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Id: biblio-886175
Autor: Ozturk, Omur; Ustebay, Sefer; Eroglu, Huseyin Avni; Günay, Murat; Adali, Yasemen; Donmez, İlksen; Erbas, Mesut.
Título: An experimental study of ascorbic acid effects in acute renal failure under general anesthesia
Fonte: Acta cir. bras;32(10):853-861, Oct. 2017. tab.
Idioma: en.
Resumo: Abstract Purpose: To evaluate the preventive effect of ascorbic acid on sevoflurane-induced acute renal failure in an experimental rat model. Methods: Twenty-four adult male Wistar rats were randomly distributed into three groups. Subjects were allocated into 3 groups: Group I received sevoflurane only, whereas Groups II and III had moderate (150 mg/kg) and high (300 mg/kg) doses of AA in addition to sevoflurane, respectively. Rhabdomyolysis and myohemoglobinuric ARF was formed by intramuscular administration of glycerol on the upper hind limb on the 15th minute of inhalation anesthesia. Biochemical parameters consisted of serum levels of blood urea nitrogen, creatinine, neutrophil gelatinase-associated lipocalin (NGAL), total antioxidant capacity (TAC), and protein carbonyl content. Histopathological variables were tubular necrosis, fibrin, and cast formation. Results: NGAL levels were significantly lower in Group III than Group II and Group I. On the other hand, TAC, PCO, urea and creatinine levels were notably higher in Group I compared with Groups II and III. There was a significant difference between 3 groups on frequencies of acute tubular necrosis (p=0.003), fibrin (p<0.001) and cast (p<0.001). Acute tubular necrosis and fibrin formation were more prominent in Group I. Casts were more common in Groups II and III. Conclusions: The ascorbic acid serve as a prophylactic agent against renal damage in patients receiving sevoflurane anesthesia and higher doses were associated with more apparent protective effects.
Descritores: Ácido Ascórbico/farmacologia
Vitaminas/farmacologia
Anestésicos Inalatórios/farmacologia
Lesão Renal Aguda/prevenção & controle
Anestesia Geral/efeitos adversos
Éteres Metílicos/farmacologia
-Biomarcadores/sangue
Distribuição Aleatória
Ratos Wistar
Modelos Animais de Doenças
Lesão Renal Aguda/induzido quimicamente
Lesão Renal Aguda/sangue
Sevoflurano
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-795997
Autor: Gökçek, Erhan; Kaydu, Ayhan; Akdemir, Mehmet Salim; Akil, Ferit; Akıncı, Ibrahim Ozkan.
Título: Early postoperative recovery after intracranial surgical procedures. Comparison of the effects of sevoflurane and desflurane
Fonte: Acta cir. bras;31(9):638-644, Sept. 2016. tab.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To compared the effects of sevoflurane and desflurane on early anesthesia recovery in patients undergoing to craniotomy for intracranial lesions. METHODS: After IRB approval, the study included 50 patients aged 18-70 years who had ASA physical statuses of I-II and were scheduled for intracranial surgery. Patients were randomly divided into two groups: sevoflurane and desflurane. Anaesthesia was routinely induced in all patients followed by desflurane 5%-6% or sevoflurane 1%-2%. Moreover remifentanil infusion (0.05-0.2 mcg/kg/min) was adjusted to maintain mean arterial pressure (MAP) within 20% baseline and heart rate <90 bpm. Postoperatively, patients were evaluated over time for responses to painful stimulus, eye opening, hand squeezing, extubation, orientation and time required to achieve a Modified Aldrete Score of 9-10. Parametric and non-parametric data were assessed using Student's t- and Mann-Whitney U tests, respectively. A p<0.05 was taken as statistically significant. RESULTS: The times to responses to painful stimuli (7.7±2.7 vs. 4.8±1.7 min.; p<0.001), emergence (9.5±2.81 vs. 6.3±2.2 min.; p<0.001), hand-squeezing (12.1±2.9 vs. 8.2±2.3 min.; p<0.001), extubation (10.1±2.87 vs. 7.1±1.6 min.; p<0.001), orientation (15.3±3.2 vs. 10.3±2.7 min.; p<0.001) and Aldrete score of 9-10 (23.3±6.1 vs. 15.8±3.8 min.; p<0.001) were significantly lower with desflurane-based anaesthesia vs. sevoflurane-based anaesthesia. CONCLUSION: Desflurane yields early recovery functions and facilitates early postoperative neurologic examinations of intracranial surgery patients.
