Base de dados : LILACS
Pesquisa : D02.442 [Categoria DeCS]
Referências encontradas : 17 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

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  1 / 17 LILACS  
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Fotocópia
Machado, Luís dos Ramos
Livramento, José Antonio
Id: lil-154972
Autor: Bresolin, Antonio Umberto.
Título: Neurotuberculose na infância: atualizaçäo terapêutica / Neurotuberculosis in childhood: therapeutic modernization
Fonte: In: Machado, Luis dos Ramos; Nóbrega, José Paulo Smith; Livramento, José Antonio; Spina França Netto, Antonio. Neuroinfecçäo 94. Säo Paulo, Hospital das Clínicas da Faculdade de Medicina da Universidade de Säo Paulo. Clínica Neurológica, 1994. p.146-146.
Idioma: pt.
Conferência: Apresentado em: Simpósio Neuroinfecçäo-94, Säo Paulo, 18-19 mar. 1994.
Descritores: Pirazinamida/uso terapêutico
Rifampina/uso terapêutico
Tuberculose/tratamento farmacológico
Estreptomicina/uso terapêutico
Hidrazinas/uso terapêutico
Doenças do Sistema Nervoso/tratamento farmacológico
-Meningoencefalite/tratamento farmacológico
Limites: Humanos
Criança
Responsável: BR1.1 - BIREME
BR1.1; 2617.27; BR599.1; 10001009554, AG


  2 / 17 LILACS  
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Texto completo SciELO Brasil
Texto completo
Texto completo
Id: biblio-1011650
Autor: Resende, Marina Ferrara de; Lino, Cleudiomar Inácio; Souza-Fagundes, Elaine Maria de; Rettore, João Vitor Paes; Oliveira, Renata Barbosa de; Labanca, Renata Adriana.
Título: Assessment of anti-diabetic activity of a novel hydrazine-thiazole derivative: in vitro and in vivo method
Fonte: Braz. j. pharm. sci;55:e18218, 2019. tab, graf.
Idioma: en.
Resumo: Diabetes mellitus is a chronic disease resulting in oxidative stress that promotes tissue damage. The appearance of this disease is highly related to lifestyle and food of the population, being of great interest to search for a dietary supplement that can also act by reducing oxidative alterations. Based on the broad range of biological activity of thiazole derivatives, this work aimed to evaluate the in vitro antioxidant activity of a novel hydrazine-thiazole derivative and studies in vivo. In in vivo experiments, the liver extracts of healthy and diabetic Wistar rats were used, with analysis to determine the enzymatic activity of SOD, CAT, GPx, and GR, and determination of lipid peroxidation. Finally, in the blood of these animals, biochemical parameters were evaluated. Statistical evidence of changes caused in liver enzymes and liquid peroxidation was not detected; however, these parameters were also not changed between control groups with and without diabetes. On the other hand, concerning biochemical parameters, significant differences were detected in uric acid, alkaline phosphatase, ALT, and urea, indicating a possible antioxidant protective role of such substances in the liver and kidney of diabetic animals that could be acting by means other than that commonly reported in the literature.
Descritores: Tiazóis/análise
Técnicas In Vitro/métodos
Hidrazinas/análise
-Estresse Oxidativo/fisiologia
Suplementos Nutricionais
Diabetes Mellitus/tratamento farmacológico
Antioxidantes/análise
Limites: Animais
Masculino
Ratos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


