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Id: biblio-838187
Autor: González Gili, Lucas O; Buffone, Ignacio R; Carrara, Laura E; Coto, María B; Fortunatti, Eliana A; Dejtera, Mabel; García Elliot, María F; Giacone, Alejandra; Luncio, Anabella C; Masnicoff, Sebastián D; Oviedo Crosta, María B; Parrou, Marianela; Romano, Mariana.
Título: Pseudotumor cerebral secundario al consumo de minociclina en un paciente pediátrico / Pseudotumor cerebri secondary to consumption of minocycline in a pediatric patient
Fonte: Arch. argent. pediatr;114(2):e78-e83, abr. 2016. ilus, graf.
Idioma: es.
Resumo: El pseudotumor cerebral se caracteriza por una elevación de la presión intracraneal mayor de 20 cmH2O, con ventrículos y líquido cefalorraquídeo de características normales. El consumo de minociclina es una de las causas asociadas a este síndrome. Presentamos una paciente de 13 años de edad con antecedentes de acné tratado con minociclina. Comenzó con cefalea intensa, diplopía y visión borrosa. Se constató el diagnóstico de pseudotumor cerebral y se indicó la suspensión inmediata del antibiótico y el inicio del tratamiento con acetazolamida. Aunque la patogénesis de pseudotumor cerebral no es totalmente conocida, se ha observado una asociación con el empleo de minociclina. Este antibiótico es de uso frecuente para el manejo del acné, por lo que es importante considerar sus complicaciones antes de ser prescrito.

Pseudotumor cerebri is a syndrome characterized by an elevated intracranial pressure greater than 20 cmH2O with ventricles and cerebrospinal fluid of normal characteristics. Consumption of minocycline have been described among the causes associated with this syndrome. We present a 13-year old female patient with a history of acne treated with minocycline who began with severe headache, diplopia and blurred vision. The diagnosis of pseudotumor cerebri was made, indicating the immediate antibiotic suspension and the beginning of the treatment with acetazolamide. Although the pathogenesis of pseudotumor cerebri is not fully known, an association with minocycline has been observed. This antibiotic is often used by health professionals for the management of acne, so it is important to consider its complications before being prescribed.
Descritores: Pseudotumor Cerebral/diagnóstico
Pseudotumor Cerebral/induzido quimicamente
Acne Vulgar/tratamento farmacológico
Minociclina/efeitos adversos
Minociclina/uso terapêutico
Antibacterianos/efeitos adversos
Antibacterianos/uso terapêutico
Limites: Seres Humanos
Feminino
Adolescente
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: biblio-995395
Autor: Luján Urviola, Eduardo; Meza Málaga, Joan Manuel; Luján Valencia , Sara Antonieta.
Título: Diseño de chip de tetraciclina y minociclina en la proliferación bacteriana de la microflora de bolsas periodontales / Design of chip of tetracycline and minocicline in the bacterial proliferation of the microflora of periodontal bags
Fonte: Evid. odontol. clín;4(2):21-30, jul.-dic. 2018. ilus, tab, graf.
Idioma: es.
Resumo: La investigación está orientada a buscar medidas más directas para tratar el problema de la proliferación bacteriana, durante el tratamiento de bolsa, favoreciendo una rápida curación en un medio libre de bacterias. Objetivos: Determinar el Chip que tenga mejor efecto en la proliferación bacteriana de la microflora de bolsas periodontales. Material y métodos: Los grupos fueron constituidos 2 grupos experimentales de chip de tetraciclina y de minociclina y un grupo control con disco de tetraciclina y un blanco, las bacterias fueron obtenidas de 16 pacientes, estas se suspendieron en Caldo peptopnado dejándose en la incubadora por 24 horas y después se sembraron en las placas Petri conteniendo Agar sangre.. La información obtenida se recopiló en Fichas de observación microbiológica a las 24, 48 y 72 horas. El estudio realizado fue de tipo experimental, prospectiva, longitudinal y el nivel de investigación fue experimental. Se utilizó el software SPSS versión 21. El análisis que se realizó se dio por la variable independiente bifactorial(chip de tetraciclina y chip de minociclina)y por la variable dependiente univariado, así mismo por la naturaleza de la investigación va a ser un análisis cuantitativo. Resultados: Los resultados obtenidos muestran un efecto inhibiendo la proliferación bacteriana de la microflora de bolsas periodontales, que se manifestaron por la presencia de halos de inhibición en las diferentes con una media de 11,94 a las 72 horas correspondiente al chip de tetraciclina y un promedio de 6.25 milímetros a las 72 horas del chip de minociclina, obteniéndose un valor de p = 0.000, es decir p <0.005. Conclusiones: El chip de minociclina presenta una acción menor que el de la tetraciclina, negando la hipótesis planteada, es decir existe diferencia estadística entre ambos. (AU)

