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Id: biblio-1090060
Autor: Rodrigues, Matheus Scarpatto; Pieri, Bruno Luiz da Silva; Silveira, Gustavo de Bem; Zaccaron, Rubya Pereira; Venturini, Ligia Milanez; Comin, Vitor Hugo; Luiz, Karine Damian; Silveira, Paulo Cesar Lock.
Título: Reduction of oxidative stress improves insulin signaling in cardiac tissue of obese mice / Redução do estresse oxidativo melhora a sinalização da insulina em tecido cardíaco de camundongos obesos
Fonte: Einstein (Säo Paulo);18:eAO5022, 2020. graf.
Idioma: en.
Resumo: ABSTRACT Objective To evaluate the effects of oxidative stress on insulin signaling in cardiac tissue of obese mice. Methods Thirty Swiss mice were equally divided (n=10) into three groups: Control Group, Obese Group, and Obese Group Treated with N-acetylcysteine. After obesity and insulin resistance were established, the obese mice were treated with N-acetylcysteine at a dose of 50mg/kg daily for 15 days via oral gavage. Results Higher blood glucose levels and nitrite and carbonyl contents, and lower protein levels of glutathione peroxidase and phosphorylated protein kinase B were observed in the obese group when compared with their respective control. On the other hand, treatment with N-acetylcysteine was effective in reducing blood glucose levels and nitrite and carbonyl contents, and significantly increased protein levels of glutathione peroxidase and phosphorylated protein kinase B compared to the Obese Group. Conclusion Obesity and/or a high-lipid diet may result in oxidative stress and insulin resistance in the heart tissue of obese mice, and the use of N-acetylcysteine as a methodological and therapeutic strategy suggested there is a relation between them.

RESUMO Objetivo Avaliar os efeitos do estresse oxidativo sobre a sinalização da insulina em tecido cardíaco de camundongos obesos. Métodos Utilizaram-se 30 camundongos Swiss subdivididos igualmente (n=10) em três grupos: Grupo Controle, Grupo Obeso e Grupo Obeso Tratado com N-acetilcisteína. Após estabelecidas a obesidade e a resistência à insulina, os camundongos obesos foram tratados diariamente, durante 15 dias, via gavagem oral, com N-acetilcisteína na dose de 50mg/kg. Resultados Observaram-se maiores níveis de glicose sanguínea, conteúdos de nitrito e carbonil, e menores níveis proteicos de glutationa peroxidase e proteína quinase B fosforilada no Grupo Obeso quando comparado a seu respectivo controle. Por outro lado, o tratamento com N-acetilcisteína se mostrou eficiente em diminuir os níveis glicêmicos, os conteúdos de nitrito e carbonil, e aumentar significativamente os níveis proteicos de glutationa peroxidase e proteína quinase B fosforilada, quando comparados ao Grupo Obeso. Conclusão Obesidade e/ou dieta hiperlipídica levam a estresse oxidativo e à resistência à insulina no tecido cardíaco de camundongos obesos, e o uso da N-acetilcisteína como estratégia metodológica e terapêutica sugeriu haver relação entre ambos.
Descritores: Acetilcisteína/farmacologia
Resistência à Insulina/fisiologia
Sequestradores de Radicais Livres/farmacologia
Estresse Oxidativo/fisiologia
Dieta Hiperlipídica
Miocárdio/metabolismo
-Valores de Referência
Espectrofotometria
Glicemia/análise
Peso Corporal
Western Blotting
Espécies Reativas de Oxigênio/análise
Estresse Oxidativo/efeitos dos fármacos
Carbonilação Proteica
Fluoresceínas/análise
Limites: Humanos
Animais
Masculino
Camundongos
Responsável: BR1.1 - BIREME


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Id: biblio-1118362
Autor: Rojas de M, Tibisay; Rincón, Gabriel.
Título: Efecto de la n-acetilcisteina inhalada en el desarrollo de fibrosis pulmonar de ratas intoxicadas con paraquat / Effect of n-acetylcisteine inhaled in the development of pulmonary fibrosis of intoxicated rats with paraquat
Fonte: Rev. Inst. Nac. Hig;50(1-2):14-21, Diciembre 2019. tab.
Idioma: es.