Descritores: Período de Recuperação da Anestesia
Anestésicos Inalatórios/administração & dosagem
Craniotomia/métodos
Isoflurano/análogos & derivados
Éteres Metílicos/administração & dosagem
-Período Pós-Operatório
Lesões Encefálicas/cirurgia
Método Duplo-Cego
Estudos Prospectivos
Isoflurano/administração & dosagem
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Adulto Jovem
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Módolo, Norma Sueli Pinheiro
Castiglia, Yara Marcondes Machado
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Id: lil-787265
Autor: Marques, Christiane D'Oliveira; Diego, Luis Antonio dos Santos; Marcondes-Machado, Jussara; Amorim, Renée Lauffer; Carvalho, Lídia Raquel; Módolo, Norma Sueli Pinheiro; Braz, Leandro Gobbo; Castiglia, Yara Marcondes Machado.
Título: Serum concentrations and renal expressions of IL-1 and TNF-a early after hemorrhage in rats under the effect of glibenclamide
Fonte: Acta cir. bras;31(7):434-441tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To investigate changes in the serum concentration and renal expression of IL-1 and TNF-α cytokines in rats that received sevoflurane and glibenclamide prior to hemorrhage. METHODS: Two groups of sevoflurane-anesthetized Wistar rats (n=10): G1 (control) and G2 (glibenclamide, 1 µg/g i.v.); hemorrhage of 30% blood volume (10% every 10 min), with replacement using Ringer solution, 5 ml/kg/h. Serum concentrations of IL-1 and TNF-α were studied in the first hemorrhage (T1) and 50 min later (T2), renal expression, at T2. RESULTS: In serum, G1 TNF-α (pg/mL) was T1=178.6±33.5, T2=509.2±118.8 (p<0.05); IL-1 (pg/mL) was T1=148.8±31.3, T2=322.6±115.4 (p<0.05); in G2, TNF-α was T1=486.2±83.6, T2=261.8±79.5 (p<0.05); IL-1 was T1=347.0±72.0, T2= 327.3±90.9 (p>0.05). The expression of TNF-α and IL-1 in the glomerular and tubular cells was significantly higher in the G2 group. CONCLUSIONS: Hemorrhage and glibenclamide elevated TNF-α and IL-1 concentrations in serum and kidneys. High levels of TNF-α already present before the hemorrhage in the glibenclamide group may have attenuated the damages found in the kidneys after the ischemia event.
Descritores: Choque Hemorrágico/metabolismo
Interleucina-1/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
Glibureto/farmacologia
Hipoglicemiantes/farmacologia
Rim/efeitos dos fármacos
-Peso Corporal/efeitos dos fármacos
Distribuição Aleatória
Ratos Wistar
Anestésicos Inalatórios/administração & dosagem
Modelos Animais
Canais KATP/antagonistas & inibidores
Rim/irrigação sanguínea
Rim/metabolismo
Túbulos Renais/efeitos dos fármacos
Túbulos Renais/metabolismo
Éteres Metílicos/administração & dosagem
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: lil-783802
Autor: Pasqualin, Rubens Campana; Mostarda, Cristiano Teixeira; Souza, Leandro Ezequiel de; Vane, Matheus Fachini; Sirvente, Raquel; Otsuki, Denise Aya; Torres, Marcelo Luís Abramides; Irigoyen, Maria Cláudia Costa; Auler Jr, José Otávio Costa.
