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Id: biblio-1040165
Autor: Vidal-Seguel, Nicolás; Montiel-Eulefi, Enrique.
Título: Efecto del ácido láctico en la respuesta celular del sistema inmunitario durante la fase inflamatoria temprana en el nervio isquiático dañado por compresión / Effect of lactic acid on the cellular response of the immune system during the early inflammatory phase in the sciatic nerve damaged by compression
Fonte: Int. j. morphol;37(4):1527-1533, Dec. 2019. tab, graf.
Idioma: es.
Projeto: Universidad de La Frontera.
Resumo: En órganos dañados, el ácido láctico (AL) modifica la respuesta inmune innata e inflamatoria, induciendo una menor expresión de citoquinas pro-inflamatorias, que provocan, la modulación del reclutamiento de células inmunes. El daño por compresión del nervio isquiático (NI) desencadena una respuesta inflamatoria y un aumento exponencial del infiltrado inflamatorio de células inmunes, produciendo la destrucción de axones y pérdida funcional del nervio. El objetivo de este estudio es evaluar el efecto agudo de la inyección de AL, sobre la proporción de células inmunes en la fase inflamatoria temprana, en el sitio de lesión del NI post compresión. Para ello, se utilizaron 15 ratas machos Sprague Dawley adultas, en tres grupos de compresión nerviosa. Un grupo control, un grupo control negativo con placebo (100 µL PBS) y un grupo experimental con inyección de 100 µL de AL [20mM]. Al tercer día los NI se analizaron histológicamente y se estableció la proporción de células inmunes en el sitio de lesión. Los resultados muestran que la inyección intraneural de AL provoca una disminución en el porcentaje de linfocitos y un aumento en el porcentaje de macrófagos. Este es el primer trabajo de inyección intraneural de AL y demuestra el efecto modulador del AL sobre las células inmunes en el sistema nervioso periférico.

In damaged organs, lactic acid (LA) modifies the innate and inflammatory immune response, inducing a lower expression of pro-inflammatory cytokines, which provoke the modulation of immune cell recruitment. Damage by compression of the sciatic nerve (SN) triggers an inflammatory response and an exponential increase in the inflammatory infiltrate of immune cells, producing the destruction of axons and functional loss of the nerve. The objective of this study is to evaluate the acute effect of the injection of LA, on the proportion of immune cells in the early inflammatory phase, in the site of SN post-compression injury. For this, 15 adult Sprague Dawley rats were used in three groups of nervous compression. A control group, a negative control group with placebo (100 mL PBS) and an experimental group with injection of 100 mL of LA [20mM]. On the third day, the SNs were histologically analyzed and the proportion of immune cells at the injury site was established. The results show that the intraneural injection of LA causes a decrease in the percentage of lymphocytes and an increase in the percentage of macrophages. This is the first work of intraneural injection of LA and demonstrates the modulating effect of LA on immune cells in the peripheral nervous system.
Descritores: Nervo Isquiático/efeitos dos fármacos
Nervo Isquiático/imunologia
Ácido Láctico/farmacologia
Síndromes de Compressão Nervosa/patologia
-Nervo Isquiático/patologia
Linfócitos/efeitos dos fármacos
Citocinas/imunologia
Citocinas/metabolismo
Ratos Sprague-Dawley
Ácido Láctico/administração & dosagem
Inflamação/imunologia
Macrófagos/efeitos dos fármacos
Limites: Animais
Masculino
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-974320
Autor: Yuwa-amornpitak, Thalisa; Chookietwatana, Kannika.
Título: Bioconversion of waste cooking oil glycerol from cabbage extract to lactic acid by Rhizopus microsporus
Fonte: Braz. j. microbiol;49(supl.1):178-184, 2018. tab, graf.
Idioma: en.
Projeto: Mahasarakham University.
Resumo: Abstract Glycerol from spent oil was processed by transesterification for biodiesel production. Although glycerol contains many types of impurities, it can be used as a C-source for lactic acid production by fungi, such as Rhizopus microsporus. In this study, we found that wild type R. microsporus (LTH23) produced more lactic acid than the mutant strains on cabbage glycerol media (CG media). More lactic acid was produced on CG media than on cabbage extract media (C media) by about two-fold in batch fermentation conditions. In addition, we found that lactic acid production in a fed-batch process was also slightly higher than in a batch process. To study the combined effects of pH, urea, and glycerol waste concentration on lactic acid production, a response surface methodology was used. The optimum pH, urea, and glycerol waste concentrations were pH 6.5, 3.75 g/L, and 17 g/L, respectively. The maximum lactic acid production predicted by this equation model was 4.03 g/L.
Descritores: Rhizopus/metabolismo
Brassica/química
Ácido Láctico/metabolismo
Glicerol/metabolismo
-Resíduos/análise
Brassica/metabolismo
Brassica/microbiologia
Biotransformação
Culinária
Meios de Cultura/metabolismo
Meios de Cultura/química
Biocombustíveis/análise
Fermentação
Concentração de Íons de Hidrogênio
Responsável: BR1.1 - BIREME


