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Id: biblio-959225
Autor: Herrmann, Ana P; Andrejew, Roberta; Benvenutti, Radharani; Gama, Clarissa S; Elisabetsky, Elaine.
Título: Effects of N-acetylcysteine on amphetamine-induced sensitization in mice
Fonte: Rev. bras. psiquiatr;40(2):169-173, Apr.-June 2018. graf.
Idioma: en.
Projeto: FIPE-HCPA.
Resumo: Objective: N-acetylcysteine (NAC) is beneficial in psychiatric conditions, including schizophrenia. Patients with schizophrenia exhibit mesolimbic dopamine hyperfunction consequent to an endogenous sensitization process. This sensitization can be modeled in rodents by repeated exposure to psychostimulants, provoking an enduring amplified response at subsequent exposure. The aim of this study was to investigate the effects of NAC on amphetamine sensitization in mice. Methods: D-amphetamine was administered to C57BL/6 mice three times a week for 3 weeks; the dose was increased weekly from 1 to 3 mg/kg. NAC (60 mg/kg) or saline was administered intraperitoneally before saline or amphetamine during the second and third weeks. After a 4-week washout period, latent inhibition (LI) and the locomotor response to amphetamine 2 mg/kg were assessed. Results: Sensitization disrupted LI and amplified the locomotor response; NAC disrupted LI in control mice. In sensitized animals, NAC attenuated the enhanced locomotion but failed to prevent LI disruption. Conclusion: NAC warrants consideration as a candidate for early intervention in ultra-high risk subjects due to its safety profile and the relevance of its mechanism of action. Supplementing this proposition, we report that NAC attenuates sensitization-induced locomotor enhancement in mice. The finding that NAC disrupted LI incites a cautionary note and requires clarification.
Descritores: Acetilcisteína/farmacologia
Esquizofrenia/tratamento farmacológico
Comportamento Animal/efeitos dos fármacos
Estimulantes do Sistema Nervoso Central/farmacologia
Atividade Motora/efeitos dos fármacos
-Acetilcisteína/administração & dosagem
Modelos Animais de Doenças
Anfetamina/administração & dosagem
Estimulantes do Sistema Nervoso Central/administração & dosagem
Camundongos Endogâmicos C57BL
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1090559
Autor: Gonçalves, Maiara Santos; Silveira, Aron Ferreira da; Murashima, Adriana de Andrade Batista; Rossato, Maria; Hippolito, Miguel Angelo.
Título: Otoprotection Mechanisms Against Oxidative Stress Caused by Cisplatin
Fonte: Int. arch. otorhinolaryngol. (Impr.);24(1):47-52, Jan.-Mar. 2020. graf.
Idioma: en.
Resumo: Abstract Introduction Cisplatin damages the auditory system and is related to the generation of free radicals. Glutathione peroxidase is an endogenous free radicals remover. Objective To investigate the mechanisms involved in otoprotection by N-acetylcys- teine through the expression of glutathione peroxidase in outer hair cells from rats treated with cisplatin. Methods Male Wistar rats were intraperitoneally injected with cisplatin (8 mg/Kg) and/or received oral administration by gavage of N-acetylcysteine (300 mg/Kg) for 3 consecutive days. On the 4th day, the animals were euthanized and beheaded. The tympanic bullae were removed and prepared for scanning electron microscopy and Results Among the groups exposed to ototoxic doses of cisplatin, there was an increase in glutathione peroxidase immunostaining in two groups, the one exposed to cisplatin alone, and the group exposed to both cisplatin and N-acetylcysteine. Conclusion The expression of glutathione peroxidase in the outer hair cells of rats exposed to cisplatin showed the synthesis of this enzyme under cellular toxicity conditions.