Resumo: El Paraquat (PQ) es un herbicida de contacto bipiridilico ampliamente utilizado en agricultura. La intoxicación en humanos por este agente ocasiona fibrosis pulmonar. Evaluamos los cambios histológicos pulmonares de ratas intoxicadas con PQ y tratadas con N-aceticisteina (NAC) administrada vía inhalatoria. Realizamos un estudio experimental descriptivo con 25 ratas adultas, machos cepa Wistar, divididas en cinco grupos. Al grupo I no se les administro ni PQ ni NAC. Grupo II, recibió NAC inhalada a 15mg/kg diaria c/12 horas. Grupo III, PQ vía oral (VO) 15mg/kg. Grupo IV, PQ a 15mg/kg, por VO y a la hora NAC 150mg/kg. Grupo V, PQ a 15mg/kg, por VO y a las seis horas NAC dosis de 150mg/kg. Los pulmones fueron extraídos y se evaluaron mediante cortes histológicos. Resultados: Los grupos I y II (supervivencia del 100%, n=10) no desarrollaron sintomatología de intoxicación. Grupos III, IV y V predominaron síntomas respiratorios, diversos grados de edema pulmonar, enfisema, congestión vascular y hemorragia intra-alveolar focal. La eficacia de la NAC sobre la intoxicación por PQ en términos de sobrevivencia al primer día, fue del 100% y al segundo día, fue del 80% (p= 0,005; prueba Chi-cuadrado). El PQ indujo un proceso inflamatorio (agudo-crónico) por infiltrado de segmentados neutrófilos y linfocitos, lo cual fue revertido parcialmente por la administración inhalada de NAC. Conclusión: Los cambios histopatológicos observados a nivel pulmonar fueron aminorados por el tratamiento con NAC, lo que sugiere un posible efecto protector de este fármaco sobre el daño oxidativo inducido por el herbicida

Paraquat (PQ) is a bipyridyl contact herbicide widely used in agriculture. Intoxication in humans by this agent causes pulmonary fibrosis. We evaluated pulmonary histological changes of rats intoxicated with PQ and treated with N-acetycysteine (NAC) administered via inhalation. We conducted a descriptive experimental study with 25 adult rats, male Wistar strain, divided into five groups. Group I was not administered PQ or NAC. Group II, received NAC inhaled at 15mg/kg daily c/12 hours. Group III, PQ orally (VO) 15mg/ kg. Group IV, PQ at 15mg/kg, by VO and at hour NAC 150mg/ kg. Group V, PQ at 15mg/kg, by VO and at six hours NAC dose of 150mg/kg. The lungs were extracted and evaluated by histological sections. Results: Groups I and II (100% survival, n=10) did not develop intoxication symptoms. Groups III, IV and V predominantly respiratory symptoms, various degrees of pulmonary edema, emphysema, vascular congestion and focal intra-alveolar hemorrhage. The efficacy of NAC on PQ poisoning in terms of survival on the first day was 100% and on the second day it was 80% (p = 0.005, Chi-square test). The PQ induced an inflammatory process (acute-chronic) by infiltration of segmented neutrophils and lymphocytes, which was partially reversed by the inhaled administration of NAC. Conclusion: The histopathological changes observed at the pulmonary level were reduced by the treatment with NAC, which suggests a possible protective effect of this drug on the oxidative damage induced by the herbicide.
Descritores: Paraquat/envenenamento
Fibrose Pulmonar/induzido quimicamente
Fibrose Pulmonar/tratamento farmacológico
Acetilcisteína/uso terapêutico
Sequestradores de Radicais Livres/uso terapêutico
Herbicidas/envenenamento
-Paraquat/administração & dosagem
Acetilcisteína/administração & dosagem
Fatores de Tempo
Administração por Inalação
Análise de Sobrevida
Sequestradores de Radicais Livres/administração & dosagem
Resultado do Tratamento
Ratos Wistar
Modelos Animais
Herbicidas/administração & dosagem
Limites: Animais
Masculino
Ratos
Responsável: VE9.1 - Biblioteca


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Id: lil-764546
Autor: Fernández-González, Felipe José; Cañigral, Aránzazu; Balbontín-Ayala, Felipe; Gonzalo-Orden, José Manuel; Carlos, Felix de; Cobo, Teresa; Fernández-Vázquez, Jose Pedro; Sánchez-Lasheras, Fernando; Vega, José Antonio.
Título: Experimental evidence of pharmacological management of anchorage in Orthodontics: A systematic review
Fonte: Dental press j. orthod. (Impr.);20(5):58-65tab, graf.
Idioma: en.
