Base de dados : LILACS
Pesquisa : D02.455.426.559.847.486 [Categoria DeCS]
Referências encontradas : 6 [refinar]
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Id: biblio-1150914
Autor: Charris Salas, Katiuska.
Título: Síntesis de derivados de, 5H-indeno (1,2-b) piridina y 4,5-dihidroindeno (1,2-b) pirano polihidroxilados con posible actividad citotóxica antitumoral y antichagasica / Synthesis of polyhydroxylated, 5H-indene (1,2-b) pyridine and 4,5-dihydroindene (1,2-b) pyran derivatives with possible anti-tumor and anti-chagasic cytotoxic activity.
Fonte: Caracas; s.n; oct. 2011. 198 p. ilus, graf, tab.
Idioma: es.
Tese: Apresentada a Universidad Central de Venezuela. Facultad de Farmacia para obtenção do grau de Doctor.
Descritores: Indenos/síntese química
-Piranos/toxicidade
Piranos/química
Piridinas/toxicidade
Piridinas/química
Carga Tumoral/efeitos dos fármacos
Indenos/toxicidade
Limites: Humanos
Tipo de Publ: Estudo de Avaliação
Responsável: VE497.1 - Biblioteca Dr. Oswaldo Enríquez Isava
VE497.1; D-QM, Ch3


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Texto completo SciELO Brasil
Texto completo
Id: lil-732822
Autor: Freitas, Maria Célia de; Guedes, Maria Vilani Cavalcante; Galiza, Francisca Tereza de; Nogueira, Jéssica de Menezes; Onofre, Marília Ribeiro.
Título: Idosos residentes em uma instituição de longa permanência: adaptação à luz de Callista Roy / Elderly residents in homes for the aged: adjustment in the light of Callista Roy / Residentes mayores en un hogares para ancianos: adaptación a la luz de Callista Roy
Fonte: Rev. bras. enferm;67(6):905-912, Nov-Dec/2014.
Idioma: pt.
Resumo: Objetivou-se avaliar o processo de adaptação de idosos que buscam, voluntariamente, residir em Instituição de Longa Permanência para Idosos (ILPI), na cidade de Fortaleza-CE, com base no modelo teórico de Roy. Pesquisa descritiva, realizada em uma IPLI com treze idosos residentes. A coleta de dados foi por meio de entrevista, nos meses de outubro e dezembro de 2011. Os dados foram tratados pela análise de conteúdo temática. Emergiram as seguintes temáticas: Eu Físico, subdividido em sensação corporal e imagem corporal; e Eu Pessoal, subdividido em auto coerência, auto ideal e ser moral-ético-espiritual. Assim, a opção de morar em ILPI não mudou efetivamente a vida dos idosos. Estes conseguiram adaptação ao local e convivem bem com os estímulos internos e externos.

This study aimed to evaluate the adaptation of elderly individuals voluntarily reside in Institution for the Aged (LTCF) in the city of Fortaleza-CE, based on the theoretical model of Roy. Descriptive study, in a IPLI involving thirteen elderly residents. Data collect was through interviews in the months of October and December 2011 and organized by thematic content analysis. The following themes has emerged: I Physical subdivided into body sensation and body image; Staff and I, subdivided into self-consistency and auto ideal be moral-ethical-spiritual. Thus, the option to live in ILPI not effectively changed the lives of elderly people. They managed to adapt to the local and coexist well with internal and external stimuli.

