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Pesquisa : D02.241.511.459.450 [Categoria DeCS]
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Id: biblio-886689
Autor: MARINHO, KETSIA S N; ANTONIO, ERIVALDO A; SILVA, CAMILLA V N S; SILVA, KEILA T DA; TEIXEIRA, VALÉRIA W; AGUIAR JUNIOR, FRANCISCO C A DE; SANTOS, KATHARINE R P DOS; SILVA, NICÁCIO H DA; SANTOS, NOEMIA P S.
Título: Hepatic toxicity caused by PLGA-microspheres containing usnic acid from the lichen C ladonia substellata (AHTI) during pregnancy in Wistar rats
Fonte: An. acad. bras. ciênc;89(2):1073-1084, Apr.-June 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT This study aimed to evaluate the teratogenic and hepatotoxic potential of the usnic acid encapsulated into PLGA-microspheres. In total, 12 female Wistar rats in pregnancy were randomly distributed in the control group (n= 6) that received 1.0 mL of physiological solution and treatment group (n= 6) that received 25 mg/kg of encapsulated usnic acid by oral administration. All females were euthanized at day 20 of pregnancy and their fetuses were removed and analyzed. During the pregnancy was observed a reduction in weight gain. There was no difference in serum transaminases levels analyzed as well as any difference in liver weight in both groups. The histomorphometric analysis of the liver from the treatment group revealed an increase in number of hepatocytes and a decrease in nuclear area of these cells. Moreover, no alteration was observed in cell area of hepatocytes or number of Kupffer cells. The fetuses had an increase in total number of hepatocytes and a reduction in the amount of megakaryocytes. These results show the hepatotoxic potential of usnic acid during pregnancy. However, its toxicity can be minimized by encapsulation in microspheres.
Descritores: Ácido Poliglicólico/toxicidade
Ascomicetos/química
Benzofuranos/toxicidade
Ácido Láctico/toxicidade
Feto/efeitos dos fármacos
Líquens/química
Fígado/efeitos dos fármacos
-Ácido Poliglicólico/química
Valores de Referência
Anormalidades Induzidas por Medicamentos
Benzofuranos/química
Distribuição Aleatória
Ratos Wistar
Exposição Materna
Ácido Láctico/química
Peso Fetal/efeitos dos fármacos
Hepatócitos/efeitos dos fármacos
Copolímero de Ácido Poliláctico e Ácido Poliglicólico
Fígado/patologia
Limites: Animais
Feminino
Gravidez
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-886863
Autor: NETTO, ALINE OLIVEIRA; MACEDO, NATHÁLIA C D; GALLEGO, FRANCIANE Q; SINZATO, YURI K; VOLPATO, GUSTAVO T; DAMASCENO, DÉBORA C.
Título: Evaluation of anaerobic threshold in non-pregnant and pregnant rats
Fonte: An. acad. bras. ciênc;89(4):2749-2756, Oct.-Dec. 2017. graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de São Paulo; . Conselho Nacional de Desenvolvimento Científico e Tecnológico.
Resumo: ABSTRACT Several studies present different methodologies and results about intensity exercise, and many of them are performed in male rats. However, the impact of different type, intensity, frequency and duration of exercise on female rats needs more investigation. From the analysis of blood lactate concentration during lactate minimum test (LacMin) in the swimming exercise, the anaerobic threshold (AT) was identified, which parameter is defined as the transition point between aerobic and anaerobic metabolism. LacMin test is considered a good indicator of aerobic conditioning and has been used in prescription of training in different exercise modalities. However, there is no evidence of LacMin test in female rats. The objective was to determine AT in non-pregnant and pregnant Wistar rats. The LacMin test was performed and AT defined for mild exercise intensity was from a load equivalent to 1% of body weight (bw), moderate exercise as carrying 4% bw and severe intensity as carrying 7% bw. In pregnant rats, the AT was reached at a lower loading from 5.0% to 5.5% bw, while in non-pregnant the load was from 5.5% to 6.0% bw. Thus, this study was effective to identify exercise intensities in pregnant and non-pregnant rats using anaerobic threshold by LacMin test.
