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Texto completo SciELO Costa Rica
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Id: biblio-841452
Autor: Barrientos Jiménez, Maryam; Esquivel Zúñiga, María Rebeca; Álvarez Umaña, Silvia Vanessa; Tencio Araya, Jose; Soto Cerdas, Jahaira.
Título: Antibioticoterapia y nuevas terapias no farmacológicas en infecciones por clostridium diffici / Antibiotic therapy and new non-pharmacological therapies in clostridium diffici infections
Fonte: Med. leg. Costa Rica;34(1):265-271, ene.-mar. 2017. tab.
Idioma: es.
Resumo: Resumen:La infección por Clostridium difficile es la principal causa de diarrea infecciosa en pacientes hospitalizados. Los pacientes pueden ser portadores asintomáticos o presentar desde una diarrea leve a una colitis pseudomembranosa, megacolon tóxico, sepsis y muerte. El manejo de esta infección sigue presentando puntos de controversia, tanto en la elección del mejor método diagnóstico como en el tratamiento. En los casos en los cuales la infección por este agente fue confirmada la primera y más efectiva medida es suspender la antibioticoterapia que el paciente este recibiendo, en la medida de lo posible. El tratamiento se basa en tres agentes clásicos: metronidazol, vancomicina y teicoplanina con la más reciente adición de fidaxomicina y ridinilazol. Pacientes con presentación severa muchas veces requieren resolución quirúrgica además de las medidas de soporte y monitoreo. El objetivo de esta revisión es ofrecer información actualizada sobre la patogénesis y estrategias terapéuticas sobre el manejo de la infección por este patógeno.

Abstract:Clostridium difficile infection is the leading cause of hospital acquired diarrhea. The patients can be asymptomatic carriers or present a mild diarrhea, a pseudomembranous colitis, toxic megacolon, sepsis and death. There is controversy in this infection's including the best method of diagnosis and also regarding therapeutic regimen.In cases in which Clostridium infection is confirmed, the first and most effective measure is the withdrawal of any antibiotic treatment the patient is receiving, if possible. The antimicrobial treatment is based on three classic agents: metronidazole, vancomycin and teicoplanin, along with the recent addition of fidaxomicin and ridinilazol.Patients presenting serious symptoms, in addition to appropriate support and monitoring measures, may require surgical treatment. This review's aim is to provide an update on the pathogenesis, and therapeutic strategies on the management of this pathogen.
Descritores: Enterocolite Pseudomembranosa
Vancomicina/uso terapêutico
Clostridium difficile/virologia
Infecções por Clostridium
Teicoplanina/uso terapêutico
Colite
Diarreia
Disenteria
Metronidazol/uso terapêutico
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CR1.1 - BINASSS - Biblioteca Nacional de Salud y Seguridad Social


