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Id: lil-789475
Autor: Oliveira, Priscila Rosalba; Felix, Cassia da Silva; Carvalho, Vladimir Cordeiro de; Giovani, Arlete Mazzini; Reis, Rosangela Suarti dos; Beraldo, Marisa; Albuquerque, Edmir Peralta; Ferreira Junior, Walter Cintra; Silva, Jorge dos Santos; Lima, Ana Lucia Lei.
Título: Outpatient parenteral antimicrobial therapy for orthopedic infections – a successful public healthcare experience in Brazil
Fonte: Braz. j. infect. dis;20(3):272-275, May.-June 2016. tab.
Idioma: en.
Resumo: Abstract Treatment of orthopedic infections usually requires prolonged antimicrobial therapy, ranging from 14 days up to 6 months. Nowadays, rising levels of antimicrobial resistance demands parenteral therapy for many patients. Outpatient parenteral antimicrobial therapy (OPAT) is a modality that allows treatment out of hospital in these situations. In Brazil, where a public universal healthcare system allows full coverage for all citizens, implantation and dissemination of OPAT programs would be beneficial for patients and for the system, because it would allow a better allocation of health resources. The Instituto de Ortopedia e Traumatologia do Hospital das Clínicas da Faculdade de Medicina da USP (IOT) started, in July 2013, a partnership with municipal health authorities in Sao Paulo, Brazil, in order to initiate an OPAT program in which patients discharged from that hospital would be able to continue antimicrobial therapy at primary care facilities. When necessary, patients could also receive their therapy at the day-hospital located at IOT. Primary care nursing and physician staff were trained about antimicrobial infusion and peripherally inserted central catheter manipulation. An OPAT specific antimicrobial protocol was designed and a special reference and counter-reference organized. As a result, 450 primary healthcare professionals were trained. In the first year of this program, 116 patients were discharged for OPAT. Chronic and acute osteomyelitis were most frequent diagnosis. Teicoplanin, ertapenem and tigecycline were the most used drugs. Duration of treatment varied from 10 to 180 days (average 101, median 42). Total sum of days in OPAT regimen was 11,698. Only 3 patients presented adverse effects. Partnership between services of different levels of complexity allowed implantation of a safe and effective public healthcare OPAT program for treatment of orthopedic infections. This program can serve as a model for developing similar strategies in other regions of Brazil and Latin America.
Descritores: Osteomielite/terapia
beta-Lactamas/uso terapêutico
Infusões Parenterais/métodos
Minociclina/análogos & derivados
Antibacterianos/administração & dosagem
-Pacientes Ambulatoriais
Doenças Ósseas Infecciosas/classificação
Doenças Ósseas Infecciosas/tratamento farmacológico
Brasil
Ertapenem
Tigeciclina
Anti-Infecciosos
Minociclina/uso terapêutico
Antibacterianos/classificação
Limites: Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-828149
Autor: Fraga, Edmir Geraldo; Nicodemo, Antonio Carlos; Sampaio, Jorge Luiz Mello.
Título: Antimicrobial susceptibility of Brazilian Clostridium difficile strains determined by agar dilution and disk diffusion
Fonte: Braz. j. infect. dis;20(5):476-481, Sept.-Oct. 2016. tab, graf.
Idioma: en.
Resumo: Abstract Clostridium difficile is a leading cause of diarrhea in hospitalized patients worldwide. While metronidazole and vancomycin are the most prescribed antibiotics for the treatment of this infection, teicoplanin, tigecycline and nitazoxanide are alternatives drugs. Knowledge on the antibiotic susceptibility profiles is a basic step to differentiate recurrence from treatment failure due to antimicrobial resistance. Because C. difficile antimicrobial susceptibility is largely unknown in Brazil, we aimed to determine the profile of C. difficile strains cultivated from stool samples of inpatients with diarrhea and a positive toxin A/B test using both agar dilution and disk diffusion methods. All 50 strains tested were sensitive to metronidazole according to CLSI and EUCAST breakpoints with an MIC90 value of 2 μg/mL. Nitazoxanide and tigecycline were highly active in vitro against these strains with an MIC90 value of 0.125 μg/mL for both antimicrobials. The MIC90 were 4 μg/mL and 2 μg/mL for vancomycin and teicoplanin, respectively. A resistance rate of 8% was observed for moxifloxacin. Disk diffusion can be used as an alternative to screen for moxifloxacin resistance, nitazoxanide, tigecycline and metronidazole susceptibility, but it cannot be used for testing glycopeptides. Our results suggest that C. difficile strains from São Paulo city, Brazil, are susceptible to metronidazole and have low MIC90 values for most of the current therapeutic options available in Brazil.
