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Id: biblio-869083
Autor: Ferreira Coronel, Maria; Dos Santos Dias, Luciana; Melo Rodovalho, Cynara de; Pereira Lima, José Bento; Gonzalez Britez, Nilza.
Título: Perfil de susceptibilidad a temefos en poblaciones de aedes aegypti (diptera: culicidae) de ciudad del este - alto Paraná, Paraguay / Aedes aegypti (díptera-culicidae) susceptibility to temephos in ciudad del este, alto Paraná, Paraguay
Fonte: Mem. Inst. Invest. Cienc. Salud (Impr.);14(2):98-105, ago. 2016. ilus, tab.
Idioma: es.
Resumo: En Paraguay, el control del mosquito Aedes aegypti involucrado en la transmisión de varias arbovirosis implica la utilización del Temefos, un organofosforado que ha sido utilizado por los programas nacionales para el control vectorial por más de dos décadas en busca de la reducción de los estadios larvarios. En vista de la necesidad de evaluar periódicamente la actividad larvicida del compuesto químico mencionado, este estudio tuvo como objetivo monitorear el perfil de susceptibilidad de larvas de Ae. aegypti al Temefos. Para ello se aplicó un estudio analítico experimental con ensayos biológicos tipo dosis - respuesta, utilizando larvas del tercer estadio de la primera generación procedentes de una colonia de mosquitos colectada en Ciudad del Este. Las larvas fueron expuestas a la acción del Temefos a diferentes concentraciones definidas por un pre- test. Se registraron valores correspondientes al número de larvas expuestas y mortalidad al término de cada ensayo. Los resultados fueron concentración letal CL50 = 0,00966 mg/L y CL90 = 0,03015mg/L, a partir de estos valores se obtuvieron los indicadores cuantitativos de resistencia, Razón de resistencia RR50 = 2,3734 y RR90 = 4,1643 respectivamente. Este último es un indicativo de resistencia baja en las poblaciones de Ae. aegypti evaluadas, acorde con rangos estandarizados (RR>3<5). Los resultados observados en las poblaciones silvestres de larvas revelan una situación de alerta, considerando que el presente estudio evidenció un proceso de resistencia incipiente al Temefos. Finalmente, basados en los resultados se recomienda plantear y ejecutar estrategias basadas en acciones que permitan preservar la actividad larvicida de este compuesto, evitando el aumento progresivo de resistencia en las poblaciones silvestres.

In Paraguay, the control of Aedes aegypti mosquitoes, involved in the transmission of several arboviruses, implies the use of temephos, an organophosphate that has been used by national vector control programs for more than two decades in search of reducing larval stages. In view of the need to evaluate periodically the larvicidal activity of this chemical compound, this study aimed to monitor the susceptibility profile to temephos of larval stages of Ae. aegypti. For this, an experimental analytical study with bioassays dose rate –response was applied, using third instar larva e of the first generation from a mosquitoescolony collected in Ciudad del Este. The larvae were exposed to different concentrations ranges of themephos that were defined by a pre-test. The number of larva e exposed and mortality at the end of each trial were recorded. The results determined the LC50 =0.00966 mg/L and LC90 = 0.03015 mg/L, from which quantitative indicators of resistance were obtained, resistance ratio RR = 2.3734 and 4.1643 respectively. The latter valueindicates characteristics related to low resistance in populations of Ae. aegypti evaluateda ccording to standardized ranges (RR> 3 <5). The results observed in larval wild populations indicate an alert situation, considering that our study showed an incipient process of resistance to temephos. Finally, based on these results, proposing and implementing strategies based in actions that allow to preserve the larvicidal activity of this compound are recommended to avoiding the progressive increase of resistance in wild populations.
Descritores: Controle de Mosquitos
Controle de Vetores
Temefós/efeitos da radiação
-Saúde Pública
Limites: Humanos
Responsável: PY3.1 - Biblioteca


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Valle, Denise
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Id: biblio-1002687
Autor: Valle, Denise; Bellinato, Diogo Fernandes; Viana-Medeiros, Priscila Fernandes; Lima, José Bento Pereira; Martins Junior, Ademir de Jesus.