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Texto completo SciELO Brasil
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Id: biblio-983681
Autor: Sampaio, Cláudia Paraguaçu Pupo; Biondo-Simões, Maria de Lourdes Pessole; Trindade, Lilian Cristine Teixeira; Olandowski, Márcia; Matias, Jorge Eduardo Fouto.
Título: Metronidazole concentration in the bloodstream following its topical application, at different concentration levels, on experimental skin wounds during healing by secondary intention
Fonte: Acta cir. bras;34(1):e20190010000004, 2019. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To characterize qualitatively and quantitatively the absorption of metronidazole solution, in greater concentrations and for longer periods, when applied topically to an experimental open skin wound model. Methods: An open skin wound, 2 cm in diameter and total skin thickness was prepared, under anesthetic, in the dorsal region of 108 Wistar rats weighing between 300 and 350 grams. The animals were allocated to groups of 18 animals in accordance with the concentration of metronidazole in the solution to be applied daily to the wound. In the control group (CG), 0.9% sodium chloride solution was used for application, and in the experimental groups (GI, GII, GIII, GIV and GV) metronidazole solution at 4%, 6%, 8%, 10% and 12%, respectively, was applied. After 3, 7 and 14 days of treatment. Blood samples collected through cardiac puncture were examined for the existence or non-existence of metronidazole, using high performance liquid chromatography (HPLC). Detected metronidazole values were compared statistically within each group (temporal analysis 3 days X 7 days X 14 days) and between the groups that used topical metronidazole (4% X 6% X 8% X 10% and 12%) using the Kruskal-Wallis test, considering a statistical significance of 95% (p<0.05). Results: Metronidazole was detected in all the samples at all times in all the groups in which topical metronidazole was applied to the wounds. Characteristically, there was no significant difference between the doses obtained within each group over time (3 days X 7 days X 14 days) GI=0.461; GII=0.154; GIII=0.888; GIV= 0.264 and GV=0.152. In the evaluation between groups, a similar degree of absorption was found after 3 days (p=0.829) and 14 days (p=0.751). Conclusion: The serum concentration of metronidazole that was achieved was not influenced by the concentration of the solution applied to the skin wound, with similar extend, or by the duration of the application.
Descritores: Cicatrização/efeitos dos fármacos
Metronidazol/administração & dosagem
Metronidazol/sangue
Anti-Infecciosos/administração & dosagem
Anti-Infecciosos/sangue
-Fatores de Tempo
Administração Tópica
Cromatografia Líquida
Ratos Wistar
Modelos Animais de Doenças
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Cuba
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Id: lil-614989
Autor: Gil Manrique, Lázaro Fidel; Soler Morejón, Caridad; Crespo Acebal, Lourdes; Villa Valdés, Miriam; Alfonso Alfonso, Lázaro; Contreras Rojas, Isis Caridad.
Título: Absceso esplénico amebiano / Amebic splenetic abscess
Fonte: Rev. cuba. cir;50(4):560-569, oct.-dic. 2011.
Idioma: es.
Resumo: La localización extraintestinal es una complicación temible de la amebiasis intestinal, con una elevada mortalidad, que oscila entre el 4 al 14 por ciento de los casos diagnosticados. La forma de presentación más común es el absceso hepático amebiano, y aunque se han reportado localizaciones pulmonares, peritoneales, y hasta cerebrales, la localización esplénica es extremadamente infrecuente. Se reporta un caso de amebiasis esplénica que evolucionó tórpidamente, a pesar del tratamiento específico con metronidazol desde su admisión al Departamento de Emergencia, y que fue intervenido quirúrgicamente al séptimo día, con evolución favorable después de la resección del bazo. Se realiza una revisión de la literatura actualizada sobre el tema(AU)

The extraintestinal location is a fearsome complication of the intestinal amebiasis, with a high mortality fluctuating between the 4 and the 14 percent of cases diagnosed. The commonest presentation way is the amebic hepatic abscess and although others have reported pulmonary, peritoneal and up to cerebral locations, the splenetic one is extremely infrequent. A case of splenetic amebiasis is reported which evolved in a torpid way despite the specific treatment with metronidazole from its admission to Emergence Department and that was operated on at seventh day with a favorable evolution after spleen resection. Authors made a review of the updated literature on this subject(AU)
Descritores: Amebíase/complicações
Amebíase/tratamento farmacológico
Esplenopatias/cirurgia
Esplenopatias/etiologia
Esplenectomia/métodos
Metronidazol/uso terapêutico
-Literatura de Revisão como Assunto
Limites: Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: lil-601297
Autor: Castellano Filho, Didier Silveira; Diniz, Cláudio Galuppo; Silva, Vânia Lúcia da.
Título: Bacterial vaginosis: clinical, epidemiologic and microbiological features / Bacterial vaginosis: clinical, epidemiologic and microbiological features
Fonte: HU rev;36(3), jul.-set. 2010.
Idioma: pt.
Resumo: Bacterial Vaginosis (BV) is a polymicrobial clinical syndrome, whose etiology has not been fully understood. It occurs in approximately 30% of the women in childbearing age and is the result of the shift of protective resident microorganisms as Lactobacillus spp. by opportunistic pathogenic bacteria such as Gardnerella vaginalis. Patients with BV generally present copious, thin, homogeneous, milky, foul-smelling flow. Vaginal pH is > 4.5 and microscopy reveals bacteria-covered epithelial cells, termed “clue cells”. Around 50% of the patients are asymptomatic and the disease is associated with gynecologic complications, such as cervicitis, salpingitis, endometritis, post-operative infections and pelvic inflammatory disease; and obstetric complications, such as premature rupture of the membranes, preterm deliveries, chorioamniotitis and postpartum endometritis. Although the Nugent´s method is accepted as the “gold standard” for diagnosing BV, Amsel criteria are generally used for diagnosis in clinical practice. The Papanicolaou method is a valid diagnostic option, chiefly when it yields a positive result (mean specificity 95% when compared to gold standard). G. vaginalis has been almost universally recovered from women with BV, plays an important role in the pathogenesis of the disease, besides it may be detected in about 50% of healthy women. According to the literature, first-line drugs for BV treatment worldwide are metronidazole and clindamycin. However, regional studies on G. vaginalis drug susceptibility patterns are needed faced the so fast growing antimicrobial resistance phenomenon.
Descritores: Vaginose Bacteriana
-Gardnerella vaginalis
Vaginose Bacteriana/microbiologia
Lactobacillus
Metronidazol
Tipo de Publ: Relatos de Casos
Responsável: BR378.1 - Biblioteca Central