Descritores: Antibacterianos/farmacologia
-Valores de Referência
Tiazóis/farmacologia
Brasil
Ensaio de Imunoadsorção Enzimática
Vancomicina/farmacologia
Contagem de Colônia Microbiana/métodos
Reprodutibilidade dos Testes
Infecções por Clostridium/microbiologia
Teicoplanina/farmacologia
Fluoroquinolonas/farmacologia
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão/métodos
Carga Bacteriana
Moxifloxacina
Tigeciclina
Metronidazol/farmacologia
Minociclina/análogos & derivados
Minociclina/farmacologia
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-671779
Autor: Vidarte-Orrego, Gladys; Tocto-Jaimes, Arelis F; Caro-Bisso, Karina E; Chian-García, César.
Título: Papilomatosis reticulada y confluente (síndrome de Gougerot-Carteaud): reporte de tres casos tratados con minociclina / Confluent and reticulated papillomatosis (Gougerot-Carteaud syndrome): three cases treated with mynocicline
Fonte: Dermatol. peru;21(4):158-162, oct.-dic. 2011. ilus.
Idioma: es.
Resumo: La papilomatosis reticulada y confluente es una dermatosis ictiosiforme crónica y recurrente que se observa en adultos jóvenes; afecta más a mujeres que a hombres. Se caracteriza por la presencia de máculas, pápulas, parches y placas escamosas colorpardo localizadas en cuello, región intermamaria, interescapular y axilas. El tratamiento resulta frustante pues ningún fármacoha dado bueno resultados a largo plazo. La minociclina es uno de los antibióticos con el que más éxito se ha obtenido. Se reportan tres casos de mujeres jóvenes con buena respuesta a la administración de este fármaco. Se presentan estos casos por ser una entidad de difícil tratamiento.

Confluent and reticulated papillomatosis is a chronic andrecurrent ichthyosiform dermatoses observed in young adults, affecting more women than men. It is characterized by the presence of macules, papules, patches and brown scaly plaqueslocated in the neck, intermamaria and interscapular region andarmpits. Treatment is frustrating because no drug has givengood long-term results. Minocycline is an antibiotic of the most successful has been obtained. We report three cases of young women with good response to the administration of the drug. Wepresent these cases as an entity of difficult treatment.
Descritores: Acantose Nigricans
Ictiose
Ilustração Médica
Minociclina/uso terapêutico
Papiloma
-Relatos de Casos
Limites: Humanos
Adolescente
Feminino
Adulto Jovem
Tipo de Publ: Relatos de Casos
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: lil-492489
Autor: Ura, Somei; Diório, Suzana Madeira; Carreira, Beatriz Gomes; Trino, Lazara Moreira; Lauris, José Roberto; Fleury, Raul Negrão; Barravieira, Benedito.
Título: Estudo terapêutico comparando a associação de rifampicina, ofloxacina e minociclina com a associação rifampicina, clofazimina e dapsona em pacientes com hanseníase multibacilar / Therapeutic study comparing the association rifampin, ofloxacinand minocycline, with the association rifampin, clofazimine anddapsone in multibacillary leprosy patients
Fonte: Hansen. int;32(1):57-65, 2007. ilus, tab, graf.
Idioma: pt.