Título: Resistance to temephos and deltamethrin in Aedes aegypti from Brazil between 1985 and 2017
Fonte: Mem. Inst. Oswaldo Cruz;114:e180544, 2019. graf.
Idioma: en.
Resumo: BACKGROUND Aedes aegypti populations in Brazil have been subjected to insecticide selection pressures with variable levels and sources since 1967. Therefore, the Brazilian Ministry of Health (MoH) coordinated the activities of an Ae. aegypti insecticide resistance monitoring network (MoReNAa) from 1999 to 2012. OBJECTIVES The objective of this study was to consolidate all information available from between 1985 and 2017 regarding the resistance status and mechanisms of Brazilian Ae. aegypti populations against the main insecticide compounds used at the national level, including the larvicide temephos (an organophosphate) and the adulticide deltamethrin (a pyrethroid). METHODS Data were gathered from two sources: a bibliographic review of studies published from 1985 to 2017, and unpublished data produced by our team within the MoReNAa between 1998 and 2012. A total of 146 municipalities were included, many of which were evaluated several times, totalling 457 evaluations for temephos and 274 for deltamethrin. Insecticide resistance data from the five Brazilian regions were examined separately using annual records of both the MoH supply of insecticides to each state and the dengue incidence in each evaluated municipality. FINDINGS Ae. aegypti resistance to temephos and deltamethrin, the main larvicide and adulticide, respectively, employed against mosquitoes in Brazil for a long time, was found to be widespread in the country, although with some regional variations. Comparisons between metabolic and target-site resistance mechanisms showed that one or another of these was the main component of pesticide resistance in each studied population. MAIN CONCLUSIONS (i) A robust dataset on the assessments of the insecticide resistance of Brazilian Ae. aegypti populations performed since 1985 was made available through our study. (ii) Our findings call into question the efficacy of chemical control as the sole methodology of vector control. (iii) It is necessary to ensure that sustainable insecticide resistance monitoring is maintained as a key component of integrated vector management. (iv) Consideration of additional parameters, beyond the supply of insecticides distributed by the MoH or the diverse local dynamics of dengue incidence, is necessary to find consistent correlations with heterogeneous vector resistance profiles.
Descritores: Resistência a Inseticidas/imunologia
Temefós/análise
Aedes
Controle de Vetores
-Brasil/epidemiologia
Limites: Humanos
Responsável: BR1.1 - BIREME


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Texto completo
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Id: lil-784141
Autor: Calderón-Arguedas, Ólger; Troyo, Adriana.
Título: Evaluación de la resistencia a insecticidas en cepas de Aedes aegypti (Diptera: Culicidae) de la Región Caribe de Costa Rica / Evaluation of insecticide resistance in strains of Aedes aegypti (Diptera: Culicidae) from the Caribbean region of Costa Rica
Fonte: Rev. cuba. med. trop;68(1):0-0, abr. 2016. tab.
Idioma: es.
Resumo: Introducción: el dengue y chikungunya son virosis antroponóticas transmitidas por Aedes aegypti que afectan extensas áreas del continente americano incluyendo Costa Rica. La reciente introducción del virus Zika representa un nuevo reto para los sistemas de salud. Dada la ausencia de tratamiento antiviral y vacunas, el control del vector Ae. aegypti, representa la única alternativa para minimizar el impacto de estas virosis. En Costa Rica, el control químico del vector se hace mediante la aplicación de piretroides (cipermetrina y deltametrina) y del organofosforado temefós; de ahí la importancia de detectar la aparición de resistencia a estos insecticidas. Objetivo: determinar el nivel de resistencia a temefós, cipermetrina y deltametrina en tres cepas de Ae. aegypti de la Región Caribe de Costa Rica, así como los mecanismos de detoxificación enzimática correspondientes. Métodos: la resistencia a temefós, cipermetrina y deltametrina se evaluó mediante bioensayos larvarios. Grupos de 20 larvas se expusieron por 24 h a 5 concentraciones de insecticidas que generaron una mortalidad entre el 2 y el 