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  1 / 21 LILACS  
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Id: biblio-839490
Autor: Lima, Isabela Angeli de; Khalil, Najeh Maissar; Mainardes, Rubiana Mara.
Título: A stability-indicating HPLC-PDA method for the determination of ferulic acid in chitosan-coated poly(lactide-co-glycolide) nanoparticles
Fonte: Braz. J. Pharm. Sci. (Online);53(2):e16138, 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT The development and validation of a simple and efficient method for the quantification of ferulic acid in poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles coated with chitosan (CS) by reverse phase high performance liquid chromatography coupled to photodiode array detection was described. For the chromatographic analysis, a reverse phase C-18 column was used, mobile phase consisting of acetonitrile and 0.5% acetic acid (37:63, v/v), isocratically eluted at a flow rate of 1 mL/min. Drug determination was performed at 320 nm. The method was validated in terms of the selectivity, linearity, precision, accuracy, robustness, limits of detection and quantification. The method was linear in the range of 10 to 100 µg/mL (r=0.999) and presented limit of detection and quantification of 102 ng/mL and 310 ng/mL, respectively. The method was precise (intra and inter-day) based on relative standard deviation values (less than 3.20%). The recovery was between 101.06 and 102.10%. Robustness was demonstrated considering change in mobile phase proportion. Specificity assay showed no interference from the components of nanoparticles or from the degradation products derived from acidic and oxidative conditions. The proposed method was suitable to be applied in determining the encapsulation efficiency of ferulic acid in PLGA-CS nanoparticles and can be employed as stability indicating one.
Descritores: Cromatografia Líquida de Alta Pressão/métodos
Quitosana/farmacologia
Nanopartículas/classificação
-Ácidos Cumáricos/farmacologia
Estudos de Validação
Antioxidantes/classificação
Responsável: BR1.1 - BIREME


  2 / 21 LILACS  
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Id: biblio-1007927
Autor: Lock, Olga; Rojas, Rosario.
Título: Phytochemistry and Biological Activities of Werneria and Xenophyllum species / Fitoquímica y actividades biológicas de especies de Werneria y Xenophyllum
Fonte: Bol. latinoam. Caribe plantas med. aromát;18(3):223-238, mayo 2019. ilus.
Idioma: en.
Resumo: Plants of the genera Werneria (Asteraceae) and Xenophyllum (genus extracted from Werneria) are used in traditional medicine of Latin America for the treatment of mountain sickness, hypertension and gastrointestinal disorders. Only a small number of species of these genera have been studied, leading to the isolation of compounds belonging to the classes of benzofurans, chromenes, acetophenones, coumarates, diterpenes and pyrrolizidine alkaloids. Some of the plant extracts and/or compounds have shown antimicrobial, anti-HIV, hypotensive and photoprotective activities.

Las plantas de los géneros Werneria (Asteraceae) y Xenophyllum (género extraido de Werneria) son usadas en la medicina tradicional de América Latina para el tratamiento del mal de montaña, hipertensión y desórdenes gastrointestinales. Solo un pequeño número de especies de estos géneros ha sido investigado, lográndose aislar compuestos que pertenecen a las clases de benzofuranos, cromenos, acetofenonas, cumaratos, diterpenos y alcaloides pirrolizidínicos. Algunos de los extractos y/o compuestos de dichas plantas han mostrado actividades antimicrobianas, anti-HIV, hipotensoras y fotoprotectoras.
Descritores: Plantas Medicinais/química
Extratos Vegetais/uso terapêutico
Asteraceae/química
-Acetofenonas/química
Terpenos/análise
Benzopiranos/química
Flavonoides/química
Ácido Clorogênico/química
Ácidos Cumáricos/química
Alcaloides/química
Doença da Altitude/tratamento farmacológico
Hipertensão/tratamento farmacológico
Medicina Tradicional
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