Este estudio tuvo como objetivo evaluar la adaptación de las personas mayores que residen voluntariamente en la Institución para la tercera edad (LTCF) en la ciudad de Fortaleza-CE, basado en el modelo teórico de Roy. Estudio descriptivo, en un IPLI con trece ancianos residentes. Los datos fueran recogidos a través de entrevistas en los meses de octubre y diciembre de 2011 y organizados mediante análisis de contenido temático. Emergieron los siguientes temas: subdivide I Física en la imagen corporal y sensación de cuerpo; El personal y yo, subdividen en auto-consistencia y auto ideal ser moral-ético-espiritual. Por lo tanto, la opción de vivir en ILPI no cambió de manera efectiva la vida de los ancianos. Se las arreglaron para adaptarse a lo local y convivir bien con los estímulos internos y externos.
Descritores: Tronco Encefálico/efeitos dos fármacos
Indenos/farmacologia
Micotoxinas/farmacologia
-Tronco Encefálico/fisiologia
Diazepam/farmacologia
Estimulação Elétrica
Neurônios Motores/efeitos dos fármacos
Formação Reticular/efeitos dos fármacos
Limites: Animais
Masculino
Coelhos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
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Id: lil-732352
Autor: Amaral, Giovanna M.; Marinho, Hellen V. R.; Ocarino, Juliana M.; Silva, Paula L. P.; Souza, Thales R. de; Fonseca, Sérgio T..
Título: Muscular performance characterization in athletes: a new perspective on isokinetic variables
Fonte: Braz. j. phys. ther. (Impr.) = Rev. bras. fisioter;18(6):521-529, 09/01/2015. tab.
Idioma: en.
Resumo: Background: Isokinetic dynamometry allows the measurement of several variables related to muscular performance, many of which are seldom used, while others are redundantly applied to the characterization of muscle function. Objectives: The present study aimed to establish the particular features of muscle function that are captured by the variables currently included in isokinetic assessment and to determine which variables best represent these features in order to achieve a more objective interpretation of muscular performance. Method: This study included 235 male athletes. They performed isokinetic tests of concentric knee flexion and extension of the dominant leg at a velocity of 60º/s. An exploratory factor analysis was performed. Results: The findings demonstrated that isokinetic variables can characterize more than muscle torque production and pointed to the presence of 5 factors that enabled the characterization of muscular performance according to 5 different domains or constructs. Conclusions: The constructs can be described by torque generation capacity; variation of the torque generation capacity along repetitions; movement deceleration capacity; mechanical/physiological factors of torque generation; and acceleration capacity (torque development). Fewer than eight out of sixteen variables are enough to characterize these five constructs. Our results suggest that these variables and these 5 domains may lead to a more systematic and optimized interpretation of isokinetic assessments. .
Descritores: Indenos/toxicidade
Neurônios Motores/efeitos dos fármacos
Medula Espinal/efeitos dos fármacos
-Clorpromazina/farmacologia
Pentobarbital/farmacologia
Reflexo/efeitos dos fármacos
Medula Espinal/citologia
Limites: Animais
Masculino
Coelhos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
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Id: lil-709489
Autor: Chaichanan, Jirapan; Wiyakrutta, Suthep; Pongtharangkul, Thunyarat; Isarangkul, Duangnate; Meevootisom, Vithaya.
Título: Optimization of zofimarin production by an endophytic fungus, Xylaria sp. Acra L38
Fonte: Braz. j. microbiol;45(1):287-293, 2014. ilus, tab.
Idioma: en.
Resumo: To optimize the medium for high zofimarin production, sucrose maltose, glucose, tryptone and peptone were used in an orthogonal array design experiment, where the highest value of zofimarin produced was 25.6 µg/mL. This value was about 3 times higher than that obtained with Czapek yeast extract (CzYE) culture medium. A study with Plackett-Burman design showed that sucrose, maltose, glucose and NaNO3 were significant factors in zofimarin production. Further studies using central composite design (CCD) showed the significance of glucose and the interactions of these critical components affecting zofimarin production. Multiple regression analysis of the data yielded a poor fit as shown by the mismatch of the model with these variable factors. When a polynomial equation was applied, the maximum zofimarin production was predicted to be 201.9 µg/mL. Experimental verification yielded a much lower amount of zofimarin, at around 70 µg/mL. Reconsideration of the CCD data and repetition of some runs with high zofimarin production resulted in reproducible zofimarin yield at 79.7 µ/mL. Even though the amount was lower than the predicted value, the medium optimization study was considered to be quite successful as the yield increased to around 8 times that obtained with the original CzYE culture medium.
Descritores: Antifúngicos/metabolismo
Meios de Cultura/química
Endófitos/metabolismo
Xylariales/metabolismo
-Indenos/metabolismo
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
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Id: lil-554963
Autor: Baker, C. M; Chitrakar, R; Obulareddy, N; Panchal, S; Williams, P; Melotto, M.
Título: Molecular battles between plant and pathogenic bacteria in the phyllosphere
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;43(8):698-704, Aug. 2010. ilus.
Idioma: en.
Resumo: The phyllosphere, i.e., the aerial parts of the plant, provides one of the most important niches for microbial colonization. This niche supports the survival and, often, proliferation of microbes such as fungi and bacteria with diverse lifestyles including epiphytes, saprophytes, and pathogens. Although most microbes may complete the life cycle on the leaf surface, pathogens must enter the leaf and multiply aggressively in the leaf interior. Natural surface openings, such as stomata, are important entry sites for bacteria. Stomata are known for their vital role in water transpiration and gas exchange between the plant and the environment that is essential for plant growth. Recent studies have shown that stomata can also play an active role in limiting bacterial invasion of both human and plant pathogenic bacteria as part of the plant innate immune system. As counter-defense, plant pathogens such as Pseudomonas syringae pv tomato (Pst) DC3000 use the virulence factor coronatine to suppress stomate-based defense. A novel and crucial early battleground in host-pathogen interaction in the phyllosphere has been discovered with broad implications in the study of bacterial pathogenesis, host immunity, and molecular ecology of bacterial diseases.
Descritores: Aminoácidos/metabolismo
Indenos/metabolismo
Lycopersicon esculentum/fisiologia
Folhas de Planta/fisiologia
Estômatos de Plantas/fisiologia
Pseudomonas syringae/patogenicidade
Fatores de Virulência/fisiologia
-Aminoácidos/genética
Lycopersicon esculentum/genética
Lycopersicon esculentum/microbiologia
Folhas de Planta/microbiologia
Estômatos de Plantas/microbiologia
Pseudomonas syringae/genética
Fatores de Virulência/genética
Tipo de Publ: Research Support, N.I.H., Extramural
Responsável: BR1.1 - BIREME