100 por ciento. Cada concentración se evaluó mediante cinco réplicas y se calculó la concentración que causa el 50 por ciento de letalidad (CL50). Como control susceptible se empleó la cepa Rockefeller. Con cada cepa se calculó un factor de resistencia 50 por ciento (FR50) para cada insecticida. Cuando se observó resistencia, se repitieron los bioensayos mediante exposición previa de las larvas a butóxido de piperonilo (PB) y S,S,S, tributilfosforotritioato (DEF) para evaluar el mecanismo detoxificante relacionado. Resultados: ninguna de las cepas evaluadas fue resistente al temefós. En las cepas Guápiles y Limón se determinó una resistencia incipiente a cipermetrina (CL50= 0,01022, FR50= 7,35 y CL 50= 0,01016, FR50= 7,30, respectivamente), mientras que en la cepa Siquirres se detectó resistencia a deltametrina (CL50= 0,01973 mg/L, FR5= 12,64). En los casos referidos hubo una disminución de la resistencia cuando se dio el pretratamiento con PB, lo que indica una detoxificación mediada por el sistema Cit P450 monooxigenasa. Conclusiones: los resultados en el presente estudio demuestran que el temefós sigue siendo efectivo para el control larvario de Ae. aegypti en las principales localidades de la región Caribe de Costa Rica. Con respecto a los piretroides se alerta ante la aparición de resistencia, lo que conlleva la necesidad de optimizar los procesos de monitoreo y la implementación de otras alternativas de control químico(AU)

Introduction: dengue and chikungunya are anthroponotic virus infections transmitted by Aedes aegypti mosquitoes. These conditions affect large areas of the American continent, including Costa Rica. The recent introduction of Zika virus infection is a new challenge for health systems. Given the absence of antiviral treatment and vaccines, Aedes aegypti control is the only alternative to minimize the impact of these viral diseases. In Costa Rica chemical control of the vector is based on the use of pyrethroids (cypermethrin and deltamethrin) and the organophosphate larvicide temephos, hence the importance of detecting the emergence of resistance to these insecticides. Objective: determine the level of resistance to temephos, cypermethrin and deltamethrin in three Aedes aegypti strains from the Caribbean region of Costa Rica, as well as the corresponding enzymatic detoxification mechanisms. Methods: resistance to temephos, cypermethrin and deltamethrin was evaluated with larval bioassays. Groups of 20 larvae were exposed to 5 insecticide concentrations for 24 h. Mortality ranged between 2 and 100 percent. Each concentration was evaluated by means of five replications, and estimation was performed of the concentration causing 50 percent lethality (CL50). The Rockefeller strain was used as susceptible control. Each strain underwent estimation of a 50 percent resistance factor (RF50) for each insecticide. Whenever resistance was observed, the bioaasays were repeated with prior exposure of the larvae to piperonyl butoxide (PBO) and S.S.S. phosphotrithiate tributyl (DEF) to evaluate the corresponding detoxification mechanism. Results: none of the strains evaluated was resistant to temephos. Incipient resistance to cypermethrin was detected in strains Guápiles and Limón (CL50= 0.01022, RF50= 7.35 and CL 50= 0.01016, RF50= 7.30, respectively), whereas resistance to deltamethrin was detected in the Siquirres strain (CL50= 0.01973 mg/L, RF50= 12.64). In the above-mentioned cases resistance decreased when pre-treatment with PBO was provided, indicating the presence of detoxification mediated by the Cyt P450 monooxygenase system. Conclusions: results show that temephos continues to be effective for larval control of Aedes aegypti in the main areas of the Caribbean region of Costa Rica. A warning is hereby given about the emergence of pyrethroid resistance, leading to the need to optimize monitoring processes and the implementation of other chemical control alternatives(AU)
Descritores: Bioensaio/métodos
Resistência a Inseticidas
Aedes
-Temefós/uso terapêutico
Controle de Vetores
Limites: Animais
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-844984
Autor: Galavíz-Parada, Juan D; Vega-Villasante, Fernando; Cupul-Magaña, Fabio G; Navarrete-Heredia, José L; Ruiz González, Luis E; Vargas-Ceballos, Manuel A; Chong-Carrillo, Olimpia.
Título: Control químico y biológico de larvas de Aedes aegypti en la costa norte de Jalisco, México / Chemical and biological control on Aedes aegypti larvae in the northern coastal region of Jalisco, Mexico
Fonte: Rev. cuba. med. trop;68(2):111-124, may.-ago. 2016. tab.
Idioma: es.
Resumo: Introducción: el aumento de enfermedades transmitidas por mosquitos se ha asociado a cambios globales: el crecimiento de la población, la urbanización y el cambio climático. Dentro de las alternativas para evitar epidemias están el control químico y biológico. Objetivos: determinar las concentraciones efectivas de tres compuestos químicos para el control de larvas de Aedes aegypti en la región costa norte de Jalisco, México, y evaluar la capacidad predatoria de diversas especies acuáticas sobre larvas de mosquitos. Métodos: se evaluaron cinco concentraciones de temefos (1,5; 1; 0,1; 0,05 y 0,01 g/L), hipoclorito de sodio (5,5; 0,55; 0,05; 0,005 y 0,0005 g/L) y detergente (10; 5; 1; 0,5; 0,1 g/L). Se determinó la muerte de las larvas a 1, 3, 6 y 24 h y se calculó la CL50. Se evaluaron cuatro especies de peces, un crustáceo y una larva de díptero culícido. Se les suministraron diferentes cantidades de larvas (5, 10, 30, 50 y 80) por quintuplicado y se registró su consumo a diferentes tiempos (1, 3, 5, 9 y 24 h). Resultados: el temefos provocó el 100 por ciento de mortalidad en todas las concentraciones probadas. El NaClO provocó mortalidad del 100 por ciento en las dos concentraciones más altas. El detergente fue más eficiente a las tres concentraciones mayores. Los peces demostraron un consumo de casi el 100 por ciento en la mayoría de las densidades probadas. La larva de díptero culícido demostró un consumo cercano al 80 por ciento, el crustáceo solo consumió el 53 por ciento Conclusiones: el uso del temefos debe continuar siendo el larvicida químico de elección en Puerto Vallarta, México. La utilización de peces nativos se sugiere como adecuada para el control biológico(AU)

Introduction: the increase of diseases transmitted by mosquitoes has been associated to global changes such as the population growth, urbanization and climate change. Among the alternatives to avoid epidemics are the chemical and biological control. Objectives: to determine effective concentrations of three chemical compounds to control Aedes aegypti larvae in the northern coastal region of Jalisco and to evaluate the predatory ability of various aquatic species on mosquito larvae. Methods: five concentrations of temephos of (1.5, 1, 0.1; 0.05 and 0.01 g/L), sodium hypochlorite (5.5, 0.55, 0.05, 0,005 and 0.0005 g/L) and detergent (10, 5, 1, 0.5, 0.1 g/L) were evaluated. Larval death was estimated at different times (1, 3, 5, 9 and 24 h) and the LC50 was calculated. Four fish species, one crustacean and one dipteral culicid larva were evaluated. All were provided with different numbers of larvae (5, 10, 30, 50 and 80) five times and the larval consumption was recorded at different times (1, 3, 5, 9 and 24 h). Results: temephos caused 100 percent mortality of larvae in all tested concentrations. The NaClO caused 100 percent mortality at the two highest concentrations. The detergent was more efficient at the three higher concentrations. Fish proved to be efficient predators of larvae, as they consumed almost 100 percent of larvae in most of tested densities. The diptera culicid larva reached around 80 percent consumption whereas crustacean consumed only 53 percent. Conclusions: the use of temephos should remain the chemical larvicide of choice in Puerto Vallarta region. Native fish are suggested to be used as appropriate biological control agents(AU)
Descritores: Temefós
Controle Biológico de Vetores/métodos
Aedes
Larva
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: lil-787552
Autor: Araujo, Adriana Faraco de Oliveira; Ribeiro-Paes, João Tadeu; Deus, Juliana Telles de; Cavalcanti, Sócrates Cabral de Holanda; Nunes, Rogéria de Souza; Alves, Péricles Barreto; Macoris, Maria de Lourdes da Graça.