  3 / 17 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: lil-670895
Autor: Brazilian Journal of Medical and Biological Research; Silva, G.A.P.; Kummerle, A.E.; Antunes, F.; Fraga, C.A.M.; Barreiro, E.J.; Zapata-Sudo, G.; Sudo, R.T..
Título: Impairment of locomotor activity induced by the novel N-acylhydrazone derivatives LASSBio-785 and LASSBio-786 in mice
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;46(3):263-269, 15/mar. 2013. graf.
Idioma: en.
Resumo: The N-acylhydrazone (NAH) analogues N-methyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-785) and N-benzyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-786) were prepared from 2-thienylidene 3,4-methylenedioxybenzoylhydrazine (LASSBio-294). The ability of LASSBio-785 and LASSBio-786 to decrease central nervous system activity was investigated in male Swiss mice. LASSBio-785 or LASSBio-786 (30 mg/kg, ip) reduced locomotor activity from 209 ± 26 (control) to 140 ± 18 (P < 0.05) or 146 ± 15 crossings/min (P < 0.05), respectively. LASSBio-785 (15 or 30 mg/kg, iv) also reduced locomotor activity from 200 ± 15 to 116 ± 29 (P < 0.05) or 60 ± 16 crossings/min (P < 0.01), respectively. Likewise, LASSBio-786 (15 or 30 mg/kg, iv) reduced locomotor activity from 200 ± 15 to 127 ± 10 (P < 0.01) or 96 ± 14 crossings/min (P < 0.01), respectively. Pretreatment with flumazenil (20 mg/kg, ip) prevented the locomotor impairment induced by NAH analogues (15 mg/kg, iv), providing evidence that the benzodiazepine (BDZ) receptor is involved. This finding was supported by the structural similarity of NAH analogues to midazolam. However, LASSBio-785 showed weak binding to the BDZ receptor. LASSBio-785 or LASSBio-786 (30 mg/kg, ip, n = 10) increased pentobarbital-induced sleeping time from 42 ± 5 (DMSO) to 66 ± 6 (P < 0.05) or 75 ± 4 min (P < 0.05), respectively. The dose required to achieve 50% hypnosis (HD50) following iv injection of LASSBio-785 or LASSBio-786 was 15.8 or 9.5 mg/kg, respectively. These data suggest that both NAH analogues might be useful for the development of new neuroactive drugs for the treatment of insomnia or for use in conjunction with general anesthesia.
Descritores: Hidrazinas/farmacologia
Hidrazonas/farmacologia
Hipnóticos e Sedativos/farmacologia
Atividade Motora/efeitos dos fármacos
Receptores de GABA/efeitos dos fármacos
Tiofenos/farmacologia
-Hidrazinas/química
Hidrazonas/química
Receptores de GABA/fisiologia
Tiofenos/química
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  4 / 17 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: lil-578846
Autor: Zarate, N; Díaz, O; Martínez, AM; Figueroa, JI; Schneider, MI; Smagghe, G; Viñuela, E; Budia, F; Pineda, S.
Título: Lethal and Sublethal Effects of Methoxyfenozide on the Development, Survival and Reproduction of the Fall Armyworm, Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae)
Fonte: Neotrop. entomol;40(1):129-137, Jan.-Feb. 2011. tab.
Idioma: en.
Projeto: International Foundation for Science; . Universidad Michoacana de San Nicolas de Hidalgo. Coordinacion de la Investigacion Cientifica. Programa de Mejoramiento del Profesorado (PROMEP-PTC-101).
Resumo: The lethal and sublethal effects of the ecdysone agonist methoxyfenozide on the fall armyworm, Spodoptera frugiperda (J. E. Smith), were investigated by feeding a methoxyfenozide-treated diet to fifth instars until pupation in doses corresponding to the LC10 and LC25 for the compound. Larval mortality reached 8 percent and 26 percent in the low and high concentration groups, respectively, on the seventh day of the experiment. A progressive larval mortality of 12 percent for the LC10 and 60 percent for the LC25 was observed before pupation. Treated larvae exhibited lower pupal weights, higher pupal mortality, presence of deformed pupae, and more deformed adults than untreated larvae. The incorporation of methoxyfenozide into the diet had a significant effect on the timing of larval development. The development period for males and females was about seven days longer than the controls for both concentrations tested. In contrast, the compound affected neither pupae nor adult longevity. Finally, S. frugiperda adults that resulted from fifth instars treated with methoxyfenozide were not affected in their mean cumulative number of eggs laid per female (fecundity), nor percentages of eggs hatched (fertility), or the sex ratio. Our results suggest that the combination of lethal and sublethal effects of methoxyfenozide may have important implications for the population dynamics of the fall armyworm.
Descritores: Hidrazinas/farmacologia
Hormônios Juvenis/farmacologia
Spodoptera/efeitos dos fármacos
Spodoptera/fisiologia
-Fertilidade/efeitos dos fármacos
Hidrazinas/toxicidade
Hormônios Juvenis/toxicidade
Larva/efeitos dos fármacos
Controle de Pragas
Spodoptera/crescimento & desenvolvimento
Limites: Animais
Feminino
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  5 / 17 LILACS  
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Id: lil-355993
Autor: Guerrero, R. O; Rivera, S. M; Rivera, S; Sueiro, L. A.
Título: Bioassay screening of Amazonian plants
Fonte: P. R. health sci. j;22(3):291-297, Sept. 2003.
Idioma: en.
Resumo: OBJECTIVE: The purpose of this study was to evaluate several biological activities of thirty plant extracts collected in the North West Amazon (Ecuador). Some of these plants are being used for their reputed medicinal properties by the natives of this region. METHODS: Five in vitro bioassays were used to screen the plant material. 1. The brine shrimp lethality examination (BSLT) in microplate is a general test that seems capable of detecting a broad spectrum of bioactivity present in crude plant extracts. 2. Free radical scavenging properties were studied in a colorimetric assay using 2,2-diphenyl-1-picrylhydrazyl (DPPH). 3. The beta-glucosidase inhibition test is thought to be a method for the evaluation of anti-AIDS, anti-diabetic or anti-obesity compounds. 4. The xanthine oxidase inhibition assay is used to identify potential anti-gout agents. 5. The antibacterial activity that is being used to isolate and identify antibiotic drugs. RESULTS: In the BSLT, we found that Piscidia carthagenensis demonstrated very good activity with a LC50: 21.81 micrograms/mL. It is considered that plant extracts with low LC50 values may contain metabolites with cytotoxic, antifungal, insecticidal or pesticide activities. In the antioxidant activity bioassay, several plant extracts were confirmed to have excellent free radical scavenging properties. Rhus juglandifolia and Clusia venusta leaves exhibited an ED50: 3.12 micrograms/mL and 3.61 micrograms/mL, respectively. Piper reticulatum (84 per cent), Inga heteroptera (77 per cent), Clusia venusta (70.9 per cent), and Rhus juglandifolia (70.5 per cent) showed fairly good inhibition activity for beta-glucosidase. On the other hand, none of the plant extracts was capable of inhibiting xanthine oxidase. Finally, the Gram-positive microorganisms Staphylococcus aureus and Corynebacterium diphteriae were found to be sensitive to the majority of the plant extracts, whereas the Gram-negative bacteria Escherichia coli, Pseudomonas aeruginosa, Proteus vulgaris, and Salmonella typhi were proved to be resistant toward the plant extracts. CONCLUSIONS: It is important to continue investigating our plant kingdom, especially the world tropical reserves as an alternative for finding new or better drugs. It should be essential to follow-up this type of investigation to isolate and elucidate the active principles of the bio-positive plants.
Descritores: Extratos Vegetais/farmacologia
Plantas Medicinais/química
-Artemia/efeitos dos fármacos
Bioensaio
Compostos de Bifenilo
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Colorimetria
Avaliação Pré-Clínica de Medicamentos
Depuradores de Radicais Livres/farmacologia
Equador
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Hidrazinas
Inibidores Enzimáticos/isolamento & purificação
Inibidores Enzimáticos/farmacologia
Testes de Sensibilidade Microbiana
Oxirredução
Plantas Medicinais/toxicidade
Xantina Oxidase/antagonistas & inibidores
beta-Glucosidase/antagonistas & inibidores
Responsável: BR1.1 - BIREME