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Id: lil-567198
Autor: Zimmermmann, Juliana Barroso; Silva, Débora Gonçalves da; Pires, Thaís Guimarães; Silva, Mariana Pires de Sousa e; Reis, Larissa Lanna; Costa, Clayse Aparecida Luiza da.
Título: Tratamento da vaginose bacteriana com ácido ascórbico / Treatment of bacterial vaginosis with ascorbic acid
Fonte: HU rev;36(2), abr.-jun. 2010.
Idioma: pt.
Resumo: Os autores apresentam através de uma comunicação breve os resultados de um estudo onde se comparou o metronidazol com o ácido ascórbico para o tratamento da vaginose bacteriana. Verificou-se que o metronidazol deve ser a escolha para este tratamento, já que o ácido ascórbico, nas dosagens utilizadas, não se mostrou eficaz no tratamento da VB.

The authors present the results of a study comparing metronidazole with ascorbic acid for the treatment of bacterial vaginosis. It was found that metronidazole should be the choice for this treatment, since the ascorbicacid at the dosages used were not effective in the treatment of BV.
Descritores: Vaginose Bacteriana
-Ácido Ascórbico
Ácido Ascórbico/uso terapêutico
Vaginose Bacteriana/tratamento farmacológico
Metronidazol/uso terapêutico
Tipo de Publ: Relatos de Casos
Responsável: BR378.1 - Biblioteca Central


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Id: biblio-1046621
Autor: Mustafina, Gulgena Raisovna; Khismatullina, Zarema Rimovna.
Título: Modern aspects of rosacea therapy
Fonte: Prensa méd. argent;105(9 especial):576-581, oct 2019.
Idioma: en.
Resumo: This work is aimed at studying the problems of timely diagnostics and therapy of various forms of rosacea, identifying the factors that influence the compliance, prognosis, and quality of life of the patients, as well as the stages of combination therapy. The efficiency of rosacea therapy is determined by the timely identification of patients, as well as the clinical variety of the disease. Complex therapy of rosacea includes identification of the precipitating factors, basic skincare, and the use of systemic and local pathogenetic preparations. The "Gold Standard" of topical rosacea therapy is the antimicrobial and antiprotozoal drug called metronidazole. An important role in disease therapy is played by active cooperation between the doctor and the patient. Comprehensiveness, timeliness, and rationality of rosacea therapy are defined not only by the mechanisms of the disease development but also by aggravating factors, the need for basic care and photosensitivity of the patients
Descritores: Transtornos de Fotossensibilidade
Retinoides/uso terapêutico
Isotretinoína/uso terapêutico
Cooperação do Paciente
Tacrolimo/uso terapêutico
Rosácea/diagnóstico
Terapia Combinada
Metronidazol/uso terapêutico
Responsável: AR392.1 - Biblioteca


