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Id: biblio-1019895
Autor: Özkidik, Mete; Coskun, Alper; Asutay, Mehmet Kazim; Bahçeci, Tuncer; Hamidi, Nurullah.
Título: Efficacy and tolerability of mirabegron in female patients with overactive bladder symptoms after surgical treatment for stress urinary incontinence
Fonte: Int. braz. j. urol;45(4):782-789, July-Aug. 2019. tab.
Idioma: en.
Resumo: ABSTRACT Purpose To evaluate the efficacy and tolerability of mirabegron in females with overactive bladder (OAB) symptoms after surgical treatment for stress urinary incontinence (SUI). Materials and Methods The study was conducted with a prospective, randomized and double-blinded design. 62 patients over the age of 40 who met the inclusion-exclusion criterias of the study were enrolled and randomly divided into two groups as Group A (mirabegron 50mg) and B (solifenacin 5mg). Patients were compared based on efficacy of treatment [Patient Perception of Bladder Condition (PPBC) scale and micturition diaries], safety of treatment (heart rate, systolic and diastolic blood pressure, adverse events), number of micturitions per day, patient's satisfaction status after treatment [Visual Analog Scale(VAS)] and quality of life. Results The mean age of the population was 48.2±3.8 years and the duration of OAB symptoms was 5.9±2.9 months. Baseline values for the mean number of micturitions, volume voided in each micturition, nocturia episodes, urgency and urgency incontinence episodes were 15.3±0.34, 128±3.88mL, 3.96±1.67, 5.72±1.35 and 4.22±0.69, respectively. After treatment, values for these parameters were 11.7±0.29, 164.7±2.9mL, 2.25±0.6, 3.38±0.71, 2.31±0.49 respectively. Quality of life score, symptom bother score, VAS for treatment satisfaction score, PPBC score after treatment were 66.1±0.85, 43.7±0.77, 4.78±0.14, 4.78±0.14, respectively. There were no significant differences between two groups on any parameter. However, mirabegron showed better tolerability than solifenacin, particularly after 6 months. Conclusion Mirabegron is safe, effective and tolerable in the long-term treatment of females with OAB symptoms after surgery for stress urinary incontinence.
Descritores: Tiazóis/uso terapêutico
Incontinência Urinária por Estresse/cirurgia
Bexiga Urinária Hiperativa/tratamento farmacológico
Agonistas de Receptores Adrenérgicos beta 3/uso terapêutico
Acetanilidas/uso terapêutico
-Qualidade de Vida
Valores de Referência
Incontinência Urinária por Estresse/fisiopatologia
Método Duplo-Cego
Estudos Prospectivos
Reprodutibilidade dos Testes
Resultado do Tratamento
Antagonistas Muscarínicos/uso terapêutico
Bexiga Urinária Hiperativa/fisiopatologia
Escala Visual Analógica
Succinato de Solifenacina/uso terapêutico
Pessoa de Meia-Idade
Limites: Humanos
Feminino
Adulto
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: biblio-950750
Autor: Pieme, Constant Anatole; Santosh, Guru Kumar; Tekwu, Emmanuel Mouafo; Askun, Tülin; Aydeniz, Hatice; Ngogang, Jeanne Yonkeu; Bhushan, Shashi; Saxena, Ajit Kumar.
Título: Fruits and barks extracts of Zanthozyllum heitzii a spice from Cameroon induce mitochondrial dependent apoptosis and Go/G1 phase arrest in human leukemia HL-60 cells
Fonte: Biol. Res;47:1-13, 2014. ilus, graf, tab.
Idioma: en.