Descritores: Acetilcisteína/uso terapêutico
Depuradores de Radicais Livres/uso terapêutico
Cisplatino/toxicidade
Estresse Oxidativo/efeitos dos fármacos
Antineoplásicos/toxicidade
-Acetilcisteína/metabolismo
Acetilcisteína/farmacologia
Microscopia Eletrônica de Varredura
Potenciais Evocados Auditivos do Tronco Encefálico
Depuradores de Radicais Livres/metabolismo
Depuradores de Radicais Livres/farmacologia
Imunofluorescência
Cisplatino/uso terapêutico
Ratos Wistar
Cóclea/anatomia & histologia
Cóclea/efeitos dos fármacos
Radicais Livres
Glutationa Peroxidase/metabolismo
Perda Auditiva Neurossensorial/prevenção & controle
Limites: Animais
Masculino
Responsável: BR66.1 - Divisão de Biblioteca e Documentação


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Id: biblio-990820
Autor: Santos, Patrícia; Herrmann, Ana P; Elisabetsky, Elaine; Piato, Angelo.
Título: Anxiolytic properties of compounds that counteract oxidative stress, neuroinflammation, and glutamatergic dysfunction: a review
Fonte: Rev. bras. psiquiatr;41(2):168-178, Mar.-Apr. 2019. tab.
Idioma: en.
Projeto: CNPq; . CAPES.
Resumo: Objective: Anxiety disorders are highly prevalent and the efficacy of the available anxiolytic drugs is less than desired. Adverse effects also compromise patient quality of life and adherence to treatment. Accumulating evidence shows that the pathophysiology of anxiety and related disorders is multifactorial, involving oxidative stress, neuroinflammation, and glutamatergic dysfunction. The aim of this review was to evaluate data from animal studies and clinical trials showing the anxiolytic effects of agents whose mechanisms of action target these multiple domains. Methods: The PubMed database was searched for multitarget agents that had been evaluated in animal models of anxiety, as well as randomized double-blind placebo-controlled clinical trials of anxiety and/or anxiety related disorders. Results: The main multitarget agents that have shown consistent anxiolytic effects in various animal models of anxiety, as well in clinical trials, are agomelatine, N-acetylcysteine (NAC), and omega-3 fatty acids. Data from clinical trials are preliminary at best, but reveal good safety profiles and tolerance to adverse effects. Conclusion: Agomelatine, NAC and omega-3 fatty acids show beneficial effects in clinical conditions where mainstream treatments are ineffective. These three multitarget agents are considered promising candidates for innovative, effective, and better-tolerated anxiolytics.
Descritores: Transtornos de Ansiedade/tratamento farmacológico
Acetilcisteína/farmacologia
Ansiolíticos/farmacologia
Ácidos Graxos Ômega-3/farmacologia
Hipnóticos e Sedativos/farmacologia
Acetamidas/farmacologia
-Neuroimunomodulação/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Modelos Animais de Doenças
Glutamina/efeitos dos fármacos
Limites: Humanos
Animais
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Andrade, Luís Eduardo Coelho
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Id: lil-731266
Autor: Correa, Marcelo José Uchoa; Mariz, Henrique Ataíde; Andrade, Luís Eduardo Coelho; Kayser, Cristiane.
Título: N-acetilcisteína oral no tratamento do fenômeno de Raynaud secundário à esclerose sistêmica: ensaio clínico randomizado, placebo-controlado e duplo-cego / Oral N-acetylcysteine in the treatment of Raynaud's phenomenon secondary to systemic sclerosis: A randomized, double-blind, placebo-controlled clinical trial
Fonte: Rev. bras. reumatol;54(6):452-458, Nov-Dec/2014. tab, graf.
Idioma: pt.
Projeto: Fundação de Amparo à Pesquisa do Estado de São Paulo.