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Id: biblio-1019752
Autor: Souza, Nauã Rodrigues de; Lima, Maria Theresa Camilo de; Batista, Rayanne Paullyne da Silva; Santos, Aline Milany da Silva; Bushatsky, Magaly; Santos, Isabel Cristina Ramos Vieira.
Título: Prescrição e uso de metronidazol para controle do odor em feridas neoplásicas / Aspectos asociados a la prescripción y uso de metronidazol en el control del olor en heridas neoplásicas / Prescription and use of metronidazole for the control of odor in neoplastic wounds
Fonte: Cogitare enferm;24:e57906, 2019. tab, graf.
Idioma: pt.
Resumo: RESUMO Objetivo verificar os aspectos relacionados à prescrição, preparo e administração do metronidazol para controle do odor em feridas neoplásicas. Metodologia estudo transversal, com 80 profissionais de saúde de cinco hospitais referência em oncologia em Recife-PE, entre agosto e outubro de 2017. Foram analisadas as variáveis: caracterização profissional, critérios para prescrição, apresentação, diluição, aplicação, frequência e cuidados na aplicação. Calculou-se média e desvio padrão para as variáveis racionais discretas, e para categóricas dicotômicas, teste qui-quadrado com correção de Yates. Resultados os enfermeiros caracterizaram-se pelo pouco tempo de experiência (1-3 anos), menor frequência de especialização comparados aos médicos, porém maior frequência de atualização em cuidados paliativos. Quanto à prescrição e utilização do produto, observou-se prescrições alternativas e empíricas, com maceração de comprimidos 14 (53,8%) ou solução injetável em cinco (19,3%). Conclusão resultados evidenciam a escassa literatura sobre a temática e levantam a necessidade de construção de protocolos fundamentados em evidências científicas.

RESUMEN Objetivo verificar los aspectos asociados a la prescripción, preparación y administración del metronidazol para control del olor en heridas neoplásicas. Metodología estudio transversal, con 80 profesionales de salud de cinco hospitales referencia en oncología en Recife, PE, entre agosto y octubre de 2017. Se analizaron las variables: caracterización profesional, criterios para prescripción, presentación, dilución, aplicación, frecuencia y cuidados en la aplicación. Se calcularon el promedio y la desviación típica para las variables racionales discretas, y para categóricas dicotómicas, test chi cuadrado con corrección de Yates. Resultados los enfermeros se caracterizaron por el poco tiempo de experiencia (1-3 años), menor frecuencia de especialización en comparación con los médicos, pero con más frecuencia de actualización en cuidados paliativos. Acerca de la prescripción y uso del producto, se observaron prescripciones alternativas y empíricas, con maceración de pastillas 14 (53,8%) o solución inyectable en cinco (19,3%). Conclusión resultados evidencian la escasa literatura sobre la temática y apuntan a la necesidad de construcción de protocolos basados en evidencias científicas.

ABSTRACT Objective To check aspects related to the prescription, preparation and administration of metronidazole for the control of odor in neoplastic wounds. Methodology Cross-sectional study with 80 health professionals from five reference hospitals in oncology in Recife-PE, between August and October 2017. The following variables were analyzed: professional characterization, criteria for prescription, presentation, dilution, application, frequency and care in the application. Mean and standard deviation were calculated for obtaining the discrete rational variables, and chi-square test with Yates correction was used for dichotomous categorical variables. Results The nurses had little professional experience (1-3 years), less specialization compared to physicians, but had greater expertise in palliative care. Regarding the prescription and use of the product, 14 (53.8%) professionals used alternative and empirical prescriptions, with maceration of tablets, and five (19.3%) used injectable solution. Conclusion According to the results obtained, there are few studies on the subject and protocols based on scientific evidence should be constructed.
Descritores: Enfermagem Oncológica
Ferimentos e Lesões
Metronidazol
-Anti-Infecciosos
Odorantes
Limites: Humanos
Responsável: BR501.1 - Biblioteca de Ciências da Saúde / Sede Botânico


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Id: biblio-1017309
Autor: Agoff, Laura Beatríz.
Título: La terapia cuádruple con bismuto durante diez días es la alterna-tiva más eficaz para erradicar el Helicobacter pylori / Quadruple therapy with bismuth for ten days is the most effective alternative to eradicate Helicobacter pylori
Fonte: Evid. actual. práct. ambul;21(1):32-32, 2018. tab..
Idioma: es.
Descritores: Compostos Organometálicos/administração & dosagem
Esquema de Medicação
Helicobacter pylori/efeitos dos fármacos
Infecções por Helicobacter/tratamento farmacológico
Quimioterapia Combinada/estatística & dados numéricos
Antiácidos/administração & dosagem
-Compostos Organometálicos/uso terapêutico
Tetraciclina/administração & dosagem
Tetraciclina/uso terapêutico
Ureia/metabolismo
Testes Respiratórios
Ensaios Clínicos Controlados Aleatórios como Assunto
Estudos Multicêntricos como Assunto
Claritromicina/administração & dosagem
Claritromicina/uso terapêutico
Inibidores da Bomba de Prótons/administração & dosagem
Inibidores da Bomba de Prótons/uso terapêutico
Lansoprazol/administração & dosagem
Lansoprazol/uso terapêutico
Amoxicilina/administração & dosagem
Amoxicilina/uso terapêutico
Antiácidos/uso terapêutico
Metronidazol/administração & dosagem
Metronidazol/uso terapêutico
Antibacterianos/administração & dosagem
Antibacterianos/uso terapêutico
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Adulto Jovem
Tipo de Publ: Comentário
Responsável: AR2.1 - Biblioteca Central