Resumo: BACKGROUND: Zanthoxylum heitzii is a spice used to prepare several dishes and to treat tumors, syphilis, malaria, cardiac palpitations, urogenital infections in the west region of Cameroon, but the antitumor mechanisms and chemical composition are not yet investigated. This study was aimed to determine the antiproliferative effects of four extracts from the fruits and barks of Zanthoxyllum heitzii (Rutaceae) on apoptosis in human promyelocytic cells, their mechanisms and the chemical composition. The 3-(4, 5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to determine the fifty percent inhibition (IC50) concentration of the cell lines after treatment. The effect on morphology was observed using a light or fluorescence microscopy. The rate of apoptosis and the cell cycle were measured using flow cytometry (FCM). The phytochemical analysis of the extract was carried with HPLC/MS methods. RESULTS: The phytochemical analysis of the extracts indicated the presence of four known polyphenols (Syringic acid, Juglon, Luteolin and Myricetin) in both fruits and barks of Z. heitzii but in different quantities. Syringic acid and Myricetin concentrations were between 17-21 fold higher in the fruits than the stem bark. Rhamnetin (393.35 µg/mL) and Oleuropein (63.10 µg/mL) were identified only in the stem barks of Z. heitzii. Among the four extracts tested for cytotoxicity properties, only the methanol extract of fruits and barks significantly inhibited cell proliferation of HL-60 cells with IC50 value of 20 µg/mL and 12 µg/mL respectively. HL-60 cells treated with Z. heitzii extracts significantly produced reactive oxygen species (ROS) with concurrent loss of mitochondrial membrane potential (MMP). Modifications in the DNA distribution and enhanced of G1/G0 phase cell cycle arrest were observed in a concentration dependent manner. CONCLUSIONS: Polyphenols from Z. heitzii plant exert inhibitory effect on HL-60 cells through the reactive oxygen species (ROS) generation, loss of mitochondrial membrane potential and cell cycle destabilization.
Descritores: Apoptose/efeitos dos fármacos
Casca de Planta/química
Zanthoxylum/química
Pontos de Checagem da Fase G1 do Ciclo Celular/efeitos dos fármacos
Frutas/química
Mitocôndrias/fisiologia
-Espectrometria de Massas
Sais de Tetrazólio
Tiazóis
Camarões
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/química
Cromatografia Líquida de Alta Pressão
Especiarias/análise
Espécies Reativas de Oxigênio/análise
Células HL-60
Concentração Inibidora 50
Proliferação de Células/efeitos dos fármacos
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Polifenóis/análise
Citometria de Fluxo
Microscopia de Fluorescência
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1016571
Autor: Duarte, Daniel Alejandro.
Título: Puntuación de riesgo útil para la selección de un anticoagulante oral directo vs antagonista de la vitamina K / Useful risk score for the selection of an antagonist vs non-antagonist of vitamin K oral anticoagulant
Fonte: Evid. actual. práct. ambul;21(2):60-60, jul. 2018. tab..
Idioma: es.
Descritores: Piridinas/uso terapêutico
Fibrilação Atrial/complicações
Tiazóis/uso terapêutico
Varfarina/uso terapêutico
Acidente Vascular Cerebral/prevenção & controle
Anticoagulantes/uso terapêutico
-Ensaios Clínicos Controlados Aleatórios como Assunto
Método Duplo-Cego
Fatores de Risco
Estudos Multicêntricos como Assunto
Resultado do Tratamento
Medição de Risco
Inibidores do Fator Xa/uso terapêutico
Hemorragia/induzido quimicamente
Limites: Humanos
Masculino
Feminino
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Comentário
Responsável: AR2.1 - Biblioteca Central


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Chieffi, Pedro Paulo
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Id: lil-761169
Autor: Lescano, Susana A Zevallos; Santos, Sergio Vieira dos; Assis, Jesiel Maurício Lemos; Chieffi, Pedro Paulo.
Título: Efficacy of nitazoxanide against toxocara canis: larval recovery and humoral immune response in experimentally infected mice / Eficácia da nitazoxanida contra Toxocara canis: recuperação larvária e resposta imune humoral em camundongos experimentalmente infectados
Fonte: Rev. Inst. Med. Trop. Säo Paulo;57(4):337-341, July-Aug. 2015. tab, ilus.
Idioma: en.