Título: Sevoflurane preconditioning during myocardial ischemia-reperfusion reduces infarct size and preserves autonomic control of circulation in rats
Fonte: Acta cir. bras;31(5):338-345, May 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To investigate the myocardial ischemia-reperfusion with sevoflurane anesthetic preconditioning (APC) would present beneficial effects on autonomic and cardiac function indexes after the acute phase of a myocardial ischemia-reperfusion. METHODS: Twenty Wistar rats were allocated in three groups: control (CON, n=10), myocardial infarction with sevoflurane (SEV, n=5) and infarcted without sevoflurane (INF, n=5). Myocardial ischemia (60 min) and reperfusion were performed by temporary coronary occlusion. Twenty-one days later, the systolic and diastolic function were evaluated by echocardiography; spectral analysis of the systolic arterial pressure (SAPV) and heart rate variability (HRV) were assessed. After the recording period, the infarct size (IS) was evaluated. RESULTS: The INF group presented greater cardiac dysfunction and increased sympathetic modulation of the SAPV, as well as decreased alpha index and worse vagal modulation of the HRV. The SEV group exhibited attenuation of the systolic and diastolic dysfunction and preserved vagal modulation (square root of the mean squared differences of successive R-R intervals and high frequency) of HRV, as well as a smaller IS. CONCLUSION: Sevoflurane preconditioning better preserved the cardiac function and autonomic modulation of the heart in post-acute myocardial infarction period.
Descritores: Sistema Nervoso Autônomo/efeitos dos fármacos
Isquemia Miocárdica/fisiopatologia
Anestésicos Inalatórios/farmacologia
Precondicionamento Isquêmico Miocárdico/métodos
Éteres Metílicos/farmacologia
Infarto do Miocárdio/fisiopatologia
-Pulso Arterial
Sistema Nervoso Autônomo/fisiologia
Fatores de Tempo
Pressão Sanguínea/efeitos dos fármacos
Pressão Sanguínea/fisiologia
Ecocardiografia
Distribuição Aleatória
Ratos Wistar
Isquemia Miocárdica/etiologia
Isquemia Miocárdica/diagnóstico por imagem
Modelos Animais
Frequência Cardíaca/efeitos dos fármacos
Frequência Cardíaca/fisiologia
Infarto do Miocárdio/patologia
Infarto do Miocárdio/prevenção & controle
Infarto do Miocárdio/diagnóstico por imagem
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-869678
Autor: Aeschlimann D, Nicolás; Chomali, Pamela; Gebauer, Laura; Rolle, Augusto; González, Alejandro; Ibacache, Mauricio.
Título: ¿Es la dosis de inducción con sevofluorano un factor determinante de la ocurrencia de agitación post-anestésica en niños? / Is the induction dose with sevoflurane a factor determining the occurrence of postanesthetic agitation in children?
Fonte: Rev. chil. anest;45(supl.1):S53-S53, 2016.
Idioma: es.
Conferência: Apresentado em: Congreso Chileno de Anestesiología, 44, Concepción, 17-19 nov. 2016.
Descritores: Acatisia Induzida por Medicamentos/etiologia
Anestesia por Inalação/efeitos adversos
Éteres Metílicos/administração & dosagem
Éteres Metílicos/efeitos adversos
Agitação Psicomotora
-Método Duplo-Cego
Limites: Humanos
Criança
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-869663
Autor: González Arellano, Alejandro; Ibacache Figueroa, Mauricio; Puga Aravena, Valentina; Carmona B, Javiera; De la Fuente L, Natalia; Zamora Heloc, Maximiliano.
Título: Determinación de factores de riesgo de agitación post-anestesica en pacientes pediatricos / Determination of risk factors for post-anesthetic agitation in pediatric patients
Fonte: Rev. chil. anest;45(supl.1):S31-S32, 2016. tab.
Idioma: es.
Conferência: Apresentado em: Congreso Chileno de Anestesiología, 44, Concepción, 17-19 nov. 2016.
Descritores: Anestésicos Gerais/efeitos adversos
Delírio do Despertar/epidemiologia
Éteres Metílicos/efeitos adversos
Medição de Risco/métodos
-Agitação Psicomotora/epidemiologia
Estudos Prospectivos
Fatores de Risco
Limites: Humanos
Masculino
Feminino
Pré-Escolar
Criança
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-869656
Autor: Ojeda, Dagoberto; López, Sebastián; Cisternas, Patricia.
Título: ¿Disminuye el desflurano la estadía postoperatoria en cirugía bariátrica en comparación al sevoflurano?: análisis con propensity scores / Does desflurane decrease the postoperative stay in bariatric surgery compared to sevoflurane?: analysis with propensity scores
Fonte: Rev. chil. anest;45(supl.1):S14-S15, 2016. ilus.
Idioma: es.
Conferência: Apresentado em: Congreso Chileno de Aneastesiología, 44, Concepción, 17-19 nov. 2016.
