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Id: biblio-839286
Autor: Leoni, RF; Oliveira, IAF; Pontes-Neto, OM; Santos, AC; Leite, JP.
Título: Cerebral blood flow and vasoreactivity in aging: an arterial spin labeling study
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(4):e5670, 2017. tab, graf.
Idioma: en.
Projeto: FAPESP; . PROCAD.
Resumo: Regional cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) in young and elderly participants were assessed using pulsed arterial spin labeling (ASL) and blood oxygenation level-dependent (BOLD) magnetic resonance imaging (MRI) techniques in combination with inhalation of CO2. Pulsed ASL and BOLD-MRI were acquired in seventeen asymptomatic volunteers (10 young adults, age: 30±7 years; 7 elderly adults, age: 64±8 years) with no history of diabetes, hypertension, and neurological diseases. Data from one elderly participant was excluded due to the incorrigible head motion. Average baseline CBF in gray matter was significantly reduced in elderly (46±9 mL·100 g-1·min-1) compared to young adults (57±8 mL·100 g-1·min-1; P=0.02). Decreased pulsed ASL-CVR and BOLD-CVR in gray matter were also observed in elderly (2.12±1.30 and 0.13±0.06 %/mmHg, respectively) compared to young adults (3.28±1.43 and 0.28±0.11 %/mmHg, respectively; P<0.05), suggesting some degree of vascular impairment with aging. Moreover, age-related decrease in baseline CBF was observed in different brain regions (inferior, middle and superior frontal gyri; precentral and postcentral gyri; superior temporal gyrus; cingulate gyri; insula, putamen, caudate, and supramarginal gyrus). In conclusion, CBF and CVR were successfully investigated using a protocol that causes minimal or no discomfort for the participants. Age-related decreases in baseline CBF and CVR were observed in the cerebral cortex, which may be related to the vulnerability for neurological disorders in aging.
Descritores: Envelhecimento/fisiologia
Encéfalo/irrigação sanguínea
Encéfalo/diagnóstico por imagem
Dióxido de Carbono/metabolismo
Circulação Cerebrovascular/fisiologia
Imagem por Ressonância Magnética/métodos
Marcadores de Spin
-Fatores Etários
Análise de Variância
Mapeamento Encefálico/métodos
Oxigênio/metabolismo
Valores de Referência
Estatísticas não Paramétricas
Fatores de Tempo
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: lil-762912
Autor: Zhang, J.; Zheng, L.; Cao, J.; Chen, B.; Jin, D..
Título: Inflammation induced by increased frequency of intermittent hypoxia is attenuated by tempol administration
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;48(12):1115-1121, Dec. 2015. graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . 12th Five-Year Plan.
Resumo: The levels of serum inflammatory cytokines and the activation of nuclear factor kappa B (NF-κB) and hypoxia inducible factor-1α (HIF-1α) in heart tissues in response to different frequencies of intermittent hypoxia (IH) and the antioxidant tempol were evaluated. Wistar rats (64 males, 200-220 g) were randomly divided into 6 experimental groups and 2 control groups. Four groups were exposed to IH 10, 20, 30, or 40 times/h. The other 2 experimental groups were challenged with IH (30 times/h) plus tempol, either beginning on day 0 (IH30T0) or on day 29 (IH30T29). After 6 weeks of challenge, serum levels of tumor necrosis factor (TNF)-α, intracellular adhesion molecule (ICAM)-1, and interleukin-10 were measured, and western blot analysis was used to detect NF-κB p65 and HIF-1α in myocardial tissues. Serum levels of TNF-α and ICAM-1 and myocardial expression of NF-κB p65 and HIF-1α were all significantly higher in IH rats than in controls (P<0.001). Increased IH frequency resulted in more significant changes. Administration of tempol in IH rats significantly reduced levels of TNF-α, ICAM-1, NF-κB and HIF-1α compared with the non-tempol-treated group (F=16.936, P<0.001). IH induced an inflammatory response in a frequency-dependent manner. Additionally, HIF-1α and NF-κB were increased following IH administration. Importantly, tempol treatment attenuated this effect.
