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Texto completo SciELO Brasil
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Id: lil-687309
Autor: Sener, Nevzat Can; Ozturk, Ufuk; Goktug, H. N. Goksel; Gucuk, Adnan; Nalbant, Ismail; Yesil, Suleyman; Imamoglu, M. Abdurrahim.
Título: Efficacy and safety of propiverine and terazosine combination for one year in male patients with luts and detrusor overactivity
Fonte: Int. braz. j. urol;39(4):513-518, Jul-Aug/2013. tab.
Idioma: en.
Resumo: Purpose To evaluate the long term efficacy and safety of the use of propiverine and terazosine combination in patients with LUTS and DO by a placebo controlled study. Materials and Methods One hundred patients were enrolled in the study. They were randomized into two groups (each group consisted of 50 patients). Terazosine and placebo were administered to the patients in Group 1 and terazosine plus propiverine HCL was administered to Group 2. The patients were evaluated by international prostate symptom score (IPSS), the first four questions of IPSS (IPSS4), the 8th question of IPSS (quality of life-QoL), overactive bladder symptom score questionnaire (OAB-q V8), PSA test, urodynamic studies, post voiding residue (PVR). All patients were followed for one year and were reassessed for comparison. Results IPSS, IPSS4, OAB symptoms, QoL score, PVR, and Qmax scores of the groups did not differ. After one year treatment, there was significant improvement in IPSS, IPSS4, OAB symptoms, QoL and Qmax values in Group 2. No significant improvement was noted for the same parameters in Group 1. Conclusion This is the first study to show long term safety and efficacy of anticholinergic therapy for patients with LUTS. In patients with OAB or DO, long term anticholinergic treatment may be regarded as a treatment option. .
Descritores: Benzilatos/uso terapêutico
Sintomas do Trato Urinário Inferior/tratamento farmacológico
Antagonistas Muscarínicos/uso terapêutico
Prazosina/análogos & derivados
Bexiga Urinária Hiperativa/tratamento farmacológico
-Método Duplo-Cego
Quimioterapia Combinada/métodos
Prazosina/uso terapêutico
Qualidade de Vida
Inquéritos e Questionários
Fatores de Tempo
Resultado do Tratamento
Limites: Adulto
Humanos
Masculino
Pessoa de Meia-Idade
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: lil-366690
Autor: Mink, Franklin; Derosa, Christopher; Stara, Jerry.
Título: Clorobencilato: Efectos sobre la salud y el ambiente / Health and environmental effects: Profile for Chlorobenzilate.
Fonte: Metepec; s.n; 1988. iv,28 p. (ECAO-CIN-PO59).
Idioma: es.
Símbolo: ECAO-CIN-PO59.
Descritores: Benzilatos
Poluentes Ambientais
REPIDISCA
Responsável: US1.1 - HQ Library
BR1.1/1261.00; US1.1, PAHO COLL/ECO/NSP/88-02



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