Descritores: Condicionamento Físico Animal
Limiar Anaeróbio/fisiologia
Ácido Láctico/metabolismo
-Resistência Física
Natação
Ratos Wistar
Ácido Láctico/sangue
Teste de Esforço/métodos
Limites: Animais
Masculino
Feminino
Gravidez
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1118832
Autor: LIMA, Adriana Ferreira; OLIVEIRA, Hyago Jovane Borges de; PEREIRA, André Silvério; SAKAMOTO, Silmara Sanae.
Título: Effect of density of fingerling and juvenile pirarucu during transportation on water quality and physiological parameters
Fonte: Acta amaz;50(3):223-231, jul. - set. 2020.
Idioma: en.
Resumo: We assessed the effect of stocking density on physiological parameters (blood lactate, glucose, cortisol, hematocrit), water quality (temperature, dissolved oxygen, pH, unionized ammonia, carbon dioxide), and survival during the transportation of fingerling (24.5 ± 4.7 g) and juvenile (615.8 ± 122.2 g) pirarucu (Arapaima gigas) for six hours in plastic bags. The tested densities were 65, 80, 95, 110 and 125 g L-1 for fingerlings, and 50, 80, 110, 140 and 170 g L-1 for juveniles (three replicates each). Parameters were measured prior to and immediately after transportation, and at 24 and 96 hours recovery after transportation. No mortality was observed, except for fingerlings (< 3%) at densities of 110 and 125 g L-1 during recovery. All the water quality parameters were significantly altered after the transportation of fingerlings and juveniles. Water temperature, dissolved oxygen, carbon dioxide and unionized ammonia increased, but pH decreased. Only carbon dioxide and unionized ammonia differed among densities. Cortisol levels did not increase over time, except for the juveniles at 170 g L-1, which still had high cortisol after 96 hours. Glucose significantly increased after transportation for all the treatments and returned to the initial values during the recovery period. Conversely, the lactate values were still high after 96 hours. Hematocrit was assessed only for juveniles and was significantly lower after transportation. We conclude that fingerling and juvenile pirarucu can be safely transported at densities up to 95 g L-1 and 140 g L-1, respectively. (AU)
Descritores: Hidrocortisona
Ácido Láctico
Glucose
-Qualidade da Água
Hematócrito
Responsável: BR6.1 - BCS - Biblioteca de Ciências da Saúde


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Id: biblio-1053462
Autor: Panyachanakul, Titiporn; Sorachart, Bodeesorn; Lumyong, Saisamorn; Lorliam, Wanlapa; Kitpreechavanich, Vichien; Krajangsang, Sukhumaporn.
Título: Development of biodegradation process for Poly(DL-lactic acid) degradation by crude enzyme produced by Actinomadura keratinilytica strain T16-1
Fonte: Electron. j. biotechnol;40:52-57, July. 2019. graf, tab.
Idioma: en.
Projeto: Srinakharinwirot University research fund, Thailand; . Center of Excellence on Biodiversity (BDC), office of higher education commission, Thailand.
Resumo: Background: Plastic waste is a serious problem because it is difficult to degrade, thereby leading to global environment problems. Poly(lactic acid) (PLA) is a biodegradable aliphatic polyester derived from renewable resources, and it can be degraded by various enzymes produced by microorganisms. This study focused on the scale-up and evaluated the bioprocess of PLA degradation by a crude microbial enzyme produced by Actinomadura keratinilytica strain T16-1 in a 5 L stirred tank bioreactor. Results: PLA degradation after 72 h in a 5 L bioreactor by using the enzyme of the strain T16-1 under controlled pH conditions resulted in lactic acid titers (mg/L) of 16,651 mg/L and a conversion efficiency of 89% at a controlled pH of 8.0. However, the PLA degradation process inadvertently produced lactic acid as a potential inhibitor, as shown in our experiments at various concentrations of lactic acid. Therefore, the dialysis method was performed to reduce the concentration of lactic acid. The experiment with a dialysis bag achieved PLA degradation by weight loss of 99.93%, whereas the one without dialysis achieved a degradation of less than approximately 14.75%. Therefore, the dialysis method was applied to degrade a commercial PLA material (tray) with a conversion efficiency of 32%, which was 6-fold more than that without dialysis. Conclusions: This is the first report demonstrating the scale-up of PLA degradation in a 5 L bioreactor and evaluating a potential method for enhancing PLA degradation efficiency.
