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Id: biblio-886983
Autor: Barroso, Livia Ariane Lopes; Sternberg, Flavia; Souza, Maria Natalia Inacio de Fraia e; Nunes, Gisele Jacobino de Barros.
Título: Trichotillomania: a good response to treatment with N-acetylcysteine
Fonte: An. bras. dermatol;92(4):537-539, July-Aug. 2017. graf.
Idioma: en.
Resumo: Abstract: Trichotillomania is considered a behavioral disorder and is characterized by the recurring habit of pulling one's hair, resulting in secondary alopecia. It affects 1% of the adult population, and 2 to 4.4% of psychiatric patients meet the diagnostic criteria. It can occur at any age and is more prevalent in adolescents and females. Its occurrence in childhood is not uncommon and tends to have a more favorable clinical course. The scalp, eyebrows and eyelashes are the most commonly affected sites. Glutamate modulating agents, such as N-acetylcysteine, have been shown to be a promising treatment. N-acetylcysteine acts by reducing oxidative stress and normalizing glutaminergic transmission. In this paper, we report a case of trichotillomania with an excellent response to N-acetylcysteine.
Descritores: Acetilcisteína/uso terapêutico
Tricotilomania/tratamento farmacológico
Antioxidantes/uso terapêutico
-Tricotilomania/diagnóstico
Diagnóstico Diferencial
Alopecia/diagnóstico
Alopecia/etiologia
Limites: Seres Humanos
Masculino
Criança
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-889206
Autor: Choi, Young-Suk; Kim, Cheul; Moon, Ji-Hoi; Lee, Jin-Yong.
Título: Removal and killing of multispecies endodontic biofilms by N-acetylcysteine
Fonte: Braz. j. microbiol;49(1):184-188, Jan.-Mar. 2018. tab, graf.
Idioma: en.
Projeto: Ministry of Health and Welfare; . Ministry of Science.
Resumo: ABSTRACT Removal of bacterial biofilm from the root canal system is essential for the management of endodontic disease. Here we evaluated the antibacterial effect of N-acetylcysteine (NAC), a potent antioxidant and mucolytic agent, against mature multispecies endodontic biofilms consisting of Actinomyces naeslundii, Lactobacillus salivarius, Streptococcus mutans and Enterococcus faecalis on sterile human dentin blocks. The biofilms were exposed to NAC (25, 50 and 100 mg/mL), saturated calcium hydroxide or 2% chlorhexidine solution for 7 days, then examined by scanning electron microscopy. The biofilm viability was measured by viable cell counts and ATP-bioluminescence assay. NAC showed greater efficacy in biofilm cell removal and killing than the other root canal medicaments. Furthermore, 100 mg/mL NAC disrupted the mature multispecies endodontic biofilms completely. These results demonstrate the potential use of NAC in root canal treatment.
Descritores: Acetilcisteína/farmacologia
Streptococcus mutans/efeitos dos fármacos
Actinomyces/efeitos dos fármacos
Enterococcus faecalis/efeitos dos fármacos
Biofilmes/efeitos dos fármacos
Doenças da Polpa Dentária/microbiologia
Lactobacillus salivarius/efeitos dos fármacos
Antibacterianos/farmacologia
-Streptococcus mutans/fisiologia
Actinomyces/fisiologia
Hidróxido de Cálcio/farmacologia
Clorexidina/farmacologia
Enterococcus faecalis/fisiologia
Cavidade Pulpar/microbiologia
Viabilidade Microbiana/efeitos dos fármacos
Lactobacillus salivarius/fisiologia
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


  3 / 108 LILACS  
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Id: biblio-888963
Autor: Shen, JC; Zhang, YC; Zhao, MF.
Título: Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(12):e6087, 2017. graf.
Idioma: en.
Projeto: National Natural Sciences Foundation; . Tianjin Science and Technique Foundation; . Seed Foundation.
Resumo: Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with 25 mg iron dextran every 3 days for 4 weeks to establish an iron overload (Fe) model. DFX or NAC were co-administered with iron dextran in two groups of mice (Fe+DFX and Fe+NAC), and the function of HSPCs was then examined. Iron overload markedly decreased the number of murine HSPCs in bone marrow. Subsequent colony-forming cell assays showed that iron overload also decreased the colony forming capacity of HSPCs, the effect of which could be reversed by DFX and NAC. The bone marrow hematopoiesis damage caused by iron overload could be alleviated by DFX and NAC.
Descritores: Acetilcisteína/farmacologia
Triazóis/farmacologia
Benzoatos/farmacologia
Células-Tronco Hematopoéticas/efeitos dos fármacos
Quelantes de Ferro/farmacologia
Depuradores de Radicais Livres/farmacologia
Sobrecarga de Ferro/prevenção & controle
Substâncias Protetoras/farmacologia
-Valores de Referência
Fatores de Tempo
Reprodutibilidade dos Testes
Resultado do Tratamento
Espécies Reativas de Oxigênio/análise
Ensaio de Unidades Formadoras de Colônias
Modelos Animais de Doenças
Citometria de Fluxo
Hematopoese/efeitos dos fármacos
Camundongos Endogâmicos C57BL
Limites: Animais
Masculino
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