Título: Larvicidal activity of Syzygium aromaticum (L) Merr and Citrus sinensis (L) Osbeck essential oils and their antagonistic effects with temephos in resistant populations of Aedes aegypti
Fonte: Mem. Inst. Oswaldo Cruz;111(7):443-449tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: Environmentally friendly botanical larvicides are commonly considered as an alternative to synthetic larvicides against Aedes aegypti Linn. In addition, mosquito resistance to currently used larvicides has motivated research to find new compounds acting via different mechanisms of action, with the goal of controlling the spread of mosquitos. Essential oils have been widely studied for this purpose. This work aims to evaluate the larvicidal potential of Syzygium aromaticum and Citrus sinensis essential oils, either alone or in combination with temephos, on Ae. aegypti populations having different levels of organophosphate resistance. The 50% lethal concentration (LC50) of the essential oils alone and in combination with temephos and the influence of essential oils on vector oviposition were evaluated. The results revealed that essential oils exhibited similar larvicidal activity in resistant populations and susceptible populations. However, S. aromaticum and C. sinensis essential oils in combination with temephos did not decrease resistance profiles. The presence of the evaluated essential oils in oviposition sites significantly decreased the number of eggs compared to sites with tap water. Therefore, the evaluated essential oils are suitable for use in mosquito resistance management, whereas their combinations with temephos are not recommended. Additionally, repellency should be considered during formulation development to avoid mosquito deterrence.
Descritores: Aedes
Citrus sinensis/química
Inseticidas
Óleos Voláteis
Syzygium/química
Temefós
-Combinação de Medicamentos
Resistência a Inseticidas/efeitos dos fármacos
Larva/efeitos dos fármacos
Controle de Mosquitos/métodos
Oviposição/efeitos dos fármacos
Reprodutibilidade dos Testes
Fatores de Tempo
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: lil-782049
Autor: Chediak, Mateus; G Pimenta Jr, Fabiano; Coelho, Giovanini E; Braga, Ima A; Lima, José Bento P; Cavalcante, Karina Ribeiro LJ; Sousa, Lindemberg C de; Melo-Santos, Maria Alice V de; Macoris, Maria de Lourdes da G; Araújo, Ana Paula de; Ayres, Constância Flávia J; Andrighetti, Maria Teresa M; Gomes, Ricristhi Gonçalves de A; Campos, Kauara B; Guedes, Raul Narciso C.
Título: Spatial and temporal country-wide survey of temephos resistance in Brazilian populations of Aedes aegypti
Fonte: Mem. Inst. Oswaldo Cruz;111(5):311-321, May 2016. tab, graf.
Idioma: en.
Resumo: The organophosphate temephos has been the main insecticide used against larvae of the dengue and yellow fever mosquito (Aedes aegypti) in Brazil since the mid-1980s. Reports of resistance date back to 1995; however, no systematic reports of widespread temephos resistance have occurred to date. As resistance investigation is paramount for strategic decision-making by health officials, our objective here was to investigate the spatial and temporal spread of temephos resistance in Ae. aegypti in Brazil for the last 12 years using discriminating temephos concentrations and the bioassay protocols of the World Health Organization. The mortality results obtained were subjected to spatial analysis for distance interpolation using semi-variance models to generate maps that depict the spread of temephos resistance in Brazil since 1999. The problem has been expanding. Since 2002-2003, approximately half the country has exhibited mosquito populations resistant to temephos. The frequency of temephos resistance and, likely, control failures, which start when the insecticide mortality level drops below 80%, has increased even further since 2004. Few parts of Brazil are able to achieve the target 80% efficacy threshold by 2010/2011, resulting in a significant risk of control failure by temephos in most of the country. The widespread resistance to temephos in Brazilian Ae. aegypti populations greatly compromise effective mosquito control efforts using this insecticide and indicates the urgent need to identify alternative insecticides aided by the preventive elimination of potential mosquito breeding sites.
Descritores: Aedes/efeitos dos fármacos
Insetos Vetores/efeitos dos fármacos
Resistência a Inseticidas
Inseticidas/farmacologia
Temefós/farmacologia
-Bioensaio
Brasil
Larva/efeitos dos fármacos
Análise Espaço-Temporal
Limites: Animais
Responsável: BR1.1 - BIREME


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Alves, Stenio Nunes
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Id: lil-770119
Autor: MELO, Aline Rocha DE; CASTRO, Débora Silva Borges de; ALVES, Stênio Nunes.
