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Pesquisa : D02.241.223.200.210 [Categoria DeCS]
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  1 / 26 LILACS  
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Id: biblio-1047456
Autor: Romero-Borbón, Evelyn; Grajales-Hernández, Daniel; Armendáriz-Ruiz, Mariana; Ramírez-Velasco, Lorena; Rodríguez-González, Jorge Alberto; Cira-Chávez, Luis Alberto; Estrada-Alvarado, María Isabel; Mateos-Díaz, Juan Carlos.
Título: Type C feruloyl esterase from Aspergillus ochraceus: a butanol specific biocatalyst for the synthesis of hydroxycinnamates in a ternary solvent system
Fonte: Electron. j. biotechnol;35:1-9, sept. 2018. graf, tab.
Idioma: en.
Projeto: Fondo Mixto del Gobierno del Estado de Jalisco.
Resumo: Background: Aspergillus ochraceus was isolated from coffee pulp and selected as an interesting hydroxycinnamoyl esterase strain producer, using an activity microplate high-throughput screening method. In this work, we purified and characterized a new type C A. ochraceus feruloyl esterase (AocFaeC), which synthesized specifically butyl hydroxycinnamates in a ternary solvent system. Results: AocFaeC was produced by solid state fermentation, reaching its maximal activity (1.1 U/g) after 48 h of culture. After purification, the monomeric protein (34 kDa) showed a specific activity of 57.9 U/mg towards methyl ferulate. AocFaeC biochemical characterization confirmed its identity as a type C feruloyl esterase and suggested the presence of a catalytic serine in the active site. Its maximum hydrolytic activity was achieved at 40°C and pH 6.5 and increased by 109 and 77% with Ca2+ and Mg2+, but decreased by 90 and 45% with Hg2+ and Cu2+, respectively. The initial butyl ferulate synthesis rate increased from 0.8 to 23.7 nmol/min after transesterification condition improvement, using an isooctane:butanol:water ternary solvent system, surprisingly the synthesis activity using other alcohols was negligible. At these conditions, the synthesis specific activities for butyl p-coumarate, sinapinate, ferulate, and caffeate were 87.3, 97.6, 168.2, and 234 U/µmol, respectively. Remarkably, AocFaeC showed 5 folds higher butyl caffeate synthesis rate compared to type B Aspergillus niger feruloyl esterase, a well-known enzyme for its elevated activity towards caffeic acid esters. Conclusions: Type C feruloyl esterase from A. ochraceus is a butanol specific biocatalyst for the synthesis of hydroxycinnamates in a ternary solvent system
Descritores: Aspergillus ochraceus/enzimologia
Hidrolases de Éster Carboxílico/metabolismo
Ácidos Cumáricos/síntese química
-Solventes
Espectrofotometria
Hidrolases de Éster Carboxílico/isolamento & purificação
Cromatografia
Café
Butanóis
Eletroforese
Fermentação
Responsável: CL1.1 - Biblioteca Central


