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  1 / 31 LILACS  
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Id: biblio-1010171
Autor: Adisakwattana, Sirichai; Thilavech, Thavaree; Sompong, Weerachat; Pasukamonset, Porntip.
Título: Interaction between ascorbic acid and gallic acid in a model of fructose-mediated protein glycation and oxidation
Fonte: Electron. j. biotechnol;27:32-36, May. 2017. tab.
Idioma: en.
Resumo: Background: Dietary plant-based foods contain combinations of various bioactive compounds such as phytochemical compounds and vitamins. The combined effect of these vitamins and phytochemicals remains unknown, especially in the prevention of diabetes and its complications. The present study aimed to investigate the combined effect of ascorbic acid and gallic acid on fructose-induced protein glycation and oxidation. Results: Ascorbic acid (15 µg/mL) and gallic acid (0.1 µg/mL) reduced fructose-induced formation of advanced glycation end products (AGEs) in bovine serum albumin (BSA; 10 mg/mL) by 15.06% and 37.83%, respectively. The combination of ascorbic acid and gallic acid demonstrated additive inhibition on the formation of AGEs after 2 weeks of incubation. In addition, synergistic inhibition on the formation of amyloid cross-ß structure and protein carbonyl content in fructose-glycated BSA was observed. At the same concentration, the combination of ascorbic acid and gallic acid produced a significant additive effect on the 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity. Conclusion: Combining natural compounds such as ascorbic acid and gallic acid seems to be a promising strategy to prevent the formation of AGEs.
Descritores: Ácido Ascórbico/metabolismo
Produtos Finais de Glicação Avançada/metabolismo
Ácido Gálico/metabolismo
-Compostos de Bifenilo
Glicosilação
Depuradores de Radicais Livres
Carbonilação Proteica
Oxidação
Frutose/metabolismo
Responsável: CL1.1 - Biblioteca Central


  2 / 31 LILACS  
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Id: biblio-1007336
Autor: Benites, Julio; Guerrero-Castilla, Angélica; Salas, Felipe; Martinez, José L; Jara-Aguilar, Rafael; Venegas-Casanova, Edmundo A; Suarez-Rebaza, Luz; Guerrero-Hurtado, Juana; Buc Calderon, Pedro.
Título: Chemical composition, in vitro cytotoxic and antioxidant activities of the essential oil of Peruvian Minthostachys mollis Griseb / Composición química, actividades citotóxicas y antioxidantes in vitro del aceite esencial de Minthostachys mollis Griseb peruano
Fonte: Bol. latinoam. Caribe plantas med. aromát;17(6):566-574, nov. 2018. tab, ilus.
Idioma: en.
Resumo: The composition of the essential oil obtained by hydrodistillation from Minthostachys mollis Griseb (Lamiaceae) aerial parts was determined by GC and GC/MS. Menthone (13.2%), pulegone (12.4%), cis-dihydrocarvone (9.8%) and carvacrol acetate (8.8%) were the main essential oil components. The cytotoxic activity of the essential oil was in vitro measured using the MTT colorimetric assay. IC50 values were calculated on healthy non-tumor cells (HEK-293) and three human cancer cell lines (T24, DU-145 and MCF-7). In such latter cells, the estimated values were around 0.2 mg/mL. In addition, the antioxidant activity was determined by interaction with the stable free radical 2,2"-diphenyl-1-picrylhydrazyl. The essential oil was almost devoid of antioxidant activity indicating that its anti-proliferative action relies on other unknown mechanism.

La composición del aceite esencial obtenido por hidrodestilación a partir de partes aéreas de Minthostachys mollis Griseb (Lamiaceae) se determinó mediante GC y GC/MS. Mentona (13.2%), pulegona (12.4%), junto con cis-dihidrocarvona (9.8%) y acetato de carvacrol (8.8%) fueron los principales componentes del aceite esencial. La actividad citotóxica del aceite esencial se midió in vitro utilizando el ensayo colorimétrico MTT tanto en células sanas no tumorales (HEK-293) como en tres líneas celulares de cáncer humano (T24, DU-145 y MCF-7). Los valores de IC50 calculados fueron de alrededor de 0.2 mg/mL. Además, se determinó la actividad antioxidante por su interacción con el radical libre 2,2"-difenil-1-picrilhidrazilo. El aceite esencial tiene baja actividad antioxidante, lo que indica que su acción antiproliferativa depende de otro mecanismo desconocido.
Descritores: Óleos Voláteis/farmacologia
Lamiaceae
Linhagem Celular Tumoral/efeitos dos fármacos
Antioxidantes/farmacologia
-Peru
Picratos
Terpenos/análise
Bioensaio
Compostos de Bifenilo
Calorimetria
Óleos Voláteis/química
Sobrevivência Celular/efeitos dos fármacos
Depuradores de Radicais Livres
Cromatografia Gasosa-Espectrometria de Massas
Antioxidantes/química
Responsável: CL1.1 - Biblioteca Central