Resumo: SUMMARYThe efficacy of nitazoxanide (NTZ) against toxocariasis was investigated in an experimental murine model and results were compared to those obtained using mebendazole. Sixty male BALB/c mice, aged six to eight weeks-old, were divided into groups of 10 each; fifty were orally infected with 300 larvaed eggs of T. canisand grouped as follows, G I: infected untreated mice; G II: infected mice treated with MBZ (15 mg/kg/day) 10 days postinfection (dpi); G III: infected mice treated with NTZ (20 mg/kg/day) 10 dpi; G IV: infected mice treated with MBZ 60 dpi; G V: infected mice treated with NTZ 60 dpi; GVI: control group comprising uninfected mice. Mice were bled via retro-orbital plexus on four occasions between 30 and 120 dpi. Sera were processed using the ELISA technique to detect IgG anti- Toxocaraantibodies. At 120 dpi, mice were sacrificed for larval recovery in the CNS, liver, lungs, kidneys, eyes and carcass. Results showed similar levels of anti- ToxocaraIgG antibodies among mice infected but not submitted to treatment and groups treated with MBZ or NTZ, 10 and 60 dpi. Larval recovery showed similar values in groups treated with NTZ and MBZ 10 dpi. MBZ showed better efficacy 60 dpi, with a 72.6% reduction in the parasite load compared with NTZ, which showed only 46.5% reduction. We conclude that administration of these anthelmintics did not modify the humoral response in experimental infection by T. canis. No parasitological cure was observed with either drug; however, a greater reduction in parasite load was achieved following treatment with MBZ.

RESUMOFoi investigada a eficácia da nitazoxanida (NTZ) na toxocaríase murina experimental e os resultados comparados com os obtidos usando mebendazol (MBZ). Sessenta camundongos BALB/c machos, com idade entre seis e oito semanas foram divididos em grupos de 10 cada, 50 foram infectados oralmente com 300 ovos larvados de T. canise agrupados a seguir: GI: camundongos infectados não tratados; GII: camundongos infectados tratados com MBZ (15 mg/kg/dia) 10 dias pós-infecção (dpi); GIII: camundongos infectados tratados com NTZ (20 mg/kg/dia) 10 dpi, GIV: camundongos infectados tratados com MBZ 60 dpi; GV: camundongos infectados tratados com NTZ 60 dpi; GVI: controle não infectado. Os camundongos foram sangrados via plexo retro orbitário em quatro ocasiões entre o 30º e 120º dpi. Os soros foram processados pela técnica de ELISA para detecção de anticorpos IgG anti- Toxocara.Aos 120 dpi, os animais foram sacrificados para a recuperação larvária do SNC, fígado, pulmões, rins, olhos e carcaça. Os resultados mostraram níveis similares de anticorpos IgG anti- Toxocaraentre os camundongos infectados mas não submetidos a tratamento e os grupos infectados e tratados com MBZ ou NTZ, aos 10 e 60 dpi. Os valores da recuperação larval foram similares nos grupos tratados com NTZ e MBZ 10 dpi. MBZ mostrou melhor eficácia aos 60 dpi, com redução de 72,6% da carga parasitária comparada com NTZ, que mostrou redução somente de 46,5%. Concluímos que a administração destes anti-helmínticos não modificou a resposta humoral na infecção experimental por T. canis. Não foi observada cura parasitológica com nenhuma das drogas; porém maior redução na carga parasitária foi obtida após o tratamento com MBZ.
Descritores: Anti-Helmínticos/administração & dosagem
Anticorpos Anti-Helmínticos/sangue
Mebendazol/administração & dosagem
Tiazóis/administração & dosagem
Toxocara canis/efeitos dos fármacos
Toxocaríase/tratamento farmacológico
-Modelos Animais de Doenças
Imunidade Humoral
Larva/efeitos dos fármacos
Camundongos Endogâmicos BALB C
Contagem de Ovos de Parasitas
Toxocaríase/imunologia
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: biblio-990335
Autor: Chen, Lingdi; Zhang, Yu.
Título: Determination of Mirabegron in rat plasma by UPLC-MS/MS after oral and intravenous administration
Fonte: Rev. Assoc. Med. Bras. (1992);65(2):141-148, Feb. 2019. tab, graf.
Idioma: en.
Projeto: Ministry of Health of the People's Republic of China.