  2 / 26 LILACS  
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Texto completo SciELO Chile
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Id: biblio-950715
Autor: Sytar, Oksana; Borankulova, Asel; Hemmerich, Irene; Rauh, Cornelia; Smetanska, Iryna.
Título: Effect of chlorocholine chlorid on phenolic acids accumulation and polyphenols formation of buckwheat plants
Fonte: Biol. Res;47:1-7, 2014. graf, tab.
Idioma: en.
Resumo: BACKGROUND: Effect of chlorocholine chloride (CCC) on phenolic acids composition and polyphenols accumulation in various anatomical parts (stems, leaves and inflorescences) of common buckwheat (Fagopyrum esculentum Moench) in the early stages of vegetation period were surveyed. RESULTS: Treatment of buckwheat seeds with 2% of CCC has been increased content of total phenolics in the stems, leaves and inflorescences. On analyzing the different parts of buckwheat plants, 9 different phenolic acids - vanilic acid, ferulic acid, trans-ferulic acid, chlorogenic acid, salycilic acid, cinamic acid, p-coumaric acid, p-anisic acid, methoxycinamic acid and catechins were identified. The levels of identified phenolic acids varied not only significantly among the plant organs but also between early stages of vegetation period. Same changes as in contents of chlorogenic acid, ferulic acid, trans-ferulic acid were found for content of salycilic acid. The content of these phenolic acids has been significant increased under effect of 2% CCC treatment at the phase I (formation of buds) in the stems and at the phase II (beginning of flowering) in the leaves and then inflorescences respectively. The content of catechins as potential buckwheat antioxidants has been increased at the early stages of vegetation period after treatment with 2% CCC. CONCLUSIONS: The obtained results suggest that influence of CCC on the phenolics composition can be a result of various mechanisms of CCC uptake, transforming and/or its translocation in the buckwheat seedlings.
Descritores: Clormequat/farmacologia
Fagopyrum/efeitos dos fármacos
Polifenóis/biossíntese
Hidroxibenzoatos/metabolismo
-Propionatos
Sementes/efeitos dos fármacos
Sementes/metabolismo
Catequina/análise
Ácido Clorogênico/análise
Cromatografia Líquida de Alta Pressão
Compostos de Tungstênio
Caules de Planta/efeitos dos fármacos
Caules de Planta/metabolismo
Folhas de Planta/efeitos dos fármacos
Folhas de Planta/metabolismo
Fagopyrum/crescimento & desenvolvimento
Fagopyrum/metabolismo
Ácidos Cumáricos/análise
Inflorescência/efeitos dos fármacos
Inflorescência/metabolismo
Éteres de Hidroxibenzoatos/análise
Hidroxibenzoatos/química
Molibdênio
Antioxidantes/análise
Antioxidantes/metabolismo
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


  3 / 26 LILACS  
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Texto completo SciELO Chile
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Id: biblio-950733
Autor: Cetin, Emine Sema.
Título: Induction of secondary metabolite production by UV-C radiation in Vitis vinifera L. Öküzgözü callus cultures
Fonte: Biol. Res;47:1-7, 2014. tab.
Idioma: en.
Resumo: BACKGROUND: The aim of the present work was to examine the role of UV-C irradiation on the production of secondary metabolites (total phenolic, total flavanols, total flavonols, catechin, ferulic acid and trans-resveratrol in phenolic compounds and α-, ß-, γ- δ-tocopherols) in callus cultures. Studies on the effects of UV-C treatment on callus culture are seldom and generally focused on UV-B. However UV-C radiation play an important role in accumule secondary metabolites. RESULTS: In this study, callus cultures from Öküzgözü grape cultivar were initiated from leaf petiole explants. Calli formed after 6 weeks on the medium supplemented with 0.5 mg L-1 benzylaminopurine (BA), 0.5 mg L-1 indole acetic acid (IAA) on B5 media. Callus tissues were exposed to UV-C irradiation at 10, 20 and 30 cm distances from the UV source for 5 and 10 minutes and samples were collected at hours 0, 24 and 48. CONCLUSIONS: The greatest total phenolic content (155.14 mg 100 g-1) was detected in calli exposed to UV-C for 5 min from 30 cm distance and sampled after 24 h. 24 h and 48 h incubation times, 30 cm and 5 min were the most appropriate combination of UV-C application in total flavanol content. Maximum total flavonol content (7.12 mg 100 g-1) was obtained on 0 h, 5 min and 20 cm combination. The highest (+)- catechin accumulation (8.89 mg g-1) was found in calli with 10 min UV-C application from 30 cm distance and sampled after 48 h. Ferulic acid content increased 6 fold in Öküzgözü callus cultures (31.37 µg g-1) compared to the control group. The greatest trans-resveratrol content (8.43 µg g-1) was detected in calli exposed to UV-C for 5 min from 30 cm distance and sampled after 24 h. The highest α-tocopherol concentration was found in calli exposed to UV-C for 10 min from 30 cm distance and sampled after 24 h. As a conclusion, it was showed that UV-C radiation had remarkable promoting effects on the accumulation of secondary metabolites in the calli of Öküzgözü grape cultivar.
Descritores: Raios Ultravioleta
Folhas de Planta/efeitos da radiação
Produtos Agrícolas/efeitos da radiação
Vitis/efeitos da radiação
Técnicas de Embriogênese Somática de Plantas/métodos
Metabolismo Secundário/efeitos da radiação
-Fenóis/análise
Estilbenos/análise
Flavonoides/análise
Catequina/análise
Cromatografia
Folhas de Planta/metabolismo
Folhas de Planta/química
Produtos Agrícolas/fisiologia
Ácidos Cumáricos/análise
Vitis/metabolismo
Vitis/química
Tocoferóis/análise
Flavonóis/análise
Metabolismo Secundário/fisiologia
Resveratrol
Responsável: CL1.1 - Biblioteca Central


  4 / 26 LILACS  
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Id: biblio-1051542
Autor: Hernández-Chávez, Georgina; Martinez, Alfredo; Gosset, Guillermo.
Título: Metabolic engineering strategies for caffeic acid production in Escherichia coli
Fonte: Electron. j. biotechnol;38:19-26, Mar. 2019. ilus, tab.
Idioma: en.
Projeto: Programa de Apoyo a Proyectos de Investigación e Innovación Tecnológica PAPIIT/UNAM.
Resumo: Caffeic acid (CA; 3,4-dihydroxycinnamic acid) is an aromatic compound obtained by the phenylpropanoid pathway. This natural product has antioxidant, antitumor, antiviral, and anti-inflammatory activities. It is also a precursor of CA phenethyl ester (CAPE), a compound with potential as an antidiabetic and liver-protective agent. CA can be found at low concentrations in plant tissues, and hence, its purification is difficult and expensive. Knowledge regarding the pathways, enzymes, and genes involved in CA biosynthesis has paved the way for enabling the design and construction of microbial strains with the capacity of synthesizing this metabolite. In this review, metabolic engineering strategies for the generation of Escherichia coli strains for the biotechnological production of CA are presented and discussed.
Descritores: Ácidos Cafeicos/metabolismo
Escherichia coli/metabolismo
Engenharia Metabólica/métodos
-Produtos Biológicos
Biotecnologia
Ácidos Cumáricos
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


  5 / 26 LILACS  
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Id: biblio-1007927
Autor: Lock, Olga; Rojas, Rosario.
Título: Phytochemistry and Biological Activities of Werneria and Xenophyllum species / Fitoquímica y actividades biológicas de especies de Werneria y Xenophyllum
Fonte: Bol. latinoam. Caribe plantas med. aromát;18(3):223-238, mayo 2019. ilus.
Idioma: en.
Resumo: Plants of the genera Werneria (Asteraceae) and Xenophyllum (genus extracted from Werneria) are used in traditional medicine of Latin America for the treatment of mountain sickness, hypertension and gastrointestinal disorders. Only a small number of species of these genera have been studied, leading to the isolation of compounds belonging to the classes of benzofurans, chromenes, acetophenones, coumarates, diterpenes and pyrrolizidine alkaloids. Some of the plant extracts and/or compounds have shown antimicrobial, anti-HIV, hypotensive and photoprotective activities.