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Id: lil-4061
Autor: Ulloa, J. E; Barrera, Amalia; Mar, R. M.
Título: Estudio comparativo de la tolerancia y seguridad de fenbufen y sulindac en pacientes con gonartrosis y coxartrosis. / Comparative study of tolerance and safety of fenbufen and sulindac in patients with gonarthrosis and coxarthrosis
Fonte: Invest. med. int;8(3):268-71, 1981.
Idioma: es.
Resumo: En estudio comparativo abierto con duracion de 6 semanas, mediante examen gastroscopico se evaluo la seguridad y tolerancia de fenbufen y sulindac em 24 pacientes; 20 gornatrosis y 4 coxartrosis. Las edades estuvieron comprendidas entre 45 y 70 anos. Tanto en la semana cero "depuracion de drogas" como al concluir el tratamiento, se practicaron examenes de laboratorio comprendiendo hematologia, quimica sanguinea, examen de orina y pruebas de funcionamiento hepatico. El estudio gastroscopico se realizo al final de las semanas cero y sexta, ignorando el endoscopista el medicamento que recibia el paciente.El esquema de tratamiento con fenbufen fue de 900 mg/24 h repartido en dos tomas (capsulas de 300 mg 1-0-2) y con sulindac de 300 mg/24 h repartido en dos tomas (tabletas de 100 mg 1-0-2). Se observo imagen endoscopica de gastritis en dos pacientes del grupo sulindac, 18% (2/11) y en ninguno del grupo fenbufen, no hubo cambios en los examenes de laboratorio relacionados con la administracion de los medicamentos. Se concluye una mejor tolerancia en el grupo fenbufen proponiendo su uso para el manejo de artropatias degenerativas
Descritores: Indenos
Osteoartrite
Propionatos
Responsável: BR1.1 - BIREME



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