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Longui, Carlos A
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Id: biblio-887576
Autor: Linardi, Alessandra; Damiani, Durval; Longui, Carlos A.
Título: The use of aromatase inhibitors in boys with short stature: what to know before prescribing?
Fonte: Arch. endocrinol. metab. (Online);61(4):391-397, July-Aug. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Aromatase is a cytochrome P450 enzyme (CYP19A1 isoform) able to catalyze the conversion of androgens to estrogens. The aromatase gene mutations highlighted the action of estrogen as one of the main regulators of bone maturation and closure of bone plate. The use of aromatase inhibitors (AI) in boys with short stature has showed its capability to improve the predicted final height. Anastrozole (ANZ) and letrozole (LTZ) are nonsteroidal inhibitors able to bind reversibly to the heme group of cytochrome P450. In this review, we describe the pharmacokinetic profile of both drugs, discussing possible drug interactions between ANZ and LTZ with other drugs. AIs are triazolic compounds that can induce or suppress cytochrome P450 enzymes, interfering with metabolism of other compounds. Hydroxilation, N-dealkylation and glucoronidation are involved in the metabolism of AIs. Drug interactions can occur with azole antifungals, such as ketoconazole, by inhibiting CYP3A4 and by reducing the clearance of AIs. Antiepileptic drugs (lamotrigine, phenobarbital, and phenytoin) also inhibit aromatase. Concomitant use of phenobarbital or valproate has a synergistic effect on aromatase inhibition. Therefore, it is important to understand the pharmacokinetics of AIs, recognizing and avoiding possible drug interactions and offering a safer prescription profile of this class of aromatase inhibitors. Arch Endocrinol Metab. 2017;61(3):391-7.
Descritores: Triazóis/farmacocinética
Estatura/efeitos dos fármacos
Inibidores da Aromatase/farmacocinética
Nitrilos/farmacocinética
-Sistema Enzimático do Citocromo P-450/metabolismo
Inibidores da Aromatase/uso terapêutico
Interações Medicamentosas
Letrozol
Anastrozol
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: lil-781334
Autor: Lara, Alessandra Cerávolo; Cândido, Eduardo Batista; Vidigal, Paula Vieira; Rocha, Ana Luiza Lunardi; Carvalho-Macedo, Alessandra Costa; Carneiro, Márcia Mendonça; Silva-Filho, Agnaldo Lopes.
Título: Effect of letrozole in carcinogen-plus-estrogen-induced endometrial hyperplasia in mice
Fonte: Acta cir. bras;31(4):286-293, Apr. 2016. tab, graf.
Idioma: en.
Resumo: PURPOSE: To evaluate the effects of letrozole (Ltz) in carcinogen+estrogen-induced endometrial hyperplasia. METHODS: BALB/c female mice were divided into four groups of 12 animals each receiving an intrauterine dose of N-ethyl-N-nitrosourea (ENU) and weekly subcutaneous injections of estradiol hexaidrobenzoate (EHB), except for group I(control). The groups were divided in I (control), II (ENU+EHB), III (ENU+EHB+MPA) and IV (ENU+EHB+Ltz). Group III also received intramuscular injections of MPA (medroxy progesterone acetate) every four weeks, while group IV received oral doses of Ltz daily. At the end of 16 weeks, the animals were sacrificed, and blood samples were collected for the measurement of serum estradiol and progesterone levels. Uterine histological sections were made to evaluate the presence of endometrial proliferative lesions. Differences between groups were evaluated with student's t test, ANOVA and chi-square test. RESULTS: Groups ENU+EHB, ENU+EHB+MPA and ENU+EHB+Ltz showed varying degrees of endometrial hyperplasia. The incidence of hyperplasia in groups ENU+EHB and ENU+EHB+Ltz was higher and more severe than in group ENU+EHB+MPA. Control group showed lower levels of serum estradiol than the other groups. CONCLUSION: There was no evidence that letrozole could act as an antiestrogenic drug in the development of endometrial proliferative lesions.
Descritores: Triazóis/farmacologia
Inibidores da Aromatase/farmacologia
Hiperplasia Endometrial/tratamento farmacológico
Carcinogênese/efeitos dos fármacos
Nitrilos/farmacologia
-Progesterona/sangue
Fatores de Tempo
Triazóis/uso terapêutico
Adenocarcinoma/etiologia
Adenocarcinoma/tratamento farmacológico
Reprodutibilidade dos Testes
Resultado do Tratamento
Neoplasias do Endométrio/etiologia
Neoplasias do Endométrio/tratamento farmacológico
Acetato de Medroxiprogesterona/farmacologia
Antineoplásicos Hormonais/farmacologia
Inibidores da Aromatase/uso terapêutico
Hiperplasia Endometrial/induzido quimicamente
Hiperplasia Endometrial/patologia
Endométrio/efeitos dos fármacos
Endométrio/patologia
Estradiol/sangue
Etilnitrosoureia
Carcinogênese/patologia
Camundongos Endogâmicos BALB C
Nitrilos/uso terapêutico
Limites: Animais
Feminino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Rangel, Elizabeth Ferreira
Romero, Gustavo Adolfo Sierra
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Id: biblio-894922
Autor: Silva, Rafaella Albuquerque e; Andrade, Andrey José de; Quint, Bruno Beust; Raffoul, Gabriel Elias Salmen; Werneck, Guilherme Loureiro; Rangel, Elizabeth Ferreira; Romero, Gustavo Adolfo Sierra.
Título: Effectiveness of dog collars impregnated with 4% deltamethrin in controlling visceral leishmaniasis in Lutzomyia longipalpis (Diptera: Psychodidade: Phlebotominae) populations
Fonte: Mem. Inst. Oswaldo Cruz;113(5):e170377, 2018. tab, graf.
Idioma: en.
Resumo: BACKGROUND There is little information on the effect of using deltamethrin-impregnated dog collars for the control of canine visceral leishmaniasis. OBJECTIVES The objective of this study was to evaluate the effectiveness of the use of 4% deltamethrin-impregnated collars (Scalibor®) in controlling visceral leishmaniasis in Lutzomyia longipalpis by comparing populations in intervention and non-intervention areas. METHODS Phlebotomine flies were captured over 30 months in four neighbourhoods with intense visceral leishmaniasis transmission in Fortaleza and Montes Claros. We calculated the rates of domicile infestation, relative abundance of Lu. longipalpis, and Lu. longipalpis distribution in each site, capture location (intra- and peridomestic locations) and area (intervention and non-intervention areas). FINDINGS In the control area in Fortaleza, the relative abundance of Lu. longipalpis was 415 specimens at each capture site, whereas in the intervention area it was 159.25; in Montes Claros, the relative abundance was 5,660 specimens per capture site in the control area, whereas in the intervention area it was 2,499.4. The use of dog collars was associated with a reduction in captured insects of 15% (p = 0.004) and 60% (p < 0.001) in Montes Claros and Fortaleza, respectively. MAIN CONCLUSIONS We observed a lower vector abundance in the intervention areas, suggesting an effect of the insecticide-impregnated collars.
Descritores: Psychodidae
Leishmaniose Visceral
-Controle de Insetos/instrumentação
Insetos Vetores/efeitos dos fármacos
Nitrilos/administração & dosagem
Limites: Animais
Cães
Responsável: BR1.1 - BIREME