  3 / 31 LILACS  
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Id: biblio-885097
Autor: Matos, Adriana Arruda.
Título: Avaliação do efeito antiproliferativo da apocinina e diapocinina em células de osteossarcoma humano / Evaluation of the antiproliferative effect of apocynin and diapocynin on human osteosarcoma cells.
Fonte: Bauru; s.n; 2018. 98 p. ilus, graf, tab.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Odontologia de Bauru para obtenção do grau de Doutor.
Resumo: O osteossarcoma (OS) é o tumor maligno primário mais comum do tecido ósseo, caracterizado pela formação de osteócitos anormais. Apesar do avanço nas terapias convencionais (quimioterapia e retirada do tumor), essas não conseguem eliminar totalmente as células tumorais e impedir a progressão da doença. Recentemente, agentes derivados de fontes naturais ganharam considerável atenção por causa de sua segurança, eficácia e disponibilidade imediata. Nesse sentido, a apocinina, inibidor do complexo NADPH-oxidase, vem sendo estudada como agente antitumoral em alguns tipos de câncer como: pâncreas, próstata, pulmão e mama. Apocinina é um pró-fármaco e sua ação parece estar relacionada à sua conversão produzindo a diapocinina, a qual se mostrou mais efetiva do que a apocinina. Portanto, o objetivo desse estudo é avaliar, in vitro, o potencial antitumoral da apocinina e diapocinina em células de osteossarcoma humano. Para isso, foram utilizados osteoblastos humanos normais (HOb) e osteossarcoma humano imortalizadas (SaOS-2) tratados ou não com apocinina e diapocinina em diversas concentrações. Foram realizados os ensaios de viabilidade celular, alterações morfológicas, apoptose celular, produção de espécies reativas de oxigênio (EROs), formação de colônias, migração, invasão e expressão do fator indutor de hipóxia-1alfa (HIF-1). Também foram conduzidos ensaios para verificar a atividade de metaloproteinase de matriz (MMP) 2 e 9. Os resultados em SaOS-2 mostraram que o tratamento com apocinina nas concentrações de 1,5 e 3 mM; e diapocinina nas concentrações de 0,75 e 1,5 mM reduziram a viabilidade; aumentaram o número de células em apoptose e diminuíram a produção de EROs; sem causar danos às células HOb. Além disso, essas mesmas concentrações inibiram a migração e invasão celular; diminuíram a expressão de HIF-1; e reduziram a atividade de MMP-2 em SaOS-2. Considerando os resultados obtidos, concluímos que a apocinina e diapocinina podem atuar como possíveis moduladores de células tumorais, sendo que a diapocinina mostrou ser mais efetiva nos parâmetros testados.(AU)