Resumo: Introduction: Orthodontic anchorage is one of the most challenging aspects of Orthodontics. Preventing undesired movement of teeth could result in safer and less complicated orthodontic treatment. Recently, several reviews have been published about the effects of different molecules on bone physiology and the clinical side effects in Orthodontics. However, the effects of local application of these substances on the rate of orthodontic tooth movement have not been assessed.Objectives: The aim of this research was to analyze the scientific evidence published in the literature about the effects of different molecules on orthodontic anchorage.Methods: The literature was systematically reviewed using PubMed/Medline, Scopus and Cochrane databases from 2000 up to July 31st, 2014. Articles were independently selected by two different researchers based on previously established inclusion and exclusion criteria, with a concordance Kappa index of 0.86. The methodological quality of the reviewed papers was performed.Results: Search strategy identified 270 articles. Twenty-five of them were selected after application of inclusion/exclusion criteria, and only 11 qualified for final analysis. Molecules involved in orthodontic anchorage were divided into three main groups: osteoprotegerin (OPG), bisphosphonates (BPs) and other molecules (OMs).Conclusions: Different drugs are able to alter the bone remodeling cycle, influencing osteoclast function and, therefore, tooth movement. Thus, they could be used in order to provide maximal anchorage while preventing undesired movements. OPG was found the most effective molecule in blocking the action of osteoclasts, thereby reducing undesired movements.

Introdução: a ancoragem ortodôntica é um dos aspectos mais desafiadores da Ortodontia. A prevenção de movimentos dentários indesejados poderia resultar em um tratamento ortodôntico mais seguro e menos complexo. Recentemente, foram publicadas várias revisões de literatura sobre os efeitos de diferentes substâncias na fisiologia do tecido ósseo e os efeitos colaterais clínicos na Ortodontia. Porém, os efeitos da aplicação local dessas substâncias no grau de movimentação dentária ortodôntica não foram avaliados.Objetivos: o objetivo da presente pesquisa foi analisar a evidência científica publicada na literatura sobre os efeitos de diferentes substâncias na ancoragem ortodôntica.Métodos: a literatura foi sistematicamente revisada utilizando-se as bases de dados PubMed/Medline, Scopus e Cochrane, de 2000 a 31 de julho de 2014. Os artigos foram selecionados, de maneira independente, por dois pesquisadores diferentes, tendo como base critérios de inclusão e exclusão previamente estabelecidos, com um índice Kappa de concordância de 0,86. A qualidade metodológica dos artigos revisados foi analisada.Resultados: a estratégia de pesquisa identificou 270 artigos; 25 artigos foram selecionados após a aplicação dos critérios de inclusão e exclusão, mas apenas 11 foram qualificados para a análise final. As substâncias envolvidas na ancoragem ortodôntica foram divididas em três grupos principais: osteoprotegerina (OPG), bisfosfonatos (BFs) e outras substâncias (OSs).Conclusões: diferentes substâncias são capazes de alterar o ciclo de remodelação óssea, influenciando na função dos osteoclastos e, portanto, na movimentação dentária. Sendo assim, essas substâncias podem ser utilizadas para promover o máximo de ancoragem e prevenir movimentos indesejados. A OPG foi a substância mais eficaz no bloqueio da ação dos osteoclastos, reduzindo os movimentos indesejados.
Descritores: Difosfonatos/uso terapêutico
Difosfonatos/farmacologia
Anti-Inflamatórios/uso terapêutico
Anti-Inflamatórios/farmacologia
Antioxidantes/uso terapêutico
Antioxidantes/farmacologia
-Acetilcisteína/uso terapêutico
Acetilcisteína/farmacologia
Diclofenaco/uso terapêutico
Diclofenaco/farmacologia
Remodelação Óssea/efeitos dos fármacos
Ácido Clodrônico/uso terapêutico
Ácido Clodrônico/farmacologia
Procedimentos de Ancoragem Ortodôntica/métodos
Celecoxib/uso terapêutico
Celecoxib/farmacologia
Resveratrol
Ácido Zoledrônico
Pamidronato
Imidazóis/farmacologia
Limites: Humanos
Animais
Ratos
Tipo de Publ: Revisão
Revisão Sistemática
Responsável: BR1.1 - BIREME


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Id: biblio-1251520
Autor: Blanco, Camilo; Barreto-Guevara, María Isabel; Walteros-Gordillo, Yenny Lucía; Pinzón-Segura, Néstor Armando; Rivera-Velasco, María del Carmen; Bareño, José.