  3 / 21 LILACS  
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Id: biblio-907560
Autor: Bach, Hernán G; Iturbe, Nicolás; Agudelo, Ignacio J; Wagner, Marcelo L; Ricco, Rafael A.
Título: Dinámica de polifenoles en ephedra tweediana fisch & C. A. Mey. emend. J. H. Hunz. (Ephedraceae) / Polyphenol dinamics in ephedra tweediana fisch & C. A. Mey. emend. J. H. Hunz. (Ephedraceae)
Fonte: Bol. latinoam. Caribe plantas med. aromát;16(1):1-13, ene. 2017. ilus, tab.
Idioma: es.
Resumo: Ephedra tweediana (Ephedraceae), conocida como “tramontana”, es empleada en la medicina popular como antiasmático. Se analizaron comparativamente los extractos acuosos de los tallos herbáceos, lignificados y partes subterráneas, provenientes de ejemplares femeninos y masculinos. En los tallos lignificados se determinó la presencia de proapigeninidina (cuya identidad fue corroborada por comparación con un testigo de apigeninidina sometido a estudios de FAB-MS, UV, HPLC, 1H-NMR y espectroscopía IR); mientras que en los órganos subterráneos se determinó la presencia de proapigeninidina y propelargonidina (la identidad de la pelargonidina fue establecida por comparación con un testigo de pelargonidina sometido a estudios de TLC/HPTLC y espectroscopía UV-Visible). Estos compuestos no se observaron en los tallos herbáceos. Los tallos herbáceos presentaron las mayores concentraciones de flavonoides y ácidos hidroxicinámicos totales. Los órganos subterráneos presentaron la mayor concentración de taninos y proantocianidinas. En los tallos herbáceos se detectó una reacción fuertemente positiva para flavonoides. No se observó reacción positiva para proantocianidinas. En el tallo aéreo lignificado se observó una reacción positiva para flavonoides y proantocianidinas a nivel de la peridermis. En los órganos subterráneos, los flavonoides y proantocianidinas se localizaron principalmente en los tejidos más externos. Este trabajo constituye el primer aporte a la dinámica de polifenoles de E. tweediana.

Ephedra tweediana (Ephedraceae), known as "tramontana" is used in folk medicine as antiasthmatic. Aqueous extracts obtained from young stems, woody stems and underground parts were analyzed and compared. In lignified stems was detected proapigeninidin (whose identity was confirmed by comparison with a control apigeninidin subjected to FAB-MS, UV, HPLC, 1H-NMR and IR spectroscopy), while underground organs were detected proapigeninidin and propelargonidin (by comparison with a control pelargonidin whose identity was established by studies of TLC/HPTLC, and UV-visible spectroscopy). These compounds were not observed in the herbaceous stems. The herbaceous stems had the highest concentrations of total flavonoids and hydroxycinnamic acids. Uderground organs had the highest concentration of tannins and proanthocyanidins. In herbaceous stems a strong positive reaction for flavonoids was detected. No positive reaction was observed for proanthocyanidins. In the periderm of woody aerial stem a positive reaction for flavonoids and proanthocyanidins were observed. In the underground organs, flavonoids and proanthocyanidins were located mainly in the more external tissues. This work is the first contribution to the dynamic of E. tweediana polyphenols.
Descritores: Ácidos Cumáricos/análise
Ephedra/química
Flavonoides/análise
Fenóis/análise
Extratos Vegetais/química
-Cromatografia Gasosa/métodos
Proantocianidinas/análise
Limites: Seres Humanos
Responsável: CL1.1 - Biblioteca Central