Descritores: Hipóxia/complicações
Antioxidantes/administração & dosagem
Óxidos N-Cíclicos/administração & dosagem
Inflamação/prevenção & controle
-Hipóxia/sangue
Gasometria
Western Blotting
Ensaio de Imunoadsorção Enzimática
Subunidade alfa do Fator 1 Induzível por Hipóxia/análise
Inflamação/metabolismo
Molécula 1 de Adesão Intercelular/sangue
/sangue
INTERLEUKIN-ABDUCENS NERVE/sangue
Miocárdio/metabolismo
Miocárdio/patologia
NF-kappa B/análise
Ratos Wistar
Marcadores de Spin
Fator de Necrose Tumoral alfa/sangue
Limites: Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-746533
Autor: JUNG, Seunggon; YANG, Hee-Young; LEE, Tae-Hoon.
Título: Differential expression of immunologic proteins in gingiva after socket preservation in mini pigs
Fonte: J. appl. oral sci;23(2):187-195, Mar-Apr/2015. graf.
Idioma: en.
Projeto: MSIP; . National Research Foundation of Korea.
Resumo: During healing following tooth extraction, inflammation and the immune response within the extraction socket are related to bone resorption. Objective : We sought to identify how the alloplastic material used for socket preservation affects the immune responses and osteoclastic activity within extraction sockets. Material and Methods : Using a porcine model, we extracted teeth and grafted biphasic calcium phosphate into the extraction sockets. We then performed a peptide analysis with samples of gingival tissue from adjacent to the sockets and compared the extraction only (EO) and extraction with socket preservation (SP) groups. We also used real-time polymerase chain reaction (PCR) to evaluate the expression level of immunoglobulins, chemokines and other factors related to osteoclastogenesis. Differences between the groups were analyzed for statistical significance using paired t tests. Results : Levels of IgM, IgG and IGL expression were higher in the EO group than in the SP group 1 week post-extraction, as were the levels of CCL3, CCL5, CXCL2, IFN-γ and TNF-α expression (p<0.05). In addition, receptor activator of nuclear factor kappa-B ligand (RANKL) was also significantly upregulated in the EO group (p<0.05), as were IL-1β, IL-6 and IL-8 (p<0.05). Conclusions : These results suggest that the beneficial effect of socket preservation can be explained by suppression of immune responses and inflammation. .
Descritores: Encéfalo/irrigação sanguínea
Encéfalo/crescimento & desenvolvimento
Imagem por Ressonância Magnética/métodos
-Circulação Cerebrovascular
Hemodinâmica
Marcadores de Spin
Limites: Adolescente
Adulto
Criança
Feminino
Humanos
Masculino
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Saúde Pública
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Id: lil-733321
Autor: Torres-Sánchez, Luisa E; Rojas-Martínez, Rosalba; Escamilla-Núñez, Consuelo; Vara-Salazar, Elvia de la; Lazcano-Ponce, Eduardo.
Título: Tendencias en la mortalidad por cáncer en México de 1980 a 2011 / Cancer mortality trends in Mexico, 1980-2011
Fonte: Salud pública Méx;56(5):473-491, sep.-oct. 2014. ilus, tab.
Idioma: es.
Resumo: Objetivo. Evaluar las tendencias de mortalidad por cáncer en México entre 1980 y 2011. Material y métodos. Se calcularon las tasas de mortalidad ajustadas por edad y sexo para todos los cánceres y para las 15 localizaciones más frecuentes mediante el método directo y tomando como población estándar la población mundial de 2010. Las tendencias en las tasas de mortalidad y el cambio porcentual anual para cada tipo de cáncer se estimaron a través de un modelo de regresión joinpoint. Resultados. A partir de 2004 y como consecuencia de la reducción de la mortalidad por cáncer de pulmón (-3.2% en hombres y -1.8% en mujeres), estómago (-2.1% en hombres y -2.4% en mujeres) y cérvix (-4.7%), se observó una disminución significativa (~1% anual) en la mortalidad por cáncer en general tanto en el grupo de todas las edades como en el de 35 a 64 años para ambos sexos. La mortalidad por otros cánceres como el de mama y el de ovario, en las mujeres o el de próstata, en los hombres, mostró un aumento sostenido. Conclusiones. Algunas de las reducciones en la mortalidad por cáncer pueden ser parcialmente atribuidas a la efectividad de los programas de prevención establecidos. Sin embargo, se requiere implementar registros adecuados de cáncer con base poblacional para evaluar el impacto real de estos programas, así como diseñar y evaluar intervenciones innovadoras que permitan desarrollar políticas de prevención más costo-efectivas.

