Base de dados : LILACS
Pesquisa : D02.540.505.495 [Categoria DeCS]
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Id: biblio-973636
Autor: Ruiz-Rivero, Juncal; Horcajada-Reales, Celia; Tardío, Juan C; Borbujo-Martínez, Jesús Manuel.
Título: Multiple spider telangiectasias in a breast cancer patient on T-DM1 treatment
Fonte: An. bras. dermatol;93(6):938-939, Nov.-Dec. 2018. graf.
Idioma: en.
Descritores: Telangiectasia/etiologia
Neoplasias da Mama/tratamento farmacológico
Erupção por Droga/etiologia
Trastuzumab/efeitos adversos
Antineoplásicos Imunológicos/efeitos adversos
-Telangiectasia/patologia
Neoplasias da Mama/química
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Erupção por Droga/patologia
Receptor ErbB-2
Trastuzumab/uso terapêutico
Antineoplásicos Imunológicos/uso terapêutico
Maitansina/análogos & derivados
Maitansina/efeitos adversos
Maitansina/uso terapêutico
Estadiamento de Neoplasias
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Carta
Responsável: BR1.1 - BIREME


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Id: lil-666049
Autor: Dagger, Francehuli; Valdivieso, Elizabeth; Marcano, Ana K; Ayesta, Carlos.
Título: Regulatory volume decrease in Leishmania mexicana: effect of anti-microtubule drugs
Fonte: Mem. Inst. Oswaldo Cruz;108(1):84-90, Feb. 2013. ilus, graf, tab.
Idioma: en.
Projeto: FONACIT.
Resumo: The trypanosomatid cytoskeleton is responsible for the parasite's shape and it is modulated throughout the different stages of the parasite's life cycle. When parasites are exposed to media with reduced osmolarity, they initially swell, but subsequently undergo compensatory shrinking referred to as regulatory volume decrease (RVD). We studied the effects of anti-microtubule (Mt) drugs on the proliferation of Leishmania mexicana promastigotes and their capacity to undergo RVD. All of the drugs tested exerted antiproliferative effects of varying magnitudes [ansamitocin P3 (AP3)> trifluoperazine > taxol > rhizoxin > chlorpromazine]. No direct relationship was found between antiproliferative drug treatment and RVD. Similarly, Mt stability was not affected by drug treatment. Ansamitocin P3, which is effective at nanomolar concentrations, blocked amastigote-promastigote differentiation and was the only drug that impeded RVD, as measured by light dispersion. AP3 induced 2 kinetoplasts (Kt) 1 nucleus cells that had numerous flagella-associated Kts throughout the cell. These results suggest that the dramatic morphological changes induced by AP3 alter the spatial organisation and directionality of the Mts that are necessary for the parasite's hypotonic stress-induced shape change, as well as its recovery.
Descritores: Citoesqueleto/efeitos dos fármacos
Leishmania mexicana/efeitos dos fármacos
Moduladores de Tubulina/farmacologia
-Clorpromazina/farmacologia
Leishmania mexicana/crescimento & desenvolvimento
Macrolídeos/farmacologia
Maitansina/análogos & derivados
Maitansina/farmacologia
Paclitaxel/farmacologia
Trifluoperazina/farmacologia
Limites: Animais
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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