Osteosarcoma (OS) is the most common primary malignant tumor of bone tissue, characterized by the formation of abnormal osteocytes. Despite advances in conventional therapies (chemotherapy and surgery) they cannot completely eliminate tumor cells and prevent the progression of the disease. Recently, agents derived from natural sources have achieved considerable attention because of their safety, efficacy and immediate availability of therapies. In this way, apocynin, an inhibitor of the NADPH-oxidase complex, has been studied as an antitumor agent in some types of cancer, such as pancreas, prostate, lung and breast. Apocynin is a prodrug and its action indicate to be related to its conversion to diapocynin, which has been shown to be more efficient than apocynin itself. Thus, the aim of this study is to evaluate, in vitro, the antitumor potential of apocynin and diapocynin in human osteosarcoma cells. For this, normal human osteoblasts (HOb) and immortalized human osteosarcoma cells (SaOS-2) were treated or no-treated with apocynin and diapocynin in various concentrations. Cell viability assay, morphological alterations, cellular apoptosis, reactive oxygen species (ROS) production, colony formation, migration, invasion and expression of hypoxia-inducible factor-1 alpha (HIF-1) were performed. We also performed assays to verify the activity of matrix metalloproteinase (MMP) 2 and 9. The results in SaOS-2 showed that treatment with apocynin at concentrations of 1,5 e 3 mM; and diapocynin at concentrations of 0,75 e 1,5 mM reduced cell viability; increased the number of cells in apoptosis and decreased the production of ROS; without damaging HOb cells. Moreover, these same concentrations inhibited cell migration and invasion; decreased HIF-1 expression; and reduced MMP 2 activity in SaOS-2. Considering the results, we suggest that apocynin and diapocynin may act as possible modulators of tumor cells, and diapocynin has been shown to be more effective.(AU)
Descritores: Acetofenonas/farmacologia
Antineoplásicos/farmacologia
Compostos de Bifenilo/farmacologia
Osteossarcoma/tratamento farmacológico
-Apoptose/efeitos dos fármacos
Movimento Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Metaloproteinase 2 da Matriz/efeitos dos fármacos
Metaloproteinase 9 da Matriz/efeitos dos fármacos
Osteoblastos/efeitos dos fármacos
Espécies Reativas de Oxigênio/análise
Reprodutibilidade dos Testes
Células Tumorais Cultivadas
Limites: Seres Humanos
Tipo de Publ: Estudos de Avaliação
Responsável: BR28.1 - Serviço de Biblioteca e Documentação Professor Doutor Antônio Gabriel Atta
BR28.1, M428a


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Id: lil-795828
Autor: Mesa-Vanegas, Ana María; Zapata-Uribe, Sebastián; Arana, Luis Miguel; Zapata, Isabel Cristina; Monsalve, Zulma; Rojano, Benjamín.
Título: Actividad antioxidante de extractos de diferente polaridad de Ageratum conyzoides L / Antioxidant activity of different polarity extracts from Ageratum conyzoides L
Fonte: Bol. latinoam. Caribe plantas med. aromát;14(1):1-10, ene.2015. ilus, tab.
Idioma: es.
Resumo: The present study aimed to investigate the antioxidant activity of extracts of different polarity of the species Ageratum conyzoides L., evaluating by different spectrophotometric methods: ABTS•+, DPPH•, FRAP and ORAC. Extracts of A. conyzoides L., showed good antioxidant activity in the methodologies evaluated. The extract was the most active of ethyl acetate (ACExtA) which showed the best evaluated values techniques with higher power as determined by the assay values of TEAC ORAC = 494048.95 +/- 29695.80 uMol Trolox/100g sample. Measurements of antioxidant activity by different techniques offer advantages in terms of predicting the in vitro antioxidant capacity of this plant, it is also recommended to explore the structural characteristics of the compounds present in the ethyl acetate extract of the plant with to explore the potential benefits and possible mechanisms of action of new antioxidants...

El presente trabajo tuvo como objetivo investigar la actividad antioxidante de extractos de diferente polaridad de la especie Ageratum conyzoides L., mediante la evaluación por diferentes métodos espectrofotométricos: ABTS•+, DPPH•, FRAP y ORAC. Los extractos de A. conyzoides L., presentaron una buena actividad antioxidante en las metodologías evaluadas. El extracto más activo fue el de acetato de etilo (ACExtA), que presentó los mejores valores por las técnicas evaluadas con la mayor potencia determinada por el ensayo ORAC con valores de TEAC = 494048,95 +/- 29695,80 uMol Trolox/100g muestra. Las mediciones de la actividad antioxidante por diferentes técnicas, ofrecen ventajas en términos de la predicción de la capacidad antioxidante in vitro de esta planta, además se recomienda explorar las características estructurales de los compuestos presentes en el extracto de acetato de etilo de esta planta con el fin de investigar los beneficios potenciales y los mecanismos de acción de posibles nuevos antioxidantes...
Descritores: Ageratum/química
Antioxidantes/farmacologia
Extratos Vegetais/farmacologia
-Antioxidantes/química
Compostos de Bifenilo
Espécies Reativas de Oxigênio
Extratos Vegetais/química
Compostos Férricos
Oxirredução
Picratos
Limites: Seres Humanos
Responsável: CL1.1 - Biblioteca Central


