kg IP/dia, por três dias) e as expressões das proteínas c-fos e Egr-1 foram analisadas por meio de Western blot e imunoistoquímica. Resultados: Após a administração de salicilato, a expressão da proteína c-fos aumentou significativamente no NCD, NCVp e CI, quando analisados por Western blot. A coloração imunoistoquímica mostrou uma marcação mais intensa de c-fos no NCD, NCVp e CI e um aumento significativo de núcleos positivos de c-fos no NCVp e CI. Não detectamos aumento da expressão de Egr-1 em qualquer dessas áreas. Conclusão: Nossos dados mostram que uma dose alta de salicilato ativa neurônios no NCD, NCVp e CI. A expressão desses genes por doses altas de salicilato sugere que as alterações plásticas nessas áreas estão envolvidas na gênese do zumbido.
Descritores: Colículos Inferiores/efeitos dos fármacos
Salicilatos/farmacologia
Regulação da Expressão Gênica/efeitos dos fármacos
Genes Precoces/efeitos dos fármacos
Núcleo Coclear/efeitos dos fármacos
-Salicilatos/administração & dosagem
Western Blotting
Genes fos/efeitos dos fármacos
Ratos Wistar
Relação Dose-Resposta a Droga
Proteína 1 de Resposta de Crescimento Precoce/efeitos dos fármacos
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1097194
Autor: Fairley, Sarah L; McKeown, Pascal P; Kee, Frank; McMullin, Mary-Francis; Stevenson, Mike; Muir, Alison R.
Título: Variabilidad de la respuesta plaquetaria a la aspirina / Assessing platelet response to aspirin
Fonte: Salud(i)ciencia (Impresa) = Salud(i)ciencia (En linea);22(3):229-235, oct. 2016. graf., tab..
Idioma: es.
Resumo: Introducción y objetivos: A pesar de que el estudio Antiplatelet Trialists' Collaboration demostró una reducción del 25% de los eventos mayores con el uso de aspirina en enfermos de alto riesgo, un porcentaje de pacientes presentan eventos isquémicos recurrentes. Esto ha llevado a la descripción de la "resistencia a la aspirina" con una tasa muy variable, de 0.4% a 83%. Este estudio evaluó la variabiliad en la función plaquetaria basal, la prevalencia de la resistencia a la aspirina, y la efectividad y reproducibilidad de los estudios de función plaquetaria. Materiales y métodos: Se llevó a cabo un estudio aleatorizado y cruzado de mediciones repetidas, con sujetos saludables de entre 18 y 60 años. Luego de firmar el consentimiento informado, los pacientes fueron distribuidos en forma aleatorizada a recibir aspirina en dosis de 75 mg o 300 mg; fueron evaluados al inicio y luego de cuatro períodos de tres semanas mediante diferentes técnicas: Optical Platelet Aggregation (OPA), PFA-100™, VerifyNow™, y los niveles séricos y urinarios de tromboxano B2 (TXB2). Se obtuvo la aprobación del comité de ética local. El análisis estadístico fue realizado con el programa SPSS17. Resultados: El índice global de resistencia a la aspirina fue variable, entre 2.4% y 63.5% en función de la técnica utilizada. Se demostró una variabilidad interindividual e intraindividual significativa al inicio y con la administración de placebo en las diferentes técnicas. La sensibilidad de los ensayos varió entre 24% (OPA ADP10) y 87.8% (tromboxano sérico), y la especificidad varió entre 81% (PFA-100™) y 97.4% (tromboxano). La selección de "valores de corte" alternativos provocó tasas de prevalencia diferentes de resistencia bioquímica a la aspirina, con un mecanismo de compensación entre la sensibilidad y la especificidad. Conclusiones: La respuesta a la aspirina mostró una marcada variabilidad interensayo, interindividual y temporal. Se requieren varias evaluaciones con diferentes técnicas para diagnosticar en forma confiable la resistencia a la aspirina. La selección de valores discriminativos alternativos debería considerarse al evaluar formalmente esta entidad