Título: Cohortes de premedicación en endoscopia alta con simeticona, N-acetilcisteína, Hedera helix y validación de la escala visual / Cohorts of premedication for endoscopy of the upper gastrointestinal tract with simethicone, N-acetylcysteine, Hedera helix and visual scale validation
Fonte: Rev. colomb. gastroenterol;36(1):39-50, ene.-mar. 2021. tab, graf.
Idioma: es.
Resumo: Resumen Los parámetros de calidad para endoscopia digestiva alta han introducido indicadores intraprocedimiento, dentro de los cuales la adecuada visibilidad de la mucosa, libre de saliva, moco o burbujas, puede aumentar la posibilidad de detección de lesiones en fase temprana. Sin embargo, el uso de mucolíticos y antiburbujas ha mostrado gran variabilidad de eficiencia según las soluciones, concentraciones, tiempos de exposición y escala de visibilidad aplicados. Objetivos: determinar la efectividad de diferentes soluciones de premedicación para la limpieza de la mucosa digestiva; validar, mediante una prueba de concordancia interobservador, una nueva escala de adecuada visualización de la mucosa (TVMS) para el esófago, estómago y duodeno; y reportar eventos adversos o complicaciones relacionadas con las soluciones utilizadas y los procedimientos realizados. Material y métodos: estudio de cohortes prospectivas comparativas. Se incluyeron 412 pacientes adultos, ASA I y ASA II, para endoscopia diagnóstica bajo sedación consciente, distribuidos en 6 cohortes similares, divididas en dos grupos: no premedicación, 2 cohortes C1 (ayuno de 6 a 8 horas)y C2 (agua 100 mL); premedicación, 4 cohortes C3 a C6 (C3: agua 100 m L + simeticona 1000 mg; C4: agua 100 mL + simeticona 200 mg + N-acetilcisteína 600 mg; C5: agua 100 mL + simeticona 200 mg + N-acetilcisteína 1000 mg; C6: agua 100 mL + simeticona 200 mg + Hedera helix 70 mg). Se ingirió la solución 15 a 30 minutos antes del paso por cricofaríngeo. Se realizó la prueba de Kappa para medir la concordancia interobservador de la escala TVMS. Resultados: De 412 pacientes, 58% fueron de sexo femenino; 23% (136) fue de cohortes C1 y C2 y 67% (276) fue de cohortes C3 a C6. El tiempo medio de exposición a cada solución fue de 24,4 minutos. El volumen de lavado para lograr una adecuada visualización fue significativamente diferente entre ambos grupos: en los pacientes con premedicación se utilizaron 75,6 mL, mientras que en los pacientes sin premedicación se utilizaron 124 mL (p = 0,000), con una calidad de TVMS excelente de 88,7% frente al 41,4%, respectivamente. La cohorte C4 (agua 100 mL + simeticona 200 mg + N-acetilcisteína 600 mg) mostró ser la más efectiva con una diferencia significativa (p = 0,001) frente a C1 (ayuno) y C2 (placebo con agua 100 mL), y también tuvo una eficiencia superior frente a C3, C5 y C6 en su orden. No se presentaron eventos adversos o complicaciones en relación con la endoscopia, la sedación y los productos usados en la premedicación. Conclusiones: la solución más efectiva como premedicación para lograr una excelente visibilidad de la mucosa digestiva correspondió a la cohorte C4 (SIM 200 + NAC 600 + H2O 100 mL). La escala TVMS propuesta es una herramienta muy completa y fácil de aplicar por más de un observador. La premedicación ingerida, con antiburbuja, mucolítico y agua hasta 100 mL, entre 15 y 30 minutos previos a endoscopia, es segura en las condiciones descritas en este estudio.