  5 / 31 LILACS  
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Id: lil-786492
Autor: Martínez, Nelvy; Almaguer, Georgina; Vázquez-Alvarado, Patricia; Figueroa, Ana; Zúñiga, Clara; Hernández-Ceruelos, Alejandra.
Título: Análisis fitoquímico de Jatropha dioica y determinación de su efectoantioxidante y quimioprotector sobre el potencial genotóxico deciclofosfamida, daunorrubicina y metilmetanosulfonato evaluadomediante el ensayo cometa / Phytochemical analysis of Jatropha dioica and determination of its antioxidant and chemopreventive effect on the genotoxic potential of cyclophosphamide, daunorubicin and methyl methane-sulfonate evaluated by the comet assay
Fonte: Bol. latinoam. Caribe plantas med. aromát;13(5):437-457, sept.2014. ilus, tab, graf.
Idioma: es.
Resumo: Dragon ́s blood root (Jatropha dioica) underwent a phytochemical screening showing the presence of flavonoids and terpenes responsible for the antioxidant potential observed in DPPH model for the decoction, aqueous and methanolic extracts. The chemoprotective effect of the root decoction was evaluated in liver, kidney and bone marrow cells of mice using the comet assay. Mutagens were administered via IP: cyclophosphamide (CCF) 50 mg/kg, daunorubicin (DAU) 10 mg/kg, and metyl metanesulfonate (MMS) 40 mg/kg, were co-administered with three doses of decoction 3.72 ml/kg, 10.71 ml/kg, and 21.42 ml/kg orally. Animals were sacrificed at 3, 9, 15 and 21 h after inoculation. The chemoprotective effect decreased DNA breaks at 3 hours in all organs, and longer against CCF and DAU, this effect probably being related to the antioxidant capacity of the decoction.

La raíz de Sangre de Drago (Jatropha dioica) se sometió a un tamizaje fitoquímico destacando la presencia de flavonoides y terpenos, posibles responsables del efecto antioxidante observado en el modelo de DPPH para la decocción, extracto acuoso y metanólico de la raíz. El efecto quimioprotector de la decocción, se evaluó en células hepáticas, renales y de médula ósea de ratón, mediante el ensayo cometa. Los mutágenos administrados vía I.P.: ciclofosfamida (CCF) 50 mg/kg, daunorrubicina (DAU) 10 mg/kg y metilmetanosulfonato (MMS) 40 mg/kg, se co-administraron con tres dosis de decocción 3,72 ml/kg, 10,71 ml/kg y 21,42 ml/kg, vía oral. Los animales fueron sacrificados a las 3, 9, 15 y 21 h posteriores a la aplicación. El efecto quimioprotector disminuyó las rupturas del DNA a las 3 horas en todos los órganos con los tres mutágenos, y permaneció por más tiempo frente a CCF y DAU, dicho efecto está relacionado con la capacidad antioxidante de la decocción.
Descritores: Antioxidantes/farmacologia
Extratos Vegetais/farmacologia
Genotoxicidade/prevenção & controle
Jatropha/química
Substâncias Protetoras/farmacologia
-Compostos de Bifenilo
Ensaio Cometa
Ciclofosfamida/toxicidade
Daunorrubicina/toxicidade
Metanossulfonato de Metila/toxicidade
Picratos
Limites: Animais
Camundongos
Responsável: CL1.1 - Biblioteca Central


  6 / 31 LILACS  
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Id: lil-785452
Autor: Forero-Doria, Oscar; Astudillo, Luis; Castro, Ricardo I; Lozano, Rafael; Díaz, Oscar; Guzmán-Jofre, Luis; Gutierrez, Margarita.
Título: Antioxidant activity of bioactive extracts obtained from rhizomes of Cyperus digitatus Roxb / Actividad antioxidante de extractos obtenidos a partir de rizomas de Cyperus digitatus Roxb
Fonte: Bol. latinoam. Caribe plantas med. aromát;13(4):344-350, jul. 2014. ilus, tab.
Idioma: en.
Resumo: Members of the family Cyperaceae such as Cyperus alopecuroides, Cyperus articulatus, Cyperus scariosus and Cyperus rotundus possess significant amount of studies about their antioxidant activities and other properties. Nevertheless, the plant Cyperus digitatus belonging to the genus Cyperus lacks of studied about any kind of intrinsic activity. Different extracts and fractions were obtained from the rhizomes of Cyperus digitatus, and a Phytochemical screening and the content of phenols and flavonoids and the antioxidant properties (FRAP, DPPH and beta-Carotene bleaching) were quantified in each of theextracts and fractions. Of all the extracts obtained, the BE and AqE extracts showed the best antioxidant potential, meanwhile, none of the fractions obtained from the EAE extract show a relevant activity.