Introduction: Despite the 25% reduction in major events with aspirin in high-risk patients reported by the Antiplatelet Trialists' Collaboration, a proportion of patients develop recurrent ischaemic events. This has led to the emergence of 'aspirin resistance' with rates between 0.4% and 83% reported. This study assessed variability in baseline platelet function, prevalence of aspirin resistance, and the performance and reproducibility of platelet function testing methods. Materials and Methods: A repeated-measures randomised crossover study was performed in healthy individuals aged 18-60 years. After informed consent, patients were randomised to aspirin dose (75 mg or 300 mg) and treatment sequence with testing at baseline and after each four 3-week treatment period via Optical Platelet Aggregation (OPA), PFA-100™, VerifyNow™, and serum and urinary thromboxane (TXB2) levels. Local ethical approval was granted. Statistical analysis was performed using SPSS17. Results: The overall rate of aspirin resistance varied from 2.4% to 63.5% depending on the assay used. Significant inter- and intra-individual variability existed at baseline and on placebo testing between assays. Assay sensitivities ranged from 24.0% (OPA ADP10) to 87.8% (serum TXB2), and specificities from 81.0% (PFA-100™) to 97.4% (serum TXB2). Selection of alternative "cut-off" values resulted in differing prevalence rates of biochemical aspirin resistance with a trade-off between sensitivity and specificity. Conclusions: Response to aspirin shows marked inter-assay, inter-individual and temporal variability. Testing on multiple occasions using several assays is necessary to reliably diagnose aspirin resistance. Selection of alternative assay "cut-off" values should be considered when formally assessing aspirin response
Descritores: Testes de Função Plaquetária
Inibidores da Agregação Plaquetária
Salicilatos
Aspirina
Limites: Humanos
Adulto
Pessoa de Meia-Idade
Tipo de Publ: Relatório Técnico
Responsável: AR392.1 - Biblioteca


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Id: biblio-886919
Autor: SOUSA-NETO, BENEDITO P; GOMES, BRUNO S; CUNHA, FRANCISCO V M; ARCANJO, DANIEL D R; GUTIERREZ, STANLEY J C; SOUZA, MARIA F V; ALMEIDA, FERNANDA R C; OLIVEIRA, FRANCISCO A.
Título: Antiedematogenic activity of the indole derivative N-salicyloyltryptamine in animal models
Fonte: An. acad. bras. ciênc;90(1):185-194, Mar. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT The N-salicyloyltryptamine (NST) is an indole derivative compound analogue to the alkaloid N-benzoyltryptamine. In the present study, the antiedematogenic activity of NST was investigated in animal models. Firstly, the acute toxicity for NST was assessed according to the OECD Guideline no. 423. The potential NST-induced antiedematogenic activity was evaluated by carrageenan-induced paw edema in rats, as well as by dextran-, compound 48/80-, histamine-, serotonin-, capsaicine-, and prostaglandin E2-induced paw edema in mice. The effect of NST on compound 48/80-induced ex vivo mast cell degranulation on mice mesenteric bed was investigated. No death or alteration of behavioral parameters was observed after administration of NST (2000 mg/kg, i.p.) during the observation time of 14 days. The NST (100 and 200 mg/kg, i.p.) inhibited the carrageenan-induced edema from the 1st to the 5th hour (**p<0.01; ***p<0.001). The edematogenic activity induced by dextran, compound 48/80, histamine, serotonin, capsaicin, and prostaglandin E2 was inhibited by NST (100 mg/kg, i.p.) throughout the observation period (**p<0.01; ***p<0.001). The pretreatment with NST (50, 100 or 200 mg/kg, i.p) attenuates the compound 48/80-induced mast cell degranulation (**p<0.01; ***p<0.001). Thus, the inhibition of both mast cell degranulation and release of endogenous mediators are probably involved in the NST-induced antiedematogenic effect.
Descritores: Triptaminas/farmacologia
Salicilatos/farmacologia
Edema/tratamento farmacológico
Anti-Inflamatórios/farmacologia
-Peptídeos/efeitos dos fármacos
Fatores de Tempo
Carragenina
Triptaminas/toxicidade
Salicilatos/toxicidade
Ratos Wistar
Mediadores da Inflamação
Modelos Animais de Doenças
Edema/induzido quimicamente
Membro Posterior
Anti-Inflamatórios/toxicidade
Limites: Animais
Masculino
Feminino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-838068
Autor: Al-Talib, Hassanain; Al-khateeb, Alyaa; Hameed, Ayad; Murugaiah, Chandrika.