Resumo: Foram comparados dois esquemas terapêuticos em pacientes com hanseníase multibacilar. O grupo controle com 14 pacientes recebeu o tratamento convencional.O grupo teste com 12 pacientes recebeu a associação de rifampicina 600 mg, ofloxacina 400 mg,e minociclina 100 mg, uma vez por mês, durante dois anos. Na avaliação inicial foram realizados exames clínicos, baciloscópicos e histológicos. A baciloscopia e a biópsia foram repetidas no final do primeiro e segundo ano de tratamento. As avaliações clínicas realizadas mensalmente. Todos pacientes apresentavam lesões cutâneas, que os caracterizavam como virchovianos ou peri-virchovianos. No grupo controle, o índice baciloscópico antes do tratamento variou de 2 a 4,8 e no grupo teste de 1,6 a 4,8. Histologicamente apresentavam quadro de hanseníase virchoviana ativa, exceto um paciente do grupo teste. Ao final do primeiro ano de tratamento estavam todos clinicamente melhorados,o índice baciloscópico diminuído e quadro histológico regressivo. Essa tendência se mantinha e ao final do segundo ano todos estavam clinicamente, baciloscopicamente e histologicamente ainda melhores. Análise estatística mostrou não haver diferença significante entre os grupos, sendo os esquemas equivalentes. No grupo controle todos apresentaram pigmentação cutânea devido a clofazimina. Os resultados deste estudo demonstraram que o esquema com rifampicina, ofloxacinae minociclina, teve eficácia e segurança equivalente a poliquimioterapia convencional para multibacilar. Além disso, não causa pigmentação cutânea, pode ser totalmente supervisionado, podendo ser utilizado como esquema alternativo

Two therapeutic schemes in multibacillary leprosy patients were compared. The control group with 14 patients received the conventional treatment (MDT-MB). The test group with 12 patients, received the association rifampin 600 mg, ofloxacin 400 mg and minocycline 100 mg (ROM), administrated under supervision once a month, during two years. Initial evaluations include clinical, bacilloscopic and histological exams. The bacilloscopy and the biopsy were repeated at the end of first and second year of treatment. Clinical evaluations were performed monthly. All patients presented skin lesions characteristic of the lepromatous type. In the control group, the bacterial index (BI) before treatment ranged from 2 to 4.8 and in the test group it ranged from 1.6 to 4.8. Histological picture resembled active lepromatous leprosy, except one patient from the test group. At the end of the first year of treatment all patients showed clinical improvement, decreased BI and regressive histological picture. This tendency was maintained and at a final evaluation at the end of the second year all patients showed improvement on clinical, bacilloscopic and histological evaluations. Statistical analysis showed no significant differences between the groups, therefore, the two schemes were similar. In the control group all patients presented skin pigmentation after clofazimine intake. The results demonstrated that monthly administration of ROM is as efficacious and safe as MDT-MB. Besides, it doesn't cause skin pigmentation, it can be given under supervision and can be used as alternative scheme.
Descritores: Clofazimina/uso terapêutico
Dapsona/uso terapêutico
Eritema Nodoso
Hanseníase Multibacilar/tratamento farmacológico
Hanseníase Virchowiana
Minociclina/uso terapêutico
Ofloxacino/uso terapêutico
Rifampina/uso terapêutico
-Quimioterapia Combinada
Limites: Humanos
Tipo de Publ: Estudo Comparativo
Responsável: BR191.1 - Biblioteca e Centro de Documentação Luiza Keffer


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Registro de Ensaios Clínicos
Id: biblio-1055366
Autor: Kavanagh, Bianca E; Williams, Lana J; Berk, Michael; Turner, Alyna; Jackson, Henry J; Mohebbi, Mohammadreza; Kanchanatawan, Buranee; Ashton, Melanie M; Ng, Chee H; Maes, Michael; Berk, Lesley; Malhi, Gin S; Dowling, Nathan; Singh, Ajeet B; Dean, Olivia M.
Título: Personality disorder and functioning in major depressive disorder: a nested study within a randomized controlled trial
Fonte: Braz. J. Psychiatry (São Paulo, 1999, Impr.);42(1):14-21, Jan.-Feb. 2020. tab.
Idioma: en.
Reg. de E.C: http://www.anzctr.org.au/ANZCTRN12612000283875.aspx
Resumo: Objective: This study aimed to determine if personality disorder (PD) predicted functional outcomes in patients with major depressive disorder (MDD). Methods: Data (n=71) from a double-blind, randomized, placebo-controlled 12-week trial assessing the efficacy of 200 mg/day adjunctive minocycline for MDD were examined. PD was measured using the Standardized Assessment of Personality Abbreviated Scale. Outcome measures included Clinical Global Impression - Improvement (CGI-I), Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q), Social and Occupational Functioning Scale (SOFAS), and Range of Impaired Functioning (RIFT). Analysis of covariance was used to examine the impact of PD (dichotomized factor [≥ 3] or continuous measure) on the outcome measures-treatment group correlation. Results: PD was identified in 69% of the sample. After adjusting for age, sex, and baseline scores for each of the outcome measures, there was no significant difference between participants with and without PD on week 12 scores for any of the outcome measures (all p > 0.14). Conclusion: In this secondary analysis of a primary efficacy study, PD was a common comorbidity among those with MDD, but was not a significant predictor of functional outcomes. This study adds to the limited literature on PD in randomized controlled trials for MDD. Clinical trial registration: ACTRN12612000283875.