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Id: biblio-893233
Autor: Mwakikunga, Anthony; Adefolaju, Gbenga A; Schepartz, Lynne; Hosie, Margot J.
Título: Focal adhesion proteins, vinculin and integrin ß5, during early pregnancy in rat uterine epithelial cells: anastrozole favors their normal distribution / Proteínas de adhesión focales, vinculina e integrina ß5, durante el embarazo temprano en células epiteliales uterinas de rata: anastrozol favorece su distribución normal
Fonte: Int. j. morphol;36(1):345-357, Mar. 2018. tab, graf.
Idioma: en.
Resumo: SUMMARY: An alternative superovulator to replace clomiphene citrate is needed as clomiphene citrate is associated with low pregnancy rates. Anastrozole is an effective superovulator, but it has not been well researched. In order to determine the effectiveness of anastrozole as a superovulator and to compare it with clomiphene citrate in similar situations, this study ascertained the effects of these drugs on the expression of the focal adhesion proteins, vinculin and integrin β5, which are uterine receptivity markers, in the uterine epithelial cells of day 1 and day 6 pregnant Wistar rats. The results show that vinculin and integrin β5 are co-localized at the base of the uterine epithelium at day 1 of pregnancy whereas at day 6, they disassemble from the basal focal adhesions and co-localize and significantly increase their expression apically (p≤0.0001). Moreover, there is a significant difference in the protein expression levels of vinculin and integrin b5 in uterine luminal epithelial cells between untreated (control) and chlomiphene citrate treated rats (p≤0.0001), anastrozole and chlomiphene citrate treated rats at day 6 (p≤0.0001) suggesting the interpretation that anastrozole seems to enhance their expression in order to perhaps assist in the implantation process of the blastocyst. The immunofluorescence experiments agree with the vinculin and integrin β5 gene expression findings in which at day 6 of pregnancy, vinculin and integrin β5 gene expression are significantly upregulated in uterine luminal epithelial cells in the anastrozole treated group relative to the calibrator sample (p≤0.0001). These findings suggest that anastrozole is implantation friendly.