Título: Efficacy and safety of superficial chemical peeling in treatment of active acne vulgaris
Fonte: An. bras. dermatol;92(2):212-216, Mar.-Apr. 2017. tab.
Idioma: en.
Resumo: Abstract: Acne vulgaris is an extremely common condition affecting the pilosebaceous unit of the skin and characterized by presence of comedones, papules, pustules, nodules, cysts, which might result in permanent scars. Acne vulgaris commonly involve adolescents and young age groups. Active acne vulgaris is usually associated with several complications like hyper or hypopigmentation, scar formation and skin disfigurement. Previous studies have targeted the efficiency and safety of local and systemic agents in the treatment of active acne vulgaris. Superficial chemical peeling is a skin-wounding procedure which might cause some potentially undesirable adverse events. This study was conducted to review the efficacy and safety of superficial chemical peeling in the treatment of active acne vulgaris. It is a structured review of an earlier seven articles meeting the inclusion and exclusion criteria. The clinical assessments were based on pretreatment and post-treatment comparisons and the role of superficial chemical peeling in reduction of papules, pustules and comedones in active acne vulgaris. This study showed that almost all patients tolerated well the chemical peeling procedures despite a mild discomfort, burning, irritation and erythema have been reported; also the incidence of major adverse events was very low and easily manageable. In conclusion, chemical peeling with glycolic acid is a well-tolerated and safe treatment modality in active acne vulgaris while salicylic acid peels is a more convenient for treatment of darker skin patients and it showed significant and earlier improvement than glycolic acid
Descritores: Abrasão Química/métodos
Acne Vulgar/terapia
Ácido Salicílico/uso terapêutico
Glicolatos/uso terapêutico
Ceratolíticos/uso terapêutico
-Abrasão Química/efeitos adversos
Salicilatos
Resultado do Tratamento
Eritema/etiologia
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-839464
Autor: Radwan, Awwad Abdoh; Alanazi, Fares Kaed; Al-Agamy, Mohammed Hamed.
Título: 1, 3, 4-Thiadiazole and 1, 2, 4-triazole-3(4 H )-thione bearing salicylate moiety: synthesis and evaluation as anti- Candida albicans
Fonte: Braz. J. Pharm. Sci. (Online);53(1):e15239, 2017. tab, graf.
Idioma: en.
Projeto: Scientific Research at King Saud University.
Resumo: Abstract Dramatically increased occurrence of both superficial and invasive fungal infections has been observed. Candida albicans appear to be the main etiological agent of invasive fungal infections. The anti-C. albicans activity of thiosemicarbazide, 1,3,4-Thiadiazole, and 1,2,4-triazole-3(4H)-thione compounds (compounds 3-23) were investigated. The MIC values of thiadiazole and triazole derivatives 10-23 were in the range of 0.08-0.17 µmol mL-1, while that of fluconazole was 0.052 µmol mL-1. Compound 11 (5-(2-(4-chlorobenzyloxy)phenyl)-N-allyl-1,3,4-thiadiazol-2-amine) and compound 18 (5-(2-(4-chlorobenzyloxy)phenyl)-4-allyl-2H-1,2,4-triazole-3(4H)-thione) were found to be the most active compounds, with MIC values of 0.08 µmol mL-1. The newly synthesized thiadiazole and triazole compounds (compounds 10-23) showed promising anti-Candida activity. The allyl substituent-bearing compounds 11 and 18 exhibited significant anti-Candida albicans activity and showed a binding mode as well as the fluconazole x-ray structure.
Descritores: Tiadiazóis/síntese química
Triazóis/síntese química
Candida albicans/isolamento & purificação
Salicilatos/farmacologia
-Simulação de Acoplamento Molecular
Infecções Fúngicas Invasivas/prevenção & controle
Responsável: BR1.1 - BIREME


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Id: biblio-889489
Autor: PELINO, José Eduardo Pelizon; PASSERO, Alan; MARTIN, Airton Abrahao; CHARLES, Christine Ann.
Título: In vitro effects of alcohol-containing mouthwashes on human enamel and restorative materials
Fonte: Braz. oral res. (Online);32:e25, 2018. tab, graf.
Idioma: en.