Descritores: Cirurgia Bariátrica/métodos
Éteres Metílicos/administração & dosagem
Isoflurano/administração & dosagem
Isoflurano/análogos & derivados
Obesidade/cirurgia
-Anestésicos Inalatórios/administração & dosagem
Tempo de Internação
Estudo Observacional
Período Pós-Operatório
Estudos Retrospectivos
Limites: Humanos
Tipo de Publ: Estudo Comparativo
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-839265
Autor: Wang, L; Ye, Y; Su, HB; Yang, JP.
Título: The anesthetic agent sevoflurane attenuates pulmonary acute lung injury by modulating apoptotic pathways
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(3):e5747, 2017. graf.
Idioma: en.
Resumo: The objective of this study was to evaluate lung protection by the volatile anesthetic sevoflurane (SEVO), which inhibits apoptosis. Male Sprague-Dawley rats (250–280 g; n=18) were randomly divided into three groups. The LPS group received 5 mg/kg endotoxin (lipopolysaccharide), which induced acute lung injury (ALI). The control (CTRL) group received normal saline and the SEVO group received sevoflurane (2.5%) for 30 min after ALI was induced by 5 mg/kg LPS. Samples were collected for analysis 12 h after LPS. Lung injury was assessed by pathological observations and tissue wet to dry weight (W/D) ratios. Apoptotic index (AI) was determined by terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay and electron microscopy. Caspase-3 and cleaved-caspase-3 protein levels were determined by immunocytochemistry and western blotting, respectively. Bcl-xl levels were measured by western blotting and Bcl-2 levels by quantitative real-time polymerase chain reaction and western blotting. In the LPS group, W/D ratios, AI values, caspase-3 and cleaved-caspase-3 levels were significantly higher than in the CTRL group and lung injury was more severe. In the SEVO group, W/D ratios, AI, caspase-3 and cleaved-caspase-3 were lower than in the LPS group. Bcl-2 and Bcl-xl expression were higher than in the LPS group and lung injury was attenuated. Sevoflurane inhalation protected the lungs from injury by regulating caspase-3 activation and Bcl-xl and Bcl-2 expression to inhibit excessive cell apoptosis, and such apoptosis might be important in the pathogenesis of LPS-induced ALI.
Descritores: Lesão Pulmonar Aguda/prevenção & controle
Anestésicos Inalatórios/uso terapêutico
Apoptose/efeitos dos fármacos
Éteres Metílicos/uso terapêutico
-Lesão Pulmonar Aguda/diagnóstico por imagem
Imuno-Histoquímica
Marcação In Situ das Extremidades Cortadas
Lipopolissacarídeos
Microscopia Eletrônica de Transmissão
Ratos Sprague-Dawley
Reação em Cadeia da Polimerase em Tempo Real
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-780336
Autor: Ojeda, Dagoberto; Agurto, Mariela; Yevenes, Fernando; Bartel, Ricardo; Alarcón, Carlos; Cisternas, Patricia.
Título: Movimientos convulsivos durante la inducción inhalatoria con sevoflurano / Convulsive movements during inhalational induction with sevoflurane
Fonte: Rev. chil. anest;41(2):120-123, sept.2012. tab, graf.
Idioma: es.
Resumo: La inducción inhalatoria con sevoflurano se ha asociado con actividad epileptógena y movimientos convulsivos. Se diseñó un estudio para determinar la incidencia de movimientos convulsivos durante la inducción inhalatoria con sevoflurano y sus posibles factores de riesgo. Para llevar a cabo estos objetivos, desde marzo a julio de 2011 se solicitó a los anestesiólogos de Clínica Dávila registrar la ocurrencia de movimientos convulsivos en todo paciente en que se realizara inducción inhalatoria con sevoflurano, en el período comprendido entre la etapa III de la anestesia y la inyección de drogas endovenosas. El tamaño muestral calculado fue de 400 pacientes para obtener un intervalo de confianza de 95 por ciento con un error menor a 2,5 por ciento. Se obtuvo información de 405 pacientes con una mediana de edad de 4 años (rango: 2 días a 16 años de edad), predominantemente hombres y ASA I. La incidencia de convulsiones fue de 3,5 por ciento (IC 95 por ciento: 1,9 por ciento; 5,7 por ciento) y fueron más frecuentes en mujeres (5,9 por ciento versus 2 por ciento en hombres, p = 0,039). En conclusión, la incidencia de convulsiones durante la inducción inhalatoria con sevoflurano fue de 3,5 por ciento y su único factor de riesgo fue pertenecer al género femenino...

