Base de dados : LILACS
Pesquisa : D02.455.849.919.277 [Categoria DeCS]
Referências encontradas : 4 [refinar]
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Texto completo SciELO Brasil
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Id: biblio-989059
Autor: Dong, Changxia; Liu, Peng; Wang, Huaizhou; Dong, Mei; Li, Guangxin; Li, Yuanbin.
Título: Ginsenoside Rb1 attenuates diabetic retinopathy in streptozotocin-induced diabetic rats
Fonte: Acta cir. bras;34(2):e201900201, 2019. graf.
Idioma: en.
Projeto: Natural Science Foundation of Shandong Province; . Science and Technology Project of Yantai.
Resumo: Abstract Purpose: To investigated the effects of ginsenoside Rb1 on diabetic retinopathy in streptozotocin-induced diabetic rats. Methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin (80 mg/kg) in male Wistar rats. Ginsenoside Rb1 (20, 40 mg/kg) was injected (i.p.) once a day for 4 weeks. Then, using fundus photography, the diameter and vascular permeability of retinal vessels were investigated. Retinal histopathology was undertaken. Contents of malondialdehyde (MDA) and glutathione (GSH) in retinas were assayed. Levels of nuclear factor erythroid 2-related factor 2 (Nrf2), glutathione cysteine ligase catalytic subunit (GCLC), and glutathione cysteine ligase modulatory subunit (GCLM) were measured. Results: Treatment with ginsenoside Rb1 attenuated the diabetes-induced increase in the diameter of retinal blood vessels. Ginsenoside Rb1 reduced extravasation of Evans Blue dye from retinal blood vessels. Ginsenoside Rb1 partially inhibited the increase in MDA content and decrease in GSH level in rat retinas. Nrf2 levels in the nuclei of retinal cells and expression of GCLC and GCLM were increased significantly in rats treated with ginsenoside Rb1. Conclusion: These findings suggest that ginsenoside Rb1 can attenuate diabetic retinopathy by regulating the antioxidative function in rat retinas.
Descritores: Diabetes Mellitus Experimental/tratamento farmacológico
Retinopatia Diabética/tratamento farmacológico
-Vasos Retinianos/efeitos dos fármacos
Vasos Retinianos/patologia
Ratos Wistar
Estreptozocina
Ginsenosídeos/uso terapêutico
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  2 / 4 LILACS  
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Id: biblio-1009753
Autor: Song, Xiaolin; Wu, Hao; Piao, Xuanchun; Yin, Zhenhao; Yin, Chengri.
Título: Microbial transformation of ginsenosides extracted from Panax ginseng adventitious roots in an airlift bioreactor
Fonte: Electron. j. biotechnol;26:20-26, Mar. 2017. ilus, graf, tab.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Natural Science Foundation of Jilin Province of China.
Resumo: Background: Ginsenoside is the most important secondary metabolite in ginseng. Natural sources of wild ginseng have been overexploited. Although root culture can reduce the length of the growth cycle of ginseng, the number of species of ginsenosides is reduced and their contents are lower in the adventitious roots of ginseng than in the roots of ginseng cultivated in the field. Results: In this study, 147 strains of ß-glucosidase-producing microorganisms were isolated from soil. Of these, strain K35 showed excellent activity for converting major ginsenosides into rare ginsenosides, and a NCBI BLAST of its 16S rDNA gene sequence showed that it was most closely related to Penicillium sp. (HQ608083.1). Strain K35 was used to ferment the adventitious root extract, and the fermentation products were analyzed by high-performance liquid chromatography. The results showed that the content of the rare ginsenoside CK was 0.253 mg mL-1 under the optimal converting conditions of 9 d of fermentation at pH 7.0 in LL medium, which was significantly higher than that in the adventitious roots of ginseng. Conclusion: These findings may not only solve the problem of low productivity of metabolite in ginseng root culture but may also result in the development of a new valuable method of manufacturing ginsenoside CK.
Descritores: beta-Glucosidase/metabolismo
Raízes de Plantas/metabolismo
Ginsenosídeos/metabolismo
Panax/metabolismo
-Penicillium
Biotransformação
Cromatografia Líquida de Alta Pressão
Raízes de Plantas/química
Reatores Biológicos
Ginsenosídeos/isolamento & purificação
Fermentação
Panax/crescimento & desenvolvimento
Panax/química
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-889060
Autor: Li, Jin-bo; Zhang, Rui; Han, Xiao; Piao, Chun-li.
Título: Ginsenoside Rg1 inhibits dietary-induced obesity and improves obesity-related glucose metabolic disorders
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(4):e7139, 2018. tab, graf.
Idioma: en.
Resumo: Obesity and its consequent type 2 diabetes are significant threats to global health. Emerging evidence indicates that ginsenosides from ginseng (Panax ginseng) have anti-diabetic activity. We hypothesized that ginsenosides Rg1 could suppress dietary-induced obesity and improve obesity-related glucose metabolic disorders. Our results showed that ginsenoside Rg1 attenuated dietary-induced body weight gain and fat accumulation in white adipocyte tissue of mice fed a high-fat diet. Furthermore, we found that ginsenosides Rg1 not only decreased fasting glucose concentration and the 2-h postprandial glucose concentration, but also improved insulin resistance and glucose intolerance in those mice. Ginsenoside Rg1 also activated the AMPK pathway in vitro and in vivo and increased plasma membrane translocation of GLUT4 in C2C12 skeletal muscle cells. In conclusion, our observations suggested that ginsenoside Rg1 inhibited dietary-induced obesity and improved obesity-related insulin resistance and glucose intolerance by activation of the AMPK pathway.
Descritores: Dieta Hiperlipídica
Ginsenosídeos/farmacologia
Transtornos do Metabolismo de Glucose/prevenção & controle
Obesidade/complicações
-Proteínas Quinases Ativadas por AMP/efeitos dos fármacos
Proteínas Quinases Ativadas por AMP/metabolismo
Transtornos do Metabolismo de Glucose/etiologia
Transtornos do Metabolismo de Glucose/metabolismo
Resistência à Insulina
Obesidade/metabolismo
Transdução de Sinais
Fatores de Tempo
Limites: Animais
Masculino
Camundongos
Responsável: BR1.1 - BIREME