Resumo: SUMMARY Mirabegron is a kind of β3 adrenergic receptor agonist which is an effective drug for the treatment of overactive bladder. In this research, a UPLC-MS/MS method is developed and validated for the study of mirabegron pharmacokinetic in rats. A protein precipitation method is applied for sample preparation with acetonitrile. m/z 397.3→379.6, m/z 326.4→121.0 for mirabegron, tolterodine (IS), respectively in the positive ion mode was performed for quantitation. The method is reliable and reproducible in our study (intra-day precision≤11.06%, inter-day precision≤11.43%) with concentration curves linear from 5 to 2500 ng/mL(R2>0.999). Stability studies demonstrated that mirabegron was stable under a variety of storage conditions. This method was successfully applied for determining mirabegron in rats after oral and intravenous administration.

RESUMO Mirabegron é um tipo de agonista do receptor adrenérgico beta 3 que demonstra eficácia no tratamento de bexiga hiperativa. Nesta pesquisa, o método UPLC-MS/MS é desenvolvido e validado para o estudo da farmacocinética mirabegron em ratos. Um método de precipitação de proteínas é aplicado para a preparação de amostras com acetonitrilo. 397.3 → 379.6 M / Z, M / Z 326.4 → 121.0 para mirabegron, tolterodina (IS), respectivamente, para o íon positivo foi realizado para quantificação. O método é fiável e reprodutível em nosso estudo (precisão intradia ≤ 11,06%; precisão entredia ≤ 11.43%), com curvas de concentração linear de 5 a 2 ng/ml (R2 > 0,999). Estudos de estabilidade demonstraram que mirabegron permanece estável sob uma variedade de condições de armazenamento. Este método foi aplicado com sucesso para a determinação de mirabegron em ratos após administração oral e intravenosa.
Descritores: Tiazóis/farmacocinética
Agonistas de Receptores Adrenérgicos beta 3/farmacocinética
Acetanilidas/farmacocinética
-Tiazóis/administração & dosagem
Tiazóis/sangue
Administração Oral
Reprodutibilidade dos Testes
Cromatografia Líquida de Alta Pressão
Ratos Sprague-Dawley
Espectrometria de Massas em Tandem
Agonistas de Receptores Adrenérgicos beta 3/administração & dosagem
Agonistas de Receptores Adrenérgicos beta 3/sangue
Administração Intravenosa
Acetanilidas/administração & dosagem
Acetanilidas/sangue
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1003062
Autor: Sacomani, Carlos Alberto Ricetto; Almeida, Fernando Gonçalves de; Silvinato, Antônio; Bernardo, Wanderley M.
Título: Overactive bladder - pharmacological treatment
Fonte: Rev. Assoc. Med. Bras. (1992);65(4):487-492, Apr. 2019.
Idioma: en.
Resumo: The Guidelines Project, an initiative of the Brazilian Medical Association, aims to combine information from the medical field in order to standardize producers to assist the reasoning and decision-making of doctors. The information provided through this project must be assessed and criticized by the physician responsible for the conduct that will be adopted, depending on the conditions and the clinical status of each patient.
Descritores: Tiazóis/administração & dosagem
Antagonistas Muscarínicos/administração & dosagem
Bexiga Urinária Hiperativa/tratamento farmacológico
Agonistas de Receptores Adrenérgicos beta 3/administração & dosagem
Acetanilidas/administração & dosagem
-Pirrolidinas/administração & dosagem
Benzilatos/administração & dosagem
Benzofuranos/administração & dosagem
Brasil
Quimioterapia Combinada
Tartarato de Tolterodina/administração & dosagem
Succinato de Solifenacina/administração & dosagem
Tomada de Decisão Clínica
Ácidos Mandélicos/administração & dosagem
Antidepressivos/administração & dosagem
Nortropanos/administração & dosagem
Limites: Humanos
Tipo de Publ: Guia de Prática Clínica
Responsável: BR1.1 - BIREME


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Id: biblio-991375
Autor: Enríquez, Andrés; Baranchuk, Adrian; Corbalán, Ramón.
Título: Manejo de hemorragia asociada a anticoagulantes orales directos: estado actual de las estrategias de reversión / Management of bleeding associated with direct oral anticoagulants: update on reversal strategies
Fonte: Rev. méd. Chile;147(1):73-82, 2019. tab, graf.
Idioma: es.
