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Id: lil-360982
Autor: Petray, Patricia B; Morilla, María J; Corral, Ricardo S; Romero, Eder L.
Título: In vitro activity of Etanidazole against the protozoan parasite Trypanosoma cruzi
Fonte: Mem. Inst. Oswaldo Cruz;99(2):233-235, Mar. 2004. ilus, graf.
Idioma: en.
Projeto: Swedish International Development Agency for the Network for Research and Training in Parasitic Diseases in the Southern Cone of Latin America and Vicerrectorado de Investigaciones de la UNQ.
Resumo: We investigated the in vitro action of an hydrosoluble 2-nitroimidazole, Etanidazole (EZL), against Trypanosoma cruzi, the etiologic agent of Chagas disease. EZL displayed lethal activity against isolated trypomastigotes as well as amastigotes of T. cruzi (RA strain) growing in Vero cells or J774 macrophages, without affecting host cell viability. Although not completely equivalent to Benznidazole (BZL), the reference drug for Chagas chemotherapy, EZL takes advantage in exertingits anti-T. cruzi activity for longer periods without serious toxic side effects, as those recorded in BZL-treated patients. Our present results encourage further experiments to study in depth the trypanocidal properties of this drug already licensed for use in human cancers.
Descritores: Etanidazol
Tripanossomicidas
Trypanosoma cruzi
-Chlorocebus aethiops
Concentração Inibidora 50
Dose Letal Mediana
Células Vero
Limites: Animais
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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