RESUMEN: Es necesario un superovulador alternativo para reemplazar el citrato de clomifeno, debido a que está asociado con bajas tasas de preñez. El anastrozol es un superovulador eficaz, sin embargo es poca su investigación. Con el fin de determinar la efectividad del anastrozol como superovulador y compararlo con citrato de clomifeno en situaciones similares, se determinaron los efectos de estos fármacos sobre la expresión de las proteínas de adhesión focal, vinculina e integrina β5, en marcadores de receptividad uterina en días 1 y 6, en las células epiteliales uterinas de ratas Wistar preñadas. Los resultados muestran que la vinculina y la integrina β5 se co-localizan en la base del epitelio uterino al día 1 de la gravidez mientras que al día 6 se desmontan de las adherencias focales basales, co-localizan y aumentan significativamente su expresión apicalmente (p≤0.0001). Además, existe una diferencia significativa en los niveles de expresión de proteína de vinculina e integrina β5 en células epiteliales luminales uterinas entre ratas no tratadas (control) y tratadas con citrato declomifeno (p≤0.0001), ratas tratadas con anastrozol y citrato declomifeno al día 6 (p≤0,0001) sugiriendo la interpretación de que el anastrozol parece mejorar su expresión con el fin de ayudar en el proceso de implantación del blastocisto. Los experimentos de inmunofluorescencia coinciden con los resultados de la expresión de los genes vinculina e integrina β5 en los cuales al día 6 de la preñez, la vinculina y la integrina β5 están significativamente reguladas en células epiteliales luminales uterinas en el grupo tratado con anastrozol con respecto a la muestra del calibrador (p<0,0001). Estos hallazgos sugieren que el anastrozol es favorable para la implantación.
Descritores: Integrinas/efeitos dos fármacos
Nitrilos/farmacologia
Triazóis/farmacologia
Útero/efeitos dos fármacos
Vinculina/efeitos dos fármacos
-Células Epiteliais/efeitos dos fármacos
Adesões Focais/efeitos dos fármacos
Integrinas/genética
Integrinas/fisiologia
Microscopia Confocal
Microscopia de Fluorescência
Ratos Wistar
Reação em Cadeia da Polimerase em Tempo Real
Vinculina/genética
Vinculina/fisiologia
Limites: Animais
Feminino
Gravidez
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-843905
Autor: Coscia, Eduardo Borges; Sabha, Maricene; Gerenutti, Marli; Groppo, Francisco Carlos; Bergamaschi, Cristiane de Cássia.
Título: Estrone and Estradiol Levels in Breast Cancer Patients Using Anastrozole Are Not Related to Body Mass Index / Níveis de estrona e estradiol em pacientes com câncer de mama usando anastrozol não estão relacionados ao índice de massa corpórea
Fonte: Rev. bras. ginecol. obstet;39(1):14-20, Jan. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective: Obesity is associated with an increased risk for breast cancer. Recent studies have shown that aromatase inhibitors may be less effective in women with a high body mass index (BMI). The aim of this study was to establish the relationship between the BMI and plasma estrone and estradiol levels in postmenopausal women with hormone receptor-positive breast cancer using anastrozole. Methods: In this cohort study, the patients were divided into three groups according to BMI (normal weight, overweight and obese) to compare and correlate plasma hormone levels before starting anastrozole hormone therapy and three months after treatment. Plasma hormone levels were compared for age and use of chemotherapy. Results: A statistically significant reduction in estrone and estradiol levels was observed between baseline and three months after starting the anastrozole treatment (p < 0.05). There was no statistically significant difference in plasma estrone and estradiol levels among the BMI groups (p > 0.05), but a significant reduction in plasma estrone levels was observed after three-months' treatment relative to baseline in all groups, as well as a reduction in estradiol in the obese group (p < 0.05). The use of chemotherapy and age > 65 years had no influence on plasma steroid levels. Conclusion: Changes in estrone and estradiol levels in the studied groups were not associated with BMI, chemotherapy or age.