Descritores: Transtornos da Personalidade/psicologia
Transtorno Depressivo Maior/psicologia
Transtorno Depressivo Maior/tratamento farmacológico
Minociclina/administração & dosagem
Antidepressivos/administração & dosagem
-Satisfação Pessoal
Testes de Personalidade
Escalas de Graduação Psiquiátrica
Qualidade de Vida
Comorbidade
Efeito Placebo
Método Duplo-Cego
Resultado do Tratamento
Autorrelato
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adulto
Idoso
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: biblio-984596
Autor: Dias, Olívia Meira; Nascimento, Ellen Caroline Toledo do; Chate, Rodrigo Caruso; Kairalla, Ronaldo Adib; Baldi, Bruno Guedes.
Título: Eosinophilic pneumonia: remember topical drugs as a potential etiology / Pneumonia eosinofílica: lembre-se de medicamentos tópicos como possível etiologia
Fonte: J. bras. pneumol;44(6):522-524, Nov.-Dec. 2018. graf.
Idioma: en.
Descritores: Eosinofilia Pulmonar/induzido quimicamente
Minociclina/efeitos adversos
Antibacterianos/efeitos adversos
-Eosinofilia Pulmonar/patologia
Eosinofilia Pulmonar/diagnóstico por imagem
Acne Vulgar/tratamento farmacológico
Limites: Humanos
Feminino
Adulto
Tipo de Publ: Relatos de Casos
Carta
Responsável: BR1.1 - BIREME


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Id: biblio-838187
Autor: González Gili, Lucas O; Buffone, Ignacio R; Carrara, Laura E; Coto, María B; Fortunatti, Eliana A; Dejtera, Mabel; García Elliot, María F; Giacone, Alejandra; Luncio, Anabella C; Masnicoff, Sebastián D; Oviedo Crosta, María B; Parrou, Marianela; Romano, Mariana.
Título: Pseudotumor cerebral secundario al consumo de minociclina en un paciente pediátrico / Pseudotumor cerebri secondary to consumption of minocycline in a pediatric patient
Fonte: Arch. argent. pediatr;114(2):e78-e83, abr. 2016. ilus, graf.
Idioma: es.
Resumo: El pseudotumor cerebral se caracteriza por una elevación de la presión intracraneal mayor de 20 cmH2O, con ventrículos y líquido cefalorraquídeo de características normales. El consumo de minociclina es una de las causas asociadas a este síndrome. Presentamos una paciente de 13 años de edad con antecedentes de acné tratado con minociclina. Comenzó con cefalea intensa, diplopía y visión borrosa. Se constató el diagnóstico de pseudotumor cerebral y se indicó la suspensión inmediata del antibiótico y el inicio del tratamiento con acetazolamida. Aunque la patogénesis de pseudotumor cerebral no es totalmente conocida, se ha observado una asociación con el empleo de minociclina. Este antibiótico es de uso frecuente para el manejo del acné, por lo que es importante considerar sus complicaciones antes de ser prescrito.

Pseudotumor cerebri is a syndrome characterized by an elevated intracranial pressure greater than 20 cmH2O with ventricles and cerebrospinal fluid of normal characteristics. Consumption of minocycline have been described among the causes associated with this syndrome. We present a 13-year old female patient with a history of acne treated with minocycline who began with severe headache, diplopia and blurred vision. The diagnosis of pseudotumor cerebri was made, indicating the immediate antibiotic suspension and the beginning of the treatment with acetazolamide. Although the pathogenesis of pseudotumor cerebri is not fully known, an association with minocycline has been observed. This antibiotic is often used by health professionals for the management of acne, so it is important to consider its complications before being prescribed.
Descritores: Pseudotumor Cerebral/diagnóstico
Pseudotumor Cerebral/induzido quimicamente
Acne Vulgar/tratamento farmacológico
Minociclina/efeitos adversos
Minociclina/uso terapêutico
Antibacterianos/efeitos adversos
Antibacterianos/uso terapêutico
Limites: Humanos
Feminino
Adolescente
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: biblio-995395
Autor: Luján Urviola, Eduardo; Meza Málaga, Joan Manuel; Luján Valencia , Sara Antonieta.
Título: Diseño de chip de tetraciclina y minociclina en la proliferación bacteriana de la microflora de bolsas periodontales / Design of chip of tetracycline and minocicline in the bacterial proliferation of the microflora of periodontal bags
Fonte: Evid. odontol. clín;4(2):21-30, jul.-dic. 2018. ilus, tab, graf.
Idioma: es.
Resumo: La investigación está orientada a buscar medidas más directas para tratar el problema de la proliferación bacteriana, durante el tratamiento de bolsa, favoreciendo una rápida curación en un medio libre de bacterias. Objetivos: Determinar el Chip que tenga mejor efecto en la proliferación bacteriana de la microflora de bolsas periodontales. Material y métodos: Los grupos fueron constituidos 2 grupos experimentales de chip de tetraciclina y de minociclina y un grupo control con disco de tetraciclina y un blanco, las bacterias fueron obtenidas de 16 pacientes, estas se suspendieron en Caldo peptopnado dejándose en la incubadora por 24 horas y después se sembraron en las placas Petri conteniendo Agar sangre.. La información obtenida se recopiló en Fichas de observación microbiológica a las 24, 48 y 72 horas. El estudio realizado fue de tipo experimental, prospectiva, longitudinal y el nivel de investigación fue experimental. Se utilizó el software SPSS versión 21. El análisis que se realizó se dio por la variable independiente bifactorial(chip de tetraciclina y chip de minociclina)y por la variable dependiente univariado, así mismo por la naturaleza de la investigación va a ser un análisis cuantitativo. Resultados: Los resultados obtenidos muestran un efecto inhibiendo la proliferación bacteriana de la microflora de bolsas periodontales, que se manifestaron por la presencia de halos de inhibición en las diferentes con una media de 11,94 a las 72 horas correspondiente al chip de tetraciclina y un promedio de 6.25 milímetros a las 72 horas del chip de minociclina, obteniéndose un valor de p = 0.000, es decir p <0.005. Conclusiones: El chip de minociclina presenta una acción menor que el de la tetraciclina, negando la hipótesis planteada, es decir existe diferencia estadística entre ambos. (AU)

The research is oriented to seek more direct measures to treat the problem of bacterial proliferation, during bag treatment, favoring a quick cure in a bacteria-free environment. Objectives: Determine the Chip that has the best effect on the bacterial proliferation of periodontal pocket microflora. Material and Methods: The groups were constituted 2 experimental groups of tetracycline chip and minocycline and a control group with tetracycline disc and a white, the bacteria were obtained from 16 patients, these were suspended in broth peptopnado leaving in the incubator for 24 hours and then they planted in the Petri dishes containing blood agar. The information obtained was compiled in microbiological observation sheets at 24, 48 and 72 hours. The study was experimental, prospective, longitudinal and the level of research was experimental. The software SPSS version 21 was used. The analysis was carried out by the independent variable bifactorial (chip of tetracycline and chip of minocycline) and by the univariate dependent variable, likewise by the nature of the research it will be a quantitative analysis. Results: The results obtained show an effect inhibiting the bacterial proliferation of the periodontal pocket microflora, which was manifested by the presence of inhibition halos in the different ones with a mean of 11.94 at 72 hours corresponding to the tetracycline chip and an average of 6.25 millimeters at 72 hours of the minocycline chip, obtaining a value of p = 0.000, that is p <0.005. Conclusions: Finally we conclude that the l chip of minocycline has a lower action than that of tetracycline, denying the hypothesis, that is, there is a statistical difference between the two. (AU)
Descritores: Bolsa Periodontal
Tetraciclina
Minociclina/uso terapêutico
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: biblio-973178
Autor: Alarcón C., Rosario; Partarrieu M., Felipe.
Título: Papilomatosis reticulada y confluente de Gougerot-Carteaud / Gougerot-Carteaud cross-linked and confluent papillomatosis
Fonte: Rev. chil. dermatol;31(1):67-67, 2015. ilus.
Idioma: es.
Descritores: Neoplasias Cutâneas/diagnóstico
Neoplasias Cutâneas/patologia
Papiloma/diagnóstico
Papiloma/patologia
-Neoplasias Cutâneas
Papiloma
Minociclina/uso terapêutico
Limites: Feminino
Humanos
Adulto
Tipo de Publ: Relatos de Casos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-835947
Autor: Yarmuch G, Paula; Chaparro R, Ximena; Fischer S, Cecilia; Benveniste, Samuel; Kaplan Z, Viera.
Título: Papilomatosis confluente y reticulada de Gougerot y Carteaud / Confluent and reticulate papillomatosis (Gougerot-Carteaud syndrome)
Fonte: Rev. chil. dermatol;30(2):194-194, 2014. ilus.
Idioma: es.
Descritores: Neoplasias Cutâneas/patologia
Neoplasias Cutâneas/tratamento farmacológico
Papiloma/patologia
Papiloma/tratamento farmacológico
-Diagnóstico Diferencial
Minociclina/uso terapêutico
Papiloma/diagnóstico
Limites: Humanos
Masculino
Adolescente
Tipo de Publ: Relatos de Casos
Responsável: CL1.1 - Biblioteca Central



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