Abstract Quality parameters for upper gastrointestinal endoscopy have introduced intraprocedural indicators, including adequate mucosal visualization free of saliva, mucus, or bubbles, which may increase the possibility of early-stage injury detection. The use of mucolytics and anti-foaming agents has shown great efficiency variability depending on the type of solution, concentrations, exposure times and visibility scale applied. Objectives: To determine the effectiveness of different premedication solutions for cleaning the digestive mucosa; to validate, by means of an interobserver concordance test, a new scale for the adequate visualization of the mucosa (TVMS) for the esophagus, stomach, and duodenum; and to report adverse events or complications associated with the solutions used and the procedures performed. Material and methods: Prospective, comparative cohort study. 412 adult patients, ASA I and ASA II, were included for diagnostic endoscopy under conscious sedation. They were distributed in 6 similar cohorts and divided into two groups: non-premedication, 2 in C1 (fasting 6 to 8 hours) and C2 (water 100 mL) cohorts; premedication, 4 C3 to C6 cohorts (C3: water 100 mL + simethicone 1000 mg; C4: water 100 ml + simethicone 200 mg + N-acetylcysteine 600 mg; C5: water 100 ml + simethicone 200 mg + N-acetylcysteine 1000 mg; C6: water 100 ml + simethicone 200 mg + Hedera helix 70 mg). The solution was swallowed 15 to 30 minutes passing through the cricopharyngeus muscle. The Kappa test was performed to measure interobserver concordance of the TVMS scale. Results: Of 412 patients, 58% were female; 23% (136) were included in the C1 and C2 cohorts; and 67% (276) were in the C3 to C6 cohorts. The average exposure time to each solution was 24.4 minutes. The wash volume for proper visualization was significantly different between the two groups. In premedicated patients, 75.6 mL of solution were used, while in patients without premedication, 124 mL were used (p = 0.000), with an excellent quality of TVMS of 88.7% versus 41.4%, respectively. The C4 cohort (water 100 mL + simethicone 200 mg + N-acetylcysteine 600 mg) was the most effective with a significant difference (p= 0.001) compared with the C1 (fasting) and C2 (placebo with water 100 mL) cohorts. It also had better efficiency compared to the C3, C5 and C6 cohorts in that order. There were no adverse events or complications associated with endoscopy, sedation, or premedication products. Conclusions: The most effective solution as a premedication to achieve excellent visibility of the digestive mucosa was that used in the C4 cohort (SIM 200 + NAC 600 + H2OR 100 mL). The proposed TVMS scale is a very complete and easy tool to apply by more than one observer. Premedication ingested, with anti-foam, mucolytic and water up to 100 mL, between 15 and 30 minutes before endoscopy, is safe under the conditions described in this study.
Descritores: Pré-Medicação
Acetilcisteína
Simeticone
Hedera
-Soluções
Endoscopia Gastrointestinal
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Tipo de Publ: Ensaio Clínico
Responsável: CO354 - Sociedad Colombiana de Gastroenterología


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Id: biblio-900721
Autor: Royero G, Henry Alberto.
Título: Aplicación de una escala de visualización de la mucosa gástrica, durante la esofagogastroduodenoscopia en pacientes premedicados con N-acetilcisteína más simeticona: experiencia en Ocaña, Norte de Santander / Experience in Ocaña, Norte de Santander, with a Scale for Visualization of the Gastric Mucosa during Esophagogastroduodenoscopy in Patients Medicated with N-acetylcysteine plus Simethicone
Fonte: Rev. colomb. gastroenterol;33(1):1-7, 2018. tab, graf.
Idioma: es.
Resumo: Resumen Introducción: la visibilidad de la mucosa gástrica puede verse limitada por el moco adherente y la formación de burbujas durante la endoscopia de vías digestivas altas. Objetivos: conocer los puntajes de visualización de la mucosa gástrica y el número de lavados para aclarar la superficie gástrica de burbujas y espumas, aplicando la escala de Kuo modificada por Chang en pacientes premedicados antes de la esofagogastroduodenoscopia. Materiales y métodos: estudio descriptivo, prospectivo, se incluyeron 120 pacientes entre octubre y diciembre de 2016 a los que se les premedicó con N-acetilcisteína (NAC) al 4%, 400 mg (10 cc) más simeticona (SIM) (dimetilpolisiloxano) 133,3 mg (2 cc) y agua tibia 100 cc, 20 minutos antes del procedimiento; los datos se tabularon en Excel y, ulteriormente, sus frecuencias y porcentajes se analizaron con el paquete estadístico Epi Info CDC (versión 7,2 para Windows, Estados Unidos); se consideró significancia estadística una p <0,05. Resultados: la puntuación total de visibilidad de la mucosa gástrica considerada como óptima con un puntaje de 4 fue 57 (47,50%), con 5 puntos fueron 36 (30%), con 6 y 7 puntos 10 (8,33%), con 8 puntos 6 (5%) y, por último, con 9 puntos 1 (0,83%); no hubo casos en las puntuaciones de 10 a 16. 100 (83,3%) pacientes no necesitaron lavados adicionales con agua para visualizar la mucosa gástrica, contra 13 (10,83%) que requirieron menos de 50 cc y 7 (5,83%) que necesitaron más de 50 cc (p = 0,00). Limitaciones: un solo observador realizó el estudio, lo que pudo generar sesgos de detección; además, la muestra es pequeña. Conclusiones: con la administración de una solución de NAC más SIM diluidas en 100 cc de agua tibia previa a la endoscopia de vías digestivas altas se obtuvo una visualización óptima de la mucosa gástrica en la mayoría de los casos y se observó la necesidad de un menor volumen de agua para aclarar la cavidad gástrica de moco y espuma.