RESUMO Objetivo: A obesidade está associada com risco aumentado de câncer de mama. Estudos recentes têm mostrado que os inibidores de aromatase podem ser menos eficazes em mulheres com alto índice de massa corporal (IMC). O objetivo deste estudo foi estabelecer a relação entre o IMC e os níveis plasmáticos de estrona e estradiol em mulheres no período pós-menopausa com câncer de mama receptor hormonal positivo, em tratamento com anastrozol. Métodos: Este estudo de coorte acompanhou três grupos de pacientes de acordo com o seu IMC (peso normal, sobrepeso e obesidade), a fim de comparar e correlacionar as dosagens dos hormônios estrona e estradiol antes e após três meses do uso do anastrozol. Os níveis plasmáticos dos hormônios foram também relacionados à idade do paciente e ao uso da quimioterapia. Resultados: Redução estatisticamente significativa de estrona e estradiol foi observada entre os níveis basais e três meses após o início do tratamento com anastrozol (p < 0,05). Não houve diferença estatisticamente significativa entre os níveis plasmáticos de estrona e estradiol em relação ao IMC (p > 0,05), mas houve redução significativa entre os níveis plasmáticos basais de estrona após o tratamento em todos os grupos, e redução de estradiol no grupo de pacientes obesas (p < 0,05). A condução da quimioterapia e da idade acima de 65 anos não interfere com os níveis plasmáticos de esteroides. Conclusão: Os níveis plasmáticos de estrona e estradiol nos grupos estudados não foram alterados em termos de IMC, quimioterapia e idade.
Descritores: Antineoplásicos Hormonais/uso terapêutico
Inibidores da Aromatase/uso terapêutico
Índice de Massa Corporal
Neoplasias da Mama/sangue
Neoplasias da Mama/tratamento farmacológico
Estradiol/sangue
Estrona/sangue
Nitrilos/uso terapêutico
Triazóis/uso terapêutico
-Estudos de Coortes
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-842766
Autor: Kayedi, Mohammad Hassan; Khamisabadi, Kiumars; Haghdoost, Ali Akbar; Kayedi, Zohreh; Fallahi, Shirzad; Abdali, Nargess.
Título: Short and long term evaluation of the efficiency of PermaNet® 2. 0 bed net against environmental factors and washing using bioassay tests
Fonte: Rev. Inst. Med. Trop. Säo Paulo;59:e18, 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT The aim of the present study was to examine the resistance of PermaNet® 2.0 bed nets against repeated washing and environmental factors by using bioassay tests. After 5, 15 and 21 washings with detergents and by using bioassay tests, the resistance of 40 PermaNet® 2.0 bed nets was compared with that of 40 bed nets conventionally treated with one K-O tablet. To examine the long-term resistance, 31 PermaNet® 2.0 bed nets were also distributed among villagers, and were re-collected to perform bioassay tests after 1, 2 and 5 years. In the first phase of this study, the insecticidal effect of the conventionally-treated nets significantly decreased due to repeated washings (P < 0.001); however, it was not significant regarding PermaNet® 2.0 bed nets (P = 0.92 in continuous exposure and P = 0.12 in mortality tests). In the long-term phase of this study, the time required for knockdown of PermaNet® 2.0 increased over the first 2 years and then decreased. In addition, the mortality rate decreased over the first 2 years and then increased. In conclusion, it seems that the technique used by the manufacturer for impregnation of PermaNet® 2.0 bed nets has an acceptable efficiency in comparison with conventional techniques.
Descritores: Mosquiteiros Tratados com Inseticida
Inseticidas
Malária/prevenção & controle
Controle de Mosquitos/métodos
Nitrilos
Piretrinas
-Bioensaio
Estudos de Avaliação como Assunto
Lavanderia
Fatores de Tempo
Limites: Animais
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: lil-764412
Autor: Brasileiro, Ana; Campos, Sara; Fidalgo, Ana.
Título: Do steroid hormones have an important role on cutaneous lupus physiopathology?
Fonte: An. bras. dermatol;90(5):766-768graf.
Idioma: en.
Descritores: Inibidores da Aromatase/efeitos adversos
Lúpus Eritematoso Discoide/fisiopatologia
Nitrilos/efeitos adversos
Triazóis/efeitos adversos
-Neoplasias da Mama/tratamento farmacológico
Carcinoma Ductal de Mama/tratamento farmacológico
Dermatoses Faciais/tratamento farmacológico
Lúpus Eritematoso Discoide/patologia
Dermatoses do Couro Cabeludo/tratamento farmacológico
Limites: Idoso de 80 Anos ou mais
Feminino
Humanos
Tipo de Publ: Relatos de Casos
Carta
Responsável: BR1.1 - BIREME