Resumo: Objetivo Avaliar a segurança e a eficácia da N-acetilcisteína (NAC) por via oral sobre o fluxo sanguíneo da microcirculação digital em pacientes com fenômeno de Raynaud (FRy) secundário à esclerose sistêmica (ES). Métodos Este foi um estudo randomizado, duplo-cego e placebo-controlado, no qual 42 pacientes com ES receberam NAC oral na dose de 600 mg, três vezes ao dia (21 pacientes, idade média 45,6±9,5 anos) ou placebo (21 pacientes, idade média 45,0±12,7 anos) durante quatro semanas. O desfecho primário do estudo foi: melhora no fluxo sanguíneo da microcirculação cutânea antes e após estímulo frio avaliado pelo laser Doppler imaging (LDI) nas semanas 0 e 4. A frequência e a gravidade do FRy e o número de úlceras digitais também foram avaliados nas semanas 0 e 4. Os efeitos adversos foram registrados na quarta semana. Resultados Não houve mudança significativa no fluxo sanguíneo digital avaliado pelo LDI antes ou depois do estímulo frio após quatro semanas de NAC ou placebo. Ambos os grupos apresentaram melhora significativa na frequência e gravidade dos ataques de FRy, sem diferença entre os dois. O grupo placebo apresentou três úlceras digitais enquanto o grupo NAC não apresentou úlceras ao final do estudo. NAC foi bem tolerada e nenhum paciente descontinuou o tratamento. Conclusões NAC por via oral na dose de 1.800mg/dia não demonstrou efeito vasodilatador sobre a microcirculação das mãos após quatro semanas de tratamento em pacientes com FRy secundário à ES. .

Objective To evaluate the safety and efficacy of oral N-acetylcysteine (NAC) on digital microcirculation blood flow in patients with Raynaud's phenomenon (RP) secondary to systemic sclerosis (SSc). Methods This was a randomized, double-blind, placebo-controlled trial in which 42 patients with SSc received oral NAC at a dose of 600mg tid (21 patients, mean age 45.6±9.5 years) or placebo (21 patients, mean age 45.0±12.7 years) for four weeks. The primary endpoint was the change in cutaneous microcirculation blood flow before and after cold stimulation measured by laser Doppler imaging (LDI) at weeks 0 and 4. The frequency and severity of RP and the number of digital ulcers were also measured at weeks 0 and 4. The adverse events were recorded in the fourth week. Results There was no significant change in digital blood flow assessed by LDI before or after cold stimulus after four weeks of NAC or placebo. Both groups showed significant improvement in the frequency and severity of RP attacks, with no difference between the two groups. At the end of the study, the placebo group had three digital ulcers, while the NAC group showed no ulcers. NAC was well tolerated and no patient discontinued the treatment. Conclusions NAC orally at a dose of 1800mg/day showed no vasodilator effect on hands’ microcirculation after four weeks of treatment in patients with RP secondary to SSc. .
Descritores: Acetilcisteína/administração & dosagem
Doença de Raynaud/tratamento farmacológico
Depuradores de Radicais Livres/administração & dosagem
-Doença de Raynaud/etiologia
Doença de Raynaud/fisiopatologia
Fluxo Sanguíneo Regional
Escleroderma Sistêmico/complicações
Método Duplo-Cego
Administração Oral
Microcirculação
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Wajner, Moacir
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Id: biblio-994866
Autor: Vanzin, Camila Simioni; Mescka, Caroline Paula; Donida, Bruna; Marchetti, Desirèe Padilha; Jacques, Carlos Eduardo; Hauschild, Tatiane; Faverzani, Jéssica Lamberty; Deon, Marion; Moura, Dinara Jaqueline; Saffi, Jenifer; Coelho, Daniella de Moura; Wajner, Moacir; Wyse, Angela Terezinha de Souza; Vargas, Carmen Regla.
Título: DNA damage in homocystinuria: 8-oxo-, 8-dihydro-2'-deoxyguanosine levels in cystathionine-ß-synthase deficient patients and the in vitro protective effect of N-acetyl­L­cysteine
Fonte: Clin. biomed. res;38(1):50-57, 2018.
Idioma: en.
Resumo: Introduction: Homocysteine (Hcy) tissue accumulation occurs in a metabolic disease characterized biochemically by cystathionine ß-synthase (CBS) deficiency and clinically by mental retardation, vascular problems, and skeletal abnormalities. Previous studies indicate the occurrence of DNA damage secondary to hyperhomocysteinemia and it was observed that DNA damage occurs in leukocytes from CBS-deficient patients. This study aimed to investigate whether an oxidative mechanism could be involved in DNA damage previously found and investigated the in vitro effect of N-acety-L-cysteine (NAC) on DNA damage caused by high Hcy levels. Methods: We evaluated a biomarker of oxidative DNA damage in the urine of CBS­deficient patients, as well as the in vitro effect of NAC on DNA damage caused by high levels of Hcy. Moreover, a biomarker of lipid oxidative damage was also measured in urine of CBS deficient patients. Results: There was an increase in parameters of DNA (8-oxo-7,8-dihydro-2'- deoxyguanosine) and lipid (15-F2t-isoprostanes levels) oxidative damage in CBS-deficient patients when compared to controls. In addition, a significant positive correlation was found between 15-F2t-isoprostanes levels and total Hcy concentrations. Besides, an in vitro protective effect of NAC at concentrations of 1 and 5 mM was observed on DNA damage caused by Hcy 50 µM and 200 µM. Additionally, we showed a decrease in sulfhydryl content in plasma from CBS-deficient patients when compared to controls. Discussion: These results demonstrated that DNA damage occurs by an oxidative mechanism in CBS deficiency together with lipid oxidative damage, highlighting the NAC beneficial action upon DNA oxidative process, contributing with a new treatment perspective of the patients affected by classic homocystinuria.
Descritores: Acetilcisteína/farmacologia
Dano ao DNA
Estresse Oxidativo
Cistationina/metabolismo
Desoxiguanosina/urina
Homocistinúria/genética
Antioxidantes/farmacologia
-Biomarcadores/urina
Estudos de Casos e Controles
Creatinina/urina
Ensaio Cometa
Cistationina/biossíntese
Cistationina/sangue
Isoprostanos/análise
Desoxiguanosina/análogos & derivados
Homocisteína/sangue
Homocistinúria/sangue
Limites: Humanos
Feminino
Criança
Adolescente
Adulto
Adulto Jovem
Responsável: BR18.1 - Biblioteca FAMED/HCPA


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Id: biblio-949360
Autor: Ozturk, Omur; Eroglu, Huseyin Avni; Ustebay, Sefer; Kuzucu, Mehmet; Adali, Yasemen.
Título: An experimental study on the preventive effects of N-acetyl cysteine and ozone treatment against contrast-induced nephropathy
Fonte: Acta cir. bras;33(6):508-517, June 2018. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To compare the preventive effects of N-acetyl cysteine (NAC), ozone preconditioning and ozone treatment against contrast-induced nephropathy (CIN) in an experimental rat model. Methods: Thirty adult male Wistar rats were randomly distributed into five groups (n=6 for each group). Group I served as control and Group II had only contrast agent, while Group III received NAC and Group IV received intraperitoneal ozone 6 hours before and 6 hours after introduction of contrast agent. Ozone treatment was applied for 5 days after the contrast agent was introduced in Group V. After induction of CIN, groups were compared in terms of serum levels of urea, creatinine, neutrophil gelatinase associated lipocalin, protein carbonyl, total antioxidant capacity (TAC) as well as degree of renal injury at histopathologic level. Results: Groups II-V displayed more obvious histopathological alterations such as hemorrhage and renal tubular injury compared with Group I. TAC (p=0.043) and creatinine (p=0.046) levels increased significantly in Group II after the intervention. In Group III, protein carbonyl level diminished remarkably (p=0.046), while creatinine level was increased (p=0.046) following the intervention. TAC level was higher in Group IV (p=0.028) and Group V (p=0.026) following the procedure. Conclusion: The N-acetyl cysteine and ozone treatment may alleviate the biochemical and histopathological deleterious effects of contrast-induced nephropathy via enhancement of total antioxidant capacity and decreasing oxidative stress.
Descritores: Ozônio/farmacologia
Acetilcisteína/farmacologia
Meios de Contraste/efeitos adversos
Nefropatias/induzido quimicamente
Nefropatias/prevenção & controle
Antioxidantes/farmacologia
-Valores de Referência
Espectrofotometria/métodos
Ureia/sangue
Ácido Ioxáglico/efeitos adversos
Distribuição Aleatória
Reprodutibilidade dos Testes
Resultado do Tratamento
Ratos Wistar
Estresse Oxidativo/efeitos dos fármacos
Creatinina/sangue
Carbonilação Proteica
Lipocalina-2/sangue
Rim/efeitos dos fármacos
Rim/patologia
Nefropatias/patologia
Limites: Animais
Masculino
Tipo de Publ: Estudo Comparativo
Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Martelli, Antonio Carlos Ceribelli
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Id: biblio-838003
Autor: Pinto, Ana Cecília Versiani Duarte; Andrade, Tatiana Cristina Pedro Cordeiro de; Brito, Fernanda Freitas de; Silva, Gardênia Viana da; Cavalcante, Maria Lopes Lamenha Lins; Martelli, Antonio Carlos Ceribelli.
Título: Trichotillomania: a case report with clinical and dermatoscopic differential diagnosis with alopecia areata
Fonte: An. bras. dermatol;92(1):118-120, Jan.-Feb. 2017. graf.
Idioma: en.
Resumo: ABSTRACT Trichotillomania is a psychodermatologic disorder characterized by uncontrollable urge to pull one's own hair. Differential diagnoses include the most common forms of alopecia such as alopecia areata. It is usually associated with depression and obsessive-compulsive disorder. Trichotillomania treatment standardization is a gap in the medical literature. Recent studies demonstrated the efficacy of N-acetylcysteine (a glutamate modulator) for the treatment of the disease. We report the clinical case of a 12-year-old female patient who received the initial diagnosis of alopecia areata, but presented with clinical and dermoscopic features of trichotillomania. She was treated with the combination of psychotropic drugs and N-acetylcysteine with good clinical response. Due to the chronic and recurring nature of trichotillomania, more studies need to be conducted for the establishment of a formal treatment algorithm.
Descritores: Psicotrópicos/uso terapêutico
Tricotilomania/diagnóstico
Alopecia em Áreas/diagnóstico
-Pimozida/uso terapêutico
Acetilcisteína/uso terapêutico
Tricotilomania/tratamento farmacológico
Fluoxetina/uso terapêutico
Diagnóstico Diferencial
Doxepina/uso terapêutico
Limites: Humanos
Feminino
Criança
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-886983
Autor: Barroso, Livia Ariane Lopes; Sternberg, Flavia; Souza, Maria Natalia Inacio de Fraia e; Nunes, Gisele Jacobino de Barros.
Título: Trichotillomania: a good response to treatment with N-acetylcysteine
Fonte: An. bras. dermatol;92(4):537-539, July-Aug. 2017. graf.
Idioma: en.
Resumo: Abstract: Trichotillomania is considered a behavioral disorder and is characterized by the recurring habit of pulling one's hair, resulting in secondary alopecia. It affects 1% of the adult population, and 2 to 4.4% of psychiatric patients meet the diagnostic criteria. It can occur at any age and is more prevalent in adolescents and females. Its occurrence in childhood is not uncommon and tends to have a more favorable clinical course. The scalp, eyebrows and eyelashes are the most commonly affected sites. Glutamate modulating agents, such as N-acetylcysteine, have been shown to be a promising treatment. N-acetylcysteine acts by reducing oxidative stress and normalizing glutaminergic transmission. In this paper, we report a case of trichotillomania with an excellent response to N-acetylcysteine.
Descritores: Acetilcisteína/uso terapêutico
Tricotilomania/tratamento farmacológico
Antioxidantes/uso terapêutico
-Tricotilomania/diagnóstico
Diagnóstico Diferencial
Alopecia/diagnóstico
Alopecia/etiologia
Limites: Humanos
Masculino
Criança
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-889206
Autor: Choi, Young-Suk; Kim, Cheul; Moon, Ji-Hoi; Lee, Jin-Yong.