  4 / 21 LILACS  
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Id: biblio-839244
Autor: de Melo, TS; Lima, PR; Carvalho, KMMB; Fontenele, TM; Solon, FRN; Tomé, AR; de Lemos, TLG; da Cruz Fonseca, SG; Santos, FA; Rao, VS; de Queiroz, MGR.
Título: Ferulic acid lowers body weight and visceral fat accumulation via modulation of enzymatic, hormonal and inflammatory changes in a mouse model of high-fat diet-induced obesity
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(1):e5630, 2017. tab, graf.
Idioma: en.
Resumo: Previous studies have reported on the glucose and lipid-lowering effects of ferulic acid (FA) but its anti-obesity potential has not yet been firmly established. This study investigated the possible anti-obesitogenic effects of FA in mice fed a high-fat diet (HFD) for 15 weeks. To assess the antiobesity potential of FA, 32 male Swiss mice, weighing 20–25 g (n=6–8 per group) were fed a normal diet (ND) or HFD, treated orally or not with either FA (10 mg/kg) or sibutramine (10 mg/kg) for 15 weeks and at the end of this period, the body weights of animals, visceral fat accumulation, plasma levels of glucose and insulin hormone, amylase and lipase activities, the satiety hormones ghrelin and leptin, and tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCH-1) were analyzed. Results revealed that FA could effectively suppress the HFD-associated increase in visceral fat accumulation, adipocyte size and body weight gain, similar to sibutramine, the positive control. FA also significantly (P<0.05) decreased the HFD-induced elevations in serum lipid profiles, amylase and lipase activities, and the levels of blood glucose and insulin hormone. The markedly elevated leptin and decreased ghrelin levels seen in HFD-fed control mice were significantly (P<0.05) reversed by FA treatment, almost reaching the values seen in ND-fed mice. Furthermore, FA demonstrated significant (P<0.05) inhibition of serum levels of inflammatory mediators TNF-α, and MCH-1. These results suggest that FA could be beneficial in lowering the risk of HFD-induced obesity via modulation of enzymatic, hormonal and inflammatory responses.
Descritores: Fármacos Antiobesidade/farmacologia
Ácidos Cumáricos/farmacologia
Ciclobutanos/farmacologia
Gordura Intra-Abdominal/efeitos dos fármacos
Obesidade/tratamento farmacológico
-Tecido Adiposo/patologia
Dieta Hiperlipídica
Modelos Animais de Doenças
Obesidade/patologia
Limites: Animais
Masculino
Camundongos
Responsável: BR1.1 - BIREME


  5 / 21 LILACS  
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Id: lil-771936
Autor: Bocco, B M; Fernandes, G W; Lorena, F B; Cysneiros, R M; Christoffolete, M A; Grecco, S S; Lancellotti, C L; Romoff, P; Lago, J H G; Bianco, A C; Ribeiro, M O.
Título: Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;49(3):e5003, Mar. 2016. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model.
Descritores: Baccharis/química
Ácidos Cafeicos/administração & dosagem
Ácidos Cumáricos/administração & dosagem
Síndrome Metabólica/prevenção & controle
Substâncias Protetoras/administração & dosagem
-Ácidos Cafeicos/química
Colesterol/metabolismo
Ácidos Cumáricos/química
Dieta Hiperlipídica/efeitos adversos
Quimioterapia Combinada/métodos
Fígado Gorduroso/metabolismo
Fígado Gorduroso/patologia
Síndrome Metabólica/tratamento farmacológico
Camundongos Endogâmicos C57BL
Modelos Animais
Substâncias Protetoras/química
Triglicerídeos/metabolismo
Limites: Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  6 / 21 LILACS  
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Id: lil-768849
Autor: Vinet, Raúl; Araos, Patricio; Gentina, Juan Carlos; Knox, Marcela; Guzmán, Leda.
Título: p-Coumaric acid reduces high glucose-mediated impairment of endothelium-dependent relaxation in rat aorta / Ácido p-cumárico reduce el deterioro mediado por alta glucosa de la relajación dependiente de endotelio en aorta de rata
Fonte: Bol. latinoam. Caribe plantas med. aromát;13(3):232-237, mayo 2014. ilus, tab.
Idioma: en.
Projeto: Universidad de Valparaíso (Chile); . P. Universidad Católica de Valparaíso (Chile).
Resumo: p-Coumaric acid (p-CA) is an ubiquitous plant metabolite with antioxidant, anti-inflammatory, and anticancer properties. The present study was designed to evaluate the preventive effects of p-CA on endothelium-dependent impairment produced by high glucose (HG) (D-Glucose 25 mM) in isolated rat thoracic aorta. Aortic rings obtained from male Sprague-Dawley rats were mounted in an organ bath and pretreated for 3 h with D-Glucose 5 mM, HG and HG plus p-CA (1, 10 and 100 uM). After this period of time endothelium-dependent relaxation was tested by cumulative addition of acetylcholine (ACh) in pre-contracted rings with phenylephrine (PE) (0.1 μM). p-CA elicited a moderate endothelium-dependent vasodilatory effect (Emax= 29.28 +/- 1.89 percent, N=6; pD2= 6.075 +/- 0.184, N=6). When aortic rings were pre-incubated for 3 h with HG, Emax for ACh decreased dramatically from 87.69 +/- 2.59 percent (N=6) to 40.54 +/- 1.78 percent (N=6). The negative effect of HG was partially reverted in rings co-incubated with p-CA in a concentration-dependent manner as shown for Emax values to each p-CA concentration: 1 uM (48.57 +/- 1.82 percent), 10 uM (60.81 +/- 1.80 percent) and 100 uM (64.51 +/- 1.80 percent). The action of p-CA was associated with a significant change in Emax. No statistical difference in pD2 was observed. Our results clearly show that p-CA protect ACh-induced endothelial-dependent relaxation affected by HG in isolated rat aortic rings.

