Base de dados : LILACS
Pesquisa : D02.241.223.601.238.306.740 [Categoria DeCS]
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Texto completo SciELO Venezuela
Texto completo
Id: lil-330975
Autor: Gutiérrez-Reyes, Elsa; Castañeda-Perozo, Darwin; Papale-Centofanti, Jhan; Nello-Pérez, Carlota; Pascuzzo-Lima, Carmine; Moreno-Yanez, José; Bonfante-Cabarcas, Rafael.
Título: Supersensitivity of the cholinergic muscarinic system in the rat's brain is induced by high concentrations of Cu+2
Fonte: Invest. clín;43(2):107-117, jun. 2002.
Idioma: en.
Resumo: Transition metals have been described as regulators of receptor's function. here, we studied the effects of chronic administration of Cu2+ or the Cu2+ chelator penicillamine (PA) on the functional and binding properties of the muscarinic receptors (MR) on selected areas of rat's brain. Groups of 10 Sprague-Dawley rats were treated daily, for 45 days with either 1) 1 mg/Kg CuSO4 (Cu2+), 2) 100 mg/Kg PA, or 3) saline solution. Double T-maze and motility cages were used for behavioral testing and the binding assays were performed using [3H]-QNB or [3H]-N-MSCP as MR's ligands. Cu2+ brain levels were measured in the cerebral cortex by atomic absorption spectrophotometer. Results showed that PA treated rats displayed a significant decrease of locomotor's activity (LA) and rearing behavior (RB), but a significant increases in memory efficiency (ME). Cu2+ treated rats displayed diminished RB with no significant changes in LA. Cu2+ treated rats displayed higher MR's density (Bmax) in cortex (C), striatum (S), and hippocampus (H). An increase in Bmax was also observed in PA treated rats, but only in C and S. Finally, Cu2+ tissue concentration was significantly higher in C of both Cu2+ and with PA treated animals. In conclusion, 45 days of Cu2+ or PA treatment induced brain hypercuprosis, which was associated with MR binding supersensitivity; however, change in ME was only observed in PA treated rats suggesting that might be still another factor in these experiments besides Cu2+ (i.e., Zn2+ or PA itself) involved in memory modulation.
Descritores: Sulfato de Cobre
Proteínas do Tecido Nervoso/efeitos dos fármacos
Química Encefálica/efeitos dos fármacos
Receptores Muscarínicos/efeitos dos fármacos
-Agonistas Muscarínicos/farmacologia
Antagonistas Muscarínicos/farmacologia
Sulfato de Cobre
Corpo Estriado
Córtex Cerebral/efeitos dos fármacos
Córtex Cerebral/metabolismo
Relação Dose-Resposta a Droga
Fibras Colinérgicas/efeitos dos fármacos
Fibras Colinérgicas/fisiologia
Aprendizagem em Labirinto
Atividade Motora
Quinuclidinil Benzilato
Ensaio Radioligante
Ratos Sprague-Dawley
Receptores Muscarínicos/metabolismo
Sulfato de Zinco
Limites: Animais
Tipo de Publ: Estudo Comparativo
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME

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Id: lil-196339
Autor: Borda, Tania G; Cremaschi, Graciela.
Título: Multireceptor interactions of haloperidol on rat cerebral frontal cortex "in vitro"
Fonte: Acta physiol. pharmacol. ther. latinoam;47(3):173-8, 1997. graf.
Idioma: en.
Resumo: As severall side effects of neuroleptics would be related to their interactions with several neurotransmitter receptors (R) haloperidol action on muscarinic cholinergic (mACh) R on frontal cerebral cortex preparations was analyzed. Here we shown that haloperidol was able to inhibit in a concentration dependent manner the binding of specific mAChR radiollabeled antagonist on cerebral cortex membranes. This effect would be related to its interaction on mAChR of the M1 subtype as haloperidol blocked the stimulation of phosphoiinositides (Pis) turnover induced by low concentrations of carbachol similarly as the M1 antagonist pirenzepine. However at high carbachol concentrations haloperidol triggered a potentiating stimulation of Pis hydrolysis that was only blocked by the alpha1 adrenergic antagonist prazosin indicating and alpha1 agonistic action of haloperidol on these Rs. These multireceptor actions of haloperidol found "in vitro"would strengthen its assocation with "in vivo"neuroleptic-induced side effects.
Descritores: Antipsicóticos/farmacologia
Córtex Cerebral/efeitos dos fármacos
Técnicas In Vitro
Antagonistas Muscarínicos
Receptores Muscarínicos/efeitos dos fármacos
-Sítios de Ligação
Fosfatos de Inositol
Agonistas Muscarínicos
Quinuclidinil Benzilato
Limites: Animais
Responsável: BR1.1 - BIREME

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Id: lil-176772
Autor: Silva, Walter I; Sanabria, P; Altieri, Pablo I.
Título: Lack of interaction of angiotensin converting enzyme inhibitors with muscarinic and neuropeptide Y receptors
Fonte: P. R. health sci. j;13(1):25-8, mar. 1994.
Idioma: en.
Resumo: In studies conducted in patients undergoing cardiac catheterizations, some hemodynamic changes were observed after the acute sublingual administration of the angiotensin converting enzyme inhibitors (ACEI) captopril, enalapril, and lisinopril. These changes consisted of an increase in pulmonary artery pressure, pulmonary vascular resistance (PVR) and induction of hypoxia. The pressure changes were transitory and disappeared after 25 min. The possible mechanisms involved in these changes may relate to interactions of the ACEI with peripheral receptor systems for hormones and neurotransmitters. We have thus undertaken the task of evaluating the potential effect of ACEI on biological receptor molecules. We have begun with studies on muscarinic receptors, and the recently characterized neuropeptide Y (NPY) receptors of endothelial cells. Equilibrium binding assays with 3H-QNB have been conducted for muscarinic receptors using rat brain synaptosomes, due to its expression of multiple muscarinic receptors subtypes. In addition 125BH-NPY binding assays were conducted on intact adrenal medullary endothelial cells. Enalapril and captopril, 10(-7) to 10(-3) M, were not able to produce significant inhibition of either muscarinic or NPY receptor probes. The paradoxical changes elicited by sublingual ACEI seems not to involve interaction with muscarinic or NPY receptors
Descritores: Inibidores da Enzima Conversora de Angiotensina/farmacologia
Endotélio Vascular/efeitos dos fármacos
Química Encefálica
Receptores Muscarínicos/efeitos dos fármacos
Receptores de Neuropeptídeo Y/efeitos dos fármacos
Sinaptossomos/efeitos dos fármacos
-Medula Suprarrenal/irrigação sanguínea
Células Cultivadas
Endotélio Vascular/química
Hemodinâmica/efeitos dos fármacos
Quinuclidinil Benzilato/metabolismo
Receptores Muscarínicos/metabolismo
Limites: Animais
Responsável: BR1.1 - BIREME

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