Título: RESPONSE OF Culex quinquefasciatus LARVAE TO THREE INSECTICIDES
Fonte: Rev. Inst. Med. Trop. Säo Paulo;57(6):540-540, Nov.-Dec. 2015. tab.
Idioma: en.
Descritores: Culex/efeitos dos fármacos
Inseticidas
Ivermectina
Piretrinas
Temefós
-Larva/efeitos dos fármacos
LETHAL DOSE ACADEMIES AND INSTITUTES
Limites: Animais
Tipo de Publ: Carta
Responsável: BR1.1 - BIREME


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Id: lil-728904
Autor: Pereira, Boscolli Barbosa; Limongi, Jean Ezequiel; Campos Júnior, Edimar Olegário de; Luiz, Denis Prudencio; Kerr, Warwick Estevam.
Título: Effects of piperonyl butoxide on the toxicity of the organophosphate temephos and the role of esterases in the insecticide resistance of Aedes aegypti
Fonte: Rev. Soc. Bras. Med. Trop;47(5):579-582, Sep-Oct/2014. tab.
Idioma: en.
Resumo: Introduction The effects of piperonyl butoxide (PBO) on the toxicity of the organophosphate temephos (TE) and the role of esterases in the resistance of Aedes aegypti to this insecticide were evaluated. Methods A. aegypti L4 larvae susceptible and resistant to TE were pre-treated with PBO solutions in acetone at concentrations of 0.125, 0.25, 0.5, 1, and 2% for 24h and subsequently exposed to a diagnostic concentration of 0.02mg/L aqueous TE solution. The esterase activity of the larvae extracts pre-treated with varying PBO concentrations and exposed to TE for three time periods was determined. Results At concentrations of 0.25, 0.5, 1, and 2%, PBO showed a significant synergistic effect with TE toxicity. High levels of esterase activity were associated with the survival of A. aegypti L4 larvae exposed to TE only. Conclusions The results of the biochemical assays suggest that PBO has a significant inhibitory effect on the total esterase activity in A. aegypti larvae. .
Descritores: Aedes/efeitos dos fármacos
Aedes/enzimologia
Esterases/fisiologia
Resistência a Inseticidas
Sinergistas de Praguicidas/farmacologia
Butóxido de Piperonila/farmacologia
Temefós/toxicidade
-Larva/efeitos dos fármacos
Organofosfatos
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: lil-728807
Autor: Lima, Estelita Pereira; Goulart, Marília Oliveira Fonseca; Rolim Neto, Modesto Leite.
Título: Evaluation of the role of ATP-binding cassette transporters as a defence mechanism against temephos in populations of Aedes aegypti
Fonte: Mem. Inst. Oswaldo Cruz;109(7):964-966, 11/2014. tab.
Idioma: en.
Resumo: The role of ATP-binding cassette (ABC) transporters in the efflux of the insecticide, temephos, was assessed in the larvae of Aedes aegypti. Bioassays were conducted using mosquito populations that were either susceptible or resistant to temephos by exposure to insecticide alone or in combination with sublethal doses of the ABC transporter inhibitor, verapamil (30, 35 and 40 μM). The best result in the series was obtained with the addition of verapamil (40 μM), which led to a 2x increase in the toxicity of temephos, suggesting that ABC transporters may be partially involved in conferring resistance to the populations evaluated.
Descritores: Transportadores de Cassetes de Ligação de ATP/fisiologia
Aedes/efeitos dos fármacos
Resistência a Inseticidas
Insetos Vetores/efeitos dos fármacos
Inseticidas/farmacologia
Temefós/farmacologia
-Transportadores de Cassetes de Ligação de ATP/efeitos dos fármacos
Aedes/metabolismo
Bloqueadores dos Canais de Cálcio/farmacocinética
Bloqueadores dos Canais de Cálcio/farmacologia
Insetos Vetores/metabolismo
Resistência a Inseticidas/efeitos dos fármacos
Inseticidas/farmacocinética
Larva/efeitos dos fármacos
Larva/metabolismo
LETHAL DOSE ACADEMIES AND INSTITUTES
Temefós/farmacocinética
Verapamil/farmacocinética
Verapamil/farmacologia
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: lil-727253
Autor: Diniz, Morgana Michele Cavalcanti de Souza Leal; Henriques, Alleksandra Dias da Silva; Leandro, Renata da Silva; Aguiar, Dalvanice Leal; Beserra, Eduardo Barbosa.
