Base de dados : LILACS
Pesquisa : D02.455.426.392.368.450.350 [Categoria DeCS]
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Texto completo SciELO Brasil
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Id: lil-249380
Autor: Molchanov, M. L; Guimarães, F. S.
Título: Defense reaction induced by a metabotropic glutamate receptor agonist microinjected into the dorsal periaqueductal gray of rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;32(12):1533-7, Dec. 1999. graf.
Idioma: en.
Conferência: Apresentado em: International Neurobiology Course, Ribeiräo Preto, May 20-27 1998.
Resumo: The behavioral effects of trans-(+ or -)-1-amino-1,3-cyclopentanedicarboxylic acid (t-ACPD), a metabotropic glutamate receptor (mGluR) agonist, or 0.9 per cent (w/v) saline, injected into the dorsal periaqueductal gray (DPAG), was investigated. Male Wistar rats showed defense reactions characterized by jumps toward the top edges of the cages (saline = 0 vs t-ACPD = 6.0, medians P<0.05) and gallops (saline = 0 vs t-ACPD = 10.0, medians P<0.05) during the 60-s period after the beginning of the injection. In another experiment animals were placed inside an open arena for 5 min immediately after injection. Their behavior was recorded by a video camera and a computer program analyzed the videotapes. Eleven of fifteen rats injected with t-ACPD showed a short-lasting (about 1 min) flight reaction. No saline-treated animal showed this reaction (P<0.0005, chi-square test). The drug induced an increase in turning behavior (P = 0.002, MANOVA) and a decrease in the number of rearings (P<0.001, MANOVA) and grooming episodes (P<0.001, MANOVA). These results suggest that mGluRs play a role in the control of defense reactions in the DPAG.
Descritores: Cicloleucina/análogos & derivados
Mecanismos de Defesa
Fármacos Neuroprotetores/farmacologia
Substância Cinzenta Periaquedutal
Receptores de Glutamato Metabotrópico/agonistas
-Microinjeções
Ratos Wistar
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Machado, B. H
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Id: lil-212424
Autor: Machado, B. H; Bonagamba, L. G. H.
Título: Cardiovascular responses to microinjection of trans -(+)-ACPD into the NTS were similar in conscious and chloralose-anesthetized rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;31(4):573-9, Apr. 1998. ilus.
Idioma: en.
Resumo: The changes in mean arterial pressure (MAP) and heart rate (HR) in response to the activation of metabotropic receptors in the nucleus tractus solitarii (NTS) with trans-(+)-1-amino-1,3-cyclopentanedicarboxylic acid (trans-(+)-ACPD) were evaluated in conscious and anesthetized Wistar, male rats weighing 240-260g (N=8). The responses obtained with trans-(+)-ACPD were compared with the responses to L-glutamate (1 nmol/100 nl), since in a previous study we showed that anesthesia converted a pressor response to L-glutamate microinjected into the NTS of conscious rats to a depressor response in the same rats under urethane or chloralose anesthesia. Microinjection of 3 doses of trans-(+)-ACPD (100, 500 and 1000 pmol/100 nl) produced a dose-dependent fall in MAP (range, -20 to -50 mmHg) and HR (range, -30 to -170 bpm) under both conscious and chloralose anesthesia conditions. These data indicate that the cardiovascular responses to the activation of metabotropic receptors by trans-(+)-ACPD are not affected by chloralose anesthesia while the cardiovascular responses to the activation of excitatory amino acid (EAA) receptors by L-glutamate are significantly altered.
Descritores: Anestésicos Intravenosos/farmacologia
Pressão Sanguínea/efeitos dos fármacos
Cloralose/farmacologia
Cicloleucina/farmacologia
Ácido Glutâmico/farmacologia
Frequência Cardíaca/efeitos dos fármacos
Núcleo Solitário/efeitos dos fármacos
-Análise de Variância
Microinjeções
Ratos Wistar
Limites: Masculino
Animais
Ratos
Tipo de Publ: Estudo Comparativo
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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