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Id: lil-755968
Autor: Pessoa, Grasielle Caldas DÁvila; Santos, Tamara Rodrigues Martins dos; Salazar, Gabriela Chadid; Dias, Letícia Sena; Mello, Bernardino Vaz de; Ferraz, Marcela Lencine; Diotaiuti, Liléia.
Título: Variability of susceptibility to deltamethrin in peridomestic Triatoma sordida from Triângulo Mineiro, State of Minas Gerais, Brazil
Fonte: Rev. Soc. Bras. Med. Trop;48(4):417-421, July-Aug. 2015. tab, ilus.
Idioma: en.
Resumo: AbstractINTRODUCTION:

Despite chemical and physical vector control strategies, persistent infestations of Triatoma sordida have been reported in a large part of Minas Gerais, Brazil, and the cause for this is little investigated. We aimed to characterize the deltamethrin toxicological profile in peridomestic T. sordidapopulations from Triângulo Mineiro area of Minas Gerais.

METHODS:

Susceptibility to deltamethrin was assessed in seventeen peridomestic T. sordida populations. Serial dilutions of deltamethrin in acetone (0.2µL) were topically applied on the first instar nymphs (F1; five days old; fasting weight, 1.2 ± 0.2mg). Dose response results were analyzed using Probit software, and the lethal doses, slope and resistance ratios were determined. Qualitative tests were also performed.

RESULTS:

The deltamethrin susceptibility profile of T. sordida populations revealed resistance ratios ranging from 0.84 to 2.8. The percentage mortality in response to a diagnostic dose was 100.0% in all populations.

CONCLUSIONS:

From our results, the lack of resistance to insecticides but persistent T. sordida infestations in the Triângulo Mineiro area may be because of: 1) environmental degradation facilitating dispersion of T. sordida , allowing colonization in artificial ecotopes; 2) operational failures; and 3) complexity of the peridomicile in the study area.These variables are being investigated.