Título: Resistance of Aedes aegypti to temephos and adaptive disadvantages / Resistência de Aedes aegypti ao temefós e desvantagens adaptativas
Fonte: Rev. saúde pública = J. public health;48(5):775-782, 10/2014. tab, graf.
Idioma: en.
Resumo: OBJECTIVE To evaluate the resistance of Aedes aegypti to temephos Fersol 1G (temephos 1% w/w) associated with the adaptive disadvantage of insect populations in the absence of selection pressure. METHODS A diagnostic dose of 0.28 mg a.i./L and doses between 0.28 mg a.i./L and 1.40 mg a.i./L were used. Vector populations collected between 2007 and 2008 in the city of Campina Grande, state of Paraíba, were evaluated. To evaluate competition in the absence of selection pressure, insect populations with initial frequencies of 20.0%, 40.0%, 60.0%, and 80.0% resistant individuals were produced and subjected to the diagnostic dose for two months. Evaluation of the development of aquatic and adult stages allowed comparison of the life cycles in susceptible and resistant populations and construction of fertility life tables. RESULTS No mortality was observed in Ae. aegypti populations subjected to the diagnostic dose of 0.28 mg a.i./L. The decreased mortality observed in populations containing 20.0%, 40.0%, 60.0%, and 80.0% resistant insects indicates that temephos resistance is unstable in the absence of selection pressure. A comparison of the life cycles indicated differences in the duration and viability of the larval phase, but no differences were observed in embryo development, sex ratio, adult longevity, and number of eggs per female. CONCLUSIONS The fertility life table results indicated that some populations had reproductive disadvantages compared with the susceptible population in the absence of selection pressure, indicating the presence of a fitness cost in populations resistant to temephos. .

OBJETIVO Avaliar a resistência de Aedes aegypti ao temefós Fersol 1G (temefós 1% p/p) quanto à desvantagem adaptativa ao inseto, na ausência de pressão de seleção. MÉTODOS Foi aplicada a dose diagnóstica de 0,28 mg i.a/L e concentrações entre 0,28 mg i.a/L e 1,4 mg i.a/L. Foram avaliadas amostras do vetor coletadas no município de Campina Grande entre 2007 e 2008, no estado da Paraíba. Para avaliar a competição na ausência de pressão de seleção, foram constituídos grupos de insetos com frequências iniciais de 20,0%, 40,0%, 60,0% e 80,0% de insetos resistentes, submetendo-os a dose diagnóstica por dois meses. Os ciclos de vida das populações suscetível e resistentes foram comparados avaliando-se as fases de desenvolvimento aquática e adulta, construindo-se tabelas de vida de fertilidade. RESULTADOS Não foram verificadas mortalidades nas populações de Ae. aegypti quando submetidas à dose diagnóstica de 0,28 mg i.a./L. A diminuição da mortalidade nas populações com 20,0%, 40,0%, 60,0% e 80,0% de indivíduos resistentes indica que a resistência ao temefós é instável na ausência de pressão de seleção. A comparação do ciclo de vida mostrou diferenças na duração da fase e viabilidade larval, mas não quanto ao desenvolvimento embrionário, razão sexual, longevidade dos adultos e número de ovos/fêmea. CONCLUSÕES Pelos parâmetros da tabela de vida de fertilidade constatou-se que algumas populações apresentaram desvantagens reprodutivas em relação à população suscetível na ausência de pressão de seleção, havendo custo adaptativo resultante da resistência ao temefós. .
Descritores: Aedes
Resistência a Inseticidas
Temefós
-Aedes/crescimento & desenvolvimento
Brasil
Dengue/prevenção & controle
Insetos Vetores/crescimento & desenvolvimento
Controle de Mosquitos/métodos
Limites: Animais
Feminino
Masculino
Responsável: BR1.1 - BIREME



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