Los miembros de la familia Cyperaceae, tales como Cyperus alopecuroides, Cyperus articulatus, Cyperus scariosus y Cyperus rotundus poseen una cantidad significativa de estudios sobre sus actividades antioxidantes y otras propiedades. Sin embargo, la planta Cyperus digitatus perteneciente al género Cyperus carece de estudio de cualquier tipo de actividad intrínseca. Razón por la cual se estudió sus propiedades antioxidantes (FRAP, DPPH y blanqueamiento del beta-caroteno), cuantificación de contenido fenolico y flavonoides totales en extractos y fracciones obtenidos de los rizomas de Cyperus digitatus, y un perfil fitoquímico. De todos los extractos obtenidos, BE y AqE mostraron el mejor potencial antioxidante, por otra parte ninguna de las fracciones obtenidas a partir del extracto EAE mostro una actividad relevante.
Descritores: Antioxidantes/farmacologia
Cyperus/química
Extratos Vegetais/farmacologia
Rizoma/química
-Compostos de Bifenilo
Extratos Vegetais/química
Compostos Ferrosos
Fenóis/análise
Flavonoides/análise
Oxirredução
Estresse Oxidativo
Técnicas de Química Analítica/métodos
Responsável: CL1.1 - Biblioteca Central


  7 / 31 LILACS  
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Texto completo SciELO Brasil
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Id: lil-767061
Autor: Mittal, A.; Tandon, S.; Singla, S.K.; Tandon, C..
Título: In vitro studies reveal antiurolithic effect of Terminalia arjuna using quantitative morphological information from computerized microscopy
Fonte: Int. braz. j. urol;41(5):935-944, Sept.-Oct. 2015. tab, graf.
Idioma: en.
Resumo: ABSTRACT Purpose: For most cases, urolithiasis is a condition where excessive oxalate is present in the urine. Many reports have documented free radical generation followed by hyperoxaluria as a consequence of which calcium oxalate (CaOx) deposition occurs in the kidney tissue. The present study is aimed to exam the antilithiatic potency of the aqueous extract (AE) of Terminalia arjuna (T. arjuna). Materials and Methods: The antilithiatic activity of Terminalia arjuna was investigated in vitro nucleation, aggregation and growth of the CaOx crystals as well as the morphology of CaOx crystals using the inbuilt software ‘Image-Pro Plus 7.0’ of Olympus upright microscope (BX53). Antioxidant activity of AE of Terminalia arjuna bark was also determined in vitro. Results: Terminalia arjuna extract exhibited a concentration dependent inhibition of nucleation and aggregation of CaOx crystals. The AE of Terminalia arjuna bark also inhibited the growth of CaOx crystals. At the same time, the AE also modified the morphology of CaOx crystals from hexagonal to spherical shape with increasing concentrations of AE and reduced the dimensions such as area, perimeter, length and width of CaOx crystals in a dose dependent manner. Also, the Terminalia arjuna AE scavenged the DPPH (2, 2-diphenyl-1-picrylhydrazyl) radicals with an IC50 at 13.1µg/mL. Conclusions: The study suggests that Terminalia arjuna bark has the potential to scavenge DPPH radicals and inhibit CaOx crystallization in vitro. In the light of these studies, Terminalia arjuna can be regarded as a promising candidate from natural plant sources of antilithiatic and antioxidant activity with high value.
Descritores: Antioxidantes/farmacologia
Oxalato de Cálcio/química
Extratos Vegetais/farmacologia
Terminalia/química
Cálculos Urinários/prevenção & controle
-Análise de Variância
Compostos de Bifenilo/química
Cristalização
Depuradores de Radicais Livres/farmacologia
Fitoterapia
Picratos/química
Valores de Referência
Reprodutibilidade dos Testes
Cálculos Urinários/química
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