Resumo: Abstract The objective of this study was to evaluate the in vitro effects, including surface morphological characteristics and chemical elemental properties, of different mouthwash formulations on enamel and dental restorative materials, simulating up to 6 months of daily use. Human enamel samples, hydroxyapatite, composite resin, and ceramic surfaces were exposed to 3 different mouthwashes according to label directions — Listerine® Cool Mint®, Listerine® Total Care, and Listerine® Whitening — versus control (hydroalcohol solution) to simulate daily use for up to 6 months. The samples were analyzed using scanning electron microscopy (SEM), infrared spectrophotometry (µ-Fourier transform infrared microscopy), energy-dispersive X-ray (EDX) spectroscopy, and color analysis before and after exposure. No relevant changes were observed in the morphological characteristics of the surfaces using SEM techniques. The physical and chemical aspects of the enamel surfaces were evaluated using mid-infrared spectroscopy, and EDX fluorescence was used to evaluate the elemental aspects of each surface. There was no variation in the relative concentrations of calcium and phosphorus in enamel, silicon and barium in composite resin, and silicon and aluminum in the ceramic material before and after treatment. No relevant changes were detected in the biochemical and color properties of any specimen, except with Listerine® Whitening mouthwash, which demonstrated a whitening effect on enamel surfaces. Long-term exposure to low pH, alcohol-containing, and peroxide-containing mouthwash formulations caused no ultra-structural or chemical elemental changes in human enamel or dental restorative materials in vitro.
Descritores: Cerâmica
Resinas Compostas
Esmalte Dentário/efeitos dos fármacos
Durapatita
Etanol/química
Etanol/farmacologia
Antissépticos Bucais/química
Antissépticos Bucais/farmacologia
Salicilatos
Terpenos
-Cor
Colorimetria
Combinação de Medicamentos
Peróxido de Hidrogênio/química
Imersão
Teste de Materiais
Microscopia Eletrônica de Varredura
Óleos Voláteis/química
Valores de Referência
Reprodutibilidade dos Testes
Espectrometria por Raios X
Espectroscopia de Infravermelho com Transformada de Fourier
Propriedades de Superfície/efeitos dos fármacos
Fatores de Tempo
Limites: Humanos
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: biblio-853659
Autor: Menezes, Karyna de Melo; Pereira, Jozinete Vieira; Nóbrega, Danúbia Roberta de Medeiros; Freitas, Andréia Fernanda Ramos de; Pereira, Maria do Socorro Vieira; Pereira, Andréia Vieira.
Título: Antimicrobial and Anti-Adherent in vitro Activity of Tannins Isolated from Anacardium occidentale Linn. (Cashew) on Dental Biolfilm Bacteria
Fonte: Pesqui. bras. odontopediatria clín. integr;14(3):191-198, jul. 2014. tab.
Idioma: en.
Resumo: Objective:To evaluate the antimicrobial and ant-adherent in vitro activity of tannins isolated from Anacardium occidentale Linn. (Cashew) on dental biofilm bacteria. Material and Methods:Streptococcus mutans ATCC 25175, Streptococcus mitis ATCC 903, Streptococcus sanguis ATCC 15300, Streptococcus oralis ATCC 10557, Streptococcus salivarius ATCC 7073 and Lactobacillus casei ATCC 9595 samples were used in this study. The tests were performed by the solid medium dilution method to determine the Minimum Inhibitory Concentration (MIC). The Minimum Inhibitory Concentration of Adherence (MICA) of bacteria to glass was determined in the presence of 5% sucrose. As a positive control, 0.12% chlorhexidine gluconate was used. The substances were tested at concentrations of 1:1 (pure solution) up to 1:512. Data were analyzed using descriptive statistics and the SPSS software,version 15.0. Results:Tannins isolated from Anacardium occidentale Linn. (cashew) formed inhibition halos ranging from 11 to 17 mm in diameter and were capable of inhibiting the growth of bacteria tested at concentrations of 1:4 (S mutans), 1:16 (S mitis), 1:8 (Ssanguis), 1:4 (S oralis), 1:8 (S salivarius) and 1:2 (L casei). The tannin solution was effective in inhibiting the adherence of microorganisms to glass, and its effect on Streptococcus sanguis (1:512) and Lactobacillus casei (1:512) stood out, showing ant-adherent effect at all concentrations tested. Conclusion:Tannin isolates produced in vitro antimicrobial and ant-adherent activity on dental biofilm-forming bacteria and can be considered as an alternative treatment in infectious processes in clinical dentistry
Descritores: Anacardium
Antibacterianos
Fitoterapia
Placa Dentária/microbiologia
Salicilatos
-Brasil
Análise Estatística
Técnicas In Vitro/métodos
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos


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Sydney, Gilson Blitzkow
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Id: lil-777235
Autor: MICHELOTTO, André Luiz da Costa; GASPARETTO, João Cleverson; CAMPOS, Francinete Ramos; SYDNEY, Gilson Blitzkow; PONTAROLO, Roberto.
