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Texto completo SciELO Brasil
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Id: biblio-974289
Autor: Charousová, Ivana; Medo, Juraj; Hleba, Lukáš; Javoreková, Soňa.
Título: Streptomyces globosus DK15 and Streptomyces ederensis ST13 as new producers of factumycin and tetrangomycin antibiotics
Fonte: Braz. j. microbiol;49(4):816-822, Oct.-Dec. 2018. tab, graf.
Idioma: en.
Projeto: Slovak Academy of Sciences.
Resumo: ABSTRACT Fifty seven soil-borne actinomycete strains were assessed for the antibiotic production. Two of the most active isolates, designed as Streptomyces ST-13 and DK-15 exhibited a broad range of antimicrobial activity and therefore they were selected for HPLC fractionation against the most suppressed bacteria Staphylococcus aureus (ST-13) and Chromobacterium violaceum (DK-15). LC/MS analysis of extracts showed the presence of polyketides factumycin (DK15) and tetrangomycin (ST13). The taxonomic position of the antibiotic-producing actinomycetes was determined using a polyphasic approach. Phenotypic characterization and 16S rRNA gene sequence analysis of the isolates matched those described for members of the genus Streptomyces. DK-15 strain exhibited the highest 16S rRNA gene sequence similarity to Streptomyces globosus DSM-40815 (T) and Streptomyces toxytricini DSM-40178 (T) and ST-13 strain to Streptomyces ederensis DSM-40741 (T) and Streptomyces phaeochromogenes DSM-40073 (T). For the proper identification, MALDI-TOF/MS profile of whole-cell proteins led to the identification of S. globosus DK-15 (accession number: KX527570) and S. ederensis ST13 (accession number: KX527568). To our knowledge, there is no report about the production of these antibiotics by S.globosus and S. ederensis, thus isolates DK15 and ST13 identified as S. globosus DK-15 and S.ederensis ST-13 can be considered as new sources of these unique antibacterial metabolites.
Descritores: Streptomyces/isolamento & purificação
Streptomyces/metabolismo
Antibacterianos/biossíntese
-Filogenia
Piridonas/metabolismo
Microbiologia do Solo
Streptomyces/classificação
Streptomyces/genética
Benzo(a)Antracenos/metabolismo
DNA Bacteriano/genética
Técnicas de Tipagem Bacteriana
Responsável: BR1.1 - BIREME


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Id: lil-8728
Autor: Goya, R. G; Gomez, C. J.
Título: Heterogeneity of nucleic acid synthesis in 7, 12-dimethylbenz (A) anthracene-induced rat mammary tumors.
Fonte: Acta physiol. pharmacol. latinoam;32(2):157-61, 1982.
Idioma: en.
Descritores: Benzo(a)Antracenos
Neoplasias Mamárias Experimentais
-DNA de Neoplasias
RNA Neoplásico
Limites: Feminino
Animais
Ratos
Responsável: BR1.1 - BIREME



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