  8 / 31 LILACS  
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Texto completo SciELO Brasil
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Id: lil-755829
Autor: Tajalli, Faezeh; Malekzadeh, Khalil; Soltanian, Hadi; Janpoor, Javad; Rezaeian, Sharareh; Pourianfar, Hamid R..
Título: Antioxidant capacity of several Iranian, wild and cultivated strains of the button mushroom
Fonte: Braz. j. microbiol;46(3):769-776, July-Sept. 2015. tab, ilus.
Idioma: en.
Resumo:

The white button mushroom, Agaricus bisporus, is the most commonly grown mushroom in Iran; however, there is a significant shortage of research on its antioxidant activity and other medicinal properties. The aim of this study was to evaluate antioxidant capacity of the methanolic extracts from four cultivated strains and four Internal Transcribed Spacer (ITS)-identified, Iranian wild isolates of A. bisporus. Evaluations were made for total phenols, flavonoids and anthocyanins, and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. Overall, results showed that all the wild isolates exhibited significantly lower DPPH-derived EC50, compared to the cultivated strains (p < 0.05). A relatively high relationship was observed between total phenols and flavonoids or anthocyanins (r2 > 0.60). However, these constituents could not statistically differentiate the group of wild samples from the cultivated ones, and there was low correlation with the DPPH-derived EC50s (r2 < 0.40). In conclusion, comparisons showed that wild isolate 4 and cultivated strains A15 and H1 had higher antioxidant capacity than the others (p < 0.05). This result identifies these mushrooms as good candidates for further investigation.

.
Descritores: Agaricus/metabolismo
Antocianinas/metabolismo
Antioxidantes/metabolismo
Compostos de Bifenilo/metabolismo
Flavonoides/metabolismo
Fenóis/metabolismo
Picratos/metabolismo
-Agaricus/genética
DNA Intergênico/genética
Irã (Geográfico)
Oxirredução
Espécies Reativas de Oxigênio/metabolismo
Limites: Seres Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  9 / 31 LILACS  
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Texto completo SciELO Chile
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Id: lil-734617
Autor: Jantakee, Kanyaluck; Tragoolpua, Yingmanee.
Título: Activities of different types of Thai honey on pathogenic bacteria causing skin diseases, tyrosinase enzyme and generating free radicals
Fonte: Biol. Res;48:1-11, 2015. graf, tab.
Idioma: en.
Projeto: Chiang Mai University. Faculty of Science; . The Thailand Research Fund-Research and Researchers for Industry; . Bee Products Industry Co.
Resumo: BACKGROUND: Honey is a natural product obtained from the nectar that is collected from flowers by bees. It has several properties, including those of being food and supplementary diet, and it can be used in cosmetic products. Honey imparts pharmaceutical properties since it has antibacterial and antioxidant activities. The antibacterial and antioxidant activities of Thai honey were investigated in this study. RESULTS: The honey from longan flower (source No. 1) gave the highest activity on MRSA when compared to the other types of honey, with a minimum inhibitory concentration of 12.5% (v/v) and minimum bactericidal concentration of 25% (v/v). Moreover, it was found that MRSA isolate 49 and S. aureus were completely inhibited by the 50% (v/v) longan honey (source No. 1) at 8 and 20 hours of treatment, respectively. Furthermore, it was observed that the honey from coffee pollen (source No. 4) showed the highest phenolic and flavonoid compounds by 734.76 mg gallic/kg of honey and 178.31 mg quercetin/kg of honey, respectively. The antioxidant activity of the honey obtained from coffee pollen was also found to be the highest, when investigated using FRAP and DPPH assay, with 1781.77 mg FeSO4•7H2O/kg of honey and 86.20 mg gallic/kg of honey, respectively. Additionally, inhibition of tyrosinase enzyme was found that honey from coffee flower showed highest inhibition by 63.46%. CONCLUSIONS: Honey demonstrates tremendous potential as a useful source that provides anti-free radicals, anti-tyrosinase and anti-bacterial activity against pathogenic bacteria causing skin diseases.
Descritores: Apiterapia
Flavonoides/análise
Mel/análise
Monofenol Mono-Oxigenase
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Fenóis/análise
Pólen/química
-Antibacterianos/farmacologia
Antioxidantes/farmacologia
Compostos de Bifenilo
Café/química
Recuperação de Fluorescência Após Fotodegradação
Flores/química
Radicais Livres/análise
Mel/classificação
Testes de Sensibilidade Microbiana
Monofenol Mono-Oxigenase/antagonistas & inibidores
Monofenol Mono-Oxigenase/efeitos dos fármacos
Picratos
Pólen/classificação
Dermatopatias/microbiologia
Dermatopatias/terapia
Preparações Clareadoras de Pele/farmacologia
Tailândia
Fatores de Tempo
Viscosidade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