The research is oriented to seek more direct measures to treat the problem of bacterial proliferation, during bag treatment, favoring a quick cure in a bacteria-free environment. Objectives: Determine the Chip that has the best effect on the bacterial proliferation of periodontal pocket microflora. Material and Methods: The groups were constituted 2 experimental groups of tetracycline chip and minocycline and a control group with tetracycline disc and a white, the bacteria were obtained from 16 patients, these were suspended in broth peptopnado leaving in the incubator for 24 hours and then they planted in the Petri dishes containing blood agar. The information obtained was compiled in microbiological observation sheets at 24, 48 and 72 hours. The study was experimental, prospective, longitudinal and the level of research was experimental. The software SPSS version 21 was used. The analysis was carried out by the independent variable bifactorial (chip of tetracycline and chip of minocycline) and by the univariate dependent variable, likewise by the nature of the research it will be a quantitative analysis. Results: The results obtained show an effect inhibiting the bacterial proliferation of the periodontal pocket microflora, which was manifested by the presence of inhibition halos in the different ones with a mean of 11.94 at 72 hours corresponding to the tetracycline chip and an average of 6.25 millimeters at 72 hours of the minocycline chip, obtaining a value of p = 0.000, that is p <0.005. Conclusions: Finally we conclude that the l chip of minocycline has a lower action than that of tetracycline, denying the hypothesis, that is, there is a statistical difference between the two. (AU)
Descritores: Bolsa Periodontal
Tetraciclina
Minociclina/uso terapêutico
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: biblio-973178
Autor: Alarcón C., Rosario; Partarrieu M., Felipe.
Título: Papilomatosis reticulada y confluente de Gougerot-Carteaud / Gougerot-Carteaud cross-linked and confluent papillomatosis
Fonte: Rev. chil. dermatol;31(1):67-67, 2015. ilus.
Idioma: es.
Descritores: Neoplasias Cutâneas/diagnóstico
Neoplasias Cutâneas/patologia
Papiloma/diagnóstico
Papiloma/patologia
-Neoplasias Cutâneas
Papiloma
Minociclina/uso terapêutico
Limites: Feminino
Seres Humanos
Adulto
Tipo de Publ: Relatos de Casos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-835947
Autor: Yarmuch G, Paula; Chaparro R, Ximena; Fischer S, Cecilia; Benveniste, Samuel; Kaplan Z, Viera.
Título: Papilomatosis confluente y reticulada de Gougerot y Carteaud / Confluent and reticulate papillomatosis (Gougerot-Carteaud syndrome)
Fonte: Rev. chil. dermatol;30(2):194-194, 2014. ilus.
Idioma: es.
Descritores: Neoplasias Cutâneas/patologia
Neoplasias Cutâneas/tratamento farmacológico
Papiloma/patologia
Papiloma/tratamento farmacológico
-Diagnóstico Diferencial
Minociclina/uso terapêutico
Papiloma/diagnóstico
Limites: Seres Humanos
Masculino
Adolescente
Tipo de Publ: Relatos de Casos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-834465
Autor: Sambrano, Gustavo Enck; Paim, Thiago Galvão da Silva; Silva, Lucas Toniolo da; d'Azevedo, Pedro Alves.
Título: In vitro antibacterial activity of tigecycIine against clinical isolates of linezolid-Intermediate and linezolid-resistant enterococci by time-kill assay
Fonte: Clin. biomed. res;34(3):281-286, 2014. tab, graf.
Idioma: en.
Resumo: Introduction: Enterococci have become the third leading cause of nosocomial bacteraemia, an infection which is significantly associated with the risk of developing infective endocarditis. Linezolid provides high rates of clinical cure and microbiologic success in complicated infections due to Enterococcus spp. However, several instances of emergence of resistance during linezolid treatment have been reported. The aim of this study was evaluate the activity of tigecycline against linezolidintermediate (LIE) and linezolid-resistant enterococcus faecalis(LRE) by the timekill assay. Methods: Five isolates of LRE and two isolates of LIE were used in this study. Minimum inhibitory concentration (MIC) was determined by broth dilution following the guidelines from the Clinical and Laboratory Standards Institute (CLSI). Time-kill assay was employed to access the in vitro response profile of tigecycline. Results: All seven isolates presented MIC of 0.125 ìg/mL. Tigecycline activity was individually evaluated according to CLSI criteria. This antibiotic showed bactericidal activity against three of the five isolates of LRE and bacteriostatic activity against the other isolates. Conclusions: Tigecycline presented both bacteriostatic and bactericidal activity against tested isolates, which is an important data that must be considered for new studies.
Descritores: Antibacterianos/farmacologia
Antibacterianos/metabolismo
Antibacterianos/química
Antibacterianos/síntese química
Enterococcus faecalis
Minociclina/análogos & derivados
Minociclina/farmacologia
-Meios de Cultura
Limites: Seres Humanos
Responsável: BR18.1 - Biblioteca FAMED/HCPA