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Texto completo SciELO Brasil
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Id: biblio-839477
Autor: Melo, Elayne Karine Souto de; Araujo, Thalita Pedon de; Silva, José Wellithom Viturino da; Chagas, Stephanye Carolyne Christino; Bedor, Danilo César Galindo; Santana, Davi Pereira de; Leal, Leila Bastos.
Título: Metronidazole thermogel improves retention and decreases permeation through the skin
Fonte: Braz. J. Pharm. Sci. (Online);53(2):e16130, 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Metronidazole (MTZ) is widely used as the standard antibiotic for the treatment of rosacea and, more recently, is being used off label in Brazilian hospitals for the treatment of wounds. Following oral administration, minimal amounts of active agent reaches the skin and side effects are strongly induced. Consequently, MTZ is currently being applied topically in order to improve the therapeutic efficacy with reduced side effects, with Rozex(r) (RZ) (an MTZ gelled formulation) being the only marketed product. This study examined whether the use of MTZ 0.75% from thermogel formulations could improve drug retention and reduce dermal exposure compared to that by Rozex(r). Following a 21 h permeation study, the highest total amount of MTZ permeated through the rat healthy and disturbed skin was seen with Rozex(r), but similar to all formulations regardless of the skin condition. On the other hand, the amount retained in the epidermis/dermis was larger for thermogel formulations; at least 4 fold that of Rozex(r), when the stratum corneum was present as a barrier. In conclusion, thermogel formulations can be favorable alternatives to Rozex(r) for the topical application of MTZ with improved efficacy and reduced side effects.
Descritores: Pele/diagnóstico por imagem
Termogênese
Metronidazol/análise
-Anormalidades da Pele/complicações
Rosácea/prevenção & controle
Poloxâmero/farmacologia
Dermatologia/classificação
Limites: Animais
Ratos
Tipo de Publ: Técnicas In Vitro
Responsável: BR1.1 - BIREME


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Id: biblio-839437
Autor: Nohemann, Laís; Almeida, Marina Penteado de; Ferrari, Priscileila Colerato.
Título: Floating ability and drug release evaluation of gastroretentive microparticles system containing metronidazole obtained by spray drying
Fonte: Braz. J. Pharm. Sci. (Online);53(1):e15218, 2017. tab, graf.
Idioma: en.
Resumo: Abstract Gastroretentive floating microparticles were developed and evaluated for the controlled metronidazole delivery for treatment of gastric disease. Floating microparticles, varying in proportions of chitosan and hydroxypropyl methylcellulose or ethylcellulose, were obtained by spray drying. Floating microparticles were characterized by physicochemical and in vitro studies, according to their floating ability and drug delivery. Microparticles presented mean diameter from 1.05 to 2.20 µm. The infrared spectroscopy confirmed the drug encapsulation and showed no chemical linkage between microparticles components. X-ray diffraction showed changes in the drug`s solid state, from crystalline to amorphous, indicating partial drug encapsulation, due to the presence of some crystalline peaks of metronidazole in microparticles. All microparticles floated immediately in contact of simulated gastric fluid and both floating and drug release profiles were dependent of microparticles composition. Microparticles samples constituted by chitosan and hydroxypropyl methylcellulose revealed the best relationship between floating duration and drug release, remaining floating during the occurrence of the drug release, ideal condition for the floating gastroretentive systems.
Descritores: Trituração
Liberação Controlada de Fármacos
Metronidazol/administração & dosagem
-Quitosana/farmacocinética
Derivados da Hipromelose
Responsável: BR1.1 - BIREME



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