  3 / 399 LILACS  
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Ayub, Marco Antonio Zachia
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Id: biblio-828200
Autor: Coghetto, Chaline Caren; Vasconcelos, Carolina Bettker; Brinques, Graziela Brusch; Ayub, Marco Antônio Záchia.
Título: Lactobacillus plantarum BL011 cultivation in industrial isolated soybean protein acid residue
Fonte: Braz. j. microbiol;47(4):941-948, Oct.-Dec. 2016. tab, graf.
Idioma: en.
Resumo: Abstract In this study, physiological aspects of Lactobacillus plantarum BL011 growing in a new, all-animal free medium in bioreactors were evaluated aiming at the production of this important lactic acid bacterium. Cultivations were performed in submerged batch bioreactors using the Plackett-Burman methodology to evaluate the influence of temperature, aeration rate and stirring speed as well as the concentrations of liquid acid protein residue of soybean, soy peptone, corn steep liquor, and raw yeast extract. The results showed that all variables, except for corn steep liquor, significantly influenced biomass production. The best condition was applied to bioreactor cultures, which produced a maximal biomass of 17.87 g L-1, whereas lactic acid, the most important lactic acid bacteria metabolite, peaked at 37.59 g L-1, corresponding to a productivity of 1.46 g L-1 h-1. This is the first report on the use of liquid acid protein residue of soybean medium for L. plantarum growth. These results support the industrial use of this system as an alternative to produce probiotics without animal-derived ingredients to obtain high biomass concentrations in batch bioreactors.
Descritores: Proteínas de Soja
Meios de Cultura
Lactobacillus plantarum/crescimento & desenvolvimento
Lactobacillus plantarum/metabolismo
-Biomassa
Ácido Láctico/biossíntese
Proteínas de Soja/metabolismo
Proteínas de Soja/química
Reatores Biológicos
Meios de Cultura/química
Metabolismo dos Carboidratos
Fermentação
Hidrólise
Responsável: BR1.1 - BIREME


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Id: lil-788973
Autor: Bernardo, Marcela Piassi; Coelho, Luciana Fontes; Sass, Daiane Cristina; Contiero, Jonas.
Título: L-(+)-Lactic acid production by Lactobacillus rhamnosus B103 from dairy industry waste
Fonte: Braz. j. microbiol;47(3):640-646, July-Sept. 2016. tab, graf.
Idioma: en.
Projeto: Fundação de Amparo a Pesquisa do Estado de São Paulo.
Resumo: ABSTRACT Lactic acid, which can be obtained through fermentation, is an interesting compound because it can be utilized in different fields, such as in the food, pharmaceutical and chemical industries as a bio-based molecule for bio-refinery. In addition, lactic acid has recently gained more interest due to the possibility of manufacturing poly(lactic acid), a green polymer that can replace petroleum-derived plastics and be applied in medicine for the regeneration of tissues and in sutures, repairs and implants. One of the great advantages of fermentation is the possibility of using agribusiness wastes to obtain optically pure lactic acid. The conventional batch process of fermentation has some disadvantages such as inhibition by the substrate or the final product. To avoid these problems, this study was focused on improving the production of lactic acid through different feeding strategies using whey, a residue of agribusiness. The downstream process is a significant bottleneck because cost-effective methods of producing high-purity lactic acid are lacking. Thus, the investigation of different methods for the purification of lactic acid was one of the aims of this work. The pH-stat strategy showed the maximum production of lactic acid of 143.7 g/L. Following purification of the lactic acid sample, recovery of reducing sugars and protein and color removal were 0.28%, 100% and 100%, respectively.
Descritores: Ácido Láctico/biossíntese
Lactobacillus rhamnosus/metabolismo
Resíduos Industriais
-Temperatura Ambiente
Biodegradação Ambiental
Biotransformação
Adsorção
Fermentação
Técnicas de Cultura Celular por Lotes
Concentração de Íons de Hidrogênio
Responsável: BR1.1 - BIREME