Descritores: Poliésteres/metabolismo
Actinomycetales/enzimologia
Enzimas/metabolismo
-Polímeros/metabolismo
Biodegradação Ambiental
Ácido Láctico/análise
Reatores Biológicos
Concentração de Íons de Hidrogênio
Responsável: CL1.1 - Biblioteca Central


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Id: lil-490270
Autor: Porras García, Willy; Ige Afuso, Manuel; Ormea Villavicencio, Antonio.
Título: Depuración de lactato como indicador pronóstico de mortalidad en pacientes con sepsis severa y choque séptico / Lactate clearance as a prognosis indicator of mortality in patients with severe sepsis and septic shock
Fonte: Rev. Soc. Peru. Med. Interna;20(4):132-138, oct.-dic. 2007. tab.
Idioma: es.
Resumo: Objetivo: Determinar la utilidad clínica de la depuración de lactato a las 12 horas como indicador de mortalidad en pacientes con sepsis severa y shock séptico. Métodos: Se diseñó un estudio prospectivo observacional en las unidades de cuidados críticos (UCIÆs) del Hospital Nacional Arzobispo Loayza de Lima, durante un período de 2 años. Se tomó una cohorte de casos por conveniencia de pacientes con diagnóstico de sepsis severa y shock séptico. Los pacientes admitidos recibieron cateterización venosa central, de línea arterial y de arteria pulmonar; uso de drogas vasoactivas, intubación y ventilación mecánica cuando lo requirieron. Al ingreso de cada paciente se registraron: datos de filiación, signos vitales, terapia instalada, análisis de laboratorio, APACHE II y SOFA. Se tomó una muestra de lactato arterial al ingreso, a las 6, 12 y 24 horas. Se realizó un seguimiento de mortalidad en los pacientes hospitalizados y los pacientes dados de alta eran seguidos por teléfono. Resultados: 46 pacientes ingresaron al estudio con un promedio de edad 61.26 +- 20.86 años. El score APACHE II fue 22.33 +-8.1: SOFA: 9.9+-3.8 y lactato de ingreso: 4.9+-2.5 mmol/L. La mortalidad en UCI y la hospitalaria fueron de 37 por ciento y 52.2 por ciento, respectivamente. La depuración de lactato a las 12 horas entre los sobrevivientes y no sobrevivientes durante la hospitalización fueron de 47.4+-18.7 vs. 21.8+-40.3 por ciento respectivamente (p=0.009). En el análisis multivariado no se observó esta asociación en un valor estadístico significativo. El grupo de alta depuración de lactato (>10 por ciento) tuvo un 54.1 por ciento de menor mortalidad hospitalaria comparado con el grupo de baja depuración de lactato (<10 por ciento, p=0.028). En el seguimiento de supervivencia a 100 días se halló mayor supervivencia para el grupo de alta depuración de lactato (p=0.001)...
Descritores: Hipóxia
Mortalidade
Prognóstico
Sepse
Choque Séptico
Ácido Láctico
-Estudos Prospectivos
Estudos Observacionais como Assunto
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: lil-645911
Autor: Aranda, Dariela; Silva, Judith; Alvarado, Patricia; Morales, Mario.
Título: Resumen de la mesa redonda No 3 sobre nutrición y deporte / Summary of the round table No 3 on nutrition and sport
Fonte: ReNut;2(4):152-155, abr.-jun. 2008. tab.