Abstract Introduction: During upper digestive tract endoscopy, visibility of the gastric mucosa can be limited by adherent mucus and bubbles. Objectives: This is a study of visualization of the gastric mucosa and the number of washes needed to clear bubbles and foam from the gastric surface. The modified Kuo scale by Chang was used with patients medicated prior to esophagogastroduodenoscopy. Materials and methods: This is a descriptive and prospective study of 120 patients who were medicated with 400 mg (10cc) of 4% N-acetylcysteine plus 133.3 mg (2cc) of simethicone (Dimethylpolysiloxane) and 100 cc of warm water 20 minutes prior to esophagogastroduodenoscopy from October to December 2016. Data were tabulated in Excel and frequencies and percentages were analyzed using the Epi Info statistical package from the Centers for Disease Control version 7.2 for Windows. Statistical significance was considered to be p <0.05. Results: The optimal score for total visibility of four was achieved 57 patients (47.50%). Thirty-six patients (30%) had scores of five points, ten patients (8.33%) had scores of six or seven points, six patients had scores of eight points (5%), and one patient (0.83%) had a score of nine points. There were no scores from 10 to 16. Hundred patients (83,3%) did not need additional washes with water to visualize the gastric mucosa, thirteen patients (10,83%) required less than 50 cc, and seven (5,83%) required more than 50 cc (p = 0.00). Limitations: This study was done by a single observer which could result in detection biases. Also, the sample is small. Conclusions: Administration of a solution of N-acetylcysteine ​​plus Simethicone diluted in 100 cc of warm water prior to upper digestive tract endoscopy provides for optimal visualization of the gastric mucosa in most cases. A smaller volume of water was needed to clear the gastric cavity of mucus and foam.
Descritores: Acetilcisteína
Simeticone
Endoscopia do Sistema Digestório
Trato Gastrointestinal
Mucosa Gástrica
Responsável: CO354 - Sociedad Colombiana de Gastroenterología


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Id: biblio-1255192
Autor: Marchetti, Desirèe; Ribas, Graziela; Donida, Bruna; Brito, Verônica; Moura, Dinara; Coelho, Daniella; Machado, Andryele; Kessler, Rejane; Coitinho, Adriana; Vargas, Carmen.
Título: Protective effect of N-acetyl-L-cysteine and rosuvastatin against oxidative stress in fibroblasts from asymptomatic patients with X-ALD: a preliminary study
Fonte: Clin. biomed. res;41(1):57-64, 2021. tab, graf.
Idioma: en.
Resumo: Introduction: Several studies in the literature have evaluated the role of oxidative stress and adjuvant therapies for X-linked adrenoleukodystrophy (X-ALD). Here, we investigated whether n-acetyl-L-cysteine (NAC) and rosuvastatin (RSV) could influence the generation of reactive species, redox status and nitrative stress in fibroblasts from asymptomatic patients with X-ALD. Methods: Skin biopsy samples were cultured and treated for 2 hours (37 °C) with NAC and RSV. Results: X-ALD fibroblasts generated high levels of reactive oxygen species. These levels were significantly lower in fibroblasts treated with NAC and RSV relative to untreated samples. The X-ALD fibroblasts from asymptomatic patients also had higher catalase activity, and only NAC was able to increase enzyme activity in the samples. Conclusions: Our results indicated that NAC and RSV were able to improve oxidative stress parameters in fibroblasts from asymptomatic patients with X-ALD, showing that adjuvant antioxidant therapy may be a promising treatment strategy for asymptomatic patients with this disease. (AU)
Descritores: Acetilcisteína
Estresse Oxidativo
Adrenoleucodistrofia/terapia
Rosuvastatina Cálcica
-Fibroblastos
Limites: Humanos
Masculino
Feminino
Responsável: BR18.1 - Biblioteca FAMED/HCPA


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Marinho, Marcia
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Id: biblio-1249580
Autor: Leite, Alberto Andrade; Reiter, Russel Joseph; Brandão, Julio Cezar Mendes; Sakae, Thiago Mamoru; Marinho, Marcia; Camargo, Celia Regina; Oliveira-Junior, Itamar Souza.