  4 / 108 LILACS  
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Calabrese, Kátia da Silva
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Id: biblio-841766
Autor: Gasparotto, Juciano; Kunzler, Alice; Senger, Mario Roberto; Souza, Celeste da Silva Freitas de; Simone, Salvatore Giovanni de; Bortolin, Rafael Calixto; Somensi, Nauana; Dal-Pizzol, Felipe; Moreira, José Claudio Fonseca; Abreu-Silva, Ana Lúcia; Calabrese, Kátia da Silva; Silva Jr, Floriano Paes; Gelain, Daniel Pens.
Título: N-acetyl-cysteine inhibits liver oxidative stress markers in BALB/c mice infected with Leishmania amazonensis
Fonte: Mem. Inst. Oswaldo Cruz;112(2):146-154, Feb. 2017. graf.
Idioma: en.
Projeto: FAPERGS.
Resumo: BACKGROUND Leishmaniasis is a parasitosis caused by several species of the genus Leishmania. These parasites present high resistance against oxidative stress generated by inflammatory cells. OBJECTIVES To investigate oxidative stress and molecular inflammatory markers in BALB/c mice infected with L. amazonensis and the effect of antioxidant treatment on these parameters. METHODS Four months after infection, oxidative and inflammatory parameters of liver, kidneys, spleen, heart and lungs from BALB/c mice were assessed. FINDINGS In liver, L. amazonensis caused thiol oxidation and nitrotyrosine formation; SOD activity and SOD2 protein content were increased while SOD1 protein content decreased. The content of the cytokines IL-1β, IL-6, TNF-α, and the receptor of advanced glycation endproducts (RAGE) increased in liver. Treatment with the antioxidant N-acetyl-cysteine (20 mg/kg b.w) for five days inhibited oxidative stress parameters. MAIN CONCLUSIONS L. amazonensis induces significant alterations in the redox status of liver but not in other organs. Acute antioxidant treatment alleviates oxidative stress in liver, but it had no effect on pro-inflammatory markers. These results indicate that the pathobiology of leishmaniasis is not restricted to the cutaneous manifestations and open perspectives for the development of new therapeutic approaches to the disease, especially for liver function.
Descritores: Acetilcisteína/farmacologia
Leishmania mexicana
Leishmaniose Cutânea/metabolismo
Leishmaniose Cutânea/patologia
Estresse Oxidativo/efeitos dos fármacos
Estresse Oxidativo/fisiologia
-Depuradores de Radicais Livres/farmacologia
Fígado/efeitos dos fármacos
Fígado/enzimologia
Camundongos Endogâmicos BALB C
Limites: Animais
Camundongos
Responsável: BR1.1 - BIREME


  5 / 108 LILACS  
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Id: biblio-1025940
Autor: Barrera-Ortiz, José Carlos; Barranco-Cuevas, Irma Aidé; Vázquez-Cruz, Eduardo; Montiel-Jarquín, Alvaro José; Loria-Castellano, Jorge; López-Colombo, Aurelio; García-Galicia, Arturo; Gaytán-Fernández, Suemmy.
Título: Acetilcisteína: Una actualización clínica y farmacológica sobre su efecto mucolítico. Estudio de revisión / Acetylcisteine. A clinical and pharmacological actualization with special. Reference to its mucolytic efect
Fonte: Prensa méd. argent;105(10):667-677, oct 2019. fig, graf.
Idioma: es.
Resumo: The authors present a clinical and farmacological evaluation of the effect and safety of N-acetylcysteine in chronic obstructive diseases. The N-actylcysteine (NAC) is a sulphorated amino acid employed as an mucolytic agent. The efficacy and tolerability of oral NAC as compared with other agents was determined, in the mucolytic treatment on mucus hypersecretion and in the management of respiratory tract fluids and sputums from cigarette smokers, and also as a bronchial mucus fluidifying agent. A sistematic review and analysis of the effect of NAC and its effectiveness. In the treatment of acute respiratory disorders in children was determined
Descritores: Acetilcisteína/uso terapêutico
Acetilcisteína/farmacologia
Bromoexina/farmacologia
Mucosa Respiratória/fisiopatologia
Muco/efeitos dos fármacos
Limites: Seres Humanos
Tipo de Publ: Revisão
Responsável: AR392.1 - Biblioteca