  6 / 17 LILACS  
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Texto completo SciELO Brasil
Laurindo, F. R. M
Texto completo
Id: lil-342859
Autor: Pertrini, C. M; Miyakawa, A. A; Laurindo, F. R. M; Krieger, J. E.
Título: Nitric oxide regulates angiotensin-I converting enzyme under static conditions but not under shear stress
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;36(9):1175-1178, Sept. 2003. tab, graf.
Idioma: en.
Projeto: FAPESP; . CNPq.
Resumo: Mechanical forces including pressure and shear stress play an important role in vascular homeostasis via the control of the production and release of a variety of vasoactive factors. An increase in vascular shear stress is accompanied by nitric oxide (NO) release and NO synthase activation. Previously, we have demonstrated that shear stress induces angiotensin-I converting enzyme (ACE) down-regulation in vivo and in vitro. In the present study, we determined whether NO participates in the shear stress-induced ACE suppression response. Rabbit aortic endothelial cells were evaluated using the NO synthase inhibitor L-NAME, and two NO donors, diethylamine NONOate (DEA/NO) and sodium nitroprusside (SNP). Under static conditions, incubation of endothelial cells with 1 mM L-NAME for 18 h increased ACE activity by 27 percent (from 1.000 ± 0.090 to 1.272 ± 0.182) while DEA/NO and SNP (0.1, 0.5 and 1 mM) caused no change in ACE activity. Interestingly, ACE activity was down-regulated similarly in the presence or absence of L-NAME (delta(0 mM) = 0.26 ± 0.055, delta(0.1 mM) = 0.21 ± 0.22, delta(1 mM) = 0.36 ± 0.13) upon 18 h shear stress activation (from static to 15 dyn/cm²). Taken together, these results indicate that NO can participate in the maintenance of basal ACE levels in the static condition but NO is not associated with the shear stress-induced inactivation of ACE
Descritores: Hemorreologia
Óxido Nítrico
Óxido Nítrico Sintase
Peptidil Dipeptidase A
-Aorta
Endotélio Vascular
Ativação Enzimática
Inibidores Enzimáticos
Hidrazinas
Luciferases
NG-Nitroarginina Metil Éster
Doadores de Óxido Nítrico
Óxido Nítrico Sintase
Nitroprussiato
Peptidil Dipeptidase A
Fatores de Tempo
Limites: Animais
Coelhos
Responsável: BR1.1 - BIREME