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Texto completo SciELO Brasil
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Id: lil-769631
Autor: Niveditha, Nagasundaram; Sujatha, Sistla.
Título: Worrisome trends in rising minimum inhibitory concentration values of antibiotics against methicillin resistant Staphylococcus aureus - Insights from a tertiary care center, South India
Fonte: Braz. j. infect. dis;19(6):585-589, Nov.-Dec. 2015. tab, graf.
Idioma: en.
Resumo: ABSTRACT INTRODUCTION: Appearance of isolated reports of resistance to anti-methicillin-resistantStaphylococcus aureus (MRSA) drugs is worrisome underscoring the need to continuously monitor the susceptibility of clinical MRSA isolates to these drugs. Hence, the present study is conducted to determine the susceptibility of MRSA isolates to various classes of anti-MRSA drugs such as vancomycin (glycopeptide), daptomycin (lipopeptide), tigecycline (glycylcycline), and linezolid (oxazolidinone) to determine the MIC50 and MIC90 values, and to observe MIC creep over a three year period, if any, with respect to these drugs. METHODS: A total of 200 isolates of MRSA obtained from clinical specimens were included. MIC was determined by E-test for anti-MRSA antibiotics vancomycin, linezolid, daptomycin, and tigecycline. Non-parametric methods (Kruskal-Wallis and Chi-square test) were used to assess MIC trends over time. In addition, MIC50 and MIC90 values were also calculated. RESULTS: No isolate was found resistant to vancomycin, daptomycin, or linezolid; five isolates were resistant to tigecycline. Seven VISA isolates were encountered with the MIC value for vancomycin of 4 µg/mL. MIC values for vancomycin, tigecycline, linezolid showed a definite increase over a 3-year period which was statistically significant with p-values <0.0001, 0.0032, 0.0242, respectively. When the percentage of isolates with a median MIC value less than or equal to that of the index year was calculated, the change was most striking with vancomycin. The proportion of isolates with higher MIC values was greater in 2014 than 2012 and 2013. CONCLUSION: MIC creep was notably observed with vancomycin, and to some extent with tigecycline and linezolid. Selection pressure may result in creeping MICs, which may herald the emergence of resistant organisms.
Descritores: Antibacterianos/farmacologia
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
-Antibacterianos/administração & dosagem
Daptomicina/administração & dosagem
Daptomicina/farmacologia
Índia
LETHAL DOSE ACADEMIES AND INSTITUTES
Testes de Sensibilidade Microbiana
Meticilina/administração & dosagem
Meticilina/farmacologia
Minociclina/administração & dosagem
Minociclina/análogos & derivados
Minociclina/farmacologia
Centros de Atenção Terciária
Vancomicina/administração & dosagem
Vancomicina/farmacologia
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: lil-768615
Autor: Chiappe, Verónica B; Gómez, Mariel B; Rodriguez, Cristina; Fresolone, Marilina; Pecci, Adali; Romanelli, Hugo Jorge.
Título: Subgingivally applied minocycline microgranules in subjects with chronic periodontitis: a randomized clinical and microbiological trial / Microgránulos de minociclina subgingival en sujetos con periodontitis crónica. Estudio clínico y microbiológico aleatorizado
Fonte: Acta odontol. latinoam;28(2):122-131, 2015. ilus, tab.
Idioma: en.
Resumo: El objetivo de este estudio fue evaluar el efecto clínico y microbiológico de microgránulos de Minociclina, colocados subgingivalmente como coadyuvante del raspaje y alisado radicular en pacientes con Periodontitis crónica severa. Participaron 26 sujetos voluntarios con Periodontitis crónica, no fumadores. Se seleccionaron 4 sitios contralaterales con Sangrado al Sondaje (SS) y Profundidad al Sondaje (PS) > 6 mm. Condición Basal (CB): se registró, PS y Nivel de Inserción (NI). Se determinó mdiante PCR la presencia de Porphyromonas gingivalis (Pg), Tannerella forsythia (Tf), Treponema denticola (Td) y Aggregatibacter actinomycetemcomitans (Aa). Un lado de la boca fue aleatoriamente asignado al tratamiento experimental: grupo T, el otro al tratamiento control: grupo C. Al día 30 y 90 se repitieron los exámenes clínicos y microbiológicos. Día 30: el SS se redujo al 81 por ciento en el grupo C y al 12 por ciento en el grupo T (p<0,05). Estas diferencias se mantuvieron al día 90 (C: 58 por ciento, T: 8 por ciento) (p<0.05). Día 30 y 90: hubo disminución de la PS en ambos grupos, siendo significativamente mayor en el grupo T (p<0,05). En ambos grupos hubo disminución significativa del NI (p<0,05), no hubo diferencias entre los grupos al día 30 y sí al día 90. A los 30 y 90 días en ambos grupos se redujo la prevalencia para Pg, Tf ,Td y Aa. A los 30 y 90 días la reducción de sitios con Pg fue mayor en el grupo T (p=0,002). A los 90 días Td disminuyó en el grupo T y aumentó en el grupo C (p=0,023). No se observaron efectos adversos. Los resultados mostraron que la aplicación subgingival de microgránulos de minociclina adjunta al raspaje y alisado radicular produjo una reducción mayor del SS, la PS y el NI que el raspaje y alisado solo, aumentó la probabilidad de suprimir Pg y retardó la recolonización con Td.