Título: Applying liquid chromatography-tandem mass spectrometry to assess endodontic sealer microleakage
Fonte: Braz. oral res. (Online);29(1):1-7, 2015. tab, ilus.
Idioma: en.
Resumo: The objective of this study was to describe a new method for the quantitative analysis of a microleakage of endodontic filling materials. Forty extracted single-rooted teeth were randomly divided into three experimental groups. After root canal shaping, the experimental groups were filled using the lateral condensation technique with the Epiphany system (G1), with gutta-percha + Sealapex (G2), and with gutta-percha + AH Plus (G3). Each root was mounted on a modified leakage testing device, and caffeine solution was used as a tracer (2000 ng mL-1, pH 6.0), applied in the coronal direction towards the tooth apex, creating a hydrostatic pressure of 2.55 kPa. Presence of caffeine in the receiving solution was measured after 10, 30, and 60 days, using high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). None of the groups presented microleakage at 10 days. At 30 days, G2 and G3 showed similar infiltration patterns (means: 16.0 and 13.9 ng mL-1, respectively), whereas G1 showed significantly higher values (mean: 105.2 ng mL-1). At 60 days, leakage values were 182.6 ng mL-1for G1, 139.0 ng mL-1 for G2, and 53.5 ng mL-1 for G3. AH Plus showed the best sealing ability and HPLC-MS/MS showed high sensitivity and specificity for tracer quantification.
Descritores: Infiltração Dentária/diagnóstico
Obturação do Canal Radicular/métodos
Preparo de Canal Radicular/métodos
-Hidróxido de Cálcio
Cromatografia Líquida
Infiltração Dentária/prevenção & controle
Resinas Epóxi
Guta-Percha
Distribuição Aleatória
Materiais Restauradores do Canal Radicular
Obturação do Canal Radicular/instrumentação
Preparo de Canal Radicular/instrumentação
Salicilatos
Espectrometria de Massas em Tandem
Limites: Humanos
Responsável: BR1.1 - BIREME


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Weckwerth, Paulo Henrique
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Id: lil-777211
Autor: WECKWERTH, Paulo Henrique; LIMA, Fellipe Lombardo de Souza; GREATTI, Vanessa Raquel; DUARTE, Marco Antonio Hungaro; VIVAN, Rodrigo Ricci.
Título: Effects of the association of antifungal drugs on the antimicrobial action of endodontic sealers
Fonte: Braz. oral res. (Online);29(1):1-7, 2015. tab.
Idioma: en.
Resumo: This in vitro study aimed to determine the susceptibility of oral specimens and ATCC lineages of Candida albicans for five endodontic sealers, which were pure and associated with two antifungal drugs, and to analyze their effect on the physical properties. For this purpose, 30 lineages of C. albicans, collected from the oral cavity of patients assisted at the endodontics clinic of the Universidade Sagrado Coração, were analyzed. Yeasts susceptibility to the sealers was tested by diffusion on agar plates. Physical properties were evaluated according to the ADA specification no. 57. The pure versions of the Sealer 26, AH Plus, Endofill, Fillapex, and Sealapex demonstrated antifungal activity, with Endofill presenting the greatest inhibition zones. All cements, except for Endofill, had their antifungal actions enhanced by addition of ketoconazole and fluconazole (p < 0.05), and the AH Plus presented the best antifungal activity. The addition of antifungal drugs did not interfere with the setting time and flowability of the sealers. It was concluded that the addition of antifungals to endodontic sealers enhanced the antimicrobial action of most cements tested without altering their physical properties.