.
Descritores: Inseticidas
Nitrilos
Piretrinas
Triatoma
-Bioensaio
Brasil
Doença de Chagas/transmissão
LETHAL DOSE ACADEMIES AND INSTITUTES
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-746229
Autor: Pessoa, Grasielle Caldas D`avila; Rosa, Aline Cristine Luiz; Bedin, Cleonara; Wilhelms, Tânia; Mello, Fernanda de; Coutinho, Helder Silveira; Fonseca, Eduardo Oyama Lins; Santos, Roberto Fonseca dos; Diotaiuti, Liléia.
Título: Susceptibility characterization of residual Brazilian populations of Triatoma infestans Klug, 1834 (Hemiptera: Reduviidae) to deltamethrin pyrethroid
Fonte: Rev. Soc. Bras. Med. Trop;48(2):157-161, mar-apr/2015. tab.
Idioma: en.
Resumo: INTRODUCTION: Despite years of efforts towards the elimination of Triatoma infestans in Brazil, residual foci still persist in some areas of the States of Bahia and Rio Grande do Sul. The persistence of these T. infestans populations in the country has two different origins of equal concern: operational failures or insecticide resistance. Thus, the objective of this study was to characterize the susceptibility profile of the residual Brazilian populations of T. infestans to deltamethrin. METHODS: The susceptibility reference lineage was derived from Cipein/Argentina. The populations studied were manually collected using a dislodging agent in peridomiciles in the States of Bahia (Novo Horizonte) and of Rio Grande do Sul (Santa Rosa and Doutor Maurício Cardoso). Serial dilutions of deltamethrin were prepared and applied at the dorsal abdomen of first instar nymphs. The control group received only pure acetone. Mortality was evaluated after 72h. Qualitative tests assessed the mortality of a diagnostic dose of 1xLD99 (2.76ng a.i./nymph) determined for the susceptibility reference lineage. RESULTS: The susceptibility profile characterization of the T. infestans populations revealed an RR50 ranging from 1.73 to 3.26. The mortality percentage in response to a diagnostic dose was 100%. The results obtained in the quantitative and qualitative assays corresponded for all populations. CONCLUSIONS: The results of this study indicate that the persistence of residual foci of T. infestans in Bahia and Rio Grande do Sul is not related to insecticide resistance but may be associated with operational failures. In Rio Grande do Sul, we must consider the possibility of continuous reinfestation by Argentinian individuals, which justifies active and efficient epidemiological surveillance. .
Descritores: Insetos Vetores
Resistência a Inseticidas
Nitrilos
Piretrinas
Triatoma
-Bioensaio
Brasil
Doença de Chagas/transmissão
LETHAL DOSE ACADEMIES AND INSTITUTES
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-736431
Autor: Santos, Franco Andrius Ache dos; Souza, Juliana Barcellos de; Antes, Danielle Ledur; d'Orsi, Eleonora.
Título: Prevalência de dor crônica e sua associação com a situação sociodemográfica e atividade física no lazer em idosos de Florianópolis, Santa Catarina: estudo de base populacional / Prevalence of chronic pain and its association with the sociodemographic situation and physical activity in leisure of elderly in Florianópolis, Santa Catarina: population-based study
Fonte: Rev. bras. epidemiol;18(1):234-247, Jan-Mar/2015. tab.
Idioma: pt.
Projeto: Conselho Nacional de Desenvolvimento Científico e Tecnológico.
Resumo: OBJETIVO: Estimar a prevalência de dor crônica e sua associação com a situação socioeconômica, demográfica e atividade física no lazer em idosos. MÉTODOS: Este estudo é parte do inquérito epidemiológico e transversal de base populacional e domiciliar EpiFloripa Idoso 2009-2010 realizado com 1.705 idosos (≥ 60 anos), residentes em Florianópolis, Santa Catarina. A partir da resposta afirmativa de dor crônica, foram investigadas as associações com as variáveis obtidas por meio de entrevista estruturada. Realizou-se a estatística descritiva, incluindo cálculos de proporções e intervalos de confiança 95% (IC95%). Na análise bruta e ajustada, empregou-se regressão de Poisson, estimando-se as razões de prevalência, com intervalos de confiança de 95% e valores p ≤ 0,05. RESULTADOS: Dentre os idosos investigados, 29,3% (IC95% 26,5 - 32,2) relataram dor crônica. Na análise ajustada, observou-se que as variáveis sexo feminino, menor escolaridade e pior situação econômica ficaram associadas significativamente com maior prevalência de dor crônica; ser fisicamente ativo no lazer ficou associado significativamente com menor prevalência do desfecho. CONCLUSÕES: Percebe-se que a dor crônica é um agravo que acomete considerável parcela de idosos, havendo desigualdades sociais na sua frequência e sendo beneficamente afetada pela atividade física no lazer. É necessário que políticas públicas de saúde subsidiem programas multidisciplinares de controle da dor incluindo a prática regular de atividade física, voltada especificamente à promoção da saúde do idoso, evitando assim que a dor crônica comprometa a qualidade de vida desta população. .

