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Texto completo SciELO Brasil
Chieffi, Pedro Paulo
Texto completo
Id: lil-761169
Autor: LESCANO, Susana A. Zevallos; SANTOS, Sergio Vieira dos; ASSIS, Jesiel Maurício Lemos; CHIEFFI, Pedro Paulo.
Título: Efficacy of nitazoxanide against toxocara canis: larval recovery and humoral immune response in experimentally infected mice / Eficácia da nitazoxanida contra Toxocara canis: recuperação larvária e resposta imune humoral em camundongos experimentalmente infectados
Fonte: Rev. Inst. Med. Trop. Säo Paulo;57(4):337-341, July-Aug. 2015. tab, ilus.
Idioma: en.
Resumo: SUMMARYThe efficacy of nitazoxanide (NTZ) against toxocariasis was investigated in an experimental murine model and results were compared to those obtained using mebendazole. Sixty male BALB/c mice, aged six to eight weeks-old, were divided into groups of 10 each; fifty were orally infected with 300 larvaed eggs of T. canisand grouped as follows, G I: infected untreated mice; G II: infected mice treated with MBZ (15 mg/kg/day) 10 days postinfection (dpi); G III: infected mice treated with NTZ (20 mg/kg/day) 10 dpi; G IV: infected mice treated with MBZ 60 dpi; G V: infected mice treated with NTZ 60 dpi; GVI: control group comprising uninfected mice. Mice were bled via retro-orbital plexus on four occasions between 30 and 120 dpi. Sera were processed using the ELISA technique to detect IgG anti- Toxocaraantibodies. At 120 dpi, mice were sacrificed for larval recovery in the CNS, liver, lungs, kidneys, eyes and carcass. Results showed similar levels of anti- ToxocaraIgG antibodies among mice infected but not submitted to treatment and groups treated with MBZ or NTZ, 10 and 60 dpi. Larval recovery showed similar values in groups treated with NTZ and MBZ 10 dpi. MBZ showed better efficacy 60 dpi, with a 72.6% reduction in the parasite load compared with NTZ, which showed only 46.5% reduction. We conclude that administration of these anthelmintics did not modify the humoral response in experimental infection by T. canis. No parasitological cure was observed with either drug; however, a greater reduction in parasite load was achieved following treatment with MBZ.

RESUMOFoi investigada a eficácia da nitazoxanida (NTZ) na toxocaríase murina experimental e os resultados comparados com os obtidos usando mebendazol (MBZ). Sessenta camundongos BALB/c machos, com idade entre seis e oito semanas foram divididos em grupos de 10 cada, 50 foram infectados oralmente com 300 ovos larvados de T. canise agrupados a seguir: GI: camundongos infectados não tratados; GII: camundongos infectados tratados com MBZ (15 mg/kg/dia) 10 dias pós-infecção (dpi); GIII: camundongos infectados tratados com NTZ (20 mg/kg/dia) 10 dpi, GIV: camundongos infectados tratados com MBZ 60 dpi; GV: camundongos infectados tratados com NTZ 60 dpi; GVI: controle não infectado. Os camundongos foram sangrados via plexo retro orbitário em quatro ocasiões entre o 30º e 120º dpi. Os soros foram processados pela técnica de ELISA para detecção de anticorpos IgG anti- Toxocara.Aos 120 dpi, os animais foram sacrificados para a recuperação larvária do SNC, fígado, pulmões, rins, olhos e carcaça. Os resultados mostraram níveis similares de anticorpos IgG anti- Toxocaraentre os camundongos infectados mas não submetidos a tratamento e os grupos infectados e tratados com MBZ ou NTZ, aos 10 e 60 dpi. Os valores da recuperação larval foram similares nos grupos tratados com NTZ e MBZ 10 dpi. MBZ mostrou melhor eficácia aos 60 dpi, com redução de 72,6% da carga parasitária comparada com NTZ, que mostrou redução somente de 46,5%. Concluímos que a administração destes anti-helmínticos não modificou a resposta humoral na infecção experimental por T. canis. Não foi observada cura parasitológica com nenhuma das drogas; porém maior redução na carga parasitária foi obtida após o tratamento com MBZ.
Descritores: Anti-Helmínticos/administração & dosagem
Anticorpos Anti-Helmínticos/sangue
Mebendazol/administração & dosagem
Tiazóis/administração & dosagem
Toxocara canis/efeitos dos fármacos
Toxocaríase/tratamento farmacológico
-Modelos Animais de Doenças
Imunidade Humoral
Larva/efeitos dos fármacos
Camundongos Endogâmicos BALB C
Contagem de Ovos de Parasitas
Toxocaríase/imunologia
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
Texto completo
Id: biblio-991375
Autor: Enríquez, Andrés; Baranchuk, Adrian; Corbalán, Ramón.
Título: Manejo de hemorragia asociada a anticoagulantes orales directos: estado actual de las estrategias de reversión / Management of bleeding associated with direct oral anticoagulants: update on reversal strategies
Fonte: Rev. méd. Chile;147(1):73-82, 2019. tab, graf.
Idioma: es.
Resumo: Direct oral anticoagulants (DOACs), including the direct thrombin inhibitor dabigatran and the direct factor Xa inhibitors rivaroxaban, apixaban and edoxaban have at least comparable efficacy as vitamin K antagonists along with a better safety profile, reflected by a lower incidence of intracranial hemorrhage. Specific reversal agents have been developed in recent years. Namely, idarucizumab, a specific antidote for dabigatran, is currently approved in most countries. Andexanet, which reverses factor Xa inhibitors, has been recently approved by the FDA, and ciraparantag, a universal antidote targeted to reverse all DOACs, is still under investigation. In this review we provide an update on the pharmacology of DOACs, the risk of hemorrhagic complications associated with their use, the measurement of their anticoagulant effect and the reversal strategies in case of DOAC-associated bleeding.
Descritores: Fatores de Coagulação Sanguínea/uso terapêutico
Antitrombinas/administração & dosagem
Antitrombinas/efeitos adversos
Anticorpos Monoclonais Humanizados/uso terapêutico
Hemorragia/induzido quimicamente
Hemorragia/terapia
-Pirazóis/administração & dosagem
Pirazóis/efeitos adversos
Piridinas/administração & dosagem
Piridinas/efeitos adversos
Piridonas/administração & dosagem
Piridonas/efeitos adversos
Tiazóis/administração & dosagem
Tiazóis/efeitos adversos
Administração Oral
Fatores de Risco
Rivaroxabana/administração & dosagem
Rivaroxabana/efeitos adversos
Dabigatrana/administração & dosagem
Dabigatrana/efeitos adversos
Antídotos/uso terapêutico
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Chile
Texto completo
Id: biblio-1011426
Autor: He, Yuzheng; Shi, Yantao; Liu, Ruilin; Wang, Zhichao; Wang, Baohua; Li, Shujun; Zhang, Helin.
Título: PELI3 mediates pro-tumor actions of down-regulated miR-365a-5p in non-small cell lung cancer
Fonte: Biol. Res;52:24, 2019. tab, graf.
Idioma: en.
Resumo: BACKGROUND: To analyze the relative expression of PELI3 and its mechanistic involvement in the non-small cell lung cancer (NSCLC). Methods: PELI3 expression in NSCLC tissue samples was determined by the immunohistochemistry. The transcripts abundance of PELI3 was measured with real-time PCR. The protein intensity was analyzed by western blot. The overall survival in respect to PELI3 or miR-365a-5p expression was plotted by the Kaplan-Meier's analysis. Cell growth was determined by colony formation assay. Cell viability was measured by MTT assay. The migration and invasion were evaluated by wound healing and transwell assay respectively. The regulatory effect of miR-365a-5p on PELI3 was interrogated with luciferase reporter assay. The direct binding between miR-365a-5p and PELI3 was analyzed by pulldown assay. RESULTS: PELI3 was aberrantly up-regulated in NSCLC both in vivo and in vitro. High level of PELI3 associated with poor prognosis. PELI3-deficiency significantly inhibited cell viability, colony formation, migration and invasion. We further identified that miR-365a-5p negatively regulated PELI3 in this disease. Ectopic expression of miR-365a-5p in both A549 and H1299 phenocopied PELI3-deficiency. Meanwhile, PELI3-silencing significantly abolished the pro-tumoral effect elicited by miR-365a-5p inhibition. CONCLUSIONS: Our results highlighted the importance of dysregulated miR-365a-5p-PELI3 signaling axis in NSCLC.
Descritores: Regulação para Baixo/fisiologia
Carcinoma Pulmonar de Células não Pequenas/metabolismo
MicroRNAs/metabolismo
Ubiquitina-Proteína Ligases/metabolismo
Neoplasias Pulmonares/metabolismo
-Sais de Tetrazólio
Tiazóis
Carcinoma Pulmonar de Células não Pequenas/patologia
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
MicroRNAs/uso terapêutico
Linhagem Celular Tumoral
Ubiquitina-Proteína Ligases/farmacologia
Modelos Animais de Doenças
Corantes
Neoplasias Pulmonares/patologia
Neoplasias Pulmonares/tratamento farmacológico
Antineoplásicos/uso terapêutico
Antineoplásicos/farmacologia
Limites: Humanos
Animais
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
Texto completo
Id: biblio-828149
Autor: Fraga, Edmir Geraldo; Nicodemo, Antonio Carlos; Sampaio, Jorge Luiz Mello.
Título: Antimicrobial susceptibility of Brazilian Clostridium difficile strains determined by agar dilution and disk diffusion
Fonte: Braz. j. infect. dis;20(5):476-481, Sept.-Oct. 2016. tab, graf.
Idioma: en.
Resumo: Abstract Clostridium difficile is a leading cause of diarrhea in hospitalized patients worldwide. While metronidazole and vancomycin are the most prescribed antibiotics for the treatment of this infection, teicoplanin, tigecycline and nitazoxanide are alternatives drugs. Knowledge on the antibiotic susceptibility profiles is a basic step to differentiate recurrence from treatment failure due to antimicrobial resistance. Because C. difficile antimicrobial susceptibility is largely unknown in Brazil, we aimed to determine the profile of C. difficile strains cultivated from stool samples of inpatients with diarrhea and a positive toxin A/B test using both agar dilution and disk diffusion methods. All 50 strains tested were sensitive to metronidazole according to CLSI and EUCAST breakpoints with an MIC90 value of 2 μg/mL. Nitazoxanide and tigecycline were highly active in vitro against these strains with an MIC90 value of 0.125 μg/mL for both antimicrobials. The MIC90 were 4 μg/mL and 2 μg/mL for vancomycin and teicoplanin, respectively. A resistance rate of 8% was observed for moxifloxacin. Disk diffusion can be used as an alternative to screen for moxifloxacin resistance, nitazoxanide, tigecycline and metronidazole susceptibility, but it cannot be used for testing glycopeptides. Our results suggest that C. difficile strains from São Paulo city, Brazil, are susceptible to metronidazole and have low MIC90 values for most of the current therapeutic options available in Brazil.
Descritores: Antibacterianos/farmacologia
-Valores de Referência
Tiazóis/farmacologia
Brasil
Ensaio de Imunoadsorção Enzimática
Vancomicina/farmacologia
Contagem de Colônia Microbiana/métodos
Reprodutibilidade dos Testes
Infecções por Clostridium/microbiologia
Teicoplanina/farmacologia
Fluoroquinolonas/farmacologia
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão/métodos
Carga Bacteriana
Moxifloxacina
Tigeciclina
Metronidazol/farmacologia
Minociclina/análogos & derivados
Minociclina/farmacologia
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
Texto completo
Id: biblio-886697
Autor: MONTE, ZENAIDE S; SILVA, AMANDA M; LIMA, GLÁUCIA M S; SILVA, TERESINHA G DA; MARQUES, KARLA M R; RODRIGUES, MARIA D; FALCÃO, EMERSON P S; MELO, SEBASTIÃO J.
Título: Synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities
Fonte: An. acad. bras. ciênc;89(2):1051-1059, Apr.-June 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT A series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. Structures of the compounds were confirmed by IR, 1H-NMR and 13C-NMR and a 2D spectroscopic study was performed. A preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteric; and against the yeast, candida albicans. Further, the Minimum Inhibitory Concentrations (MIC) against the bacteria and yeast were determined. All compounds 3a-d, 3f, 3g, 3i and 3j were also investigated for their low cytotoxic effects on tested cell lines. Compounds 3d and 3f were the most effective derivatives against HL-60 and HEp-2 cells, respectively, with IC50 value (2µg/mL), and low normal cells toxicity.
Descritores: Candida albicans/efeitos dos fármacos
Amidinas/síntese química
Amidinas/farmacologia
Bactérias Gram-Negativas/efeitos dos fármacos
Anti-Infecciosos/síntese química
Anti-Infecciosos/farmacologia
-Espectrofotometria Infravermelho
Sais de Tetrazólio
Tiazóis
Teste de Materiais
Testes de Sensibilidade Microbiana
Reprodutibilidade dos Testes
Testes de Toxicidade
Linhagem Celular Tumoral
Proliferação de Células/efeitos dos fármacos
Limites: Humanos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
Texto completo
Id: biblio-886716
Autor: BASTOS, ISLA V G A; OLIVEIRA, TATIANE B DE; RODRIGUES, MARIA D; MILITÃO, GARDÊNIA C G; SILVA, TERESINHA G DA; TURATTI, IZABEL C C; LOPES, NORBERTO P; MELO, SEBASTIÃO J DE.
Título: Use of GC/MS to identify chemical constituents and cytotoxic activity of the leaves of Phoradendron mucronatum and Phoradendron microphyllum (Viscaceae)
Fonte: An. acad. bras. ciênc;89(2):991-1001, Apr.-June 2017. tab.
Idioma: en.
Resumo: ABSTRACT Phoradendron mucronatum and P. microphyllum are plants that found in tropical and subtropical areas, used in traditional medicine and popularly known as mistle-thrush. The aim of this study was to identify the chemical constituents of different leaf extracts from P. mucronatum and P. microphyllum and assess cytotoxic activity against strains from a human tumour cells. Extracts obtained with hexane, dichloromethane, chloroform and ethyl acetate from the leaves were analysed by gas chromatography coupled with mass spectrometry (GC-MS) and the cytotoxicity was assessed by the MTT method (bromide (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide)). The tested human tumour cells were NCI-H292 (human pulmonar mucoepidermoid carcinoma), MCF-7 (human breast adenocarcinoma) and HEp-2 (epidermoid carcinoma of the larynx). Analysis by GC/MS of the extracts from leaves of P. microphyllum and P. mucronatum detected 51 different compounds, such as alkaloids, diterpenes, triterpenes, sterols, alcohols, aldehydes, fatty acids and hydrocarbons. In the cytotoxic evaluation, hexane and ethyl acetate extracts from the leaves P. microphyllum inhibited cell growth of NCI-H292 strains (72.97%) and HEp-2 (87.53%), respectively. The extracts of P. mucronatum species showed an inhibitory effect towards NCI-H292 (83.19%/hexane), MCF-7 (88.69%/dichloromethane) and HEp-2 (93.40%/hexane). The extracts showed cytotoxic activity against the tested strains, especially the P. mucronatum, which presented the highest percentages of inhibition of cell growth.
Descritores: Extratos Vegetais/química
Folhas de Planta/química
Viscaceae/química
Phoradendron/química
-Sais de Tetrazólio
Tiazóis
Extratos Vegetais/farmacologia
Clorofórmio/química
Reprodutibilidade dos Testes
Testes de Toxicidade
Linhagem Celular Tumoral
Proliferação de Células/efeitos dos fármacos
Células MCF-7
Hexanos/química
Cromatografia Gasosa-Espectrometria de Massas
Cloreto de Metileno/química
Acetatos/química
Limites: Humanos
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-317000
Autor: Silva, Maria Elizabeth Rossi da.
Título: Diabetes Mellitus tipo 2 / Type 2 diabetes mellitus
Fonte: RBM rev. bras. med;58(n.esp):23:28:32:passim-26-30-32, dez. 2001. tab.
Idioma: pt.
Resumo: Atualizaçäo no tratamento do diabetes mellitus tipo 2: dieta, exercícios, novas drogas, importancia da associaçäo de medicamentos para o controle adequado e prevençäo de complicaçöes crônicas.(au)
Descritores: Biguanidas
Acarbose
Insulina
Compostos de Sulfonilureia/efeitos adversos
Compostos de Sulfonilureia/farmacologia
Diabetes Mellitus Tipo 2/diagnóstico
Diabetes Mellitus Tipo 2/terapia
Tiazóis/farmacologia
Limites: Humanos
Responsável: BR12.1 - Biblioteca Setorial da Ciências da Saúde


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Texto completo SciELO Brasil
Malafaia, Osvaldo
Texto completo
Id: lil-783801
Autor: Sousa, Eros Luiz de; Wouk, Antônio Felipe Paulino de Figueiredo; Malafaia, Osvaldo; Ribas-Filho, Jurandir Marcondes; Noronha, Lucia; Cirio, Silvana Maris; PimpãoVII, Claudia Turra; Marinho Júnior, Carlos Hespanha; Torres, Maria Fernanda; Graça, Yorgos Luiz Santos de Salles; Ferrarin, Daniel Dantas.
Título: Immediate postoperative evaluation of enteric anastomosis after the use of meloxicam in rats
Fonte: Acta cir. bras;31(5):320-326, May 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE : To compare ileal anastomoses in the immediate postoperative healing period after meloxicam use. METHODS: Forty two male Wistar rats were randomly divided into two groups of 21, COX and control group. To COX meloxicam in combination with morphine was given in 3 days period. Control group received only morphine during the same period. Each group was divided into three sub-groups of 7, which were euthanized at 5, 10, and 21 days postoperatively. Comparison was based in histological evaluation of collagen type I and III using sirius red, immunohistochemical through vascular endothelial growth factor and matrix metalloproteinase-9. RESULTS: Healing process in scheduled periods did not show significant differences (p>0.05) between the COX and control groups during any of the periods. CONCLUSION: The use of meloxicam in the postoperative period following ileal anastomosis did not affect healing.
Descritores: Tiazinas/farmacologia
Tiazóis/farmacologia
Cicatrização/efeitos dos fármacos
Anti-Inflamatórios não Esteroides/farmacologia
Inibidores de Ciclo-Oxigenase/farmacologia
Íleo/cirurgia
-Período Pós-Operatório
Fatores de Tempo
Anastomose Cirúrgica
Distribuição Aleatória
Ratos Wistar
Neovascularização Fisiológica/efeitos dos fármacos
Metaloproteinase 9 da Matriz/efeitos dos fármacos
Metaloproteinase 9 da Matriz/metabolismo
Modelos Animais
Colágeno Tipo I/metabolismo
Colágeno Tipo III/metabolismo
Receptores de Fatores de Crescimento do Endotélio Vascular/efeitos dos fármacos
Receptores de Fatores de Crescimento do Endotélio Vascular/metabolismo
Íleo/irrigação sanguínea
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-1016571
Autor: Duarte, Daniel Alejandro.
Título: Puntuación de riesgo útil para la selección de un anticoagulante oral directo vs antagonista de la vitamina K / Useful risk score for the selection of an antagonist vs non-antagonist of vitamin K oral anticoagulant
Fonte: Evid. actual. práct. ambul;21(2):60-60, jul. 2018. tab..
Idioma: es.
Descritores: Piridinas/uso terapêutico
Fibrilação Atrial/complicações
Tiazóis/uso terapêutico
Varfarina/uso terapêutico
Acidente Vascular Cerebral/prevenção & controle
Anticoagulantes/uso terapêutico
-Ensaios Clínicos Controlados Aleatórios como Assunto
Método Duplo-Cego
Fatores de Risco
Estudos Multicêntricos como Assunto
Resultado do Tratamento
Medição de Risco
Inibidores do Fator Xa/uso terapêutico
Hemorragia/induzido quimicamente
Limites: Humanos
Masculino
Feminino
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Comentário
Responsável: AR2.1 - Biblioteca Central


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Texto completo SciELO Brasil
Texto completo
Texto completo
Id: biblio-1011650
Autor: Resende, Marina Ferrara de; Lino, Cleudiomar Inácio; Souza-Fagundes, Elaine Maria de; Rettore, João Vitor Paes; Oliveira, Renata Barbosa de; Labanca, Renata Adriana.
Título: Assessment of anti-diabetic activity of a novel hydrazine-thiazole derivative: in vitro and in vivo method
Fonte: Braz. j. pharm. sci;55:e18218, 2019. tab, graf.
Idioma: en.
Resumo: Diabetes mellitus is a chronic disease resulting in oxidative stress that promotes tissue damage. The appearance of this disease is highly related to lifestyle and food of the population, being of great interest to search for a dietary supplement that can also act by reducing oxidative alterations. Based on the broad range of biological activity of thiazole derivatives, this work aimed to evaluate the in vitro antioxidant activity of a novel hydrazine-thiazole derivative and studies in vivo. In in vivo experiments, the liver extracts of healthy and diabetic Wistar rats were used, with analysis to determine the enzymatic activity of SOD, CAT, GPx, and GR, and determination of lipid peroxidation. Finally, in the blood of these animals, biochemical parameters were evaluated. Statistical evidence of changes caused in liver enzymes and liquid peroxidation was not detected; however, these parameters were also not changed between control groups with and without diabetes. On the other hand, concerning biochemical parameters, significant differences were detected in uric acid, alkaline phosphatase, ALT, and urea, indicating a possible antioxidant protective role of such substances in the liver and kidney of diabetic animals that could be acting by means other than that commonly reported in the literature.
Descritores: Tiazóis/análise
Técnicas In Vitro/métodos
Hidrazinas/análise
-Estresse Oxidativo/fisiologia
Suplementos Nutricionais
Diabetes Mellitus/tratamento farmacológico
Antioxidantes/análise
Limites: Animais
Masculino
Ratos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas



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