The aim of this study was to evaluate clinical and microbiological effects of subgingival minocycline microgranules when used as an adjunct to scaling and root planing in subjects with Chronic periodontitis. Twenty-six non-smoker volunteers participated in the study. Four opposite sites, clinically standardized, with bleeding on probing (BOP) and pocket depth (PD) ≥ 6 mm were selected. Baseline BOP, PD and Clinical attachment level (CAL) were measured and microbiological samples were collected from the study sites and analyzed using PCR. Porphyromonas gingivalis (Pg) Tannerella forsythia (Tf), Treponema denticola (Td) and Aggregatibacter actinomycetemcomitans (Aa) were detected. One side of the mouth was randomly allocated to the experimental treatment: scaling and root planing plus minocycline microgranules (Test group=T) and the other side of the mouth toscaling and root planing alone (Control group=C). At days 30 and 90, clinical and microbiological examination was repeated. After 30 days BOP was reduced to 81% in C and to 12% in T and at day 90 to 58% in C and to 8% in T (p<0.05). PD wassignificantly reduced in both groups (C: 4.8mm, T: 4.2mm) favoring T at days 30 and 90 (p<0.05). CAL reduction at day 30 showed no difference between groups. At day 90, CAL reduction was higher in T (p<0.05). At days 30 and 90 Pg, Tf, Td and Aa was reduced in both groups. Pg reduction wassignificantly greater in group T. At day 90 frequency of sites with Td decreased in T and increased in C (p<0.05). No adverse effect was observed. This study showed that minocycline microgranules adjunct to scaling and root planing resulted in grater reduction of BOP and PD, higher CAL gain, increased probability of Pg suppression and retarded recolonization of Td than root instrumentation alone.
Descritores: Minociclina/uso terapêutico
Periodontite Crônica/microbiologia
Periodontite Crônica/tratamento farmacológico
Raspagem Dentária/métodos
-Administração Tópica
Análise de Variância
Argentina
Aggregatibacter actinomycetemcomitans/isolamento & purificação
Faculdades de Odontologia
Técnicas Microbiológicas
Porphyromonas gingivalis/isolamento & purificação
Reação em Cadeia da Polimerase/métodos
Análise Estatística
Treponema denticola/isolamento & purificação
Limites: Seres Humanos
Masculino
Feminino
Adulto
Tipo de Publ: Ensaio Clínico Controlado
Responsável: AR29.1 - Biblioteca