Descritores: Antifúngicos/farmacologia
Candida albicans/efeitos dos fármacos
Fluconazol/farmacologia
Cetoconazol/farmacologia
Materiais Restauradores do Canal Radicular/farmacologia
-Antifúngicos/química
Bismuto/química
Bismuto/farmacologia
Hidróxido de Cálcio/química
Hidróxido de Cálcio/farmacologia
Candida albicans/isolamento & purificação
Resinas Epóxi/química
Resinas Epóxi/farmacologia
Fluconazol/química
Cetoconazol/química
Testes de Sensibilidade Microbiana
Reprodutibilidade dos Testes
Materiais Restauradores do Canal Radicular/química
Estatísticas não Paramétricas
Salicilatos/química
Salicilatos/farmacologia
Responsável: BR1.1 - BIREME


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Id: lil-756388
Autor: Portella, Fernando Freitas; Collares, Fabrício Mezzomo; Santos, Paula Dapper; Sartori, Cláudia; Wegner, Everton; Leitune, Vicente Castelo Branco; Samuel, Susana Maria Werner.
Título: Glycerol Salicylate-based Pulp-Capping Material Containing Portland Cement
Fonte: Braz. dent. j;26(4):357-362, July-Aug. 2015. tab, ilus.
Idioma: en.
Resumo:

The purpose of this study was to evaluate the water sorption, solubility, pH and ability to diffuse into dentin of a glycerol salicylate-based, pulp-capping cement in comparison to a conventional calcium hydroxide-based pulp capping material (Hydcal). An experimental cement was developed containing 60% glycerol salicylate resin, 10% methyl salicylate, 25% calcium hydroxide and 5% Portland cement. Water sorption and solubility were determined based on mass changes in the samples before and after the immersion in distilled water for 7 days. Material discs were stored in distilled water for 24 h, 7 days and 28 days, and a digital pHmeter was used to measure the pH of water. The cement's ability to diffuse into bovine dentin was assessed by Raman spectroscopy. The glycerol salicylate-based cement presented higher water sorption and lower solubility than Hydcal. The pH of water used to store the samples increased for both cements, reaching 12.59±0.06 and 12.54±0.05 after 7 days, for Hydcal and glycerol salicylate-based cements, respectively. Both cements were able to turn alkaline the medium at 24 h and sustain its alkalinity after 28 days. Hydcal exhibited an intense diffusion into dentin up to 40 µm deep, and the glycerol salicylate-based cement penetrated 20 µm. The experimental glycerol salicylate-based cement presents good sorption, solubility, ability to alkalize the surrounding tissues and diffusion into dentin to be used as pulp capping material.

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O objetivo deste estudo foi avaliar a sorção e solubilidade em água, pH e habilidade de difusão na dentina de um cimento para capeamento pulpar à base de glicerol salicilato e compará-lo a um cimento comercial para capeamento pulpar à base de hidróxido de cálcio (Hydcal). Um cimento experimental contendo 60% de resina de glicerol salicilato, 10% de salicilato de metila, 25% de hidróxido de cálcio e 5% de cimento Portland foi formulado. Sorção e solubilidade em água foram determinadas a partir da alteração na massa de espécimes antes e após a imersão em água destilada por 7 dias. Discos dos cimentos foram armazenados em água destilada por 24h, 7 dias e 28 dias e o pH da água foi aferido após cada período. A habilidade de difundir-se no interior de dentina bovina foi avaliada por espectroscopia Raman. O cimento à base de glicerol salicilato apresentou maior sorção e menor solubilidade em comparação com o Hydcal. O pH da água de armazenamento dos espécimes aumentou para ambos os cimentos, chegando a 12,59±0,06 e 12,54±0,05 após 7 dias, para o Hydcal e o cimento à base de glicerol salicilato, respectivamente. Os cimentos foram capazes de promover a alcalinização do meio após 24h e sustentaram a alcalinidade após 28 dias. Hydcal exibiu intensa difusão na dentina até 40 μm de profundidade e o cimento à base de glicerol salicilato penetrou 20 μm. O cimento experimental à base de glicerol salicilato apresentou adequada sorção, solubilidade, habilidade de alcalinizar o meio e difundir-se no interior da dentina para uso como um material para capeamento pulpar.

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Descritores: Capeamento da Polpa Dentária/instrumentação
Glicerol/química
-Salicilatos/química
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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