Objective. To evaluate trends in cancer mortality in Mexico between 1980-2011. Material and methods. Through direct method and using World Population 2010 as standard population, mortality rates for all cancers and the 15 most frequent locations, adjusted for age and sex were calculated. Trends in mortality rates and annual percentage change for each type of cancer were estimated by joinpoint regression model. Results. As a result of the reduction in mortality from lung cancer (-3.2% -1.8% in men and in women), stomach (-2.1% -2.4% in men and in women) and cervix (-4.7%); since 2004 a significant (~1% per year) decline was observed in cancer mortality in general, in all ages, and in the group of 35-64 years of both sexes. Other cancers such as breast and ovarian cancer in women; as well as for prostate cancer in men, showed a steady increase. Conclusions. Some of the reductions in cancer mortality may be partially attributed to the effectiveness of prevention programs. However, adequate records of population-based cancer are needed to assess the real impact of these programs; as well as designing and evaluating innovative interventions to develop more cost-effective prevention policies.
Descritores: Endotoxemia/metabolismo
Intestino Delgado/metabolismo
Rim/metabolismo
Fígado/metabolismo
Óxido Nítrico/análise
-Ditiocarb/química
Ditiocarb/farmacocinética
Endotoxinas/toxicidade
Compostos Férricos/química
Intestino Delgado/efeitos dos fármacos
Rim/efeitos dos fármacos
Fígado/efeitos dos fármacos
Óxido Nítrico/sangue
Óxido Nítrico/metabolismo
Ratos Sprague-Dawley
Sensibilidade e Especificidade
Marcadores de Spin
Detecção de Spin/métodos
Fatores de Tempo
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, U.S. Gov't, P.H.S.
Responsável: BR1.1 - BIREME


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Id: lil-699771
Autor: Bassi, E.; Liberman, M.; Martinatti, M.K.; Bortolotto, L.A.; Laurindo, F.R.M..
Título: Lipoic acid, but not tempol, preserves vascular compliance and decreases medial calcification in a model of elastocalcinosis
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;47(2):119-127, 2/2014. graf.
Idioma: en.
Projeto: FAPESP; . FAPESP; . FAPESP; . FAPESP; . FAPESP.
Resumo: Vascular calcification decreases compliance and increases morbidity. Mechanisms of this process are unclear. The role of oxidative stress and effects of antioxidants have been poorly explored. We investigated effects of the antioxidants lipoic acid (LA) and tempol in a model of atherosclerosis associated with elastocalcinosis. Male New Zealand white rabbits (2.5-3.0 kg) were fed regular chow (controls) or a 0.5% cholesterol (chol) diet+104 IU/day vitamin D2 (vitD) for 12 weeks, and assigned to treatment with water (vehicle, n=20), 0.12 mmol·kg-1·day-1 LA (n=11) or 0.1 mmol·kg-1·day-1 tempol (n=15). Chol+vitD-fed rabbits developed atherosclerotic plaques associated with expansive remodeling, elastic fiber disruption, medial calcification, and increased aortic stiffness. Histologically, LA prevented medial calcification by ∼60% and aortic stiffening by ∼60%. LA also preserved responsiveness to constrictor agents, while intima-media thickening was increased. In contrast to LA, tempol was associated with increased plaque collagen content, medial calcification and aortic stiffness, and produced differential changes in vasoactive responses in the chol+vitD group. Both LA and tempol prevented superoxide signals with chol+vitD. However, only LA prevented hydrogen peroxide-related signals with chol+vitD, while tempol enhanced them. These data suggest that LA, opposite to tempol, can minimize calcification and compliance loss in elastocalcionosis by inhibition of hydrogen peroxide generation.