El ácido p-cumárico (p-CA) es un metabolito ubicuo en plantas, con propiedades antioxidantes, anti-inflamatoria, y anticancerígenas. El presente estudio fue diseñado para evaluar los efectos preventivos de p-CA sobre la relajación dependiente de endotelio, deteriorada por niveles altos de glucosa (HG) (D-glucosa 25 mM) en aorta torácica aislada de rata. Los anillos aórticos obtenidos de ratas macho Sprague-Dawley se montaron en un baño de órganos y fueron pre-tratados durante 3 h con D-glucosa 5 mM, HG, y HG más de p-CA (1, 10 y 100 uM). Después de este período de tiempo se evaluó la relajación dependiente de endotelio mediante la adición acumulativa de acetilcolina (ACh) en anillos pre-contraídos con fenilefrina (PE) (0,1 uM). p-CA mostró un moderado efecto vasodilatador dependiente de endotelio (Emax = 29,28 +/- 1,89 por ciento, N = 6; pD2 = 6,075 +/- 0,184, N = 6). Cuando los anillos aórticos se pre-incubaron durante 3 h con HG, la Emax para ACh se redujo drásticamente desde 87,69 +/- 2,59 por ciento (N = 6) a 40,54 +/- 1,78 por ciento (N = 6). El efecto negativo de HG se revirtió parcialmente, de manera dependiente de concentración, en los anillos co-incubados con p-CA tal como lo muestra el valor de Emax para cada concentración de p-CA: 1 u M (48,57 +/- 1,82 por ciento), 10 uM (60,81 +/- 1,80 por ciento) y 100 uM (64,51 +/- 1,80 por ciento). La acción de p-CA se asoció con un cambio significativo en la Emax. No se observó diferencia estadísticamente significativa en el pD2. Nuestros resultados muestran claramente que p-CA protege la relajación dependiente de endotelio inducida por ACh, la cual es afectada por HG en anillos aislados de aorta de rata.
Descritores: Aorta
Ácidos Cumáricos/farmacologia
Endotélio Vascular
Glucose/fisiologia
-Acetilcolina/fisiologia
Ratos Sprague-Dawley
Limites: Animais
Ratos
Responsável: CL1.1 - Biblioteca Central


  7 / 21 LILACS  
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Id: lil-741267
Autor: Abou-Dobara, M.I.; Omar, N.F..
Título: Poly R decolorization and APPL production by Streptomyces violaceoruber and Streptomyces spiroverticillatus
Fonte: Braz. j. microbiol;45(4):1179-1186, Oct.-Dec. 2014. graf, tab.
Idioma: en.
Resumo: Two mesophilic streptomycetes (S. violaceoruber and S. spiroverticillatus) were selected to study their Poly R-478 decolorization ability and lignocellulose solubilizing activity. Both strains were able to degrade Poly R-478 dye and ferulic acid during growth on a minimal salts medium. The Poly R-478 decolorizing activities of both strains were induced by adding different carbon sources to the culture media. S. violaceoruber could decolorize 63% of Poly R-478 after 24 h. Both strains could solubilize straw and produce acid-precipitable polymeric lignin (APPL) with different efficiency. From the major extracellular enzymes recovery of both strains on rice and wheat straw, we can predicate that the biodegradation process was partial indicating a possible utilization in biological delignification.
Descritores: Antraquinonas/metabolismo
Lignina/metabolismo
Polímeros/metabolismo
Streptomyces/metabolismo
-Biotransformação
Ácidos Cumáricos/metabolismo
Meios de Cultura/química
Oryza/metabolismo
Caules de Planta/metabolismo
Streptomyces/crescimento & desenvolvimento
Triticum/metabolismo
Responsável: BR1.1 - BIREME