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Wajner, Moacir
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Id: biblio-994866
Autor: Vanzin, Camila Simioni; Mescka, Caroline Paula; Donida, Bruna; Marchetti, Desirèe Padilha; Jacques, Carlos Eduardo; Hauschild, Tatiane; Faverzani, Jéssica Lamberty; Deon, Marion; Moura, Dinara Jaqueline; Saffi, Jenifer; Coelho, Daniella de Moura; Wajner, Moacir; Wyse, Angela Terezinha de Souza; Vargas, Carmen Regla.
Título: DNA damage in homocystinuria: 8-oxo-, 8-dihydro-2'-deoxyguanosine levels in cystathionine-ß-synthase deficient patients and the in vitro protective effect of N-acetyl­L­cysteine
Fonte: Clin. biomed. res;38(1):50-57, 2018.
Idioma: en.
Resumo: Introduction: Homocysteine (Hcy) tissue accumulation occurs in a metabolic disease characterized biochemically by cystathionine ß-synthase (CBS) deficiency and clinically by mental retardation, vascular problems, and skeletal abnormalities. Previous studies indicate the occurrence of DNA damage secondary to hyperhomocysteinemia and it was observed that DNA damage occurs in leukocytes from CBS-deficient patients. This study aimed to investigate whether an oxidative mechanism could be involved in DNA damage previously found and investigated the in vitro effect of N-acety-L-cysteine (NAC) on DNA damage caused by high Hcy levels. Methods: We evaluated a biomarker of oxidative DNA damage in the urine of CBS­deficient patients, as well as the in vitro effect of NAC on DNA damage caused by high levels of Hcy. Moreover, a biomarker of lipid oxidative damage was also measured in urine of CBS deficient patients. Results: There was an increase in parameters of DNA (8-oxo-7,8-dihydro-2'- deoxyguanosine) and lipid (15-F2t-isoprostanes levels) oxidative damage in CBS-deficient patients when compared to controls. In addition, a significant positive correlation was found between 15-F2t-isoprostanes levels and total Hcy concentrations. Besides, an in vitro protective effect of NAC at concentrations of 1 and 5 mM was observed on DNA damage caused by Hcy 50 µM and 200 µM. Additionally, we showed a decrease in sulfhydryl content in plasma from CBS-deficient patients when compared to controls. Discussion: These results demonstrated that DNA damage occurs by an oxidative mechanism in CBS deficiency together with lipid oxidative damage, highlighting the NAC beneficial action upon DNA oxidative process, contributing with a new treatment perspective of the patients affected by classic homocystinuria.
Descritores: Dano ao DNA
Estresse Oxidativo
Homocistinúria
-Acetilcisteína
Desoxiguanosina/análogos & derivados
Homocisteína
Limites: Seres Humanos
Feminino
Criança
Adolescente
Adulto
Tipo de Publ: Ensaio Clínico Controlado
Responsável: BR18.1 - Biblioteca FAMED/HCPA


  7 / 108 LILACS  
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Id: biblio-1015318
Autor: Marriot, Andrew.
Título: Efectos de la NAC sobre la función cognitiva en los seres humanos / Effect of NAC on human cognition
Fonte: Salud(i)ciencia (Impresa) = Salud(i)ciencia (En linea);23(4):365-367, mar. 2019.
Idioma: en; es.
Descritores: Acetilcisteína/efeitos adversos
Saúde Mental
Cognição/efeitos dos fármacos
Cisteína
Neurologia
Limites: Seres Humanos
Tipo de Publ: Relatório Técnico
Responsável: AR392.1 - Biblioteca