  7 / 17 LILACS  
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Id: lil-226199
Autor: Gomes, Ligia Ferreira.
Título: Participaçäo de radicais livres centrados em átomos de carbono na toxicidade de hidrazina / Centered participation free radicals in carbon atoms in the hidrazone toxicity.
Fonte: Säo Paulo; s.n; 1996. 100 p. ilus, tab, graf.
Idioma: pt.
Tese: Apresentada a Universidade de Säo Paulo. Instituto de Química para obtenção do grau de Doutor.
Resumo: A produçäo de radicais de carbono "in vivo" durante a biotransformaçäo da hidrazina foi demonstrada por ressonância paramagnética eletrônica, utilizando o método do captador de spin. Eritrócitos de rato também oxidaram a hidrazina, formando radicais de carbono e nitrogênio, além de espécies reativas de oxigênio. Todas estas espécies, possivelmente formadas "in vivo", säo potencialmente causadoras de dano a macromoléculas. Podem, por exemplo, iniciar reaçöes secundárias formando radicais de componentes celulares, como ocorreu com a hemoglobina que foi oxidada a radicais tiil-hemoglobina em eritrócitos tratados com hidrazina. Radicais de carbono formados durante a biotransformaçäo da hidrazina em animais expostos provêm necessariamente de substâncias endógenas e podem ser direta ou indiretamente responsáveis pela modificaçäo (alquilaçäo) de bases no DNA "in vivo"...
Descritores: Alquilação
Linhagem Celular
DNA
Formaldeído
Radicais Livres
Hidrazinas/toxicidade
-Carcinógenos
Cromatografia Líquida/métodos
Espectroscopia de Ressonância de Spin Eletrônica
Eritrócitos
Limites: Animais
Ratos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas
BR40.1; 574.192


  8 / 17 LILACS  
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Id: lil-226198
Autor: Gamberini, Márcia.
Título: Papel de radicais alquila gerados no metabolismo de derivados de hidrazina na citotoxicidade e transformaçäo de fibroblastos de camundongo transfectados com o proto-oncogene c-myc / Alkyl radicals paper generated in the hidrazine derivatives metabolism in the cytotoxicity and transformation of transfected mouse fibroblasts with c-myc proto-oncogene.
Fonte: Säo Paulo; s.n; 1998. 118 p. ilus, tab, graf.
Idioma: pt.
Tese: Apresentada a Universidade de Säo Paulo. Instituto de Química para obtenção do grau de Doutor.
Resumo: Existem diversos derivados de hidrazina com atividade farmacológica, todos apresentando propriedades carcinogênicas em animais experimentais. Muitos derivados mono e dissubstituídos produzem radicais alquila quando da oxidaçäo por sistemas biológicos. Nossos resultados demonstraram que neutrófilos ativados säo capazes de metabolizar derivados de hidrazina mono e dissubstituídos a radicais alquila, detectados por ressonância paramagnética electrônica/captaçäo de spin, sendo caracterizado o papel de mieloperoxidase e de espécies reativas de oxigênio. Na investigaçäo dos mecanismos de toxicidade dos DH, nossos resultados estabeleceram uma correlaçäo entre a citotoxicidade sobre os fibroblastos de camundongo (medida pela inibiçäo da incorporaçäo de [nH]-dT) e a formaçäo de radicais alquila...
Descritores: Carcinógenos
Linhagem Celular
Fibroblastos
Hidrazinas/toxicidade
Neutrófilos
Proto-Oncogenes
-Espectroscopia de Ressonância de Spin Eletrônica
Limites: Animais
Ratos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas
BR40.1; 574.192


  9 / 17 LILACS  
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Leite, Luciana C. C
Id: lil-191248
Autor: Leite, Luciana C. C; Gamberini, Marcia.
Título: Malignant transformation by hydrazine derivatives: a role for carbon-centered radicals?
Fonte: Ciênc. cult. (Säo Paulo);48(1/2):96-102, Jan.-Apr. 1996. ilus.
Idioma: en.
Resumo: There are several hydrazine derivatives with pharmacological activity, all of which have carcinogenic properties in experimental animals. Several mono- and disubstituted derivatives have been shown to produce carbon-centered radicals upon oxidation by enzymatic systems such as HbO2' Cytochrome P-450, monoamine oxidases, horseradish peroxidase and myeloperoxidase. Proposed mechanisms of hydrazine metabolism leading to alkylating species are discussed. The in vitro induction of DNA alterations by carbon-centered radicals generated in hydrazine metabolism ascertains the possibility of its occurrence in vivo. Our results, discussed herein, established the induction of cytotoxicity, proliferation and transformation of cultured mouse fibroblasts by systems in which hydrazine-derived alkyl radicals are formed. These studies represent another step towards distinguishing the possible involvement of metabolism-generated carbon-centered radicals in the onset of carcinogenic processes, which reinforces the importance of additional experimental approaches in order to consolidate this hypothesis.
Descritores: Carbono/química
Carcinógenos/farmacologia
Hidrazinas/farmacologia
-Carcinógenos/metabolismo
Carcinógenos/toxicidade
Divisão Celular
Dano ao DNA/efeitos dos fármacos
Fibroblastos/citologia
Fibroblastos/metabolismo
Radicais Livres
Hidrazinas/metabolismo
Hidrazinas/toxicidade
Responsável: BR1.1 - BIREME


  10 / 17 LILACS  
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Augusto, O
Id: lil-134496
Autor: Augusto, O; Netto, L. E; Gomes, L. F.
Título: DNA alkylation by carbon-centered radicals
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;25(12):1171-83, 1992. ilus.
Idioma: en.
Resumo: 1. Over the last two decades, the prevalent view in chemical carcinogenesis has been that most free radicals do not bind to DNA. Recent studies, however, are demonstrating formation of adducts between DNA and free radicals such as hydroxyl radicals and aromatic cation radicals. 2. Within this context, we discuss the recent work from our group demonstrating DNA alkylation by carbon-centered radicals formed during biotransformation of genotoxic hydrazine derivatives both in vitro and in vivo. 3. The mutagenic potential of the identified methyl radical adduct, C8-methylguanine, is discussed, and other possible biological sources of carbon-centered radicals are presented
Descritores: Carbono/metabolismo
DNA/metabolismo
-Alquilação
Biotransformação
Radicais Livres/metabolismo
Genes/efeitos dos fármacos
Hidrazinas/farmacocinética
Hidrazinas/toxicidade
Oxirredução
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR26.1 - Biblioteca Central



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