Las plantas de los géneros Werneria (Asteraceae) y Xenophyllum (género extraido de Werneria) son usadas en la medicina tradicional de América Latina para el tratamiento del mal de montaña, hipertensión y desórdenes gastrointestinales. Solo un pequeño número de especies de estos géneros ha sido investigado, lográndose aislar compuestos que pertenecen a las clases de benzofuranos, cromenos, acetofenonas, cumaratos, diterpenos y alcaloides pirrolizidínicos. Algunos de los extractos y/o compuestos de dichas plantas han mostrado actividades antimicrobianas, anti-HIV, hipotensoras y fotoprotectoras.
Descritores: Plantas Medicinais/química
Extratos Vegetais/uso terapêutico
Asteraceae/química
-Acetofenonas/química
Terpenos/análise
Benzopiranos/química
Flavonoides/química
Ácido Clorogênico/química
Ácidos Cumáricos/química
Alcaloides/química
Doença da Altitude/tratamento farmacológico
Hipertensão/tratamento farmacológico
Medicina Tradicional
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


  6 / 26 LILACS  
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Texto completo SciELO Brasil
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Id: biblio-886629
Autor: CALEGARI, MATHEUS A; PRASNIEWSKI, ANA CLARA; SILVA, CLEIDIANE DA; SADO, RICARDO Y; MAIA, FABIANA M C; TONIAL, LARISSA M S; OLDONI, TATIANE L C.
Título: Propolis from Southwest of Parana produced by selected bees: Influence of seasonality and food supplementation on antioxidant activity and phenolic profile
Fonte: An. acad. bras. ciênc;89(1):45-55, Jan,-Mar. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Propolis produced by selected bees Apis mellifera were collected from March to June of 2013 and in March of 2015 and analyzed in order to evaluate the influence of climate, colony of origin, and food supplementation of colonies on the content of total phenolic and flavonoid by chromatographic analysis and antioxidant activity by radical scavenging of 2,2-diphenyl-1-picrylhydrazyl hydrate (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) and ferric reducing antioxidant power (FRAP) methods. The Principal Component Analysis (PCA) was carried out with propolis collected in 2013 and two clusters were formed. Propolis produced in the months of March and April showed a higher content of total phenolic compounds (TPC) and antioxidant capacity than those produced in May and June. The results of PCA obtained from samples collected in March of 2013 and 2015 showed two clusters, and propolis collected in 2015 were more bioactive and presented a higher content of TPC. The chromatographic analysis of extracts allowed the identification of phenolic acids p-coumaric, ferulic and caffeic with similar chemical profiles that could be closely related to the botanical origin of propolis. It can be concluded that the season and food supplementation of colonies influenced the chemical composition and the biological activity of samples analysed.
Descritores: Própole/química
Estações do Ano
Abelhas/fisiologia
Suplementos Nutricionais
Hidroxibenzoatos/análise
Antioxidantes/análise
-Valores de Referência
Temperatura
Flavonoides/análise
Ácidos Cafeicos/análise
Análise Multivariada
Reprodutibilidade dos Testes
Cromatografia Líquida de Alta Pressão
Ácidos Cumáricos/análise
Análise de Componente Principal
Indicadores e Reagentes
Limites: Animais
Responsável: BR1.1 - BIREME


  7 / 26 LILACS  
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Id: biblio-839490
Autor: Lima, Isabela Angeli de; Khalil, Najeh Maissar; Mainardes, Rubiana Mara.
Título: A stability-indicating HPLC-PDA method for the determination of ferulic acid in chitosan-coated poly(lactide-co-glycolide) nanoparticles
Fonte: Braz. J. Pharm. Sci. (Online);53(2):e16138, 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT The development and validation of a simple and efficient method for the quantification of ferulic acid in poly (D,L-lactide-co-glycolide) (PLGA) nanoparticles coated with chitosan (CS) by reverse phase high performance liquid chromatography coupled to photodiode array detection was described. For the chromatographic analysis, a reverse phase C-18 column was used, mobile phase consisting of acetonitrile and 0.5% acetic acid (37:63, v/v), isocratically eluted at a flow rate of 1 mL/min. Drug determination was performed at 320 nm. The method was validated in terms of the selectivity, linearity, precision, accuracy, robustness, limits of detection and quantification. The method was linear in the range of 10 to 100 µg/mL (r=0.999) and presented limit of detection and quantification of 102 ng/mL and 310 ng/mL, respectively. The method was precise (intra and inter-day) based on relative standard deviation values (less than 3.20%). The recovery was between 101.06 and 102.10%. Robustness was demonstrated considering change in mobile phase proportion. Specificity assay showed no interference from the components of nanoparticles or from the degradation products derived from acidic and oxidative conditions. The proposed method was suitable to be applied in determining the encapsulation efficiency of ferulic acid in PLGA-CS nanoparticles and can be employed as stability indicating one.
Descritores: Cromatografia Líquida de Alta Pressão/métodos
Quitosana/farmacologia
Nanopartículas/classificação
-Ácidos Cumáricos/farmacologia
Estudo de Validação
Antioxidantes/classificação
Responsável: BR1.1 - BIREME


  8 / 26 LILACS  
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Id: biblio-907560
Autor: Bach, Hernán G; Iturbe, Nicolás; Agudelo, Ignacio J; Wagner, Marcelo L; Ricco, Rafael A.
Título: Dinámica de polifenoles en ephedra tweediana fisch & C. A. Mey. emend. J. H. Hunz. (Ephedraceae) / Polyphenol dinamics in ephedra tweediana fisch & C. A. Mey. emend. J. H. Hunz. (Ephedraceae)
Fonte: Bol. latinoam. Caribe plantas med. aromát;16(1):1-13, ene. 2017. ilus, tab.
Idioma: es.
Resumo: Ephedra tweediana (Ephedraceae), conocida como “tramontana”, es empleada en la medicina popular como antiasmático. Se analizaron comparativamente los extractos acuosos de los tallos herbáceos, lignificados y partes subterráneas, provenientes de ejemplares femeninos y masculinos. En los tallos lignificados se determinó la presencia de proapigeninidina (cuya identidad fue corroborada por comparación con un testigo de apigeninidina sometido a estudios de FAB-MS, UV, HPLC, 1H-NMR y espectroscopía IR); mientras que en los órganos subterráneos se determinó la presencia de proapigeninidina y propelargonidina (la identidad de la pelargonidina fue establecida por comparación con un testigo de pelargonidina sometido a estudios de TLC/HPTLC y espectroscopía UV-Visible). Estos compuestos no se observaron en los tallos herbáceos. Los tallos herbáceos presentaron las mayores concentraciones de flavonoides y ácidos hidroxicinámicos totales. Los órganos subterráneos presentaron la mayor concentración de taninos y proantocianidinas. En los tallos herbáceos se detectó una reacción fuertemente positiva para flavonoides. No se observó reacción positiva para proantocianidinas. En el tallo aéreo lignificado se observó una reacción positiva para flavonoides y proantocianidinas a nivel de la peridermis. En los órganos subterráneos, los flavonoides y proantocianidinas se localizaron principalmente en los tejidos más externos. Este trabajo constituye el primer aporte a la dinámica de polifenoles de E. tweediana.

Ephedra tweediana (Ephedraceae), known as "tramontana" is used in folk medicine as antiasthmatic. Aqueous extracts obtained from young stems, woody stems and underground parts were analyzed and compared. In lignified stems was detected proapigeninidin (whose identity was confirmed by comparison with a control apigeninidin subjected to FAB-MS, UV, HPLC, 1H-NMR and IR spectroscopy), while underground organs were detected proapigeninidin and propelargonidin (by comparison with a control pelargonidin whose identity was established by studies of TLC/HPTLC, and UV-visible spectroscopy). These compounds were not observed in the herbaceous stems. The herbaceous stems had the highest concentrations of total flavonoids and hydroxycinnamic acids. Uderground organs had the highest concentration of tannins and proanthocyanidins. In herbaceous stems a strong positive reaction for flavonoids was detected. No positive reaction was observed for proanthocyanidins. In the periderm of woody aerial stem a positive reaction for flavonoids and proanthocyanidins were observed. In the underground organs, flavonoids and proanthocyanidins were located mainly in the more external tissues. This work is the first contribution to the dynamic of E. tweediana polyphenols.
Descritores: Ácidos Cumáricos/análise
Ephedra/química
Flavonoides/análise
Fenóis/análise
Extratos Vegetais/química
-Cromatografia Gasosa/métodos
Proantocianidinas/análise
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


  9 / 26 LILACS  
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Id: biblio-839244
Autor: de Melo, TS; Lima, PR; Carvalho, KMMB; Fontenele, TM; Solon, FRN; Tomé, AR; de Lemos, TLG; da Cruz Fonseca, SG; Santos, FA; Rao, VS; de Queiroz, MGR.
Título: Ferulic acid lowers body weight and visceral fat accumulation via modulation of enzymatic, hormonal and inflammatory changes in a mouse model of high-fat diet-induced obesity
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(1):e5630, 2017. tab, graf.
Idioma: en.
Resumo: Previous studies have reported on the glucose and lipid-lowering effects of ferulic acid (FA) but its anti-obesity potential has not yet been firmly established. This study investigated the possible anti-obesitogenic effects of FA in mice fed a high-fat diet (HFD) for 15 weeks. To assess the antiobesity potential of FA, 32 male Swiss mice, weighing 20–25 g (n=6–8 per group) were fed a normal diet (ND) or HFD, treated orally or not with either FA (10 mg/kg) or sibutramine (10 mg/kg) for 15 weeks and at the end of this period, the body weights of animals, visceral fat accumulation, plasma levels of glucose and insulin hormone, amylase and lipase activities, the satiety hormones ghrelin and leptin, and tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCH-1) were analyzed. Results revealed that FA could effectively suppress the HFD-associated increase in visceral fat accumulation, adipocyte size and body weight gain, similar to sibutramine, the positive control. FA also significantly (P<0.05) decreased the HFD-induced elevations in serum lipid profiles, amylase and lipase activities, and the levels of blood glucose and insulin hormone. The markedly elevated leptin and decreased ghrelin levels seen in HFD-fed control mice were significantly (P<0.05) reversed by FA treatment, almost reaching the values seen in ND-fed mice. Furthermore, FA demonstrated significant (P<0.05) inhibition of serum levels of inflammatory mediators TNF-α, and MCH-1. These results suggest that FA could be beneficial in lowering the risk of HFD-induced obesity via modulation of enzymatic, hormonal and inflammatory responses.
Descritores: Fármacos Antiobesidade/farmacologia
Ácidos Cumáricos/farmacologia
Ciclobutanos/farmacologia
Gordura Intra-Abdominal/efeitos dos fármacos
Obesidade/tratamento farmacológico
-Tecido Adiposo/patologia
Dieta Hiperlipídica
Modelos Animais de Doenças
Obesidade/patologia
Limites: Animais
Masculino
Camundongos
Responsável: BR1.1 - BIREME


  10 / 26 LILACS  
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Id: lil-771936
Autor: Bocco, B M; Fernandes, G W; Lorena, F B; Cysneiros, R M; Christoffolete, M A; Grecco, S S; Lancellotti, C L; Romoff, P; Lago, J H G; Bianco, A C; Ribeiro, M O.
Título: Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;49(3):e5003, Mar. 2016. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model.
Descritores: Baccharis/química
Ácidos Cafeicos/administração & dosagem
Ácidos Cumáricos/administração & dosagem
Síndrome Metabólica/prevenção & controle
Substâncias Protetoras/administração & dosagem
-Ácidos Cafeicos/química
Colesterol/metabolismo
Ácidos Cumáricos/química
Dieta Hiperlipídica/efeitos adversos
Quimioterapia Combinada/métodos
Fígado Gorduroso/metabolismo
Fígado Gorduroso/patologia
Síndrome Metabólica/tratamento farmacológico
Camundongos Endogâmicos C57BL
Modelos Animais
Substâncias Protetoras/química
Triglicerídeos/metabolismo
Limites: Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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