||Molchanov, M. L; Guimarães, F. S.|
||Defense reaction induced by a metabotropic glutamate receptor agonist microinjected into the dorsal periaqueductal gray of rats|
||Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;32(12):1533-7, Dec. 1999. graf.
||Apresentado em: International Neurobiology Course, Ribeiräo Preto, May 20-27 1998.
||The behavioral effects of trans-(+ or -)-1-amino-1,3-cyclopentanedicarboxylic acid (t-ACPD), a metabotropic glutamate receptor (mGluR) agonist, or 0.9 per cent (w/v) saline, injected into the dorsal periaqueductal gray (DPAG), was investigated. Male Wistar rats showed defense reactions characterized by jumps toward the top edges of the cages (saline = 0 vs t-ACPD = 6.0, medians P<0.05) and gallops (saline = 0 vs t-ACPD = 10.0, medians P<0.05) during the 60-s period after the beginning of the injection. In another experiment animals were placed inside an open arena for 5 min immediately after injection. Their behavior was recorded by a video camera and a computer program analyzed the videotapes. Eleven of fifteen rats injected with t-ACPD showed a short-lasting (about 1 min) flight reaction. No saline-treated animal showed this reaction (P<0.0005, chi-square test). The drug induced an increase in turning behavior (P = 0.002, MANOVA) and a decrease in the number of rearings (P<0.001, MANOVA) and grooming episodes (P<0.001, MANOVA). These results suggest that mGluRs play a role in the control of defense reactions in the DPAG.|
||Cicloleucina/análogos & derivados|
Mecanismos de Defesa
Substância Cinzenta Periaquedutal
Receptores de Glutamato Metabotrópico/agonistas
| Tipo de Publ:
||Research Support, Non-U.S. Gov't|
||BR1.1 - BIREME|