Idioma: es.
Descritores: Esportes
Exercício Físico
Fosfocreatina
Glicólise
Ciências da Nutrição
Ácido Láctico
-Congressos como Assunto
Limites: Humanos
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: lil-713977
Autor: Paccori-García, Efraín.
Título: Relación entre la concentración de ácido láctico en saliva y caries dental en escolares de 6 a 12 años / Relationship between the concentration of lactic acid in saliva and dental caries in schoolchildren of 6 to 12 years old
Fonte: Kiru;9(1):3-6, ene.-jul. 2012. ilus.
Idioma: es.
Resumo: Objetivo. Determinar la relación que hay entre la concentración de ácido láctico en saliva y caries dental en escolares de 6 a 12 años. Material y métodos. Estudio correlacional, diseño transversal. La muestra fue de 83 escolares entre 6 y 12 años de edad. Se realizó un examen intraoral cuyos datos se registraron en el odontograma. Se colectó la saliva de cada escolar (3ml) y se determinó los índices del CPOD y ceod, para relacionarlos con los datos de las concentraciones del ácido láctico de la saliva, obtenidas a través del método calorimétrico utilizando el reactivo parahidroxidifenilo. Resultados. El promedio correspondiente a la concentración de ácido láctico en saliva fue de 1,71mg/dl, y el de las piezas con caries dental fue de 3,39. El índice del CPOD fue de 1,02, y del ceod fue de 2,36. Del total de escolares, 44 tuvieron ácido láctico bajo y de cuatro a más dientes con caries dental, 19 escolares tuvieron ácido láctico medio y presentaron de cuatro a más caries, 20 escolares con ácido láctico alto, tienen de cuatro a más caries. La correlación entre el ácido láctico y el nº de piezas dentales con caries es estadísticamente significativa según Pearson con un nivel de confianza del 95%. Conclusiones. Esta técnica pudiera ser utilizada en la evaluación del diagnóstico de riesgo individual. Existe una correlación lineal positiva perfecta, ya que ambas variables tienen una relación directamente proporcional.

Objective. To determine the relationship between the concentration of lactic acid in saliva and dental caries in schoolchildren of 6 to 12 year old. Material andmethods. Correlation study, cross design. The sample consisted of 83 schoolchildren of 6 to 12 years old. I made the intraoral examination which data were recorded in the odontogram. Saliva was collected from each schoolchild (3ml). CPOD and ceod index were determined to relate them with the data from lacticacid concentrations of saliva, obtained by calorimetric method using the parahidroxidifenilo reagent. Results. The average for the lactic acid concentration insaliva was 1.71mg/dl, and those of of the pieces of dental caries were 3.39. The CPOD index is 1.02, and ceod is 2.36. 44 schoolchildren with low lactic acid, they do not have four or more cavities, 19 schoolchildren with medium lactic acid, they have four or more cavities, 20 schoolchildren with high lactic acid, have fouror more cavities. The correlation between lactic acid and the number of teeth with caries was statistically significant for Pearson with a confidence level of 95%.Conclusions. This technique could be used in the diagnostic evaluation of individual risk. There is a perfect positive linear correlation, as both variables have adirect relationship.
Descritores: Cárie Dentária
Diagnóstico Bucal
Saliva
Ácido Láctico
Índice CPO
-Estudo Observacional
Estudos Transversais
Limites: Humanos
Masculino
Feminino
Criança
Responsável: PE264.3 - Biblioteca


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Id: lil-676674
Autor: Rosas Díaz, Sara; Muñoz Jaúregui, Ana María; Serván Torres, Karin; Alvarado-Ortiz Ureta, Carlos Eduardo.
Título: Evaluación del estado nutricional y concentración de lactato sérico en futbolistas del club deportivo Universidad de San Martín de Porres / Evaluation of nutritional state and seric lactic acid concentrations in football players of Universidad de San Martin de Porres sports club
Fonte: Horiz. méd. (Impresa);7(2):71-78, jul.-dic. 2007. graf, tab.
Idioma: es.
Resumo: En este estudio se evalúa el estado nutricional y la concentración de lactato sérico en relación al rendimiento físico de los futbolistas profesionales del Club Deportivo Universidad San Martín de Porres, se tomaron medidas antropométricas obteniendo un 88% que está en un Índice de Masa Corporal dentro del rango normal establecido para adultos entre 20 -25 kg/mt², y el 88% tiene un porcentaje de grasa corporal por encima del valor ideal recomendado para el deporte que practican. Sobre las costumbres alimenticias cerca del 68% no consume con frecuencia frutas y/ o verduras prefiriendo un consumo de otros alimentos como gaseosas, café, té, etc. Hay una menor frecuencia de consumo de pescados con otros tipos de carnes. El 100% de los futbolistas estudiados tiene una hemoglobina con una diferencia significativa de p< 0,05 por encima de la media 15g/dl. El 23,5% tiene un colesterol total mayor a 200mg/dl, el 71% se encuentra en cantidad menor de 130 mg/dl de Lipoproteína de baja densidad (LDL), un 64,7% tiene valores menores a 45 mg/dl de Lipoproteína de alta densidad (HDL) y el 94% de futbolistas tiene < 160 mg/ dl de triglicéridos. Aunque no existe diferencia significativa entre lactato y frecuencia cardiaca, estos varían de manera proporcional de acuerdo a la actividad física que realizan antes del ejercicio, al término de un ejercicio intenso y luego de un descanso de media hora.

This study evaluates the nutritional state and seric lactic acid concentration related to physical yield on professional football players of Universidad de San Martin de Porres Sports Club. Anthropometric measurements were taken and we found that 88% of the players have their Corporal Mass Index within the established normal rank for adults between 20 -25 kg/m ², and 88% have a body fat percentage over the ideal value recommended . On nutritional habits, nearly 68% do not consume fruits and or vegetables frequently, preferring consumption of other foods like beverages, coffee, tea, etc. There is a small frequency of consumption of fish and other types of meats. One hundred percent of soccer players have hemoglobin values over the average 15g/dl with a significant difference of p< 0.05. Also, 23.5% have total cholesterol values over 200mg/dl, 71% have Low Density Lipoprotein (LDL) under 130 mg/dl, 64.7% have High Density Lipoprotein (HDL) under 45 mg/dl and 94% of them have triglycerides values of < 160mg/ dl. Although there is no significant difference between lactate and cardiac frequency, these varied proportionally according to the physical activity made before exercise, during intense exercise and after half an hour rest.
Descritores: Estado Nutricional
Avaliação Nutricional
Futebol
Ácido Láctico
Limites: Humanos
Masculino
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: lil-677710
Autor: Zavaleta Caja, Cecilia E; Véliz, José Luis; Zavaleta Caja, Wilson; Garay Calderón, César; Belzusarri Padilla, Odórico Iván.
Título: Respuesta cardiorrespiratoria en futbolistas profesionales del Club Deportivo Universidad San Martín de Porres, al ser sometidos a ejercicio físico: estudio comparativo / Cardiorespiratory response in professional soccer players of universidad de San Martin de Porres Sports Club when placed under physical activity: comparative study
Fonte: Horiz. méd. (Impresa);5(2):12-21, dic. 2005. graf.
Idioma: es.
Resumo: Este estudio fue realizado en la Villa Deportiva del Club Deportivo Universidad San Martín de Porres, Facultad de Medicina Humana de la Universidad San Martín de Porres - Laboratorio de Bioquímica y Nutrición, Febrero-Marzo 2005. El tipo de estudio fue de intervención, comparativo, longitudinal y prospectivo, y responde a un diseño de investigación pre y post test. El objetivo de este estudio fue evaluar la respuesta cardiorespiratoria en futbolistas profesionales y no profesionales al ser sometidos a ejercicio físico. La edad promedio fue de 27 años en el grupo conformado por futbolistas profesionales y en el grupo referencial de futbolistas no profesionales fue de 18 años. La variación de los niveles de ácido láctico en los futbolistas profesionales guarda relación inversa con la disminución en la variación de la saturación de oxígeno y en los futbolistas no profesionales una relación directa en estas variables. La variación del ácido láctico, tanto en futbolistas profesionales como en no profesionales, tiene relación con el incremento de la frecuencia cardiaca, observándose mayor diferencia y relación en el grupo de futbolistas no profesionales.

The study was carried out at the Villa Deportiva del Club Deportivo Universidad San Martin de Porres, the School of Human Medicine of San Martin de Porres University and the Biochemistry and Nutrition Laboratories between. February - March 2005. The study was of intervention, comparative, longitudinal and prospective type, and it corresponds to a pre and post test design investigation. The objective was to evaluate the cardio-respiratory answer in professional and non professional soccer players after physical exercise. The average age of the participants in the study was 27 years old in the group of professional soccer players, and 18 years old in the reference group of non professional soccer players. The variation of lactic acid levels in professional footballers shows an inverse relation with regard to the decrease in variation of oxygen saturation and in non professional soccer players a direct relation in these variables was observed. The variation of lactic acid in professional as in non professional soccer players is in relation with the increment of cardiac frequency, where a bigger difference and relation in the non professional soccer players group was observed.
Descritores: Esportes
Exercício Físico
Frequência Cardíaca/fisiologia
Futebol
Pressão Sanguínea
Ácido Láctico
-Estudos Longitudinais
Estudos Prospectivos
Limites: Humanos
Masculino
Adolescente
Adulto
Feminino
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: biblio-847107
Autor: Furlan, Julia Pedrosa; Depieri, André Luiz Veronez; Pedrosa, Maria Montserrat Diaz.
Título: Metabolismo do lactato e avaliação de desempenho: dois lados do mesmo processo / Lactate metabolism and performance assessment: two sides of the same process
Fonte: Saude e pesqui. (Impr.);10(1):171-179, jan.-abr. 2017.
Idioma: pt.
Resumo: A mensuração do lactato sanguíneo com determinação do limiar anaeróbio é uma forma simples e difundida de avaliar o desempenho físico. O lactato é o produto final da glicólise anaeróbia, um dos processos geradores de energia no corpo humano, junto com os sistemas dos fosfagênios e aeróbio. A contribuição relativa de cada um deles para as demandas energéticas do músculo esquelético depende do tipo, intensidade e duração do exercício, e o lactato é uma forma de medir essa contribuição. Há intensa transferência de lactato entre tecidos e dentro das células musculares. O propósito desta revisão é interligar esses aspectos em uma estrutura coerente a partir da qual novas hipóteses possam ser exploradas. Foram consultados artigos das bases PubMed e Scielo usando os termos treinamento, performance, lactato e metabolismo e livros de fisiologia. O metabolismo sistêmico de lactato e a variação sanguínea do lactato, registrada em avaliações de desempenho, são aspectos inter-relacionados do mesmo processo fisiológico.

The measuring of blood lactate to determine anaerobic threshold is the commonest method to evaluate physical performance. Lactate is the final product of anaerobic glycolysis, one of the energy-producing processes in the human body, coupled to phosphagenic and aerobic systems. Since relative contribution of each for energy demands of the skeleton muscle depends on the type, intensity and duration of the exercise, lactate measures such contribution. There is intense transfer of lactate among tissues and within muscle cells. This review interlinks the above aspects within a coherent structure so that new hypotheses may be taken. Physiology textbooks and articles from PubMed and Scielo databases were consulted by employing the terms training, performance, lactate and metabolism. Lactate systemic metabolism and lactate blood variation registered in performance assessments are inter-related aspects of the same physiological process.
Descritores: Ácido Láctico
Metabolismo Energético
Desempenho Atlético
Responsável: BR313.1 - Biblioteca Ana Bove



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