Resumo: Direct oral anticoagulants (DOACs), including the direct thrombin inhibitor dabigatran and the direct factor Xa inhibitors rivaroxaban, apixaban and edoxaban have at least comparable efficacy as vitamin K antagonists along with a better safety profile, reflected by a lower incidence of intracranial hemorrhage. Specific reversal agents have been developed in recent years. Namely, idarucizumab, a specific antidote for dabigatran, is currently approved in most countries. Andexanet, which reverses factor Xa inhibitors, has been recently approved by the FDA, and ciraparantag, a universal antidote targeted to reverse all DOACs, is still under investigation. In this review we provide an update on the pharmacology of DOACs, the risk of hemorrhagic complications associated with their use, the measurement of their anticoagulant effect and the reversal strategies in case of DOAC-associated bleeding.
Descritores: Fatores de Coagulação Sanguínea/uso terapêutico
Antitrombinas/administração & dosagem
Antitrombinas/efeitos adversos
Anticorpos Monoclonais Humanizados/uso terapêutico
Hemorragia/induzido quimicamente
Hemorragia/terapia
-Pirazóis/administração & dosagem
Pirazóis/efeitos adversos
Piridinas/administração & dosagem
Piridinas/efeitos adversos
Piridonas/administração & dosagem
Piridonas/efeitos adversos
Tiazóis/administração & dosagem
Tiazóis/efeitos adversos
Administração Oral
Fatores de Risco
Rivaroxabana/administração & dosagem
Rivaroxabana/efeitos adversos
Dabigatrana/administração & dosagem
Dabigatrana/efeitos adversos
Antídotos/uso terapêutico
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1011426
Autor: He, Yuzheng; Shi, Yantao; Liu, Ruilin; Wang, Zhichao; Wang, Baohua; Li, Shujun; Zhang, Helin.
Título: PELI3 mediates pro-tumor actions of down-regulated miR-365a-5p in non-small cell lung cancer
Fonte: Biol. Res;52:24, 2019. tab, graf.
Idioma: en.
Resumo: BACKGROUND: To analyze the relative expression of PELI3 and its mechanistic involvement in the non-small cell lung cancer (NSCLC). Methods: PELI3 expression in NSCLC tissue samples was determined by the immunohistochemistry. The transcripts abundance of PELI3 was measured with real-time PCR. The protein intensity was analyzed by western blot. The overall survival in respect to PELI3 or miR-365a-5p expression was plotted by the Kaplan-Meier's analysis. Cell growth was determined by colony formation assay. Cell viability was measured by MTT assay. The migration and invasion were evaluated by wound healing and transwell assay respectively. The regulatory effect of miR-365a-5p on PELI3 was interrogated with luciferase reporter assay. The direct binding between miR-365a-5p and PELI3 was analyzed by pulldown assay. RESULTS: PELI3 was aberrantly up-regulated in NSCLC both in vivo and in vitro. High level of PELI3 associated with poor prognosis. PELI3-deficiency significantly inhibited cell viability, colony formation, migration and invasion. We further identified that miR-365a-5p negatively regulated PELI3 in this disease. Ectopic expression of miR-365a-5p in both A549 and H1299 phenocopied PELI3-deficiency. Meanwhile, PELI3-silencing significantly abolished the pro-tumoral effect elicited by miR-365a-5p inhibition. CONCLUSIONS: Our results highlighted the importance of dysregulated miR-365a-5p-PELI3 signaling axis in NSCLC.
Descritores: Regulação para Baixo/fisiologia
Carcinoma Pulmonar de Células não Pequenas/metabolismo
MicroRNAs/metabolismo
Ubiquitina-Proteína Ligases/metabolismo
Neoplasias Pulmonares/metabolismo
-Sais de Tetrazólio
Tiazóis
Carcinoma Pulmonar de Células não Pequenas/patologia
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
MicroRNAs/uso terapêutico
Linhagem Celular Tumoral
Ubiquitina-Proteína Ligases/farmacologia
Modelos Animais de Doenças
Corantes
Neoplasias Pulmonares/patologia
Neoplasias Pulmonares/tratamento farmacológico
Antineoplásicos/uso terapêutico
Antineoplásicos/farmacologia
Limites: Humanos
Animais
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-828149
Autor: Fraga, Edmir Geraldo; Nicodemo, Antonio Carlos; Sampaio, Jorge Luiz Mello.