  8 / 21 LILACS  
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Id: lil-734615
Autor: Eyduran, Sadiye Peral; Akin, Meleksen; Ercisli, Sezai; Eyduran, Ecevit; Maghradze, David.
Título: Sugars, organic acids, and phenolic compounds of ancient grape cultivars (Vitis vinifera L.) from Igdir province of Eastern Turkey
Fonte: Biol. Res;48:1-8, 2015. tab.
Idioma: en.
Resumo: BACKGROUND: The Eurasian grapevine (Vitis vinifera L.) is the most widely cultivated and economically important horticultural crop in the world. As a one of the origin area, Anatolia played an important role in the diversification and spread of the cultivated form V. vinifera ssp. vinifera cultivars and also the wild form V. vinifera ssp. sylvestris ecotypes. Although several biodiversity studies have been conducted with local cultivars in different regions of Anatolia, no information has been reported so far on the biochemical (organic acids, sugars, phenolic acids, vitamin C) and antioxidant diversity of local historical table V. vinifera cultivars grown in Igdir province. In this work, we studied these traits in nine local table grape cultivars viz. 'Beyaz Kismis' (synonym name of Sultanina or Thompson seedless), 'Askeri', 'El Hakki', 'Kirmizi Kismis', 'Inek Emcegi', 'Hacabas', 'Kerim Gandi', 'Yazen Dayi', and 'Miskali' spread in the Igdir province of Eastern part of Turkey. RESULTS: Variability of all studied parameters is strongly influenced by cultivars (P < 0.01). Among the cultivars investigated, 'Miskali' showed the highest citric acid content (0.959 g/l) while 'Kirmizi Kismis' produced predominant contents in tartaric acid (12.71 g/l). The highest glucose (16.47 g/100 g) and fructose (15.55 g/100 g) contents were provided with 'Beyaz Kismis'. 'Kirmizi Kismis' cultivar had also the highest quercetin (0.55 mg/l), o-coumaric acid (1.90 mg/l), and caffeic acid (2.73 mg/l) content. The highest ferulic acid (0.94 mg/l), and syringic acid (2.00 mg/l) contents were observed with 'Beyaz Kismis' cultivar. The highest antioxidant capacity was obtained as 9.09 μmol TE g-1 from 'Inek Emcegi' in TEAC (Trolox equivalent Antioxidant Capacity) assay. 'Hacabas' cultivar had the highest vitamin C content of 35.74 mg/100 g. CONCLUSIONS: Present results illustrated that the historical table grape cultivars grown in Igdir province of Eastern part of Turkey contained diverse and valuable sugars, organic acids, phenolic acids, Vitamin C values and demonstrated important antioxidant capacity for human health benefits. Further preservation and use of this gene pool will be helpful to avoid genetic erosion and to promote continued agriculture in the region.
Descritores: Ácido Cítrico/análise
Carboidratos da Dieta/análise
Frutas/química
Polifenóis/análise
Vitis/química
-Ácidos/análise
Antioxidantes/análise
Ácido Ascórbico/análise
Ácidos Cafeicos/análise
Ácidos Cumáricos/análise
Produtos Agrícolas/química
Produtos Agrícolas/classificação
Ácido Gálico/análise
Ácido Gálico/análogos & derivados
Hidroxibenzoatos/análise
Turquia
Tartaratos/análise
Vitis/classificação
Responsável: CL1.1 - Biblioteca Central


