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Pesquisa : D02.241.223.268.637 [Categoria DeCS]
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Texto completo SciELO Chile
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Id: biblio-950765
Autor: Park, Hee-Sook; Choi, Hye-Young; Kim, Gun-Hee.
Título: Preventive effect of Ligularia fischeri on inhibition of nitric oxide in lipopolysaccharide-stimulated RAW 264. 7 macrophages depending on cooking method
Fonte: Biol. Res;47:1-6, 2014. graf, tab.
Idioma: en.
Projeto: Globalization of Korean Foods R& D program; . Ministry of Agriculture, Food, and Rural Affairs, Republic of Korea; . National Research Foundation of Korea; . Ministry of Education. Basic Science Research Program.
Resumo: BACKGROUND: Ligularia fischeri (common name Gomchwi) is known for its pharmaceutical properties and used in the treatment of jaundice, scarlet-fever, rheumatoidal arthritis, and hepatic diseases; however, little is known about its anti-inflammatory effect. In this study the influence of blanching and pan-frying on the anti-inflammatory activity of Ligularia fischeri (LF) was evaluated. RESULTS: Fresh LF and cooked LF showed no significant effect on the viability of macrophages after 24 h incubation. Fresh LF was found to be the most potent inhibitor of nitric oxide (NO) production at 100 µg/ml, while pan-fried LF showed little inhibitory effect on lipoloysaccharide (LPS) stimulated murine machrophage RAW264.7 cells. In contrast with its effect on NO production, pan-fried LF showed significant attenuation of the expression of inducible nitiric oxide synthase (iNOS) compared with fresh LF. In the cooking method of LF, PGE2 production was not affected in the LPS-induced RAW 264.7 cells. In LPS-induced RAW 264.7 cells, pretreatment by fresh and cooked LF increased COX2 mRNA expression. The 3-O-caffeoylquinic acid content of blanching and pan-frying LF increased by 4.92 and 9.7 fold with blanching and pan-frying respectively in comparison with uncooked LF. CONCLUSIONS: Regardless of the cooking method, Ligularia fischeri exhibited potent inhibition of NO production through expression of iNOS in LPS-induced RAW264.7 cells.
Descritores: Culinária/métodos
Asteraceae/química
Preparações de Plantas/farmacologia
Óxido Nítrico Sintase Tipo II/metabolismo
Macrófagos/efeitos dos fármacos
Óxido Nítrico/biossíntese
-Ácido Quínico/análise
Ácido Quínico/análogos & derivados
Ácido Quínico/classificação
RNA Mensageiro/efeitos dos fármacos
RNA Mensageiro/metabolismo
Dinoprostona/análise
Dinoprostona/biossíntese
Sobrevivência Celular
Lipopolissacarídeos
Cromatografia Líquida de Alta Pressão
Asteraceae/classificação
Ciclo-Oxigenase 2/análise
Ciclo-Oxigenase 2/metabolismo
Células RAW 264.7
Temperatura Alta
Macrófagos/fisiologia
Anti-Inflamatórios/farmacologia
Limites: Animais
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: lil-454543
Autor: Souza, Janaina Moreira de; Taleb-Contini, Silvia Helena; Oliveira, Dionéia Camilo Rodrigues de.
Título: Estudo fitoquímico de Mikania pseudohoffmanianna G. M. Barroso ex W. C. Holmes / Phytochemical study of Mikania pseudohoffmanianna G. M. Barroso ex W. C. Holmes
Fonte: RBCF, Rev. bras. ciênc. farm. (Impr.);42(2):265-268, abr.-jun. 2006.
Idioma: pt.
Resumo: This work describes the fractionation of methanol and dichloromethane extracts of aerial parts from the Mikania pseudohoffmanniana G. M. Barroso ex W. C. Holmes. The phytochemical study of extracts led to isolation and the identification of 16 known compounds, including: steroids: campesterol, stigmasterol and 'beta'-sitosterol, diterpenes: ent-15'beta'-E-cinnamoyloxy-kaur-16-en-19-oic acid, ent-15'beta'-Z-cinnamoyloxy-kaur-16-en-19-oic acid and ent-kaur-16-en-19-oic acid, triterpenes: 'alpha'-amyrin, 'beta'-amyrin, 'alpha'-amyrin acetate, 'beta'-amyrin acetate, lupeol, lupeol acetate and friedelin, coumarin: scopoletin, flavonoid: quercetin and caffeoyl quinic acid derivative: 4,5-di-O-[E]-caffeoyl quinic acid

O fracionamento dos extratos diclorometânico e metanólico das partes aéreas de Mikania pseudohoffmanniana G. M. Barroso ex W. C. Holmes resultou na identificação de 16 substâncias: os esteróides: campesterol, estigmasterol e b-sitosterol; os diterpenos: ácido ent-15b-E-cinamoiloxi-caur-16-en-19-óico, ácido ent-15b-Z-cinamoiloxi-caur-16-en-19-óico e ácido ent-caur-16-en-19-óico; os triterpenos: a-amirina, b-amirina, acetato de a-amirina, acetato de b-amirina, lupeol, acetato de lupeol e friedelina; a cumarina: escopoletina; o flavonóide: quercetina e o derivado do ácido cafeoilquínico: 4,5-di-O-[E] -cafeoilquínico
Descritores: Asteraceae
Flavonoides/uso terapêutico
Mikania
Fitoterapia
-Extratos Vegetais
Ácido Quínico
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas



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