OBJECTIVE: To estimate the prevalence of chronic pain and its association with socioeconomic and demographic status, and leisure physical activity in the elderly population. METHODS: This study is part of an epidemiological cross-sectional population-based household survey called EpiFloripa Elderly 2009-2010, which was conducted with 1,705 elderly individuals (≥ 60 years) residents of Florianópolis, Santa Catarina. From the positive response to chronic pain, the associations with the variables were investigated through a structured interview. Descriptive statistics were conducted, including ratio calculation and 95% confidence intervals. In crude and adjusted analysis, Poisson regression was utilized, estimating prevalence ratios, with 95% confidence intervals and ≤ 0.05 p-values. RESULTS: Among the subjects, 29.3% (IC95% 26.5 - 32.2) reported chronic pain. Adjusted analysis showed that being female, having less years of schooling, and being in worse economic situation were significantly associated with a higher prevalence of chronic pain. Being physically active during leisure time was significantly associated with lower prevalence of the outcome. CONCLUSIONS: Therefore, it is clear that chronic pain affects a considerable amount of elderly individuals. Social inequalities are a harmful influence in these individuals' quality of life, inasmuch as those inequalities increase the frequency with which chronic pain afflicts them. At the same time, physical activity during leisure time decreases chronic pain frequency. It is fundamental that public health policies subsidize multidisciplinary pain management programs, which should include health targeted physical activity for the elderly, thus preventing the decrease in quality of life that chronic pain brings to this population. .
Descritores: Proteína 1 de Resposta de Crescimento Precoce/genética
Células Epiteliais/efeitos dos fármacos
Proteína Quinase 1 Ativada por Mitógeno/metabolismo
/metabolismo
MITOGEN-ACTIVATED PROTEIN KINASE ABATTOIRS/metabolismo
Sulindaco/análogos & derivados
-Apoptose/efeitos dos fármacos
Western Blotting
Butadienos/farmacologia
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Proteína 1 de Resposta de Crescimento Precoce/metabolismo
Células Epiteliais/citologia
Células Epiteliais/metabolismo
HCTACETYLATION CELLS
HTABORTION, INCOMPLETE CELLS
Imidazóis/farmacologia
Intestinos/citologia
Intestinos/efeitos dos fármacos
Intestinos/metabolismo
Luciferases/genética
Luciferases/metabolismo
Microscopia Confocal
Proteína Quinase 1 Ativada por Mitógeno/antagonistas & inibidores
/antagonistas & inibidores
MITOGEN-ACTIVATED PROTEIN KINASE ABATTOIRS/antagonistas & inibidores
Nitrilos/farmacologia
Piridinas/farmacologia
Reação em Cadeia da Polimerase Via Transcriptase Reversa
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Transdução de Sinais/efeitos dos fármacos
Sulindaco/farmacologia
Transfecção
Regulação para Cima/efeitos dos fármacos
Proteínas Elk-1 do Domínio ets/genética
Proteínas Elk-1 do Domínio ets/metabolismo
Limites: Animais
Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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