  10 / 31 LILACS  
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Texto completo SciELO Saúde Pública
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Id: lil-733236
Autor: Moya, José; Pimentel, Raquel; Puello, José.
Título: Chikungunya: un reto para los servicios de salud de la República Dominicana / Chikungunya: a challenge for the Dominican Republic's health services
Fonte: Rev. panam. salud pública = Pan am. j. public health;36(5):331-335, nov. 2014.
Idioma: es.
Resumo: Desde diciembre de 2013, la Región de las Américas se enfrenta por primera vez a una epidemia de chikungunya. Los casos iniciales se registraron en el Caribe francés y, debido al comercio y la movilización de personas, esta epidemia no tardó en llegar a la República Dominicana, cuya población es de 10 millones de habitantes y comparte con Haití la isla La Española. En este artículo se difunde información extraída de diversos artículos y documentos oficiales sobre el virus, la infección y la epidemia de chikungunya, que han sido de gran ayuda para orientar la respuesta en la República Dominicana y pueden ser útiles para mejorar tanto el conocimiento como las actuaciones frente a la epidemia de los trabajadores del sector salud de la Región. Se destaca la importancia que revisten las investigaciones realizadas en países y territorios afectados del océano Índico, como la isla de Reunión, durante la epidemia declarada entre 2005 y 2007, cuando se registró una tasa de ataque mayor de 30%, se identificaron los grupos de riesgo, las formas graves y atípicas de la infección, la transmisión vertical del virus, las formas crónicas, que pueden provocar dolores recurrentes durante tres años, y las defunciones directa o indirectamente relacionadas con el virus chikungunya. Por su alta tasa de ataque, el virus chikungunya se convierte en un reto sin precedentes para los ministerios de salud, que exige una adecuada organización de los servicios de salud, la priorización de la atención a los grupos de riesgo y a los pacientes con formas graves de la enfermedad, así como una adecuada comunicación social y respuesta intersectorial.

The Region of the Americas has been affected since December 2013 by a chikungunya epidemic for the first time. Although the first cases were recorded in the French Caribbean, the epidemic quickly spread to the Dominican Republic due to trade and people movements. The Dominican Republic, which shares the island of Hispaniola with Haiti, has a population of 10 million. This article contains information from a range of different publications and official documents about the chikungunya virus infection and epidemic. These papers were extremely helpful for guiding the response to the epidemic in the Dominican Republic and may also be useful for enhancing knowledge of the virus and responses among health workers elsewhere in the region. Particular attention is drawn to the important research undertaken in countries and territories affected by the epidemic in the Indian Ocean area. This is the case, for example, of the island of La Réunion, where the epidemic had an attack rate of more than 30% between 2005 and 2007. Researchers were able to identify risk groups, severe and atypical forms of the infection, cases of vertical transmission, chronic disease causing recurrent pain over three years, and directly- or indirectly-related deaths from the virus. Given its high attack rate, the chikungunya virus has emerged as an exceptional challenge for health ministries and calls for appropriate organized responses from the health services, prioritization of care for risk groups and patients exhibiting severe forms of the disease, and effective social communication and intersectoral actions.
Descritores: Angiotensina II/farmacologia
DNA
Músculo Liso Vascular/efeitos dos fármacos
Inibidores da Agregação de Plaquetas/farmacologia
/análogos & derivados
THROMBOXANE ATEMEFOS/análogos & derivados
Vasoconstritores/farmacologia
-Anti-Hipertensivos/farmacologia
Benzimidazóis/farmacologia
Compostos de Bifenilo/farmacologia
Células Cultivadas
Divisão Celular/fisiologia
Músculo Liso Vascular/fisiologia
Proteínas Proto-Oncogênicas c-fos/biossíntese
Ratos Endogâmicos WKY
RNA Mensageiro/metabolismo
Tetrazóis/farmacologia
/farmacologia
THROMBOXANE ATEMEFOS/farmacologia
Limites: Animais
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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