  8 / 108 LILACS  
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Id: biblio-946809
Autor: Aranibar, Ligia; Vega, Nadia; Neely, Gabriel.
Título: Uso de N-acetilcisteína tópica en ictiosis: experiencia clínica en una serie de casos / Use of topical N-acetylcysteine ​​in ichthyosis: clinic experience in a series of cases
Fonte: Rev. chil. dermatol;32(1):61-64, 2016. ilus, tab.
Idioma: es.
Resumo: Las ictiosis son trastornos generalizados de la queratinización, que se caracterizan por presentar hiperqueratosis y/o descamación. El tratamiento es sintomático e incluye terapias tópicas y sistémicas. La N-Acetilcisteína (NAC) tópica ha mostrado utilidad en algunos reportes. Se describirá la experiencia con el uso de NAC 10% y urea 5% en novobase II (NB II) en 6 pacientes con distintos tipos de ictiosis hereditarias. Caso Nº1: Escolar masculino de 7 años con Ictiosis lamelar (IL) en tratamiento con fórmula de NAC hace 4 años con buena respuesta. Caso N°2, 3 y 4: Escolar masculino de 7 años, escolar masculino de 5 años y lactante masculino de 1 año 8 meses con Ictiosis recesiva ligada a X (IRLX), en tratamiento con fórmula de NAC con buena respuesta. Caso N°5: Mujer de 18 años con Eritrodermia ictiosiforme congénita (EIC), inicia tratamiento con fórmula de NAC, pero se suspende por mala tolerancia. Caso N°6: Preescolar femenina de 3 años, con Ictiosis epidermolítica (IE), inicia tratamiento con fórmula de NAC con mala tolerancia por lo que también se suspende. Se evaluaron los efectos de la fórmula de NAC en diferentes tipos de ictiosis, mostrando un buen perfil de seguridad y eficacia en IL e IRLX, sin embargo, en EIC e IE su uso estuvo restringido por efectos adversos. El tratamiento con fórmula de NAC presenta buena respuesta y tolerancia en pacientes con IL e IRLX, por lo que podría considerarse en el tratamiento habitual de estos pacientes.

Ichthyosis are generalized disorders of keratinization, characterized by hyperkeratosis and/or scaling. Treatment is symptomatic and includes topical and systemic therapies. Topical N-acetylcysteine (NAC) has shown utility in some reports. We describe the experience using 10% NAC and 5% urea in novobase II (NB II) in 6 patients with different types of hereditary ichthyosis. Case N°1: 7-year-old boy with lamellar Ichthyosis (IL) in treatment with NAC formula 4 years ago, with good response. Case N°2, 3 and 4: 7-year-old boy, 5-year-old boy and 1-year-8-month-old male infant, with X-recessive recessive Ichthyosis (IRLX) in treatment with NAC formula with good response. Case N°5: An 18-year-old woman with congenital ichthyosiform erythroderma (EIC) begins treatment with NAC formula but is discontinued because of poor tolerance. Case No. 6:3-year-old girl, with epidermolytic Ichthyosis (IE), starts treatment with NAC formula with poor tolerance and is also suspended. The effects of the NAC formula on different types of ichthyosis were evaluated, showing a good safety and efficacy profile in IL and IRLX, however, in EIC and IE, its use was restricted by adverse effects. Treatment with NAC formula has a good response and tolerance in patients with IL and IRLX, so it could be considered in the usual treatment of these patients.
Descritores: Acetilcisteína/uso terapêutico
Depuradores de Radicais Livres/uso terapêutico
Ictiose/tratamento farmacológico
-Acetilcisteína/administração & dosagem
Acetilcisteína/efeitos adversos
Ureia/uso terapêutico
Administração Tópica
Depuradores de Radicais Livres/efeitos adversos
Resultado do Tratamento
Limites: Seres Humanos
Masculino
Feminino
Pré-Escolar
Criança
Adolescente
Tipo de Publ: Relatos de Casos
Responsável: CL126.2 - Biblioteca Médica Dr. Profesor Hernán Alessandri R.