Título: Melatonin can be, more effective than N-acetylcysteine, protecting acute lung injury induced by intestinal ischemia-reperfusion in rat model
Fonte: Clinics;76:e2513, 2021. graf.
Idioma: en.
Resumo: OBJECTIVES: The current study compared the impact of pretreatment with melatonin and N-acetylcysteine (NAC) on the prevention of rat lung damage following intestinal ischemia-reperfusion (iIR). METHODS: Twenty-eight Wistar rats were subjected to intestinal ischemia induced by a 60 min occlusion of the superior mesenteric artery, followed by reperfusion for 120 min. Animals were divided into the following groups (n=7 per group): sham, only abdominal incision; SS+iIR, pretreated with saline solution and iIR; NAC+iIR, pretreated with NAC (20 mg/kg) and iIR; MEL+iIR, pretreated with melatonin (20 mg/kg) and iIR. Oxidative stress and inflammatory mediators were measured and histological analyses were performed in the lung tissues. RESULTS: Data showed a reduction in malondialdehyde (MDA), myeloperoxidase (MPO), and TNF-alpha in the animals pretreated with NAC or MEL when compared to those treated with SS+iIR (p<0.05). An increase in superoxide dismutase (SOD) levels in the NAC- and MEL-pretreated animals as compared to the SS+iIR group (34±8 U/g of tissue; p<0.05) was also observed. TNF-α levels were lower in the MEL+iIR group (91±5 pg/mL) than in the NAC+iIR group (101±6 pg/mL). Histological analysis demonstrated a higher lung lesion score in the SS+iIR group than in the pretreated groups. CONCLUSION: Both agents individually provided tissue protective effect against intestinal IR-induced lung injury, but melatonin was more effective in ameliorating the parameters analyzed in this study.
Descritores: Traumatismo por Reperfusão/prevenção & controle
Lesão Pulmonar Aguda/etiologia
Lesão Pulmonar Aguda/prevenção & controle
Melatonina/uso terapêutico
-Acetilcisteína/uso terapêutico
Reperfusão
Ratos Wistar
Isquemia
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-843466
Autor: Savluk, Omer Faruk; Guzelmeric, Fusun; Yavuz, Yasemin; Cevirme, Deniz; Gurcu, Emre; Ogus, Halide; Orki, Tulay; Kocak, Tuncer.
Título: N-acetylcysteine versus dopamine to prevent acute kidney injury after cardiac surgery in patients with preexisting moderate renal insufficiency
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);32(1):8-14, Jan.-Feb. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Objective: Acute kidney injury after cardiac surgery is associated with mortality and morbidity. Therefore, strategies to prevent acute kidney injury are very important. The aim of this placebo-controlled randomized double-blind study was to compare the prophylactic efficacy of N-Acetylcysteine and dopamine administration in patients with pre-existing moderate renal insufficiency who were undergoing cardiopulmonary bypass. Methods: This study included 135 patients with pre-existing moderate renal insufficiency who were scheduled for coronary artery bypass grafting surgery. Serum creatinine and GFR were recorded preoperatively and on the first and second postoperative days. Results: On the first and second postoperative days, the drugs used showed statistically significant differences among the creatinine groups (P<0.001). According to Tukey’s HSD, on the first and second PO, the creatinine of Group N, D and P were significantly different (P<0.001). On the first and second PO, the used drugs showed statistically significant differences among the effects of eGFR (P<0.001). According to Tukey’s HSD on the first postoperative day, the average eGFR score of Group N compared to D and P were significantly difference (P<0.001). On the second postoperative day, the eGFR of Group N and D showed no difference (P=0.37), but P showed a difference (P<0.001). Conclusion: We found that the prophylactic use of intravenous N-Acetylcysteine had a protective effect on renal function, whereas the application of renal dose dopamine did not have a protective effect in patients with pre-existing moderate renal failure.