Descritores: Arteriosclerose/prevenção & controle
Óxidos N-Cíclicos/administração & dosagem
Ácido Tióctico/administração & dosagem
Calcificação Vascular/prevenção & controle
-Aorta Torácica
Arteriosclerose/induzido quimicamente
Arteriosclerose/metabolismo
Complacência (Medida de Distensibilidade)/efeitos dos fármacos
Complacência (Medida de Distensibilidade)/fisiologia
Modelos Animais de Doenças
Marcadores de Spin
Resistência Vascular
Calcificação Vascular/induzido quimicamente
Vasoconstrição/efeitos dos fármacos
Vasoconstrição/fisiologia
Limites: Animais
Masculino
Coelhos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
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Id: lil-695018
Autor: Delgado, Jorge; Rascovsky, Simón; Calvo, Victor; López, Fredy; Castrillón, Gabriel; Foerster, Bernd.
Título: Angiografía no contrastada con Arterial Spin Labeling / Non-contrast angioresonance with Arterial Spin Labeling
Fonte: Rev. chil. radiol;19(3):109-113, 2013. ilus.
Idioma: es.
Resumo: Introducción: La angiografía por resonancia magnética no contrastada realizada con "Arterial Spin Labeling" (ARM ASL) es un método diseñado para marcar los espines sanguíneos y así crear un contraste endógeno adecuado para evaluar territorios vasculares selectivamente sin la necesidad de aplicar medio de contraste intravenoso (compuestos de Gadolinio). Metodología: Se realizó un estudio descriptivo de una serie de casos, donde se describen los detalles técnicos y los resultados de la aplicación de la ARM ASL en equipos de 1.5 y 3 Tesla en voluntarios sanos. Resultados: Se observaron dos casos: Para la técnica angiográfica del primer caso (ASL "Flow-in") se usó un resonador de 3T, sincronización cardiaca, una secuencia b-SSFP 3D y un pre-pulso de inversión, este último para saturar los tejidos estáticos. El volumen de examen se ubicó en el plano axial teniendo la precaución de cubrir la anatomía vascular renal, lo cual se logra en la mayoría de los casos con 60 a 70 cortes de 2 mm solapados en 50 porciento, voxel de 2x1x1 mm y campo de visión (FOV) de 250x100 mm. El protocolo del segundo caso fue obtenido en un equipo de 1.5T, sin sincronización cardiaca, con un navegador respiratorio dia fragmático y con una secuencia coronal Turbo SE 3D después de aplicar dos pre-pulsos de marcación sanguínea, el primero similar al del caso anterior y el segundo, o pulso selectivo, para marcar el flujo del vaso de interés. Con este método (ASL "Flow-Out") sólo la sangre marcada emite señal. Conclusión: Las técnicas de angiografía b-SSFP 3D y Turbo SE 3D no contrastadas con pre-pulsos de ASL en 1.5 y 3T son alternativas disponibles y, por lo tanto, pueden considerarse como complemento a otros métodos de angiografía por resonancia magnética al momento de evaluar la patología vascular.

Introduction: Non-contrast magnetic resonance angiography using "Arterial Spin Labeling" (MRA ASL) is a technique designed to label blood spins and therefore create an endogenous contrast suitable for selectively evaluating vascular territories without intravenous contrast (Gadolinium compounds). Methodology: Technical details and results of the implementación of the MRA ASL using 1.5 and 3.0 Tesla systems in healthy volunteers is described. Results: Two cases were observed: for the angiographic technique of the first case (ASL "Flow-in") in a 3.0 T unit, cardiac synchronization (cardiac gating), a 3D b-SSFP sequence, and an inversion pre-pulse was used, the latter to saturate the static tissues. The examination volume was located in the axial plane taking care to cover the renal vascular anatomy, which is achieved in most cases with 60 to 70 2 mm slices overlapped in 50%, voxel of 2x1x1 mm and a field of vision (FOV) of 250 x100 mm. The protocol for the second case was obtained on a 1.5 T system, without cardiac gating, with a diaphragmatic respiratory navigator and a 3D Turbo SE coronal sequence after applying two pre-pulse blood saturation bands, the first similar to the previous case and the second, or selective pulse, to label the flow of the vessel of interest. With this method (ASL "Flow-Out") only the labeled blood emits a signal. Discussion: 3D b-SSFP and 3D Turbo SE non-contrast angiography techniques with ASL pre-pulses in 1.5 and 3T are available alternatives and, therefore, can be considered as a complement to other methods of magnetic resonance angiography when assessing vascular pathology.
Descritores: Angiografia por Ressonância Magnética/métodos
Marcadores de Spin
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


  7 / 16 LILACS  
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Texto completo SciELO Brasil
Cabral, A. M
Vasquez, E. C
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Id: lil-517800
Autor: Pereira, T. M. C; Balarini, C. M; Silva, I. V; Cabral, A. M; Vasquez, E. C; Meyrelles, S. S.
Título: Endogenous angiotensin II modulates nNOS expression in renovascular hypertension
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;42(7):685-691, July 2009. graf, tab.
Idioma: en.
Resumo: Nitric oxide (NO) influences renal blood flow mainly as a result of neuronal nitric oxide synthase (nNOS). Nevertheless, it is unclear how nNOS expression is modulated by endogenous angiotensin II, an inhibitor of NO function. We tested the hypothesis that the angiotensin II AT1 receptor and oxidative stress mediated by NADPH oxidase contribute to the modulation of renal nNOS expression in two-kidney, one-clip (2K1C) hypertensive rats. Experiments were performed on male Wistar rats (150 to 170 g body weight) divided into 2K1C (N = 19) and sham-operated (N = 19) groups. nNOS expression in kidneys of 2K1C hypertensive rats (N = 9) was compared by Western blotting to that of 2K1C rats treated with low doses of the AT1 antagonist losartan (10 mg·kg-1·day-1; N = 5) or the superoxide scavenger tempol (0.2 mmol·kg-1·day-1; N = 5), which still remain hypertensive. After 28 days, nNOS expression was significantly increased by 1.7-fold in the clipped kidneys of 2K1C rats and by 3-fold in the non-clipped kidneys of 2K1C rats compared with sham rats, but was normalized by losartan. With tempol treatment, nNOS expression increased 2-fold in the clipped kidneys and 1.4-fold in the non-clipped kidneys compared with sham rats. The changes in nNOS expression were not followed by changes in the enzyme activity, as measured indirectly by the cGMP method. In conclusion, AT1 receptors and oxidative stress seem to be primary stimuli for increased nNOS expression, but this up-regulation does not result in higher enzyme activity.
Descritores: Angiotensina II/fisiologia
Hipertensão Renovascular/enzimologia
NADPH Oxidases/efeitos dos fármacos
Óxido Nítrico Sintase Tipo I/metabolismo
Estresse Oxidativo/efeitos dos fármacos
-Bloqueadores do Receptor Tipo 1 de Angiotensina II/farmacologia
Angiotensina II/antagonistas & inibidores
Óxidos N-Cíclicos/farmacologia
Modelos Animais de Doenças
Hipertensão Renovascular/fisiopatologia
Losartan/farmacologia
NADPH Oxidases/fisiologia
Estresse Oxidativo/fisiologia
Ratos Wistar
Marcadores de Spin
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-511086
Autor: Rochitte, Carlos Eduardo; Fernandes, Juliano de Lara.
Título: Ressonância magnética e tomografia computadorizada na pesquisa clínica e básica em cardiologia / Magnetic resonance and computed tomographic in basic and clinical research in cardiology
Fonte: In: Krieger, José Eduardo. Bases moleculares das Doenças Cardiovasculares: a integração entre a pesquisa e a prática clínica. São Paulo, Atheneu, 2008. p.175-190.
Idioma: pt.
Descritores: Pesquisa Biomédica
Miocárdio/patologia
-Angiografia/efeitos da radiação
Marcadores de Spin/síntese química
Limites: Humanos
Tipo de Publ: Livro-Texto
Responsável: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt


  9 / 16 LILACS  
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Texto completo SciELO Brasil
Augusto, Ohara
Texto completo
Id: lil-477425
Autor: Augusto, Ohara; Trindade, Daniel F; Linares, Edlaine; Vaz, Sandra M.
Título: Cyclic nitroxides inhibit the toxicity of nitric oxide-derived oxidants: mechanisms and implications
Fonte: An. acad. bras. ciênc;80(1):179-189, Mar. 2008. ilus, graf, tab.
Idioma: en.