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Id: lil-757820
Autor: Silva, Rúbia Menêses; Rodrigues, Jorbênnia Mamede Carneiro; Belém, Nayara Moura; Nóbrega, Patrícia Vidal de Negreiros; Nascimento, Helena Aguiar Ribeiro do; Lins, Ruthinéia Diógenes Alves Uchôa; Gomes, Raquel Christina Barboza.
Título: Aplicabilidade clínica de antimicrobianos locais e sistêmicos no tratamento periodontal básico: uma abordagem conceitual / Clinical feasibility of local and systemic antimicrobial for initial periodontal treatment: a conceptual approach
Fonte: Clín. int. j. braz. dent;6(4):464-471, out.-dez.2010.
Idioma: pt.
Resumo: Este artigo apresenta uma revisão de literatura que aborda a ação dos antimicrobianos locais e sistêmicos como coadjuvantes ao tratamento mecânico básico (raspagem e alisamento radicular) das doenças periodontais. Além disso, engloba o correto conhecimento das drogas no tratamento dessas patologias, principalmente, nos casos agudos com envolvimento sistêmico, em pacientes com comprometimento do sistema imune e em periodontites agressivas, com ênfase em seus mecanismos de ação e aplicabilidade clínica...

This literature review addressed the action of local and systemic antibiotics as adjuncts to the basic mechanical (scaling and root planing) treatment of periodontal diseases. The correct knowledge of drugs for the treatment of such disorders, especially in acute cases with systemic involvement in patients with impaired immune systems and highly aggressive periodontitis is described, focusing on their mechanisms of action and its clinical applicability...
Descritores: Antibacterianos
Periodontite
Periodontite/terapia
-Clorexidina
Clindamicina
Doxiciclina
Metronidazol
Minociclina
Tetraciclina
Responsável: BR186.1 - Biblioteca Honório Monteiro


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Texto completo SciELO Venezuela
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Id: lil-740345
Autor: Mora, Marylú; Medina-Leendertz, Shirley J; Bonilla, Ernesto; Terán, Raikelin E; Paz, Milagros C; Arcaya, José Luis.
Título: Minocycline, but not ascorbic acid, increases motor activity and extends the life span of Drosophila melanogaster / La minociclina, pero no el ácido ascórbico, incrementa la actividad motora y extiende el período de vida de Drosophila melanogaster
Fonte: Invest. clín;54(2):161-170, jun. 2013. ilus.
Idioma: en.
Resumo: In the present study we compared the effects of minocycline and ascorbic acid in the life span, motor activity and lipid peroxidation of Drosophila melanogaster, in an effort to find a substance capable of providing protection against oxidative stress in aging. In the flies treated with minocycline a very significant increase in the life span (101 ± 1.33 days) was observed when compared to those treated with ascorbic acid and controls (42.3% and 38.4%, respectively). The motor activity of minocycline treated flies also increased significantly with respect to control and ascorbic acid fed flies, from the 3rd to the 9th week of treatment. With regard to lipid peroxidation, it was found that the levels of malondialdehyde (MDA) in flies treated with minocycline showed no statistical differences to the control on the first day of treatment, but a significantly lower content on the day of 50% survival. In contrast, in flies treated with ascorbic acid significantly elevated levels of MDA compared to control and minocycline treated flies were detected throughout. These results suggest a protective effect of minocycline against oxidative stress and aging in D. melanogaster. An inhibitory effect on reactive oxygen species production may be an important contributing factor.

En el presente estudio se compararon los efectos del ácido ascórbico y la minociclina en la duración del periodo de vida, la actividad motora y la peroxidación lipídica de Drosophila melanogaster en un esfuerzo por encontrar una sustancia capaz de proporcionar protección contra el estrés oxidativo en el envejecimiento. En las moscas tratadas con minociclina se observó un aumento significativo en la duración de la vida (101 ± 1,33 días) en comparación con los tratados con ácido ascórbico y los controles (42,3% y 38,4%, respectivamente). La actividad motora de las moscas tratadas con minociclina aumentó significativamente cuando se comparó con las tratadas con ácido ascórbico y el control, desde la 3ra hasta la 9na semana de tratamiento. Con respecto a la peroxidación lipídica, se encontró que los niveles de malondialdehído (MDA) en moscas tratadas con minociclina no mostraron diferencias estadísticas con relación al control en el primer día de tratamiento; sin embargo, se detecto una disminución significativa de la concentración de MDA cuando se alcanzó el 50% de sobrevida. En contraste, en moscas tratadas con ácido ascórbico observamos que los niveles de MDA estaban significativamente elevados, cuando se compararon con las moscas tratadas con minociclina y el control a lo largo de todo el tratamiento. Estos resultados sugieren un efecto protector de la minociclina frente al estrés oxidativo y el envejecimiento en D. melanogaster, aunque un efecto inhibidor sobre la producción de especies reactivas del oxígeno puede ser un factor contribuyente importante.
Descritores: Ácido Ascórbico/farmacologia
Drosophila melanogaster/efeitos dos fármacos
Longevidade/efeitos dos fármacos
Minociclina/farmacologia
Atividade Motora/efeitos dos fármacos
-Envelhecimento/efeitos dos fármacos
Drosophila melanogaster/fisiologia
Peroxidação de Lipídeos/efeitos dos fármacos
Malondialdeído/análise
Estresse Oxidativo/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
Limites: Animais
Masculino
Responsável: VE1.1 - Biblioteca Humberto Garcia Arocha


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Id: lil-724389
Autor: Parra, Viviana; Marabini, Noelia; Larralde, Margarita; Luna, Paula; Aguirre, Marta; Pafnik, Romina; Días Mathe, Alicia; Abeldaño, Alejandra; Eguillor, Clara; Martín, María Alejandra; Di Pietro, Yolanda.
Título: Papilomatosis reticulada y confuente de Gougerot-Carteaud: comunicación de 20 casos tratados con minociclina / Confluent and reticulated papillomatosis (Gougerot-Carteaud) report of 20 casis treated with minocycline
Fonte: Dermatol. argent;17(6):441-445, nov.-dic.2011. ilus, graf.
Idioma: es.
Resumo: La papilomatosis reticulada y confluente (PRC) es una rara dermatosis, de causa desconocida, que afecta principalmente a mujeres adolescentes. Objetivos. Definir las características clínicas e histopatológicas de la enfermedad, establecer los parámetros demográficos, evaluar la respuesta terapéutica a la minociclina y la incidencia de recidivas,y determinar la agregación familiar.Métodos. Se realizó un estudio retrospectivo, observacional, de 20 pacientes con diagnóstico confirmado histológicamente de PRC en siete centros dermatológicos. Se evaluó edad, sexo, sintomatología, localización, tratamiento, recurrencia y agregación familiar. Resultados. La edad promedio de aparición de las lesiones fue de 19,3 años, 3 pacientes (15%) fueron varones y 17 (85%) mujeres. La localización más frecuente fue el tórax. El principal motivo de consulta fue estético. Se realizó tratamiento con minociclina en todos los pacientes, con un alto porcentaje de recidiva. Cinco pacientes recibieron tratamiento post recidiva con buena evolución. La incidencia familiar se observó en el 25% de los pacientes (dos familias).Conclusiones. La PRC es una patología poco frecuente, de curso indolente, que predomina en el sexo femenino. Afecta principalmente a adultos jóvenes en la zona anterior del tórax. Generalmente es asintomática y presenta buena respuesta al tratamiento con minociclina y eventual recidiva. Destacamos la alta incidencia familiar en nuestros casos en relación con la literatura.

Confluent and reticulate papillomatosis (CRP) is a rare skin disorder, with an unknown cause thatinvolves mainly teenage women.Objetive:Define clinical and pathological features, demographic parameters, therapeuticresponse to minocycline and recurrence incidence, and to determine the familial aggregation. Methods: We performed a retrospective, observational study of 20 patients on whom CRPwas diagnosed and histologically confirmed. The study involved seven Dermatology centres.The following parameters: age, sex, symptoms, location, treatment, recurrence and familialaggregation were evaluated Results:The average age of onset was 19.3 years; three patients (15%) were male and 17(85%) women. The most common location was the chest. The main reason for consultation wascosmetic. Minocycline was administered to all patients with a high recurrence rate. Five patientswere treated post-recurrence with a positive result. The familial incidence was observed in 25%of patients (two families). Conclusions: CRP is an uncommon pathology, with an indolent course, prevalent in females. It mainly affects young adults in the anterior chest. It is usually asymptomatic, with a good responseto minocycline and eventual recurrence. We emphasize a higher familial incidence in our series incomparison to published data.
Descritores: Papiloma/patologia
Papiloma/tratamento farmacológico
-Antibacterianos/uso terapêutico
Minociclina/uso terapêutico
Neoplasias Cutâneas/patologia
Neoplasias Cutâneas/tratamento farmacológico
Limites: Feminino
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco



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