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Id: biblio-1017707
Autor: Koliski, Adriana1; Cat, Izrail2; Giraldi, Dinarte J2; Cat, Monica L3.
Título: Lactato sérico como marcador prognostico em criancas gravemente doentes / Blood lactate concentration as prognostic marker in critically ill children
Fonte: Pediatr. (Asunción);34(1):77-83, 2007. tab.
Idioma: pt; pt.
Resumo: OBJETIVO: Verificar a utilidade do lactato como marcador de hipoperfusao tecidual e como índice prognóstico em criancas criticamente doentes. METODOS: Estudo prospectivo, longitudinal, tipo observacional de 75 pacientes admitidos na UTI pediátrica do Hospital de Clínicas (UFPR) entre novembro de 1998 e maio de 1999. De acordo com o nivel de lactato na admissao, os pacientes foram divididos em grupo A (lactato > 18 mg/dl) e grupo B (lactato 18 mg/dl evidenciou sinais clinicos de hipoperfusao na admissao. A normalizacao ou diminuicao dos niveis de lactato a partir de 24 horas de internacao esteve significativamente relacionada com a maior probabilidade de sobrevida.
Descritores: Acidose Láctica
Prognóstico
Ácido Láctico
Limites: Criança
Tipo de Publ: Artigo Clássico
Responsável: PY30.1 - Biblioteca


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Id: biblio-839382
Autor: Rezvani, Fazlollah; Ardestani, Fatemeh; Najafpour, Ghasem.
Título: Growth kinetic models of five species of Lactobacilli and lactose consumption in batch submerged culture
Fonte: Braz. j. microbiol;48(2):251-258, April.-June 2017. tab, graf.
Idioma: en.
Resumo: Abstract Kinetic behaviors of five Lactobacillus strains were investigated with Contois and Exponential models. Awareness of kinetic behavior of microorganisms is essential for their industrial process design and scale up. The consistency of experimental data was evaluated using Excel software. L. bulgaricus was introduced as the most efficient strain with the highest biomass and lactic acid yield of 0.119 and 0.602 g g-1 consumed lactose, respectively. The biomass and carbohydrate yield of L. fermentum and L. lactis were slightly less and close to L. bulgaricus. Biomass and lactic acid production yield of 0.117 and 0.358 for L. fermentum and 0.114 and 0.437 g g-1 for L.actobacillus lactis were obtained. L. casei and L. delbrueckii had the less biomass yield, nearly 11.8 and 22.7% less than L. bulgaricus, respectively. L. bulgaricus (R 2 = 0.9500 and 0.9156) and L. casei (R 2 = 0.9552 and 0.8401) showed acceptable consistency with both models. The investigation revealed that the above mentioned models are not suitable to describe the kinetic behavior of L. fermentum (R 2 = 0.9367 and 0.6991), L. delbrueckii (R 2 = 0.9493 and 0.7724) and L. lactis (R 2 = 0.8730 and 0.6451). Contois rate equation is a suitable model to describe the kinetic of Lactobacilli. Specific cell growth rate for L. bulgaricus, L. casei, L. fermentum, L. delbrueckii and L. lactis with Contois model in order 3.2, 3.9, 67.6, 10.4 and 9.8-fold of Exponential model.
Descritores: Lactobacillus/crescimento & desenvolvimento
Lactobacillus/metabolismo
Lactose/metabolismo
Modelos Teóricos
-Edulcorantes/metabolismo
Biomassa
Ácido Láctico/metabolismo
Fermentação
Responsável: BR1.1 - BIREME


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Id: biblio-839362
Autor: Park, Gun-Seok; Hong, Sung-Jun; Park, Seulki; Jin, Hyewon; Lee, Sang-Jae; Shin, Jae-Ho; Lee, Han-Seung.
Título: Draft genome sequence of alcohol-tolerant bacteria Pediococcus acidilactici strain K3
Fonte: Braz. j. microbiol;48(1):1-2, Jan.-Mar. 2017.
Idioma: en.
Projeto: Ministry of Education, Science and Technology.
Resumo: Abstract Pediococcus acidilactici strain K3 is an alcohol-tolerant lactic acid bacterium isolated from nuruk, which is a traditional Korean fermentation starter for makgeolli brewing. Draft genome of this strain was approximately 1,991,399 bp (G+C content, 42.1%) with 1525 protein-coding sequences (CDS), of which 44% were assigned to recognized functional genes. This draft genome sequence data of the strain K3 will provide insights into the genetic basis of its alcohol-tolerance.
Descritores: Adaptação Biológica/efeitos dos fármacos
Adaptação Biológica/genética
Genoma Bacteriano
Etanol/farmacologia
Pediococcus acidilactici/efeitos dos fármacos
Pediococcus acidilactici/genética
-Ácido Láctico/biossíntese
Biologia Computacional/métodos
Genômica/métodos
Etanol/metabolismo
Fermentação
Sequenciamento de Nucleotídeos em Larga Escala
Anotação de Sequência Molecular
Pediococcus acidilactici/isolamento & purificação
Pediococcus acidilactici/metabolismo
Responsável: BR1.1 - BIREME


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Id: lil-792717
Autor: Sperling, Milena P. R; Simões, Rodrigo P; Caruso, Flávia C. R; Mendes, Renata G; Arena, Ross; Borghi-Silva, Audrey.
Título: Is heart rate variability a feasible method to determine anaerobic threshold in progressive resistance exercise in coronary artery disease?
Fonte: Braz. j. phys. ther. (Impr.) = Rev. bras. fisioter;20(4):289-297, July-Aug. 2016. tab, graf.
Idioma: en.
Projeto: CAPES; . FAPESP.
Resumo: ABSTRACT Background Recent studies have shown that the magnitude of the metabolic and autonomic responses during progressive resistance exercise (PRE) is associated with the determination of the anaerobic threshold (AT). AT is an important parameter to determine intensity in dynamic exercise. Objectives To investigate the metabolic and cardiac autonomic responses during dynamic resistance exercise in patients with Coronary Artery Disease (CAD). Method Twenty men (age = 63±7 years) with CAD [Left Ventricular Ejection Fraction (LVEF) = 60±10%] underwent a PRE protocol on a leg press until maximal exertion. The protocol began at 10% of One Repetition Maximum Test (1-RM), with subsequent increases of 10% until maximal exhaustion. Heart Rate Variability (HRV) indices from Poincaré plots (SD1, SD2, SD1/SD2) and time domain (rMSSD and RMSM), and blood lactate were determined at rest and during PRE. Results Significant alterations in HRV and blood lactate were observed starting at 30% of 1-RM (p<0.05). Bland-Altman plots revealed a consistent agreement between blood lactate threshold (LT) and rMSSD threshold (rMSSDT) and between LT and SD1 threshold (SD1T). Relative values of 1-RM in all LT, rMSSDT and SD1T did not differ (29%±5 vs 28%±5 vs 29%±5 Kg, respectively). Conclusion HRV during PRE could be a feasible noninvasive method of determining AT in CAD patients to plan intensities during cardiac rehabilitation.
Descritores: Doença da Artéria Coronariana/fisiopatologia
Limiar Anaeróbio
Exercício/fisiologia
Ácido Láctico/química
Treinamento de Resistência/métodos
Frequência Cardíaca/fisiologia
Limites: Seres Humanos
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-1039077
Autor: Er, Sevda; Erim, Ümit Can; Koç, Fatma; Kivanç, Merih.
Título: Identifying probiotic characteristics of Lactobacillus crispatus isolated from the vagina
Fonte: Braz. J. Pharm. Sci. (Online);55:e17507, 2019. tab, graf.
Idioma: en.
Projeto: Anadolu of University and Research.
Resumo: Lactobacilli prevent overproduction of pathogenic microorganisms and contribute protecting vaginal microbiota. Many probiotic microorganisms are categorized as Lactic Acid Bacteria. In this study, it was aimed identifying probiotic characteristics of Lactobacillus crispatus isolated from the vagina of a healthy woman. For this purpose, lactic acid, hydrogen peroxide and proteolytic activity quantities and auto-aggregation, co-aggregation and hydrophobicity abilities of Lactobacillus crispatus, which has been isolated and identified by 16s rRNA sequence analysis, were determined. Additionally, bile salt and acid resistance, along with antibiotic susceptibility of Lactobacillus crispatus were analyzed by the end of 3 hours. Lactic acid, hydrogen peroxide and proteolytic activity quantities of Lactobacillus crispatus were measured 2.275%, 0.334±0.075 µg/mL and 2.131±0,000 mg/mL respectively. The findings include existence of co-aggregation and auto-aggregation ability, but not hydrophobicity. By the end of 3 hours, the viability was preserved in 0.1% and 0.3% bile salt medium and, at pH 3. L. crispatus exhibited resistance to methicillin, metronidazole, oxacillin, and sulfamethoxazole + trimethoprim, but the bacteria exhibited susceptibility to tested the other antibiotics. This study will make an important contribution to the literature about probiotic characteristics of L. crispatus and our strain isolated from the vagina might be considered as a candidate probiotic.
Descritores: Vagina/lesões
Probióticos/análise
Lactobacillus crispatus/metabolismo
-Ácido Láctico/farmacologia
Microbiota
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: lil-767868
Autor: Trombeta, Joice Cristina dos Santos; Vieira Junior, Roberto Carlos; Fernandes, Túlio Augusto Bonfim; Rubim, Cássio Charnoski; Prestes, Jonato; Voltarelli, Fabrício Azevedo.
Título: Parâmetros bioquímicos e cinética de lactato sanguíneo de sujeitos HIV+ submetidos ao treinamento físico combinado / Biochemical parameters and blood lactate kinetics of HIV+ individuals subject to combined physical training
Fonte: Rev. bras. educ. fís. esp;29(4):519-534, out.-dez. 2015. tab, graf.
Idioma: pt.
Projeto: FAPEMAT.
Resumo: Resumo O objetivo deste estudo foi verificar a cinética de lactato sanguíneo (CLS) e a sua resposta ao treinamento físico combinado (TFC) bem como avaliar os efeitos sobre os aspectos bioquímicos, imunológicos, cardiorrespiratório e composição corporal de pessoas vivendo com HIV/AIDS. Doze voluntários HIV+ realizaram o TFC, por um período de 16 semanas, e foram submetidos às avaliações nos momentos pré, oito e 16 semanas de TFC. Ao final, houve um aumento das células TCD4+ e manutenção da carga viral, aumento do consumo máximo de oxigênio e da força muscular e, ainda, aumento do HDL-c e diminuição dos triglicerídeos e glicemia de jejum. Ainda, ocorreu aumento da CLS após o período de treinamento. Concluímos que o TFC influenciou positivamente os parâmetros imunológicos, bioquímicos, cardiorrespiratório e muscular, no entanto, a questão relacionada à CLS necessita de estudos futuros para maiores esclarecimentos.

Abstract The aim of the study was to verify the blood lactate kinetics (BLK) and the response to combined physical training (CPT) as well as to evaluate the effects on markers related to biochemical, immunological, cardiorespiratory and body composition in HIV + people. Twelve HIV+ volunteers performed CPT during 16 weeks, and were subjected to evaluations in 3 moments: pre, 8 and 16 weeks of CPT. At the end, there was improvement in immune and cardiorespiratory parameters, muscular strength and of glycemic and lipid profiles. Concerning BLK, the concentrations were increased after the CPT. We conclude that CPT improved the measured variables, nevertheless, the issue related to the BLK requires further studies in order to clarify this occurrence.
Descritores: Aptidão Física
HIV
Ácido Láctico/farmacocinética
Força Muscular
Sistema Imunitário
Limites: Seres Humanos
Responsável: BR1.1 - BIREME



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