  9 / 21 LILACS  
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Id: lil-734576
Autor: Kuhar, Francisco; Papinutti, Leandro.
Título: Optimization of laccase production by two strains of Ganoderma lucidum using phenolic and metallic inducers / Optimización de la producción de lacasa por dos cepas de Ganoderma lucidum utilizando inductores fenólicos y metálicos
Fonte: Rev. argent. microbiol;46(2):144-149, jun. 2014. tab, ilus, graf.
Idioma: en.
Resumo: Ganoderma lucidum (Curtis) P. Karst es un hongo causante de pudrición blanca, capaz de degradar la lignina de la madera y otros sustratos en los que crece. En este trabajo se evaluó la capacidad de dos cepas de esta especie de producir la enzima ligninolítica lacasa. Asimismo, se ensayó la inducción de esta enzima con diferentes compuestos fenólicos e iones metálicos, y se encontró que el ácido ferúlico y el cobre fueron los mejores inductores de la lacasa entre los agentes evaluados. También se encontró que los dos tipos de inductores (fenólicos y metálicos) producen distintos patrones electroforéticos de actividad lacasa. Las concentraciones óptimas de los inductores fueron establecidas mediante un diseño factorial. Se estimó la estabilidad térmica de la lacasa en un amplio rango de pH ácidos, y se comprobó que a pH más altos la enzima es más termoestable.

Ganoderma lucidum (Curtis) P. Karst is a white rot fungus that is able to degrade the lignin component in wood. The ability of two strains of this species to produce the ligninolytic enzyme laccase was assessed. After the evaluation of induction with heavy metals and phenolic compounds, it was found that among the tested substances, copper and ferulic acid are the best laccase inducers. It was also observed that the two types of inducers (phenolic and metallic) produce different electrophoretic patterns of laccase activity. Optimized concentrations of inducers were obtained through a factorial design and the thermal stability of optimized supernatants was studied at a wide range of acidic pH. We found that the enzyme is more thermostable at higher pH values.
Descritores: Lacase/biossíntese
Reishi/efeitos dos fármacos
Reishi/metabolismo
-Ácidos Cumáricos
Cobre/farmacologia
Manganês/farmacologia
Fenóis/farmacologia
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


  10 / 21 LILACS  
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Id: lil-686901
Autor: Ricco, Rafael Alejandro; Wagner, Marcelo Luis; Gurni, Alberto Ángel.
Título: Dinámica de polifenoles de “Cedrón” (Aloysia citrodora Palau -Verbenaceae-) en relación al desarrollo foliar / Polyphenol dinamics on “cedrón” (Aloysia citrodora Palau -Verbenaceae-) according to leave development
Fonte: Bol. latinoam. Caribe plantas med. aromát;10(1):67-74, ene. 2011. ilus, tab.
Idioma: es.
Projeto: UBA B120; . ANPCYT-PICT.
Resumo: Leaf infusions from Aloysia citrodora Palau –Verbenaceae-, known as “cedrón” were analyzed in order to establish the possible influence of their development on polyphenols profile. Chromatographic fingerprints of infusions from young and full expanded leaves were performed and total phenols, total tannins, total flavonoids and total hydroxycinnamic acids were quantified. Young leaves had significative higher total phenols, total flavonoids and total hydroxycinnamic acids concentrations than full expanded leaves. This research suggest that the analyzed parameter should be considered when elaborating products from “cedrón” leaves, as the variation in compound concentration may translate in different biological activities.

Se analizaron las infusiones realizadas a partir de las hojas de Aloysia citrodora Palau –Verbenaceae-, conocida vulgarmente como “cedrón”, con el objeto de establecer la influencia del grado de desarrollo foliar en el perfil de polifenoles. Se obtuvieron los perfiles cromatográficos y se cuantificaron los fenoles totales, taninos totales, flavonoides totales y ácidos hidroxicinámicos totales provenientes de los extractos acuosos de las hojas jóvenes y adultas. Se observaron diferencias cuali-cuantitativas en el perfil de polifenoles cuando se comparan las hojas jóvenes con las hojas adultas. En las hojas jóvenes, las concentraciones de fenoles totales, flavonoides totales y ácidos hidroxicinámicos totales resultaron ser significativamente superiores a las determinadas en las hojas adultas. Los estudios realizados sugieren que la variable aquí analizada debe ser considerada al momento de elaborar productos en base a hojas de cedrón, dado que las diferentes concentraciones detectadas podrían traducirse en diferentes actividades biológicas.
Descritores: Flavonoides/análise
Folhas de Planta/química
Polifenóis/análise
Taninos/análise
Verbenaceae/química
-Ácidos Cumáricos/análise
Cedron
Extratos Vegetais/química
Folhas de Planta/crescimento & desenvolvimento
Verbenaceae/crescimento & desenvolvimento
Responsável: CL1.1 - Biblioteca Central



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