Título: Antimicrobial susceptibility of Brazilian Clostridium difficile strains determined by agar dilution and disk diffusion
Fonte: Braz. j. infect. dis;20(5):476-481, Sept.-Oct. 2016. tab, graf.
Idioma: en.
Resumo: Abstract Clostridium difficile is a leading cause of diarrhea in hospitalized patients worldwide. While metronidazole and vancomycin are the most prescribed antibiotics for the treatment of this infection, teicoplanin, tigecycline and nitazoxanide are alternatives drugs. Knowledge on the antibiotic susceptibility profiles is a basic step to differentiate recurrence from treatment failure due to antimicrobial resistance. Because C. difficile antimicrobial susceptibility is largely unknown in Brazil, we aimed to determine the profile of C. difficile strains cultivated from stool samples of inpatients with diarrhea and a positive toxin A/B test using both agar dilution and disk diffusion methods. All 50 strains tested were sensitive to metronidazole according to CLSI and EUCAST breakpoints with an MIC90 value of 2 μg/mL. Nitazoxanide and tigecycline were highly active in vitro against these strains with an MIC90 value of 0.125 μg/mL for both antimicrobials. The MIC90 were 4 μg/mL and 2 μg/mL for vancomycin and teicoplanin, respectively. A resistance rate of 8% was observed for moxifloxacin. Disk diffusion can be used as an alternative to screen for moxifloxacin resistance, nitazoxanide, tigecycline and metronidazole susceptibility, but it cannot be used for testing glycopeptides. Our results suggest that C. difficile strains from São Paulo city, Brazil, are susceptible to metronidazole and have low MIC90 values for most of the current therapeutic options available in Brazil.
Descritores: Antibacterianos/farmacologia
-Valores de Referência
Tiazóis/farmacologia
Brasil
Ensaio de Imunoadsorção Enzimática
Vancomicina/farmacologia
Contagem de Colônia Microbiana/métodos
Reprodutibilidade dos Testes
Infecções por Clostridium/microbiologia
Teicoplanina/farmacologia
Fluoroquinolonas/farmacologia
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão/métodos
Carga Bacteriana
Moxifloxacina
Tigeciclina
Metronidazol/farmacologia
Minociclina/análogos & derivados
Minociclina/farmacologia
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-886697
Autor: MONTE, ZENAIDE S; SILVA, AMANDA M; LIMA, GLÁUCIA M S; SILVA, TERESINHA G DA; MARQUES, KARLA M R; RODRIGUES, MARIA D; FALCÃO, EMERSON P S; MELO, SEBASTIÃO J.
Título: Synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities
Fonte: An. acad. bras. ciênc;89(2):1051-1059, Apr.-June 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT A series of arylamidines 3a-j was designed, synthesized and investigated for antimicrobial activity. Structures of the compounds were confirmed by IR, 1H-NMR and 13C-NMR and a 2D spectroscopic study was performed. A preliminary screening of the antimicrobial tests clearly showed that three out of ten arylamidines, viz, 3f, 3g and 3i, were effective against all the gram-negative bacteria: Klebsiella pneumoniae, Pseudomonas aeruginosa and Salmonella enteric; and against the yeast, candida albicans. Further, the Minimum Inhibitory Concentrations (MIC) against the bacteria and yeast were determined. All compounds 3a-d, 3f, 3g, 3i and 3j were also investigated for their low cytotoxic effects on tested cell lines. Compounds 3d and 3f were the most effective derivatives against HL-60 and HEp-2 cells, respectively, with IC50 value (2µg/mL), and low normal cells toxicity.
Descritores: Candida albicans/efeitos dos fármacos
Amidinas/síntese química
Amidinas/farmacologia
Bactérias Gram-Negativas/efeitos dos fármacos
Anti-Infecciosos/síntese química
Anti-Infecciosos/farmacologia
-Espectrofotometria Infravermelho
Sais de Tetrazólio
Tiazóis
Teste de Materiais
Testes de Sensibilidade Microbiana
Reprodutibilidade dos Testes
Testes de Toxicidade
Linhagem Celular Tumoral
Proliferação de Células/efeitos dos fármacos
Limites: Humanos
Responsável: BR1.1 - BIREME



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde