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Id: biblio-840857
Autor: Tokgöz, Hüsnü; Taş, Selim; Giray, Özlem; Yalçınkaya, Soner; Tokgöz, Özlem; Koca, Cemile; Savaş, Murat; Erel, Özcan.
Título: The change in serum Thiol/Disulphide homeostasis after transrectal ultrasound guided prostate biopsy
Fonte: Int. braz. j. urol;43(3):455-461, May.-June 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objectives The aim of this prospective clinical study was to investigate variations in a novel oxidative stress marker (thiol/disulphide homeostasis) in men who underwent transrectal ultrasound guided prostate biopsy (TRUSB). Materials and Methods A total of 22 men undergoing TRUSB of the prostate were enrolled in the study. Patients with abnormal digital rectal examination and/or total prostate specific antigen (PSA) over 4ng/mL underwent TRUSB with 12 cores. Serum samples were obtained before and just after the procedure to evaluate the possible changes in thiol/disulphide homeostasis. Mean age, total PSA and free PSA, prostate volume and histopathological data were also recorded. Results Mean age of the study population was 65.05±8.89 years. Significant decreases in native and total thiol levels were documented after the biopsy procedure. However, serum disulphide levels and disulphide/native thiol, disulphide/total thiol and native/total thiol ratios did not significantly change after TRUSB. No correlation was observed between oxidative parameters and total PSA and free PSA levels, prostate volume and histopathology of the prostate. However, mean patient age was significantly correlated with mean native and total thiol levels. Conclusion Significant decreases in serum native and total thiol levels related to the prostate biopsy procedure suggest that TRUSB causes acute oxidative stress in the human body. Since our trial is the first in the current literature to investigate these oxidative stress markers in urology practice, additional studies are warranted.
Descritores: Neoplasias da Próstata/metabolismo
Neoplasias da Próstata/diagnóstico por imagem
Compostos de Sulfidrila/metabolismo
Ultrassonografia
Antígeno Prostático Específico/metabolismo
Estresse Oxidativo
Dissulfetos/metabolismo
-Próstata/patologia
Biópsia
Biomarcadores
Estudos Prospectivos
Exame Retal Digital
Aspiração por Agulha Fina Guiada por Ultrassom Endoscópico
Biópsia Guiada por Imagem
Limites: Humanos
Masculino
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-1012326
Autor: Solakhan, Mehmet; Çiçek, Hülya; Orhan, Nuri; Yildirim, Mustafa.
Título: Role of native thiol, total thiol and dynamic Disulphide in diagnosis of patient with prostate cancer and prostatitis
Fonte: Int. braz. j. urol;45(3):495-502, May-June 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT Background: Our study investigates whether Native Thiol, Total Thiol and disulphide levels measured in serum of patients with prostate cancer and prostatitis and of healthy subjects, have any role in differential diagnosis. Materials and Methods: Patients followed up for histopathologically verified diagnosis of prostate cancer and prostatitis in 2016-2017 at the Medicalpark Gaziantep Hospital Urology Clinic were included in the study. Native Thiol (NT), Total Thiol (TT), Dynamic Disulphide (DD) levels in serum were measured by a novel automated method. Results: NT, TT, DD, NT / TT ratios, DD / TT ratio and DD / NT ratio were measured as 118.4 ± 36.8μmoL / L, 150.3 ± 45.3μmoL / L, 15.9 ± 7μmoL / L, 78.8 ± 7μmoL / L, 10.5 ± 3.5μmoL / L, 13.8 ± 5.8μmoL / L respectively in patients with prostate cancer; as 116.4 ± 40.5μmoL / L, 147.5 ± 50.1μmoL / L, 15.5 ± 8.7μmoL / L, 79.7 ± 9μmoL / L, 10.1 ± 4.5μmoL / L, 13.5 ± 7.2μmoL / L in patients with prostatitis and as 144.1 ± 21.2μmoL / L, 191 ± 32.3μmoL / L, 23.4 ± 10.1μmoL / L, 76.1 ± 98.3μmoL / L, 11.9 ± 4.1μmoL / L, 16.4 ± 6.9μmoL / L in healthy subjects. Significant difference was detected between groups of NT, TT and DD levels (p = 0.008, p = 0.001, p = 0.002). No significant difference was detected in terms of the NT / TT, DD / TT and DD / NT rates (p = 0.222, p = 0.222, p = 0.222). Conclusions: Serum NT, TT, DD levels in patients with prostatitis and prostate cancer were found significantly lower compared to the control group. This indicates that just as inflammation, prostate cancer also increases oxidative stress on tissues.
Descritores: Neoplasias da Próstata/sangue
Prostatite/sangue
Compostos de Sulfidrila/sangue
Dissulfetos/sangue
-Neoplasias da Próstata/diagnóstico
Prostatite/diagnóstico
Valores de Referência
Biomarcadores Tumorais/sangue
Estudos de Casos e Controles
Reprodutibilidade dos Testes
Estudos Retrospectivos
Fatores de Risco
Análise de Variância
Estatísticas não Paramétricas
Medição de Risco
Estresse Oxidativo/fisiologia
Diagnóstico Diferencial
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-1020487
Autor: Ozgunay, Seyda Efsun; Ozsin, Kadir Kaan; Ustundag, Yasemin; Karasu, Derya; Ozyaprak, Buket; Balcı, Burak; Erel, Ozcan; Yavuz, Senol.
Título: The effect of continuous ventilation on thiol-disulphide homeostasis and albumin-adjusted ischemia-modified albumin during cardiopulmonary bypass
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);34(4):436-443, July-Aug. 2019. tab, graf.
Idioma: en.
Resumo: Abstract Objective: To investigate the effect of continuous lung ventilation with low tidal volume on oxidation parameters, such as thiol/disulphide homeostasis and albumin-adjusted ischemia-modified albumin (AAIMA), during cardiopulmonary bypass (CBP) in coronary artery bypass grafting (CABG). Methods: Seventy-four patients who underwent elective CABG with CPB were included in the study. Blood samples were taken in the preoperative period, 10 minutes after CPB, and six and 24 hours postoperatively. Patients were assigned to the continuous ventilation group (Group 1, n=37) and the non-ventilated group (Group 2, n=37). The clinical characteristics, thiol/disulphide homeostasis, ischemia-modified albumin (IMA), and AAIMA levels of the patients were compared. Results: A significant difference was found between the groups regarding native thiol, total thiol, and IMA levels at the postoperative 24th hour (P=0.030, P=0.031, and P=0.004, respectively). There was no difference between the groups in terms of AAIMA. AAIMA levels returned to preoperative levels in Groups 1 and 2, at the 6th and 24th postoperative hours, respectively. Length of hospital stay was significantly shorter in Group 1 (P<0.001) than in Group 2. Conclusion: Continuous ventilation during CPB caused an increase in native and total thiol levels, an earlier return of AAIMA levels, and shorter hospital stay. Continuous ventilation may reduce the negative effects of CPB on myocardium (Table 2, Figure 1, and Reference 31).
Descritores: Respiração Artificial
Compostos de Sulfidrila/sangue
Albumina Sérica/análise
Ponte Cardiopulmonar/efeitos adversos
Dissulfetos/sangue
-Complicações Pós-Operatórias/prevenção & controle
Biomarcadores/sangue
Ponte Cardiopulmonar/métodos
Ponte de Artéria Coronária
Método Duplo-Cego
Estudos Prospectivos
Lesão Pulmonar/etiologia
Albumina Sérica Humana
Homeostase/fisiologia
Antioxidantes
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: lil-796042
Autor: Rajaei, Z; Hosseini, M; Alaei, H.
Título: Effects of crocin on brain oxidative damage and aversive memory in a 6-OHDA model of Parkinson's disease / Efeitos da crocina no dano oxidativo cerebral e na memória aversiva em um modelo 6-OHDA de doença de Parkinson
Fonte: Arq. neuropsiquiatr;74(9):723-729, Sept. 2016. graf.
Idioma: en.
Resumo: ABSTRACT The purpose of the present study was to investigate the effect of crocin on brain oxidative damage and memory deficits in a 6-hydroxydopamine (6-OHDA) model of Parkinson’s disease. Male Wistar rats were subjected to unilateral injection of 6-OHDA (16 µg) into the medial forebrain bundle and treated with crocin (30 and 60 mg/kg) for six weeks. The rats were tested for memory performance at six weeks after 6-OHDA infusion, and then were killed for the estimation of biochemical parameters. The increase in thiobarbituric acid reactive substances (TBARS) and nitrite levels in the hippocampus were observed in the 6-OHDA lesioned rats, which was accompanied by memory deficits in a passive avoidance test at the end of week 6. Moreover, treatment with crocin decreased TBARS and nitrite levels in the hippocampus, and improved aversive memory. The present study conclusively demonstrated that crocin acts as an antioxidant and anti-inflammatory agent in the hippocampus of parkinsonian rats and could improve aversive memory through its properties.

RESUMO O objetivo do presente estudo foi investigar o efeito da crocina no dano oxidativo cerebral e nos déficits de memória em um modelo 6-OHDA de doença de Parkinson. Ratos Wistar machos foram submetidos à injeção unilateral de 6-OHDA (16 μg) em MFB e tratados com crocina (30 e 60 mg/kg), durante 6 semanas. Os ratos foram testados quanto ao desempenho da memória 6 semanas após a infusão de 6-OHDA, e, em seguida, foram sacrificados para a estimativa dos parâmetros bioquímicos. O aumento nos níveis de TBARS e de nitrito no hipocampo foram observados em ratos 6-OHDA lesionados, acompanhado por déficits de memória em um teste de esquiva passiva no final da semana 6. Além disso, o tratamento com crocina diminuiu os níveis de nitrito e de TBARS no hipocampo e melhorou a memória aversiva. O presente estudo demonstrou conclusivamente que a crocina age como um antioxidante e um agente anti-inflamatório no hipocampo de ratos parkinsonianos e pode melhorar a memória aversiva através de suas propriedades.
Descritores: Doença de Parkinson/tratamento farmacológico
Carotenoides/farmacologia
Córtex Cerebral/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Transtornos da Memória/prevenção & controle
Antioxidantes/farmacologia
-Doença de Parkinson/fisiopatologia
Doença de Parkinson/metabolismo
Compostos de Sulfidrila/análise
Peroxidação de Lipídeos/efeitos dos fármacos
Distribuição Aleatória
Córtex Cerebral/fisiopatologia
Córtex Cerebral/metabolismo
Oxidopamina
Substâncias Reativas com Ácido Tiobarbitúrico/análise
Ratos Wistar
Modelos Animais de Doenças
Glutationa Peroxidase/análise
Glutationa Peroxidase/efeitos dos fármacos
Memória/efeitos dos fármacos
Memória/fisiologia
Transtornos da Memória/fisiopatologia
Transtornos da Memória/metabolismo
Nitritos/análise
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-888359
Autor: Haddadi, Hossein; Rajaei, Ziba; Alaei, Hojjatallah; Shahidani, Somayeh.
Título: Chronic treatment with carvacrol improves passive avoidance memory in a rat model of Parkinson's disease / O tratamento com carvacrol melhora a memória de esquiva passiva em um modelo da doença de Parkinson em ratos
Fonte: Arq. neuropsiquiatr;76(2):71-77, Feb. 2018. graf.
Idioma: en.
Resumo: ABSTRACT The present study investigated the effects of carvacrol on motor and memory deficits as well as hyperalgesia in the 6-OHDA-lesioned rat model of Parkinson's disease. The animals were subjected to unilateral microinjection of 6-OHDA into the medial forebrain bundle and treated with carvacrol (25, 50 and 100 mg/kg, ip) for six weeks after surgery. The 6-OHDA-lesioned rats showed contralateral rotations towards the lesion side, which was accompanied by learning and memory deficits in a passive avoidance test and a decrease in tail withdrawal latency in a tail flick test at the end of week 6. The results also showed that treatment with carvacrol at a dose of 25 mg/kg ameliorated memory deficits, with no effect on rotations and hyperalgesia in lesioned rats. In conclusion, carvacrol improves memory impairments in rats with Parkinson's disease; therefore, it may serve as an adjunct therapy for the alleviation of memory deficits in Parkinson's disease patients.

RESUMO O presente estudo investigou os efeitos do carvacrol nos déficits motores e de memória, bem como na hiperalgesia, em um modelo da doença de Parkinson (DP) em ratos com lesões 6-OHDA. Os animais foram submetidos a microinjeção unilateral de 6-OHDA no feixe mediano do prosencéfalo e tratados com carvacrol (25, 50 e 100 mg / kg, ip) durante 6 semanas após a cirurgia. Os ratos com lesões 6-OHDA mostraram rotações contralaterais para o lado da lesão, que foram acompanhadas de déficits de aprendizagem e de memória em um teste de evitação passiva, e de uma diminuição da latência de retirada da cauda em um teste de cauda no final da semana 6. Os resultados também mostraram que o tratamento crônico com carvacrol a uma dose de 25 mg / kg aliviou os déficits de memória, sem efeito sobre rotações e hiperalgesia em ratos lesados. Em conclusão, o carvacrol melhora a deficiência de memória em ratos com DP e, portanto, pode servir como uma terapia complementar para aliviar os déficits de memória em pacientes com DP.
Descritores: Doença de Parkinson/tratamento farmacológico
Monoterpenos/uso terapêutico
Transtornos da Memória/tratamento farmacológico
Memória de Curto Prazo/efeitos dos fármacos
Antiparkinsonianos/uso terapêutico
-Doença de Parkinson/fisiopatologia
Compostos de Sulfidrila/análise
Peroxidação de Lipídeos/efeitos dos fármacos
Distribuição Aleatória
Reprodutibilidade dos Testes
Oxidopamina
Ratos Wistar
Monoterpenos/farmacologia
Modelos Animais de Doenças
Cimenos
Transtornos da Memória/fisiopatologia
Atividade Motora/efeitos dos fármacos
Neuralgia/fisiopatologia
Neuralgia/tratamento farmacológico
Antioxidantes/uso terapêutico
Antioxidantes/farmacologia
Antiparkinsonianos/farmacologia
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-888132
Autor: Aktaş, Serdar; Sağdık, Hacı Murat; Tetikoğlu, Mehmet; Aktaş, Hatice; Özcura, Fatih; Uçar, Fatma; Alışık, Murat; Ergin, Merve.
Título: Dynamic thiol/disulfide homeostasis in patients with age-related macular degeneration / Homeostase dinâmica de tiol/dissulfureto em pacientes com degeneração macular relacionada à idade
Fonte: Arq. bras. oftalmol;80(4):234-237, July-Aug. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Purpose: We evaluated dynamic thiol/disulfide homeostasis (TDH), malondialdehyde (MDA) levels, and catalase (CAT) activity in patients with age-related macular degeneration (AMD). All analyzes were conducted on plasma samples. Methods: Thirty-two patients with AMD and 38 age-matched healthy controls were included. Native thiol, total thiol, and disulfide levels and TDH status were determined using a novel, automated assay. MDA levels and CAT activity were determined. Percentages were compared using the chi-squared test. The Student's t-test and Mann-Whitney U-test were used to compare quantitative variables. Results: Native thiol levels were significantly lower (p=0.004) in patients with AMD (272.02 ± 52.41 µmol/l) than in healthy individuals (307.82 ± 47.18 µmol/l), whereas disulfide levels were significantly higher (p<0.001) in patients with AMD than in controls (21.64 ± 5.59 vs. 14.48 ± 5.37 µmol/L). Dynamic TDH was also significantly lower (p<0.001) in patients with AMD than in controls (13.41 ± 4.3 vs. 25.41 ± 14.52 µmol/l). No significant differences were evident in total thiol or MDA levels. Mean CAT activity was significantly higher (p=0.043) in patients with AMD compared with controls (0.035 vs. 0.018 k/ml). Conclusions: The antioxidant/oxidant balance demonstrated by dynamic TDH is shifted to the oxidative side in patients with AMD.

RESUMO Objetivo: Avaliar a homeostase dinâmica de tiol/dissulfureto e os níveis de malon dialdeído (MDA) e catalase (CAT) em pacientes com degeneração macular relacionada à idade (DMRI). Todas as análises foram realizadas em amostras de plasma. Métodos: Foram incluídos 32 pacientes com degeneração macular relacionada à idade e 38 controles saudáveis de idade similar. Os níveis de tiol, tiol total, dissulfureto e estado de homeostase de tiol/dissulfureto foram determinados utilizando um novo ensaio automatizado. Os níveis de atividade de MDA e CAT foram também determinados. As porcentagens foram comparadas pelo teste do qui-quadrado. O teste t de Student e o teste U de Mann Whitney foram utilizados para comparar variáveis quantitativas. Resultados: Os níveis de tiol nativo foram significativamente menores (p=0,004) nos pacientes com degeneração macular relacionada à idade (272,02 ± 52,41 µmol/l) do que nos indivíduos saudáveis (307,82 ± 47,18 µmol/l), enquan to os dissulfetos foram significativamente maiores em pacientes com degeneração macular relacionada à idade (21,64 ± 5,59 µmol/l versus 14,48 ± 5,37 µmol/l, respectivamente, p<0,001). A homeostase dinâmica de tiol/dissulfureto também foi significativamente menor nos pacientes com degeneração macular re la cionada à idade (13,41 ± 4,3 µmol/l) versus os controles (versus 25,41 ± 14,52 µmol/l, p<0,001). Não foram observadas diferenças significativas nos níveis de tiol total ou MDA. A atividade média de CAT foi significativamente mais elevada (p=0,043) em doentes com degeneração macular relacionada à idade (0,035 k/ml vs. 0,018 k/ml). Conclusões: O equilíbrio antioxidante/oxidante demonstrado pela homeostase dinâmica de tiol/dissulfeto é deslocado para o lado oxidativo em pacientes com de generação macular relacionada à idade.
Descritores: Compostos de Sulfidrila/sangue
Catalase/metabolismo
Dissulfetos/sangue
Degeneração Macular/sangue
Malondialdeído/sangue
Antioxidantes
-Biomarcadores/sangue
Estudos de Casos e Controles
Fatores Etários
Estresse Oxidativo/fisiologia
Homeostase
Limites: Humanos
Masculino
Feminino
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: biblio-838433
Autor: Chielle, Eduardo Ottobelli; Casarin, Jeferson Noslen.
Título: Evaluation of salivary oxidative parameters in overweight and obese young adults
Fonte: Arch. endocrinol. metab. (Online);61(2):152-159, Mar.-Apr. 2017. tab.
Idioma: en.
Resumo: ABSTRACT Background Obesity is characterized by a deposition of abnormal or excessive fat in adipose tissue, and is linked with a risk of damage to several metabolic and pathological processes associated with oxidative stress. To date, salivary oxidative biomarkers have been minimally explored in obese individuals. Thus, the aim of this study was to assess the concentrations of salivary oxidative biomarkers (ferric-reducing antioxidant power, uric acid, sulfhydryl groups) and lipid peroxidation in obese and overweight young subjects. Materials and methods Levels of lipid peroxidation, ferric-reducing antioxidant power, uric acid, and SH groups were determined in the saliva and serum of 149 young adults, including 54 normal weight, 27 overweight, and 68 obese individuals. Anthropometric measurements were also evaluated. Results Salivary levels of ferric-reducing antioxidant power, sulfhydryl groups, and lipid peroxidation, as well as serum levels of ferric-reducing antioxidant power, uric acid, and lipid peroxidation were higher in obese patients when compared with individuals with normal weight. There were correlations between salivary and serum ferric-reducing antioxidant power and salivary and serum uric acid in the obese and normal-weight groups. Conclusions Our results indicate that the increase in salivary levels of ferric-reducing antioxidant power, sulfhydryl groups, and lipid peroxidation, and serum levels of ferric-reducing antioxidant power, uric acid, and lipid peroxidation could be related to the regulation of various processes in the adipose tissue. These findings may hold promise in identifying new oxidative markers to assist in diagnosing and monitoring overweight and obese patients.
Descritores: Saliva/metabolismo
Saliva/química
Ácido Úrico/análise
Peroxidação de Lipídeos/fisiologia
Sobrepeso/sangue
Antioxidantes/análise
Obesidade/sangue
-Oxirredução
Valores de Referência
Compostos de Sulfidrila/análise
Biomarcadores/análise
Estudos de Casos e Controles
Antropometria
Espécies Reativas de Oxigênio/metabolismo
Estatísticas não Paramétricas
Estresse Oxidativo/fisiologia
Limites: Humanos
Masculino
Feminino
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-886834
Autor: BIANCHINI, MATHEUS C; GALVÃO, DENNYURA O; TAMBORENA, TATIANA; ALVES, CLAUDIA O; PUNTEL, ROBSON L.
Título: Mentha pulegium crude extracts induce thiol oxidation and potentiate hemolysis when associated to t-butyl hydroperoxide in human's erythrocytes
Fonte: An. acad. bras. ciênc;89(4):2901-2909, Oct.-Dec. 2017. tab, graf.
Idioma: en.
Projeto: Coordenação de Aperfeiçoamento Pessoal de Nível Superior (CAPES), Financiadora de Estudos e Projetos (FINEP), Instituto Nacional de Ciência e Tecnologia - Excitotoxicidade e Neuroproteção (INCT-EN), UNIPAMPA.
Resumo: ABSTRACT Mentha pulegium (Lamiaceae) tea has been used as a traditional medicine; however, the modulatory effect of M. pulegium extracts on damage to human erythrocytes associated to t-butyl hydroperoxide (t-BHP) exposure remains to be investigated. Accordingly, we perform this study in order to test the hypothesis that aqueous and ethanolic extracts of M. pulegium could modulate the hemolysis associated to t-BHP exposure, non-protein thiol (NPSH) oxidation and lipid peroxidation (measured as thiobarbituric acid reactive substances - TBARS) in human erythrocytes. Samples were co-incubated with t-BHP (4 mmol/L) and/or aqueous or ethanolic extracts (10-1000 mg/mL) during 120 min to further analysis. We found that both extracts, when associated to t-BHP, potentiate NPSH oxidation and hemolysis. Moreover, both extracts significantly prevents against t-BHP-induced TBARS production. A significant correlation among hemolysis and NPSH levels was found. Taking together, our data points that the association of M. pulegium extracts with t-BHP culminates in toxic effect to exposed erythrocytes, besides its protective effect against t-BHP-induced TBARS production. So, we infer that the use of this extract may exert negative effect during painful crisis in sickle cell anemia. However, more studies are still necessary to better investigate/understand the mechanism(s) involved in the toxic effect resultant from this association.
Descritores: Extratos Vegetais/farmacologia
Peroxidação de Lipídeos/efeitos dos fármacos
Mentha pulegium/química
terc-Butil Hidroperóxido/farmacologia
Eritrócitos/efeitos dos fármacos
Hemólise/efeitos dos fármacos
-Oxirredução
Compostos de Sulfidrila
Cromatografia Líquida de Alta Pressão
Estresse Oxidativo
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-886876
Autor: RECH, VIRGINIA C; MEZZOMO, NATHANA J; ATHAYDES, GENARO A; FEKSA, LUCIANE R; FIGUEIREDO, VANDRÉ C; KESSLER, ADRIANA; FRANCESCHI, ITIANE D DE; WANNMACHER, CLOVIS M D.
Título: Thiol/disulfide status regulates the activity of thiol-containing kinases related to energy homeostasis in rat kidney
Fonte: An. acad. bras. ciênc;90(1):99-108, Mar. 2018. graf.
Idioma: en.
Resumo: ABSTRACT Considering that thiol-containing enzymes like kinases are critical for several metabolic pathways and energy homeostasis, we investigated the effects of cystine dimethyl ester and/or cysteamine administration on kinases crucial for energy metabolism in the kidney of Wistar rats. Animals were injected twice a day with 1.6 µmol/g body weight cystine dimethyl ester and/or 0.26 µmol/g body weight cysteamine from the 16th to the 20th postpartum day and euthanized after 12 hours. Pyruvate kinase, adenylate kinase, creatine kinase activities and thiol/disulfide ratio were determined. Cystine dimethyl ester administration reduced thiol/disulfide ratio and inhibited the kinases activities. Cysteamine administration increased the thiol/disulfide ratio and co-administration with cystine dimethyl ester prevented the inhibition of the enzymes. Regression between the thiol/disulfide ratio, and the kinases activities were significant. These results suggest that redox status may regulate energy metabolism in the rat kidney. If thiol-containing enzymes inhibition and oxidative stress occur in patients with cystinosis, it is possible that lysosomal cystine depletion may not be the only beneficial effect of cysteamine administration, but also its antioxidant and thiol-protector effect.
Descritores: Compostos de Sulfidrila
Cisteamina/farmacologia
Cistina/análogos & derivados
Dissulfetos
Homeostase/efeitos dos fármacos
Rim/efeitos dos fármacos
-Adenilato Quinase/análise
Adenilato Quinase/efeitos dos fármacos
Reprodutibilidade dos Testes
Ratos Wistar
Creatina Quinase/análise
Creatina Quinase/efeitos dos fármacos
Cistina/farmacologia
Eliminadores de Cistina/farmacologia
Limites: Animais
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
Rodrigues, Luiz E. A
Texto completo
Id: lil-792749
Autor: Lázaro, Cristiane P; Pondé, Milena P; Rodrigues, Luiz E. A.
Título: Opioid peptides and gastrointestinal symptoms in autism spectrum disorders
Fonte: Rev. bras. psiquiatr;38(3):243-246, July-Sept. 2016.
Idioma: en.
Resumo: Autism spectrum disorders (ASDs) are characterized by deficits in the individual’s ability to socialize, communicate, and use the imagination, in addition to stereotyped behaviors. These disorders have a heterogenous phenotype, both in relation to symptoms and regarding severity. Organic problems related to the gastrointestinal tract are often associated with ASD, including dysbiosis, inflammatory bowel disease, exocrine pancreatic insufficiency, celiac disease, indigestion, malabsorption, food intolerance, and food allergies, leading to vitamin deficiencies and malnutrition. In an attempt to explain the pathophysiology involved in autism, a theory founded on opioid excess has been the focus of various investigations, since it partially explains the symptomatology of the disorder. Another hypothesis has been put forward whereby the probable triggers of ASDs would be related to the presence of bacteria in the bowel, oxidative stress, and intestinal permeability. The present update reviews these hypotheses.
Descritores: Peptídeos Opioides/efeitos adversos
Peptídeos Opioides/metabolismo
Transtorno do Espectro Autista/etiologia
Transtorno do Espectro Autista/metabolismo
Gastroenteropatias/metabolismo
-Compostos de Sulfidrila/metabolismo
Estresse Oxidativo
Peptídeos Opioides/análise
Trato Gastrointestinal/fisiopatologia
Trato Gastrointestinal/metabolismo
Trato Gastrointestinal/microbiologia
Transtorno do Espectro Autista/fisiopatologia
Microbioma Gastrointestinal
Gastroenteropatias/fisiopatologia
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME



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