Resumo: The substantial therapeutic potential of tempol (4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy) and related cyclic nitroxides as antioxidants has stimulated innumerous studies of their reactions with reactive oxygen species. In comparison, reactions of nitroxides with nitric oxide-derived oxidants have been less frequently investigated. Nevertheless, this is relevant because tempol has also been shown to protect animals from injuries associated with inflammatory conditions, which are characterized by the increased production of nitric oxide and its derived oxidants. Here, we review recent studies addressing the mechanisms by which cyclic nitroxides attenuate the toxicity of nitric oxidederived oxidants. As an example, we present data showing that tempol protects mice from acetaminophen-induced hepatotoxicity and discuss the possible protection mechanism. In view of the summarized studies, it is proposed that nitroxides attenuate tissue injury under inflammatory conditions mainly because of their ability to react rapidly with nitrogen dioxide and carbonate radical. In the process the nitroxides are oxidized to the corresponding oxammonium cation, which, in turn, can be recycled back to the nitroxides by reacting with upstream species, such as peroxynitrite and hydrogen peroxide, or with cellular reductants. An auxiliary protection mechanism may be down-regulation of inducible nitric oxide synthase expression. The possible therapeutic implications of these mechanisms are addressed.

O considerável potencial terapêutico de tempol (4-hidroxi-2,2, 6,6-tetrametil-1piperiniloxila) e nitróxidos cíclicos relacionados como antioxidantes tem estimulado inúmeros estudos de suas reações com espécies reativas derivadas de oxigênio. Em comparação, as reações de nitróxidos com oxidantes derivados do óxido nítrico têm sido investigadas menos frequentemente. Todavia, essas reações são relevantes porque o tempol é também capaz de proteger animais de injúrias associadas a condições inflamatórias, as quais são caracterizadas por uma aumentada produção de óxido nítrico e derivados oxidantes. Aqui, discutimos estudos recentes abordando os mecanismos pelos quais nitróxidos cíclicos atenuam a toxicidade de oxidantes derivados do óxido nítrico. Como um exemplo, apresentamos dados que demonstram que o tempol protege camundongos do dano hepatotóxico promovido por altas doses de acetaminofeno e discutimos o possível mecanismo de proteção. Com base nos estudos sumarizados, é proposto que nitróxidos atenuam a injúria tecidual em condições inflamatórias devido principalmente a sua capacidade de reagir rapidamente com ambos, dióxido de nitrogênio e radical carbonato. Em conseqüência, os nitróxidos são oxidados ao cátion oxamônio correspondente, o qual, por sua vez, pode ser reciclado ao nitróxido através de reações com espécies precursoras, como peroxinitrito e peróxido de hidrogênio, ou com redutores celulares. Um possível mecanismo auxiliar de proteção é a regulação negativa da expressão da sintase do óxido nítrico induzível. As possíveis implicações terapêuticas desses mecanismos são abordadas.
Descritores: Antioxidantes/uso terapêutico
Doença Hepática Induzida por Substâncias e Drogas
Óxidos N-Cíclicos/uso terapêutico
Oxirredução/efeitos dos fármacos
-Acetaminofen/efeitos adversos
Acetaminofen/antagonistas & inibidores
Analgésicos não Entorpecentes/efeitos adversos
Analgésicos não Entorpecentes/antagonistas & inibidores
Antioxidantes/química
Doença Hepática Induzida por Substâncias e Drogas
Óxidos N-Cíclicos/química
Inflamação/metabolismo
Inflamação/prevenção & controle
Óxido Nítrico Sintase/antagonistas & inibidores
Marcadores de Spin
Limites: Animais
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Revisão
Responsável: BR1.1 - BIREME


  10 / 16 LILACS  
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Id: lil-436815
Autor: Poletti, Erick Fernando.
Título: Síntese, estudos biológicos e conformacionais de análogos da angiotensina II e bradicinina contendo um marcador de spin com estrutura do tipo pirrolidina / Synthesis, biological study and conformation analogs of angiotensin II and bradykinin containing a spin labels with structure pirrolidin type.
Fonte: São Paulo; s.n; 2005. [151] p.
Idioma: pt.
Tese: Apresentada a Universidade Federal de São Paulo. Escola Paulista de Medicina. Curso de Biologia Molecular para obtenção do grau de Doutor.
Descritores: Dicroísmo Circular
Espectroscopia de Ressonância de Spin Eletrônica
Peptídeos
Marcadores de Spin
Responsável: BR1.2 - Biblioteca Central
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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde