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Pesquisa : D02.455.849.919 [Categoria DeCS]
Referências encontradas : 60 [refinar]
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Id: biblio-1153529
Autor: Chen, Dayin; Chen, Tingyu; Guo, Yingxue; Wang, Chennan; Dong, Longxin; Lu, Chunfeng.
Título: Suppressive effect of platycodin D on bladder cancer through microRNA-129-5p-mediated PABPC1/PI3K/AKT axis inactivation
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;54(3):10222-0, 2021. tab, graf.
Idioma: en.
Resumo: Platycodin D (PD) is a major constituent of Platycodon grandiflorum and has multiple functions in disease control. This study focused on the function of PD in bladder cancer cell behaviors and the molecules involved. First, we administered PD to the bladder cancer cell lines T24 and 5637 and the human uroepithelial cell line SV-HUC-1. Cell viability and growth were evaluated using MTT, EdU, and colony formation assays, and cell apoptosis was determined using Hoechst 33342 staining and flow cytometry. The microRNAs (miRNAs) showing differential expression in cells before and after PD treatment were screened. Moreover, we altered the expression of miR-129-5p and PABPC1 to identify their functions in bladder cancer progression. We found that PD specifically inhibited the proliferation and promoted the apoptosis of bladder cancer cells; miR-129-5p was found to be partially responsible for the cancer-inhibiting properties of PD. PABPC1, a direct target of miR-129-5p, was abundantly expressed in T24 and 5637 cell lines and promoted cell proliferation and suppressed cell apoptosis. In addition, PABPC1 promoted the phosphorylation of PI3K and AKT in bladder cancer cells. Altogether, PD had a concentration-dependent suppressive effect on bladder cancer cell growth and was involved in the upregulation of miR-129-5p and the subsequent inhibition of PABPC1 and inactivation of PI3K/AKT signaling.
Descritores: Neoplasias da Bexiga Urinária/genética
Neoplasias da Bexiga Urinária/tratamento farmacológico
-Saponinas
Triterpenos
Regulação Neoplásica da Expressão Gênica
Apoptose
Fosfatidilinositol 3-Quinases/metabolismo
MicroRNAs
Linhagem Celular Tumoral
Proliferação de Células
Proteínas Proto-Oncogênicas c-akt/metabolismo
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-1001608
Autor: Zhang, Liqiong; Deng, Shaolin.
Título: Effects of astragaloside IV on inflammation and immunity in rats with experimental periodontitis
Fonte: Braz. oral res. (Online);33:e032, 2019. tab, graf.
Idioma: en.
Resumo: Abstract: This study aimed to investigate the effects of astragaloside IV (AsIV) on inflammation and immunity in rats with experimental periodontitis. Periodontitis was established in 48 Wistar rats, which were then randomly divided into model and 10, 20 and 40 mg/kg AsIV groups, with 12 rats in each group. The latter 3 groups were treated with AsIV at doses of 10, 20 and 40 mg/kg, respectively. The control group (12 rats, without periodontitis) and model group were given the same amount of 5% sodium carboxymethyl cellulose. The treatment was performed once per day for 8 weeks. Before and after treatment, the tooth mobility scores of the rats were determined. After treatment, the salivary occult blood index (SOBI), plaque index (PLI), peripheral blood T lymphocyte subsets, and serum inflammatory factor and immunoglobulin levels were determined. The results showed that, after treatment, compared with that in model group, in 40 mg/kg AsIV group, the general state of rats was improved, while the tooth mobility score, SOBI and PLI were significantly decreased (p < 0.05); the peripheral blood CD4+ T cell percentage and CD4+/CD8+ ratio were significantly increased (p < 0.05), while the CD8+ T cell percentage was significantly decreased (p < 0.05); the serum tumor necrosis factor-α, interleukin-1β and interleukin-2 levels were significantly decreased (p < 0.05); the serum immunoglobulin A and immunoglobulin G levels were significantly decreased (p < 0.05). In conclusion, AsIV can alleviate inflammation and enhance immunity in rats with experimental periodontitis.
Descritores: Periodontite/tratamento farmacológico
Saponinas/farmacologia
Triterpenos/farmacologia
Sistema Imunitário/efeitos dos fármacos
-Periodontite/imunologia
Periodontite/patologia
Valores de Referência
Mobilidade Dentária
Imunoglobulinas/sangue
Distribuição Aleatória
Reprodutibilidade dos Testes
Subpopulações de Linfócitos T
Interleucina-2/sangue
Fator de Necrose Tumoral alfa/sangue
Resultado do Tratamento
Ratos Wistar
Interleucina-1beta/sangue
Limites: Animais
Masculino
Feminino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-1047976
Autor: Yang, Xiulian; Ding, Wenjie; Yue, Yuanzheng; Xu, Chen; Wang, Xi; Wang, Lianggui.
Título: Cloning and expression analysis of three critical triterpenoid pathway genes in Osmanthus fragrans
Fonte: Electron. j. biotechnol;36:1-8, nov. 2018. ilus, graf.
Idioma: en.
Projeto: Application Demonstration of the Key Technology and Innovation in Breeding the Six Precious Colored Tree Species of Jiangsu Province; . Academic Programs Project of Jiangsu Higher Education Institutions.
Resumo: Background: Osmanthus fragrans is an important ornamental tree and has been widely planted in China because of its pleasant aroma, which is mainly due to terpenes. The monoterpenoid and sesquiterpenoid metabolic pathways of sweet osmanthus have been well studied. However, these studies were mainly focused on volatile small molecule compounds. The molecular regulation mechanism of synthesis of large molecule compounds (triterpenoids) remains unclear. Squalene synthase (SQS), squalene epoxidase (SQE), and beta-amyrin synthase (BETA-AS) are three critical enzymes of the triterpenoid biosynthesis pathway. Results: In this study, the full-length cDNA and gDNA sequences of OfSQS, OfSQE, and OfBETA-AS were isolated from sweet osmanthus. Phylogenetic analysis suggested that OfSQS and OfSQE had the closest relationship with Sesamum indicum, and OfBETA-AS sequence shared the highest similarity of 99% with that of Olea europaea. The qRT-PCR analysis revealed that the three genes were highly expressed in flowers, especially OfSQE and OfBETA-AS, which were predominantly expressed in the flowers of both "Boye" and "Rixiang" cultivars, suggesting that they might play important roles in the accumulation of triterpenoids in flowers of O. fragrans. Furthermore, the expression of OfBETA-AS in the two cultivars was significantly different during all the five flowering stages; this suggested that OfBETA-AS may be the critical gene for the differences in the accumulation of triterpenoids. Conclusion: The evidence indicates that OfBETA-AS could be the key gene in the triterpenoid synthesis pathway, and it could also be used as a critical gene resource in the synthesis of essential oils by using bioengineered bacteria.
Descritores: Triterpenos/metabolismo
Clonagem Molecular
Oleaceae/genética
-Farnesil-Difosfato Farnesiltransferase/metabolismo
Óleos Voláteis
Expressão Gênica
Reação em Cadeia da Polimerase
Oleaceae/enzimologia
Esqualeno Mono-Oxigenase/metabolismo
Odorantes
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1132190
Autor: Mendoza, Dary; Arias, Juan Pablo; Cuaspud, Olmedo; Arias, Mario.
Título: Phytochemical Screening of Callus and Cell Suspensions Cultures of Thevetia peruviana
Fonte: Braz. arch. biol. technol;63:e20180735, 2020. tab, graf.
Idioma: en.
Projeto: Patrimonio Autónomo Fondo Nacional de Financiamiento para la Ciencia, la Tecnología y la Innovación Francisco José de Caldas - Departamento Administrativo de Ciencia, Tecnología e Innovación de Colombia.
Resumo: Abstract Thevetia peruviana is an ornamental shrub grown-up in many tropical region of the world. This plant produces secondary metabolites with biological properties of interest for the pharmaceutical industry. The objective was to determine the secondary metabolites profile of callus and cell suspension cultures of T. peruviana and compare them with those from explant (fruit pulp). Extracts in 50% aqueous ethanol and ethyl acetate were prepared. The phytochemical analysis was performed using standard chemical tests and thin layer chromatography. In addition, total phenolic and flavonoids compounds (TPC and TFC), total cardiac glycosides (TCG) and total antioxidant activity (TAA) was determined during the cell suspension growth. Phenolic chemical profile was also analyzed by high performance liquid chromatography (HPLC). Common metabolites (alkaloids, amino acids, antioxidants, cardiac glycosides, leucoanthocyanidins, flavonoids, phenols, sugars and triterpenes) were detected in all samples. The maximum production of extracellular TCG, TPC, TFC and TAA in cells suspensions were at 6-12 days; in contrast, intracellular content was relatively constant during the exponential grown phase (0 to 12-days). HPLC analysis detected one compound with retention time at 11.6 min; this compound was tentatively identified as dihydroquercetin, a flavonoid with anti-cancer properties. These results provide evidence on the utility of the in vitro cell cultures of T. peruviana for valuable pharmaceutical compounds production.
Descritores: Células Cultivadas
Thevetia/citologia
Compostos Fitoquímicos/biossíntese
-Triterpenos
Flavonoides
Cromatografia Líquida de Alta Pressão
Anticarcinógenos
Thevetia/química
Técnicas de Cultura
Compostos Fitoquímicos/análise
Antioxidantes
Responsável: BR1.1 - BIREME


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Id: lil-784185
Autor: Liang, Wenna; Zhao, Xiaoyang; Feng, Jinping; Song, Fenghua; Pan, Yunzhi.
Título: Ursolic acid attenuates beta-amyloid-induced memory impairment in mice / Ácido ursólico atenua a perda de memória induzida por beta-amilóide em ratos
Fonte: Arq. neuropsiquiatr;74(6):482-488, June 2016. graf.
Idioma: en.
Resumo: ABSTRACT Objective Increasing evidence demonstrates that oxidative stress and inflammatory are involved in amyloid β (Aβ)-induced memory impairments. Ursolic acid (UA), a triterpenoid compound, has potent anti-inflammatory and antioxidant activities. However, it remains unclear whether UA attenuates Aβ-induced neurotoxicity. Method The aggregated Aβ25-35 was intracerebroventricularly administered to mice. Results We found that UA significantly reversed the Aβ25-35-induced learning and memory deficits. Our results indicated that one of the potential mechanisms of the neuroprotective effect was attenuating the Aβ25-35-induced accumulation of malondialdehyde (MDA) and depletion of glutathione (GSH) in the hippocampus. Furthermore, UA significantly suppressed the upregulation of IL-1β, IL-6, and tumor necrosis-α factor levels in the hippocampus of Aβ25-35-treated mice. Conclusion These findings suggest that UA prevents memory impairment through amelioration of oxidative stress, inflammatory response and may offer a novel therapeutic strategy for the treatment of Alzheimer’s disease.

RESUMO Objetivo Há evidências crescentes de que o estresse oxidativo e a inflamação estão envolvidos na perda de memória induzida pelo peptídeo beta-amilóide (βA). O ácido ursólico (AU), um composto triterpenóide, apresenta atividades anti-inflamatórias e antioxidantes potentes. Entretanto, não se sabe ainda se o AU atenua a neurotoxicidade induzida pelo βA. Método O agregado βA 25-35 foi administrado aos ratos por via intracerebroventricular. Resultados Observou-se que o AU reverteu significativamente os déficits de aprendizado e de memória induzidos pelo βA 25-35. Portanto, um dos potenciais mecanismos do efeito neuroprotetor seria a atenuação do acúmulo de malondialdeído e a depleção de glutationa no hipocampo induzidos pelo βA 25-35. Além disso, o AU suprimiu significativamente a supra regulação dos níveis de IL-1β, IL-6 e do fator de necrose tumoral α no hipocampo dos ratos tratados com βA 25-35. Conclusão Esses achados sugerem que o AU previne a perda de memória através da melhora do estresse oxidativo e da resposta inflamatória, podendoproporcionar uma nova estratégia terapêutica para o tratamento da doença de Alzheimer.
Descritores: Triterpenos/administração & dosagem
Peptídeos beta-Amiloides/toxicidade
Estresse Oxidativo/efeitos dos fármacos
Fármacos Neuroprotetores/administração & dosagem
Transtornos da Memória/prevenção & controle
-Aprendizagem em Labirinto
Transtornos da Memória/induzido quimicamente
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1007935
Autor: Estrella-Parra, Edgar; Flores-Cruz, María; Blancas-Flores, Gerardo; Koch, Stephen D; Alarcón-Aguilar, Francisco J.
Título: The Tillandsia genus: history, uses, chemistry, and biological activity / El género Tillandsia: historia, usos, química y actividad biológica
Fonte: Bol. latinoam. Caribe plantas med. aromát;18(3):239-264, mayo 2019. tab, ilus.
Idioma: en.
Projeto: PRODEP-SEP; . UAM.
Resumo: Tillandsia L. genus comprises 649 species, with different uses at different times. T. usneoides L. uses are reported since the late- archaic and pre-Columbian cultures. In XIX-XX centuries, T. usneoides was used in some manufactured products, as polish and packing fruit. Tillandsia has a favorable reputation as medicine: for leucorrhea, rheumatism, ulcers, hemorrhoid treatment, as an anti-diabetic remedy, emetic, analgesic, purgative, contraceptive, antispasmodic and diuretic. Tillandsia chemical composition includes cycloartane triterpenes and hydroxy-flavonoids, which are present in at least 24 species. Several extracts and compounds from Tillandsia spp. have been reported with pharmacological actions, as anti-neoplasia, hypolipidemic, antifungal, anti-HSV-1, hypoglycemic and microbicide. This review communicates the economic importance, ethnobotany, chemistry composition and biological activities of the Tillandsia genus, and analyze its biological and economic perspective. Tillandsia genus has cultural, economic and pharmacological relevance, with a high potential in many essential aspects of the modern society.

El género Tillandsia L. comprende 649 especies, con diferentes usos en diferentes épocas. T. usneoides L. se han reportado desde el arcáico tardío hasta las culturas precolombinas. En los siglos XIX-XX, T. usneoides se usó en productos manufacturados: como abrasivo y embalaje de fruta. Como medicina tradicional, el género Tillandsia se reporta para leucorrea, reumatismo, úlceras, hemorroides, remedio antidiabético, emético, analgésico, purgante, anticonceptivo, antiespasmódico y diurético. Su composición química incluye triterpenos de tipo ciclo-artano e hidroxi-flavonoides, presentes en al menos 24 especies. Los extractos y compuestos del género Tillandsia se han reportado con propiedades antineoplásicas, hipolipidémicas, antifúngicas, anti-HSV-1, hipoglucemiantes y microbicidas. Esta revisión comunica la importancia económica, etnobotánica, composición química y las actividades biológicas del género Tillandsia, y analiza su perspectiva biológica y potencial económica. Tillandsia tiene importancia cultural, económica y farmacológica, con gran potencial en muchos aspectos esenciales de la sociedad moderna.
Descritores: Plantas Medicinais/química
Extratos Vegetais/química
Etnobotânica
Tillandsia/química
-Triterpenos/análise
Extratos Vegetais/farmacologia
Bromeliaceae/química
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1008172
Autor: Bashir, Samra.
Título: Pharmacological importance of Manilkara zapota and its bioactive constituents / Importancia farmacologica de Manilkara zapota y sus constituyentes bioactivos
Fonte: Bol. latinoam. Caribe plantas med. aromát;18(4):347-358, jul. 2019. ilus.
Idioma: en.
Resumo: Manilkara zapota (Sapotaceae), commonly known as Sapodilla, is widely known for its delicious fruit. Various parts of this plant are also used in folk medicine to treat a number of conditions including fever, pain, diarrhoea, dysentery, haemorrhage and ulcers. Scientific studies have demonstrated analgesic, anti-inflammatory, antioxidant, cytotoxic, antimicrobial, antidiarrheal, anti-hypercholesteremic, antihyperglycemic and hepatoprotective activities in several parts of the plant. Phytochemical studies have revealed the presence of phenolic compounds including protocatechuic acid quercitrin, myricitrin, catechin, gallic acid, vanillic acid, caffeic acid, syringic acid, coumaric acid, ferulic acid, etc. as main constituents of the plant. Several fatty acids, carotenoids, triterpenes, sterols, hydrocarbons and phenylethanoid compounds have also been isolated from M. zapota. The present review is a comprehensive description focused on pharmacological activities and phytochemical constituents of M. zapota.

Manilkara zapota (Sapotaceae), comúnmente conocida como Sapodilla, es ampliamente conocida por su delicioso fruto. Variadas partes de esta planta se usan en medicina popular para tratar una serie de afecciones, como fiebre, dolor, diarrea, disentería, hemorragia y úlceras. Estudios científicos han demostrado actividad analgésica, antiinflamatoria, antioxidante, citotóxica, antimicrobiana, antidiarreica, antihipercolesterolémica, antihiperglucémica y hepatoprotectora en diferentes partes de la planta. Los estudios fitoquímicos han revelado la presencia de compuestos fenólicos que incluyen ácido protocatechúico, quercitrina, miricitrina, catequina, ácido galico, ácido vanílico, ácido cafeico, ácido sirínico, ácido cumárico, ácido fúnico y ácido ferúlico como componentes principales de la planta. Varios ácidos grasos, carotenoides, triterpenos, esteroles, hidrocarburos y compuestos feniletanoides también han sido aislados de M. zapota. La presente revisión es una descripción exhaustiva centrada en las actividades farmacológicas y los constituyentes fitoquímicos de M. zapota.
Descritores: Extratos Vegetais/farmacologia
Manilkara/química
-Fenóis/isolamento & purificação
Fenóis/farmacologia
Saponinas/isolamento & purificação
Saponinas/farmacologia
Esteróis/isolamento & purificação
Esteróis/farmacologia
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
Carotenoides/isolamento & purificação
Carotenoides/farmacologia
Sapotaceae/química
Compostos Fenólicos/análise
Medicina Tradicional
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Amaral, Ieda Leao do
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Id: lil-515760
Autor: Cursino, Lorena Mayara de Carvalho; Mesquita, Adriana Spirotto Stein; Mesquita, Denny William de Oliveira; Fernandes, Carromberth Carioca; Pereira Junior, Orlando Libório; Amaral, Ieda Leão do; Nunez, Cecilia Veronica.
Título: Triterpenos das folhas de Minquartia guianensis Aubl. (Olacaceae) / Triterpenes from the leaves of Minquartia guianensis Aubl. (Olacaceae)
Fonte: Acta amaz;39(1):181-185, mar. 2009. ilus, tab.
Idioma: pt.
Resumo: Este artigo descreve o isolamento dos triterpenos lupeol, taraxerol, lupen-3-ona e esqualeno obtido do extrato diclorometânico das folhas da espécie Minquartia guianensis Aubl., pertencente à família Olacaceae. Estes terpenóides foram isolados através de técnicas cromatográficas e identificados utilizando Ressonância Magnética Nuclear (RMN) de ¹H e de 13C. Na literatura disponível, este é o primeiro relato destes triterpenos em M. guianensis.

This article describes the isolation of the triterpenes lupeol, taraxerol, lupen-3-one and squalene from the dichloromethane extract of the leaves of Minquartia guianensis Aubl. belonging to the Olacaceae family. These terpenoids were isolated through chromatographic techniques and identified using ¹H and 13C Nuclear Magnetic Resonance (NMR). At the best of our knowledge, this is the first report of these triterpenes in M. guianensis.
Descritores: Triterpenos
Olacaceae
Responsável: BR6.1 - BCS - Biblioteca de Ciências da Saúde


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Id: lil-546976
Autor: Costa, Danielly Albuquerque; Chaves, Mariana Helena; Silva, Wisllan Cesar Santos; Cost, Charllyton Luis Sena.
Título: Constituintes químicos, fenóis totais e atividade antioxidante de Sterculia striata St. Hil. et Naudin / Chemical constituents, total phenolics and antioxidant activity of Sterculia striata St. Hil. et Naudin
Fonte: Acta amaz;40(1):207-212, mar. 2010. ilus.
Idioma: pt.
Resumo: A investigação fitoquímica das cascas do caule de Sterculia striata St. Hil. et Naudin, através de métodos cromatográficos, conduziu ao isolamento dos esteróides sitosterol, estigmasterol e sitosterol-3-O-β-D-glicopiranosídeo, além de quatro triterpenóides pentacíclicos, o lupeol, 3-β-O-acil lupeol, lupenona e ácido betulínico. As estruturas desses compostos foram identificadas por análise dos espectros de RMN ¹H e 13C e comparações com dados da literatura. Para determinação do teor de fenóis totais do extrato etanólico de S. striata utilizou-se o reativo Folin Ciocalteu, enquanto na avaliação da atividade antioxidante empregou-se o radical livre DPPH. Este é o primeiro trabalho descrevendo o estudo químico com as cascas do caule desta espécie.

The phytochemical investigation of the stem bark of Sterculia striata St. Hil. et Naudin by chromatographic methods led to the isolation of sitosterol, stigmasterol and sitosterol-3-O-β-D-glucopyranoside, besides pentacyclic triterpenoids, lupeol, 3-β-O-acyl-lupeol, lupenone and betulinic acid. The structures of these compounds were identified by ¹H and 13C NMR spectral data analysis and comparison with literature data. For determining of the phenolic content of the etanolic extract of Sterculia striata we used the Folin Ciocalteu reagent, and for the evaluation of antioxidant activity, we utilized the DPPH free radical. This is the first work reporting the chemical study with the stem bark of this species.
Descritores: Esteroides
Triterpenos
Sterculia
Antioxidantes
Responsável: BR6.1 - BCS - Biblioteca de Ciências da Saúde


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Id: biblio-886626
Autor: PEREIRA, JOQUEBEDE R; QUEIROZ, RAPHAEL F; SIQUEIRA, ERLÂNIA A DE; BRASILEIRO-VIDAL, ANA CHRISTINA; SANT'ANA, ANTÔNIO E G; SILVA, DANIEL M; AFFONSO, PAULO R A DE MELLO.
Título: Evaluation of cytogenotoxicity, antioxidant and hypoglycemiant activities of isolate compounds from Mansoa hirsuta D.C. (Bignoniaceae)
Fonte: An. acad. bras. ciênc;89(1):317-331, Jan,-Mar. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Mansoa hirsuta (Bignoniaceae) is a native plant from caatinga in Brazilian semiarid. This plant has been locally used as antimicrobial and hypoglycemiant agents, but their action mechanisms and toxicity remain largely unknown. Therefore, we evaluated the composition and antioxidant, cytoprotective and hypoglycemiant effects of raw extract, fractions and compounds from leaves of M. hirsuta. The cytogenotoxic effects of ursolic and oleanolic acids, the main phytotherapic components of this plant, were assessed. The raw extract and fractions presented steroids, saponins, flavonols, flavanonols, flavanones, xanthones, phenols, tannins, anthocyanins, anthocyanidins and flavonoids. The ethyl acetate fraction inhibited efficiently the cascade of lipid peroxidation while the hydroalcoholic fraction was richer in total phenols and more efficient in capturing 2,2-diphenyl-1-picrylhydrazyl (·DPPH) and 2,2'-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS·+) radicals. The isolated fraction of M. hirsuta also inhibited the α-amylase activity. Cytotoxic effects were absent in both raw extract and fractions while ursolic+oleanolic acids were efficient in protecting cells after exposure to hydrogen peroxide. Moreover, this mixture of acid shad no significant interference on the mitotic index and frequency of nuclear and/or chromosomal abnormalities in Allium cepa test. Therefore, M. hirsuta represents a potential source of phytochemicals against inflammatory and oxidative pathologies, including diabetes.
Descritores: Extratos Vegetais/farmacologia
Bignoniaceae/química
Hipoglicemiantes/farmacologia
Antioxidantes/farmacologia
-Valores de Referência
Triterpenos/química
Brasil
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Reprodutibilidade dos Testes
Cricetinae
Folhas de Planta/química
Cebolas/efeitos dos fármacos
Citoproteção
Etanol/química
alfa-Amilases/química
Fibroblastos/efeitos dos fármacos
Hipoglicemiantes/isolamento & purificação
Antioxidantes/isolamento & purificação
Limites: Animais
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME



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