Descritores: Acetilcisteína/administração & dosagem
Dopamina/administração & dosagem
Injúria Renal Aguda/prevenção & controle
Injúria Renal Aguda/tratamento farmacológico
Procedimentos Cirúrgicos Cardíacos/efeitos adversos
-Placebos
Complicações Pós-Operatórias
Ponte Cardiopulmonar
Ponte de Artéria Coronária
Método Duplo-Cego
Insuficiência Renal
Injúria Renal Aguda/etiologia
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-958390
Autor: Amini, Shahram; Robabi, Hojat Naghavi; Tashnizi, Mohammad Abbasi; Vakili, Vida.
Título: Selenium, vitamin c and n-acetylcysteine do not reduce the risk of acute kidney injury after off-pump cabg: a randomized clinical trial
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);33(2):129-134, Mar.-Apr. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Objective: The aim of this study was to investigate the impact of perioperative administration of N-acetylcysteine, selenium and vitamin C on the incidence and outcomes of acute kidney injury after off-pump coronary bypass graft surgery. Methods: 291 patients requiring elective off-pump coronary bypass graft surgery were randomized to receive either N-acetylcysteine, vitamin C and selenium 600 mg, 1500 mg, 0.5 mg, and nothing orally twice a day, respectively, from the day before to 2 days after surgery. They were assessed for the development of acute kidney injury using Acute Kidney Injury Network criteria, time of onset, its severity and duration, duration of mechanical ventilation, intensive care unit and hospital length of stay, and in-hospital mortality. Results: 272 patients completed the study. The total incidence of acute kidney injury was 22.1% (n=60) with 14 (20.9%), 15 (22.1%), 21 (31.8%), and 10 (14.1%) patients in the vitamin C, NAC, selenium, and control groups, respectively (P=0.096). We did not register significant differences in the incidence, the time of occurrence, the severity and the duration of acute kidney injury, as well as the duration of mechanical ventilation, the intensive care unit and hospital length of stay, and the in-hospital mortality among the four groups. Conclusion: We found that perioperative administration of N-acetylcysteine, vitamin C and selenium were not effective in preventing acute kidney injury and associated morbidity and mortality after off-pump coronary bypass graft surgery.
Descritores: Acetilcisteína/uso terapêutico
Ácido Ascórbico/uso terapêutico
Selênio/uso terapêutico
Ponte de Artéria Coronária sem Circulação Extracorpórea/efeitos adversos
Injúria Renal Aguda/etiologia
Injúria Renal Aguda/prevenção & controle
Antioxidantes/uso terapêutico
-Respiração Artificial
Índice de Gravidade de Doença
Resultado do Tratamento
Mortalidade Hospitalar
Terapia de Substituição Renal
Medição de Risco
Creatinina/sangue
Ponte de Artéria Coronária sem Circulação Extracorpórea/mortalidade
Injúria Renal Aguda/mortalidade
Taxa de Filtração Glomerular
Tempo de Internação
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: biblio-1133612
Autor: García Pérez, Alicia; Mora Viera, Leydi; Abreu Reyes, David.
Título: La N-acetilcisteína reduce el progreso de daño cardíaco en modelos experimentales / N-acetylcysteine reduces myocardial injury progression in experimental models
Fonte: CorSalud;12(2):214-218
Idioma: es.
Resumo: RESUMEN La N-acetilcisteína es conocida en varias especialidades médicas. Su empleo en cardiología se ha incrementado desde hace décadas, por su potencial para disminuir el impacto del daño por reperfusión en el infarto miocárdico agudo. Pero el espectro de sus efectos es aún mayor, tiene acciones sobre los radicales de oxígeno, con un papel protector, por la vía de los grupos sulfhidrilos de regiones importantes de la membrana celular, los cuales interfieren y tienen efecto en la función endotelial y en los procesos complejos de adhesión como efectos secundarios; así como otros fenómenos del compartimento extravascular. Estos procesos están estrechamente relacionados con el aparato cardiovascular.

ABSTRACT N-acetylcysteine is known in a number of medical specialties and its ability to decrease the impact of reperfusion injury in acute myocardial infarction has boosted its use in cardiology over the past decades. N-acetylcysteine has a far-reaching range of effects since it functions as a protective agent against oxygen radicals through sulfhydryl groups in important regions of the cell membrane that interfere and affect endothelial functioning and complex adhesion processes as side effects; as well as other phenomena of the extravascular compartment. These processes are closely related to the cardiovascular system.
Descritores: Acetilcisteína
Traumatismo por Reperfusão Miocárdica
Traumatismo por Reperfusão
Estresse Oxidativo
Responsável: CU425.1 - Centro Provincial de Información de Ciencias Médicas de Villa Clara



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