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Almeida, F. R. C
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Id: lil-623938
Autor: Rao, V. S. N; Almeida, F. R. C; Moraes, A. P; Silva, J. V; Nascimento, S. C; Moraes, M. O.
Título: Evaluation of the purified fraction of Wilbrandia (c. f. ) verticillata for antitumour activity
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):43-45, 1991. tab.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: Cucurbatacins are known to produce cytotoxic and anticancer activities. Two novel norcucurbitacin glucosides (Wvl and Wv2) have recently been isolated from a purified fraction obtained from the rhizome of Wilbrandia verticillata. The present study evaluates the cytotoxic and anti-tumour activities of the norcucurbitacins. We have found a regular cytotoxicity in KB cells (Cy50 = 12µg/ml) as well as a significant inhibition in the Walker 256 carcinosarcoma growth (approximately 75%).
Descritores: Triterpenos/isolamento & purificação
Triterpenos/uso terapêutico
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/uso terapêutico
-Brasil
Ensaios de Seleção de Medicamentos Antitumorais
Células KB
Carcinoma 256 de Walker
Fitoterapia
Limites: Seres Humanos
Animais
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1007935
Autor: Estrella-Parra, Edgar; Flores-Cruz, María; Blancas-Flores, Gerardo; Koch, Stephen D; Alarcón-Aguilar, Francisco J.
Título: The Tillandsia genus: history, uses, chemistry, and biological activity / El género Tillandsia: historia, usos, química y actividad biológica
Fonte: Bol. latinoam. Caribe plantas med. aromát;18(3):239-264, mayo 2019. tab, ilus.
Idioma: en.
Projeto: PRODEP-SEP; . UAM.
Resumo: Tillandsia L. genus comprises 649 species, with different uses at different times. T. usneoides L. uses are reported since the late- archaic and pre-Columbian cultures. In XIX-XX centuries, T. usneoides was used in some manufactured products, as polish and packing fruit. Tillandsia has a favorable reputation as medicine: for leucorrhea, rheumatism, ulcers, hemorrhoid treatment, as an anti-diabetic remedy, emetic, analgesic, purgative, contraceptive, antispasmodic and diuretic. Tillandsia chemical composition includes cycloartane triterpenes and hydroxy-flavonoids, which are present in at least 24 species. Several extracts and compounds from Tillandsia spp. have been reported with pharmacological actions, as anti-neoplasia, hypolipidemic, antifungal, anti-HSV-1, hypoglycemic and microbicide. This review communicates the economic importance, ethnobotany, chemistry composition and biological activities of the Tillandsia genus, and analyze its biological and economic perspective. Tillandsia genus has cultural, economic and pharmacological relevance, with a high potential in many essential aspects of the modern society.

El género Tillandsia L. comprende 649 especies, con diferentes usos en diferentes épocas. T. usneoides L. se han reportado desde el arcáico tardío hasta las culturas precolombinas. En los siglos XIX-XX, T. usneoides se usó en productos manufacturados: como abrasivo y embalaje de fruta. Como medicina tradicional, el género Tillandsia se reporta para leucorrea, reumatismo, úlceras, hemorroides, remedio antidiabético, emético, analgésico, purgante, anticonceptivo, antiespasmódico y diurético. Su composición química incluye triterpenos de tipo ciclo-artano e hidroxi-flavonoides, presentes en al menos 24 especies. Los extractos y compuestos del género Tillandsia se han reportado con propiedades antineoplásicas, hipolipidémicas, antifúngicas, anti-HSV-1, hipoglucemiantes y microbicidas. Esta revisión comunica la importancia económica, etnobotánica, composición química y las actividades biológicas del género Tillandsia, y analiza su perspectiva biológica y potencial económica. Tillandsia tiene importancia cultural, económica y farmacológica, con gran potencial en muchos aspectos esenciales de la sociedad moderna.
Descritores: Plantas Medicinais/química
Extratos Vegetais/química
Etnobotânica
Tillandsia/química
-Triterpenos/análise
Extratos Vegetais/farmacologia
Bromeliaceae/química
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-951943
Autor: Birgani, Golshan Arzani; Ahangarpour, Akram; Khorsandi, Layasadat; Moghaddam, Hadi Fathi.
Título: Anti-diabetic effect of betulinic acid on streptozotocin-nicotinamide induced diabetic male mouse model
Fonte: Braz. J. Pharm. Sci. (Online);54(2):e17171, 2018. tab, graf.
Idioma: en.
Projeto: Physiology Research Center of Ahvaz Jundishapur Medical Sciences University.
Resumo: ABSTRACT Diabetes is a metabolic disease caused by abnormal insulin secretion or action. In the present study, the effects of betulinic acid (BA, a triterpene) are evaluated on glucose, α-amylase and plasma insulin levels, insulin resistance and the histopathology of pancreatic islets in streptozotocin-nicotinamide (STZ-NA) diabetic mice. Seventy adult male NMRI mice were randomly divided into seven groups: control, sham, diabetic, diabetic treated with BA (10, 20 and 40 mg/kg) and diabetic treated with metformin (200 mg/kg). Diabetes was induced in mice by intraperitoneal injection of streptozotocin 50 mg/kg after a dose of nicotinamide 120 mg/kg. Two weeks after treatment with BA, blood samples were collected for measuring glucose, α-amylase and insulin levels, and the pancreas was isolated for histopathology evaluation. Diabetes reduced the number and diameter of pancreatic islets, and increased α-amylase and insulin resistance. BA treatment reduced blood glucose, α-amylase and improved insulin sensitivity as well as pancreas histopathology. In addition, BA showed stronger effects on the pancreatic histology and insulin resistance compared to the metformin group
Descritores: Estreptozocina
Niacinamida
Diabetes Mellitus Experimental/prevenção & controle
-Triterpenos/classificação
Diabetes Mellitus/induzido quimicamente
Hipoglicemiantes/efeitos adversos
Limites: Animais
Masculino
Camundongos
Responsável: BR1.1 - BIREME


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Carvalho, Joäo Ernesto de
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Id: biblio-889402
Autor: Silva, Aline Teixeira Maciel e; Magalhães, Cássia Gonçalves; Duarte, Lucienir Pains; Mussel, Wagner da Nova; Ruiz, Ana Lucia Tasca Gois; Shiozawa, Larissa; Carvalho, João Ernesto de; Trindade, Izabel Cristina; Vieira Filho, Sidney Augusto.
Título: Lupeol and its esters: NMR, powder XRD data and in vitro evaluation of cancer cell growth
Fonte: Braz. J. Pharm. Sci. (Online);53(3):e00251, 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT The triterpene lupeol (1) and some of its esters are secondary metabolites produced by species of Celastraceae family, which have being associated with cytotoxic activity. We report herein the isolation of 1, the semi-synthesis of eight lupeol esters and the evaluation of their in vitro activity against nine strains of cancer cells. The reaction of carboxylic acids with 1 and DIC/DMAP was used to obtain lupeol stearate (2), lupeol palmitate (3) lupeol miristate (4), and the new esters lupeol laurate (5), lupeol caprate (6), lupeol caprilate (7), lupeol caproate (8) and lupeol 3',4'-dimethoxybenzoate (9), with high yields. Compounds 1-9 were identified using FT-IR, 1H, 13C-NMR, CHN analysis and XRD data and were tested in vitro for proliferation of human cancer cell activity. In these assays, lupeol was inactive (GI50> 250µg/mL) while lupeol esters 2 -4 and 7 - 9 showed a cytostatic effect. The XRD method was a suitable tool to determine the structure of lupeol and its esters in solid state. Compound 3 showed a selective growth inhibition effect on erythromyeloblastoid leukemia (K-562) cells in a concentration-dependent way. Lupeol esters 4 and 9 showed a selective cytostatic effect with low GI50 values representing promising prototypes for the development of new anticancer drugs.
Descritores: Triterpenos/análise
Celastraceae/classificação
-Produtos Biológicos
Quimioprevenção/estatística & dados numéricos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-1008172
Autor: Bashir, Samra.
Título: Pharmacological importance of Manilkara zapota and its bioactive constituents / Importancia farmacologica de Manilkara zapota y sus constituyentes bioactivos
Fonte: Bol. latinoam. Caribe plantas med. aromát;18(4):347-358, jul. 2019. ilus.
Idioma: en.
Resumo: Manilkara zapota (Sapotaceae), commonly known as Sapodilla, is widely known for its delicious fruit. Various parts of this plant are also used in folk medicine to treat a number of conditions including fever, pain, diarrhoea, dysentery, haemorrhage and ulcers. Scientific studies have demonstrated analgesic, anti-inflammatory, antioxidant, cytotoxic, antimicrobial, antidiarrheal, anti-hypercholesteremic, antihyperglycemic and hepatoprotective activities in several parts of the plant. Phytochemical studies have revealed the presence of phenolic compounds including protocatechuic acid quercitrin, myricitrin, catechin, gallic acid, vanillic acid, caffeic acid, syringic acid, coumaric acid, ferulic acid, etc. as main constituents of the plant. Several fatty acids, carotenoids, triterpenes, sterols, hydrocarbons and phenylethanoid compounds have also been isolated from M. zapota. The present review is a comprehensive description focused on pharmacological activities and phytochemical constituents of M. zapota.

Manilkara zapota (Sapotaceae), comúnmente conocida como Sapodilla, es ampliamente conocida por su delicioso fruto. Variadas partes de esta planta se usan en medicina popular para tratar una serie de afecciones, como fiebre, dolor, diarrea, disentería, hemorragia y úlceras. Estudios científicos han demostrado actividad analgésica, antiinflamatoria, antioxidante, citotóxica, antimicrobiana, antidiarreica, antihipercolesterolémica, antihiperglucémica y hepatoprotectora en diferentes partes de la planta. Los estudios fitoquímicos han revelado la presencia de compuestos fenólicos que incluyen ácido protocatechúico, quercitrina, miricitrina, catequina, ácido galico, ácido vanílico, ácido cafeico, ácido sirínico, ácido cumárico, ácido fúnico y ácido ferúlico como componentes principales de la planta. Varios ácidos grasos, carotenoides, triterpenos, esteroles, hidrocarburos y compuestos feniletanoides también han sido aislados de M. zapota. La presente revisión es una descripción exhaustiva centrada en las actividades farmacológicas y los constituyentes fitoquímicos de M. zapota.
Descritores: Extratos Vegetais/farmacologia
Manilkara/química
-Fenóis/isolamento & purificação
Fenóis/farmacologia
Saponinas/isolamento & purificação
Saponinas/farmacologia
Esteróis/isolamento & purificação
Esteróis/farmacologia
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
Carotenoides/isolamento & purificação
Carotenoides/farmacologia
Sapotaceae/química
Compostos Fenólicos/análise
Medicina Tradicional
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-971914
Autor: Carvalho, Karine Maria Martins Bezerra.
Título: A resina de protium heptaphyllum e seu principal constituinte, a mistura de triterpenosalfa e beta-amirina, previnem a obesidade induzida por dieta em camundongos: evidências e potenciais mecanismos.
Fonte: Fortaleza; s.n; 2016. 122 p. ilus, tab.
Idioma: pt.
Tese: Apresentada a Universidade Federal do Ceará para obtenção do grau de Doutor.
Resumo: A obesidade, que se caracterizada pelo acúmulo excessivo de gordura corporal decorrente principalmente do aumento do consumo de alimentos calóricos e do sedentarismo, está associada a várias condições patológicas como doenças cardiovasculares, diabetes,desordens musculoesqueléticas e câncer. As opções farmacológicas para o tratamento da obesidade são limitadas e apresentam diversos efeitos colaterais. No Brasil apenas dois fármacos estão disponíveis, sibutramina e orlistate. Na busca de novas opções terapêuticas para o tratamento da obesidade, as plantas medicinais têm sido uma importante fonte de pesquisa, em especial os compostos terpênicos, conhecidos reguladores da glicemia e do metabolismo lipídico. O presente estudo investigou o efeito anti-obesidade da resina do Protium heptaphyllum (RPH) e de seu principal constituinte, a mistura de triterpenos alfa ebeta-amirina (AMI), na obesidade induzida por dieta hipercalórica em camundongos e seus possíveis mecanismos de ação. Foram utilizados camundongos Swiss, albinos, machos,pesando entre 20-25g, que após uma semana de livre acesso a ração padrão (Purina®,Brasil) foram divididos em 7 grupos de 10 animais e tratados com dieta padrão (DP), dieta hipercalórica (DH), DH+RPH 10mg/kg, DH+RPH 20mg/kg, DH+AMI 10mg/kg, DH+AMI 20mg/kg ou DH+sibutramina 10mg/kg (SIB) por 15 semanas. RPH e AMI foram inicialmente diluídas em 2% Tween 80 em água...

Obesity which is characterized by excessive accumulation of body fat mainly due to theincreased consumption of high-calorie foods and sedentary lifestyle is associated withvarious pathological conditions such as cardiovascular disease, diabetes, musculoskeletaldisorders and cancer. Pharmacologic options for the treatment of obesity are limited andhave many side effects. In Brazil only two drugs are available, sibutramine and orlistat. In thesearch for new therapeutic options for the treatment of obesity, medicinal plants have beenan important source of research, particularly the terpene compounds, known regulators ofblood glucose and lipid metabolism. This study investigated the antiobesity effect of Protiumheptaphyllum resin (RPH) and its main constituent, the mixture of triterpenes alpha and betaamyrin(AMY), in obesity induced by high calorie diet in mice and its possible mechanisms ofaction. Swiss albino male mice were used, weighing between 20-25g, which after a week offree access to standard chow (Purina®, Brazil) were divided into 7 groups of 10 animals eachand treated with standard diet (SD), high-fat diet (HFD), HFD+RPH 10mg/kg, HFD+RPH20mg/kg, HFD+AMY 10mg/kg, HFD+AMY 20 mg/kg or HFD+sibutramine 10mg/kg (SIB) for15 weeks. RPH and AMY were initially diluted in 2% Tween 80 in water...
Descritores: Triterpenos
Obesidade
Dieta
Limites: Seres Humanos
Responsável: BR6.1 - BCS - Biblioteca de Ciências da Saúde
BR6.1


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Id: biblio-907545
Autor: Arancibia-Radich, Jorge; Peña-Cerda, Marcelo; Jara, Daniela; Valenzuela-Bustamante, Paula; Goity, León; Valenzuela-Barra, Gabriela; Silva, Ximena; Garrido, Gabino; Delporte, Carla; Seguel, Ivette.
Título: Comparative study of anti-inflammatory activity and qualitative-quantitative composition of triterpenoids from ten genotypes of Ugni molinae / Estudio comparativo de la actividad antiinflamatoria y composición química cualitativa y cuantitativa de triterpenoides de diez genotipos de Ugni molinae
Fonte: Bol. latinoam. Caribe plantas med. aromát;15(5):274-287, Sept. 2016. ilus, tab.
Idioma: en.
Projeto: CONICYT; . FONDECYT.
Resumo: The aim of this study was to assess the differences in qualitative-quantitative composition of triterpenoids and total phenolic contents, together with anti-inflammatory activity of Ugni molinae leaves obtained from ten genotypes. The ethyl acetate (EAE) and ethanol extracts (ETE) were obtained and analyzed. The plant genotypes were grown under same soil and climate conditions and under same agronomic management; the leaves were also harvested under the same conditions. Anti-inflammatory activity was evaluated by mice ear edema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) at a single dose of 200 mg/kg BW of each extract. Composition of triterpenoids and total phenolic contents was determined by HPLC-DAD and Folin-Ciocalteu method, respectively. Ugni molinae leaves of different plant genotypes exhibited significant differences in regard to their anti-inflammatory activity, as well as in qualitative-quantitative composition of triterpenoids and total phenolic content.

El objetivo de este estudio fue establecer las diferencias en la composición cualitativa y cuantitativa de triterpenoides y en los contenidos totales de fenoles, junto con la actividad antiinflamatoria de las hojas de Ugni molinae provenientes de diez genotipos. Los extractos de acetato de etilo (EAE) y etanólicos (ETE) fueron obtenidos y analizados. Los genotipos fueron cultivados bajo las mismas condiciones edafo-climáticas y con el mismo manejo agronómico; las hojas fueron cosechadas bajo las mismas condiciones. La actividad antiinflamatoria fue evaluada en ratones a los que se les indujo un edema en la oreja mediante la aplicación del 12-O-tetradecanoilforbol-13 acetato (TPA) y los extractos fueron evaluados a una dosis única de 200 mg/kg de peso corporal. La composición en triterpenoides y los contenidos de fenoles totales fueron determinados por CLAE-DAD y por el método de Folin-Ciocalteu, respectivamente. Las hojas provenientes de los diferentes genotipos de U. molinae, exhibieron significativas diferencias en sus actividades antiinflamatorias, así como, en el contenido cualitativo y cuantitativo de triterpenoides y en el contenido de fenoles totales.
Descritores: Anti-Inflamatórios/química
Anti-Inflamatórios/uso terapêutico
Edema/tratamento farmacológico
Myrtaceae/química
Extratos Vegetais/química
Triterpenos/análise
-Cromatografia Líquida de Alta Pressão/métodos
Extratos Vegetais/uso terapêutico
Limites: Animais
Camundongos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-907538
Autor: Alarcon, Julio; Cespedes, Carlos L.
Título: Triterpenes and Beta-agarofurane sesquiterpenes from tissue culture ofMaytenus boaria / Triterpenos y Beta-agarofuranos sesquiterpenos desde cultivo de tejidos de Maytenus boaria
Fonte: Bol. latinoam. Caribe plantas med. aromát;15(4):206-214, jul. 2016. tab, ilus, graf.
Idioma: en.
Projeto: Comisión Nacional de Investigación Científica y Tecnológica de Chile. FONDECYT.
Resumo: Leaf explants of Maytenus boaria were induced towards callus tissue culture with different mixture of cytokinins and auxins. MeOH extract of callus was partitioned with AcOEt and water, and through repeated chromatography procedures were isolated and identified, four triterpenes and three beta-agarofuran sesquiterpenes.

Explantes de hojas de Maytenus boaria fueron inducidos a formar callos mediante diferentes mezclas de citoquininas y auxinas. Un extracto metanólico de los callos fue fraccionado con AcOEt y agua, y mediante repetidas cromatografías fueron aislados e identificados siete compuestos, cuatro triterpenos y 3 sesquiterpenos del tipo agarofurano.
Descritores: Maytenus/química
Extratos Vegetais/química
Folhas de Planta/química
Sesquiterpenos/análise
Triterpenos/análise
-Sesquiterpenos/isolamento & purificação
Triterpenos/isolamento & purificação
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-907502
Autor: Salazar, J Rodrigo; Torres, Patrício; Serrato, Blanca; Dominguez, Mariana; Alarcón, Julio; Céspedes, Carlos L.
Título: Insect Growth Regulator (IGR) effects of Eucalyptus citriodora Hook (Myrtaceae) / Efectos tóxicos e IGR de Eucalyptus citriodora Hook (Myrtaceae)
Fonte: Bol. latinoam. Caribe plantas med. aromát;14(5):403-422, Sept. 2015. ilus, tab.
Idioma: en.
Projeto: DGAPA-UNAM.
Resumo: In addition to eucalyptin the methanol extract from leaves of Eucalyptus citriodora (Myrtaceae) afforded the known compounds apigenin, chrysin, luteolin, naringenin, quercetin; together with betulinic acid, oleanolic, ursolic acid, and two remaining complex mixtures of unidentified flavonoids and triterpenes. These compounds together with triterpenes mixtures, hexane and ethyl acetate extracts showed antifeedant, insecticidal and insect growth regulatory activities against fall armyworm [Spodoptera frugiperda JE Smith (Lepidoptera: Noctuidae)] an important pest of corn, and yellow mealworm [Tenebrio molitor (Coleoptera:Tenebrionidae)] a pest of stored grains. The most active compounds were chrysin, eucalyptin, quercetin, luteolin, and betulinic and oleanolic acids and the mixtures of flavonoids and triterpenes (M1 and M2). These compounds and mixtures had IGR activity between 0.2 to 5.0 ug/mL and insecticidal effects between 5.0 and 10.0 μg/mL.The extracts were insecticidal to larvae, with lethal doses between 20-100 ug/mL. These compounds appear to have selective effects on the pre-emergence metabolism of the Lepidoptera, since in all treatments of the larvae of S. frugiperda the pupation was shortened and this process showed precociousness in relation to control. Thus, these substances may be useful as potential natural insecticidal agents.

Extracto metanolico de hojas de Eucalyptus citriodora (Myrtaceae) proporcionó además de eucalyptin, flavonoides tales como apigenina, crisina, luteolina, naringenina, quercetina; los triterpenos, ácido oleanólico, ácido ursólico betulínico, y dos mezclas complejas de flavonoides y triterpenos no identificados M1 y M2. Los flavonoides, triterpenos y mezclas de triterpenos, extractos de acetato de etilo y hexano mostraron efectos antialimentarios, insecticida y actividad reguladora de crecimiento (IGR) frente al gusano cogollero [Spodoptera frugiperda JE Smith (Lepidoptera: Noctuidae)], una plaga importante del maíz y frente al gusano de la harina [Tenebrio molitor (Coleoptera: Tenebrionidae)], una plaga de los granos almacenados. Los compuestos más activos fueron crisina, eucalyptin, quercetina, luteolina, ácido betulínico y ácido oleanólico y las mezclas de flavonoides y triterpenos (M1 y M2). Estos compuestos y mezclas mostraron actividad IGR entre 0,2 y 5,0 ug/mL y efectos insecticidas entre 5,0 y 10,0 μg/mL. Los extractos mostraron carácter insecticida para las larvas a dosis letales entre 20-100 ug/mL. Estas muestras parecen tener efectos selectivos sobre el metabolismo de pre-emergencia de los lepidópteros, ya que en todos los tratamientos de las larvas de S. frugiperda el tiempo de la pupación se acortó; este proceso muestra precocidad en relación con el control, las substancias ensayadas en este trabajo pueden ser útiles como potenciales agentes insecticidas naturales.
Descritores: Coleópteros
Eucalyptus/química
Inseticidas/farmacologia
Extratos Vegetais/farmacologia
Spodoptera
-Coleópteros/crescimento & desenvolvimento
Flavonoides/farmacologia
Metanol
Myrtaceae/química
Spodoptera/crescimento & desenvolvimento
Triterpenos/farmacologia
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-907483
Autor: Hossain, Mohammad J; Sikder, Md. A.A; Kaisar, Mohammad A; Haque, Mohammad R; Chowdhury, Abu A; Rashid, Mohammad A.
Título: Phytochemical and biological investigations of methanol extract of leaves of ziziphus mauritiana lam / Investigaciones fitoquímicas y biológicas de extractos metanólicos de hojas de ziziphus mauritiana lam
Fonte: Bol. latinoam. Caribe plantas med. aromát;14(3):179-189, mayo 2015. tab, ilus.
Idioma: en.
Resumo: Seven compounds were isolated from the methanol extract of leaves of Ziziphus mauritiana. The structures of the isolated compounds were elucidated as y-fagarine (1), beta-sitosterol (2), stigmasterol (3), alfa-amyrin (4), lupeol (5), beta-amyrin (6) and betulin (7) by extensive spectroscopic studies and by co-TLC with authentic samples. This is the first report of isolation of compounds 1-7 from this plant species. The extractives from leaves were investigated for thrombolytic, membrane stabilizing, antimicrobial, antidiarrheal and analgesic potentials along with sleep inducing property on animal model. The thrombolytic and membrane stabilizing activities were assessed by using human erythrocyte comparing with standard streptokinase and acetylsalicylic acid, respectively. The methanolic extract reduced frequency of diarrheal faeces when compared to the standard loperamide. In castor oil induced diarrhea in mice a dose dependent decrease of gastrointestinal transits were observed. In radiant heat tail-flick method the methanol extract showed moderate antinociceptive activity, compared to standard morphine.

Siete compuestos fueron aislados del extracto metanólico de hojas de Ziziphus mauritiana. Las estructuras de los compuestos aislados fueron identificadas como y-fagarina (1), beta-sitosterol (2), estigmasterol (3), alfa-amirina (4), lupeol (5), beta-amirina (6) y betulina (7 ) por medio de extensivos estudios espectroscópicos y por co-TLC con muestras auténticas. Este es el primer informe de aislamiento de los compuestos 1-7 a partir de esta especie vegetal. Los extractos de las hojas fueron investigados por efectos trombolíticos, estabilizadores de membrana, antimicrobianos, antidiarreicos y potenciales analgésicos junto a la propiedad de inducir sueño en el modelo animal. Las actividades trombolíticos y la estabilización de la membrana se evaluaron mediante el uso de eritrocitos humanos comparando con estreptoquinasa estándar y el ácido acetilsalicílico, respectivamente. El extracto metanólico redujo la frecuencia de las heces diarreicas en comparación con el estándar de loperamida. En la inducción por aceite de ricino de diarrea en ratones, se observó una disminución dosis dependiente de los tránsitos gastrointestinales. En el método del coletazo producido por calor radiante, el extracto metabólico mostró una actividad antinociceptiva moderada, en comparación con la morfina estándar.
Descritores: Anti-Infecciosos/farmacologia
Antidiarreicos/farmacologia
Folhas de Planta/química
Triterpenos/farmacologia
Ziziphus/química
-Fibrinolíticos/farmacologia
Metanol
Triterpenos/isolamento & purificação
Limites: Animais
Camundongos
Ratos
Responsável: CL1.1 - Biblioteca Central



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