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Almeida, Reinaldo Nóbrega de
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Id: lil-618845
Autor: Braga, João Euclides Fernandes; Diniz, Margareth de Fátima Formiga Melo; Almeida, Reinaldo Nóbrega de.
Título: Avanços no estudo da atividade ansiolítica do panax ginseng C. A. Meyer: [revisão] / Advances in the study of anxiolytic activity of panax ginseng C. A. Meyer: [review]
Fonte: Bol. latinoam. Caribe plantas med. aromát;10(6):491-499, ene. 2011. ilus.
Idioma: pt.
Resumo: To focus on the current evidence on the anxiolytic activity of Panax ginseng C.A Meyer. Recent studies showed the anxiolytic effects of the constituents of the roots of this species. Triterpenoid saponins of ginseng known as ginsenosides, are the active chemical components of the roots of this plant likely related to its anxiolytic activity. The interaction of these components with ligands of GABA receptor, increasing its affinity for the receptor, decreased production of mRNA catabolic enzyme (Abat) and this inhibitory neurotransmitter GABA transporter (GAT1) are related events so far to the anxiolytic effect of ginseng.Both the white ginseng and red ginseng have anxiolytic properties.

Estudo enfoca as atuais evidências sobre a atividade ansiolítica do Panax ginseng C.A Meyer. Recentes pesquisas evidenciaram os efeitos ansiolíticos dos constituintes das raízes desta espécie. Saponinas triterpenóides de ginseng, conhecidos como ginsenosídeos, são os componentes químicos ativos das raízes desta planta relacionados à sua provável atividade ansiolítica. A interação destes constituintes com ligantes do receptor GABA, aumentando a sua afinidade pelo receptor, a diminuição da produção de RNAm da enzima catabólica (Abat) deste neurotransmissor inibitório e do transportador GABA (GAT1) são eventos relacionados até o momento ao efeito ansiolítico do ginseng. Tanto o ginseng branco como o ginseng vermelho apresentam propriedades ansiolíticas.
Descritores: Ansiedade/tratamento farmacológico
Ansiolíticos/farmacologia
Ginsenosídeos/farmacologia
Panax/química
-Ácido gama-Aminobutírico
Raízes de Plantas/química
Saponinas/farmacologia
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central



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