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Id: biblio-888965
Autor: Horst, A; de Souza, JA; Santos, MCQ; Riffel, APK; Kolberg, C; Partata, WA.
Título: Effects of N-acetylcysteine on spinal cord oxidative stress biomarkers in rats with neuropathic pain
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(12):e6533, 2017. graf.
Idioma: en.
Resumo: N-acetylcysteine (NAC) inhibits nociceptive transmission. This effect has been associated partly with its antioxidant properties. However, the effect of NAC on the levels of lipid hydroperoxides (a pro-oxidant marker), content of ascorbic acid (a key antioxidant molecule of nervous tissue) and total antioxidant capacity (TAC) is unknown. Thus, our study assessed these parameters in the lumbosacral spinal cord of rats with chronic constriction injury (CCI) of the sciatic nerve, one of the most commonly employed animal models of neuropathic pain. Thirty-six male Wistar rats weighing 200-300 g were equally divided into the following groups: Naive (rats did not undergo surgical manipulation); Sham (rats in which all surgical procedures involved in CCI were used except the ligature), and CCI (rats in which four ligatures were tied loosely around the right common sciatic nerve). All rats received intraperitoneal injections of NAC (150 mg·kg−1·day−1) or saline for 1, 3, or 7 days. Rats were killed 1, 3, and 7 days after surgery. NAC treatment prevented the CCI-induced increase in lipid hydroperoxide levels only at day 1, although the amount was higher than that found in naive rats. NAC treatment also prevented the CCI-induced increase in ascorbic acid content, which occurred at days 1, 3, and 7. No significant change was found in TAC with NAC treatment. The changes observed here may be related to the antinociceptive effect of NAC because modulation of oxidative-stress parameters seemed to help normalize the spinal cord oxidative status altered by pain.
Descritores: Acetilcisteína/farmacologia
Depuradores de Radicais Livres/farmacologia
Neuralgia/tratamento farmacológico
Neuralgia/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Medula Espinal/efeitos dos fármacos
Medula Espinal/metabolismo
-Antioxidantes
Ácido Ascórbico/análise
Biomarcadores/análise
Constrição
Peróxidos Lipídicos/análise
Ratos Wistar
Espécies Reativas de Oxigênio/metabolismo
Reprodutibilidade dos Testes
Neuropatia Ciática
Fatores de Tempo
Resultado do Tratamento
Limites: Animais
Masculino
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-839250
Autor: Horst, A; de Souza, JA; Santos, MCQ; Riffel, APK; Kolberg, C; Ribeiro, MFM; de Fraga, LS; Partata, WA.
Título: N-acetylcysteine downregulates phosphorylated p-38 expression but does not reverse the increased superoxide anion levels in the spinal cord of rats with neuropathic pain
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(2):e5801, 2017. graf.
Idioma: en.
Resumo: We determined the effect of N-acetylcysteine (NAC) on the expression of the phosphorylated p38 (p-p38) protein and superoxide anion generation (SAG), two important players in the processing of neuropathic pain, in the lumbosacral spinal cord of rats with chronic constriction injury (CCI)-induced neuropathic pain. The sciatic functional index (SFI) was also measured to assess the functional recovery post-nerve lesion. Thirty-six male Wistar rats were divided equally into the following groups: Naive (rats did not undergo surgical manipulation); Sham (rats in which all surgical procedures involved in CCI were used except the ligature), and CCI (rats in which four ligatures were tied loosely around the right common sciatic nerve), which received 2, 4, or 8 intraperitoneal injections of NAC (150 mg·kg-1·day-1) or saline beginning 4 h after CCI. Rats were sacrificed 1, 3, and 7 days after CCI. The SFI was measured on these days and the lumbosacral spinal cord was used for analysis of p-p38 expression and SAG. CCI induced a decrease in SFI as well as an increase in p-p38 expression and SAG in the spinal cord. The SFI showed a partial recovery at day 7 in saline-treated CCI rats, but recovery was improved in NAC-treated CCI rats. NAC induced a downregulation in p-p38 expression at all time-points evaluated, but did not reverse the increased SAG induced by CCI. Since p-p38 is a mediator in neuropathic pain and/or nerve regeneration, modulation of this protein may play a role in NAC-induced effects in CCI rats.
Descritores: Acetilcisteína/uso terapêutico
Neuralgia/tratamento farmacológico
Proteínas Quinases p38 Ativadas por Mitógeno/efeitos dos fármacos
Medula Espinal/efeitos dos fármacos
Superóxidos/metabolismo
-Western Blotting
Constrição Patológica
Modelos Animais de Doenças
Regulação para Baixo/efeitos dos fármacos
Neuralgia/etiologia
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
Limiar da Dor
Fosforilação/efeitos dos fármacos
Ratos Wistar
Medula Espinal/metabolismo
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME



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