Introduction: Mask induction with Sevoflurane has been associated with epileptic form changes of the EEG and sometimes with tonic-clonic movements. Objectives: To determine the incidence rate of convulsive movements during the induction of anesthesia with Sevoflurane and its risk factors. Methods: From march 1st to july 31st 2011, we asked to the anesthesiologists of our institution to watch the occurrence of tonic-clonic movements during Sevoflurane induction, after the loss of eyelash reflex and before the injection of intravenous drugs. The sample size was calculated in 400 patients to obtain a 95 percent confidence interval with an error lesser than 2.5 percent. Results: We obtain data from 405 patients with a median age of 4 years old (range 2 days to 16 years old), predominantly males and ASA physical status I. The incidence rate of convulsions was 3.5 percent (CI 95 percent 1.9; 5.7), more frequent in females (5.9 percent versus 2.0 percent in males, p = 0.039). Conclusions: The incidence rate of convulsions during inhalatory induction with Sevoflurane was 3.5 percent and associated to female gender...
Descritores: Anestésicos Inalatórios/efeitos adversos
Convulsões/epidemiologia
Éteres Metílicos/efeitos adversos
-Intervalos de Confiança
Convulsões/induzido quimicamente
Incidência
Estudos Prospectivos
Fatores de Risco
Limites: Humanos
Masculino
Adolescente
Feminino
Pré-Escolar
Criança
Responsável: CL1.1 - Biblioteca Central


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Id: lil-769713
Autor: Oshiro, Alexandre Hideaki; Otsuki, Denise Aya; Hamaji, Marcelo Waldir M.; Rosa, Kaleizu T.; Ida, Keila Kazue; Fantoni, Denise T.; Auler Jr, José Otavio Costa.
Título: Pulse pressure variation and stroke volume variation under different inhaled concentrations of isoflurane, sevoflurane and desflurane in pigs undergoing hemorrhage
Fonte: Clinics;70(12):804-809, Dec. 2015. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: OBJECTIVES: Inhalant anesthesia induces dose-dependent cardiovascular depression, but whether fluid responsiveness is differentially influenced by the inhalant agent and plasma volemia remains unknown. The aim of this study was to compare the effects of isoflurane, sevoflurane and desflurane on pulse pressure variation and stroke volume variation in pigs undergoing hemorrhage. METHODS: Twenty-five pigs were randomly anesthetized with isoflurane, sevoflurane or desflurane. Hemodynamic and echocardiographic data were registered sequentially at minimum alveolar concentrations of 1.00 (M1), 1.25 (M2), and 1.00 (M3). Then, following withdrawal of 30% of the estimated blood volume, these data were registered at a minimum alveolar concentrations of 1.00 (M4) and 1.25 (M5). RESULTS: The minimum alveolar concentration increase from 1.00 to 1.25 (M2) decreased the cardiac index and increased the central venous pressure, but only modest changes in mean arterial pressure, pulse pressure variation and stroke volume variation were observed in all groups from M1 to M2. A significant decrease in mean arterial pressure was only observed with desflurane. Following blood loss (M4), pulse pressure variation, stroke volume variation and central venous pressure increased (p <0.001) and mean arterial pressure decreased in all groups. Under hypovolemia, the cardiac index decreased with the increase of anesthesia depth in a similar manner in all groups. CONCLUSION: The effects of desflurane, sevoflurane and isoflurane on pulse pressure variation and stroke volume variation were not different during normovolemia or hypovolemia.
Descritores: Anestésicos Inalatórios/farmacologia
Pressão Sanguínea/efeitos dos fármacos
Hipovolemia/fisiopatologia
Volume Sistólico/efeitos dos fármacos
-Relação Dose-Resposta a Droga
Hemorragia/fisiopatologia
Isoflurano/análogos & derivados
Isoflurano/farmacologia
Éteres Metílicos/farmacologia
Distribuição Aleatória
Valores de Referência
Suínos
Fatores de Tempo
Limites: Animais
Feminino
Masculino
Tipo de Publ: Estudo Comparativo
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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