Título: Removal and killing of multispecies endodontic biofilms by N-acetylcysteine
Fonte: Braz. j. microbiol;49(1):184-188, Jan.-Mar. 2018. tab, graf.
Idioma: en.
Projeto: Ministry of Health and Welfare; . Ministry of Science.
Resumo: ABSTRACT Removal of bacterial biofilm from the root canal system is essential for the management of endodontic disease. Here we evaluated the antibacterial effect of N-acetylcysteine (NAC), a potent antioxidant and mucolytic agent, against mature multispecies endodontic biofilms consisting of Actinomyces naeslundii, Lactobacillus salivarius, Streptococcus mutans and Enterococcus faecalis on sterile human dentin blocks. The biofilms were exposed to NAC (25, 50 and 100 mg/mL), saturated calcium hydroxide or 2% chlorhexidine solution for 7 days, then examined by scanning electron microscopy. The biofilm viability was measured by viable cell counts and ATP-bioluminescence assay. NAC showed greater efficacy in biofilm cell removal and killing than the other root canal medicaments. Furthermore, 100 mg/mL NAC disrupted the mature multispecies endodontic biofilms completely. These results demonstrate the potential use of NAC in root canal treatment.
Descritores: Acetilcisteína/farmacologia
Streptococcus mutans/efeitos dos fármacos
Actinomyces/efeitos dos fármacos
Enterococcus faecalis/efeitos dos fármacos
Biofilmes/efeitos dos fármacos
Doenças da Polpa Dentária/microbiologia
Lactobacillus salivarius/efeitos dos fármacos
Antibacterianos/farmacologia
-Streptococcus mutans/fisiologia
Actinomyces/fisiologia
Hidróxido de Cálcio/farmacologia
Clorexidina/farmacologia
Enterococcus faecalis/fisiologia
Cavidade Pulpar/microbiologia
Viabilidade Microbiana/efeitos dos fármacos
Lactobacillus salivarius/fisiologia
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-888963
Autor: Shen, JC; Zhang, YC; Zhao, MF.
Título: Protective effects of deferasirox and N-acetyl-L-cysteine on iron overload-injured bone marrow
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(12):e6087, 2017. graf.
Idioma: en.
Projeto: National Natural Sciences Foundation; . Tianjin Science and Technique Foundation; . Seed Foundation.
Resumo: Using an iron overload mouse model, we explored the protective effect of deferasirox (DFX) and N-acetyl-L-cysteine (NAC) on injured bone marrow hematopoietic stem/progenitor cells (HSPC) induced by iron overload. Mice were intraperitoneally injected with 25 mg iron dextran every 3 days for 4 weeks to establish an iron overload (Fe) model. DFX or NAC were co-administered with iron dextran in two groups of mice (Fe+DFX and Fe+NAC), and the function of HSPCs was then examined. Iron overload markedly decreased the number of murine HSPCs in bone marrow. Subsequent colony-forming cell assays showed that iron overload also decreased the colony forming capacity of HSPCs, the effect of which could be reversed by DFX and NAC. The bone marrow hematopoiesis damage caused by iron overload could be alleviated by DFX and NAC.
Descritores: Acetilcisteína/farmacologia
Triazóis/farmacologia
Benzoatos/farmacologia
Células-Tronco Hematopoéticas/efeitos dos fármacos
Quelantes de Ferro/farmacologia
Depuradores de Radicais Livres/farmacologia
Sobrecarga de Ferro/prevenção & controle
Substâncias Protetoras/farmacologia
-Valores de Referência
Fatores de Tempo
Reprodutibilidade dos Testes
Resultado do Tratamento
Espécies Reativas de Oxigênio/análise
Ensaio de Unidades Formadoras de Colônias
Modelos Animais de Doenças
Citometria de Fluxo
Hematopoese/efeitos dos fármacos
Camundongos Endogâmicos C57BL
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME



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